Higher education increasingly emphasizes the unique role of aesthetic education in cultivating virtue and morality.From the perspective of integrating aesthetic education with teaching,this study develops an analytica...Higher education increasingly emphasizes the unique role of aesthetic education in cultivating virtue and morality.From the perspective of integrating aesthetic education with teaching,this study develops an analytical framework to explore the theoretical foundations,practical pathways,and teaching mechanisms involved in interdisciplinary aesthetic education course construction at Sichuan University.Employing literature analysis and case studies,the paper systematically examines the theoretical basis of aesthetic education and its contemporary demands in higher education.Specifically,it focuses on Sichuan University’s initiatives in aesthetic education curriculum reform,covering practices such as curriculum design,faculty team development,resource coordination,and collaboration between internal and external institutions.Findings suggest that interdisciplinary aesthetic education courses enrich the content of aesthetic education in universities and enhance students’overall competence;however,these courses also face challenges like insufficient faculty and inadequate evaluation mechanisms during implementation.Consequently,this paper proposes strengthening top-level design,refining the curriculum system,enhancing faculty training,and improving evaluation mechanisms as recommendations for future improvement.This research aims to provide valuable references for aesthetic education reform in higher education in the new era,significantly contributing to interdisciplinary synergy and the comprehensive educational goal of integrating moral,intellectual,physical,aesthetic,and labor education.展开更多
China has entered the era of post-poverty alleviation,which effectively links poverty alleviation achievements with rural revitalization strategies.In the era of post-poverty alleviation,in order to effectively promot...China has entered the era of post-poverty alleviation,which effectively links poverty alleviation achievements with rural revitalization strategies.In the era of post-poverty alleviation,in order to effectively promote the sustainable development of poor rural areas,local colleges and universities should actively nurture the self-development skills of the needy.Local colleges and universities should guide the transformation of ideas and concepts,scientifically optimize the allocation of poverty alleviation resources,improve the interest linkage mechanism between colleges and universities,strengthen the investigation and analysis of poverty alleviation projects,improve the convergence of assistance and practice,actively create a good spiritual and cultural environment,uphold the mission of helping cadres,attach importance to the support for the development of characteristic industries,and lastly,promote the convergence of rural revitalization strategies.展开更多
Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of ...Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012.展开更多
Under the background of new liberal arts,in order to run a major well as well as highlight its characteristics and advantages,private colleges and universities cannot do without the construction of professional teachi...Under the background of new liberal arts,in order to run a major well as well as highlight its characteristics and advantages,private colleges and universities cannot do without the construction of professional teaching teams and teaching reforms.Taking Sichuan University of Media and Communication as an example,a series of explorations and practices has been carried out from the aspects of professional team construction,personnel training objectives,professional curriculum system,professional teaching mode,and professional teaching quality,in which good results have been achieved.On this basis,a training base for journalism and communication talents serving the whole Sichuan Province and even the western region is constructed,so that the results of the project have a certain demonstration and promotion value for the construction and development of similar majors in new institutions of higher learning in Sichuan Province.展开更多
The polymer science discipline at Sichuan University(SCU)was founded in 1953 by Prof.Xi Xu,one of the pioneers in polymer materials science and engineering in China and honored as the“Father of Chinese Plastics,”who...The polymer science discipline at Sichuan University(SCU)was founded in 1953 by Prof.Xi Xu,one of the pioneers in polymer materials science and engineering in China and honored as the“Father of Chinese Plastics,”who was also an academician of the Chinese Academy of Sciences.Over a glorious 70-year journey,polymer science at SCU has evolved into a top-notch,globally recognized,and the largest research and teaching center in the realm of polymer science and engineering in China.On the occasion of the 70th anniversary of the establishment of the polymer science discipline at SCU,we extend our deepest gratitude to the visionary founders and every indi-vidual who has contributed to the development of this discipline.展开更多
In China's Republican era(1911-1949)universities were divided into two categories,national and provincial.The president of a national university was in principle appointed by the central government,and its financi...In China's Republican era(1911-1949)universities were divided into two categories,national and provincial.The president of a national university was in principle appointed by the central government,and its financial outlays provided by the treasury;while a provincial university was established by the respective province government,who bore as well its financing and management.In reality,national universities tended to develop from provincial ones,and the process of nationalization was often accompanied by a contest of strength between the central and provincial authorities.展开更多
The Yellow River Basin in Sichuan Province(YRS)is undergoing severe soil erosion and exacerbated ecological vulnerability,which collectively pose formidable challenges for regional water conservation(WC)and sustainabl...The Yellow River Basin in Sichuan Province(YRS)is undergoing severe soil erosion and exacerbated ecological vulnerability,which collectively pose formidable challenges for regional water conservation(WC)and sustainable development.While effectively enhancing WC necessitates a comprehensive understanding of its driving factors and corresponding intervention strategies,existing studies have largely neglected the spatiotemporal heterogeneity of both natural and socio-economic drivers.Therefore,this study explored the spatiotemporal heterogeneity of WC drivers in YRS using multi-scale geographically weighted regression(MGWR)and geographically and temporally weighted regression(GTWR)models from an eco-hydrological perspective.We discovered that downstream regions,which are more developed,achieved significantly better WC than upstream regions.The results also demonstrated that the influence of temperature and wind speed is consistently dominant and temporally stable due to climate stability,while the influence of vegetation shifted from negative to positive around 2010,likely indicating greater benefits from understory vegetation.Economic growth positively impacted WC in upstream regions but had a negative effect in the more developed downstream regions.These findings highlight the importance of targeted water conservation strategies,including locally appropriate revegetation,optimization of agricultural and economic structures,and the establishment of eco-compensation mechanisms for ecological conservation and sustainable development.展开更多
This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analys...This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.展开更多
As an integral component of China’s revolutionary culture,Sichuan’s red culture,with its abundant historical resources and distinctive regional characteristics,provides high-quality educational materials for ideolog...As an integral component of China’s revolutionary culture,Sichuan’s red culture,with its abundant historical resources and distinctive regional characteristics,provides high-quality educational materials for ideological and political education in higher education institutions.The integration of Sichuan’s red culture into university ideological and political education demonstrates both theoretical necessity and practical feasibility,having already yielded remarkable outcomes.This integration must adhere to the principle of unifying teacher guidance with student initiative,comprehensive coverage with focused emphasis,and cultural inheritance with innovative development,thereby fully realizing the educational value of Sichuan’s red culture in collegiate ideological and political education.展开更多
"Sichuan Cuisine Cooking Skills"is a course that focuses on the traditional cooking skills of Sichuan Province in China.It covers not only the historical and cultural background of Sichuan cuisine,but also t..."Sichuan Cuisine Cooking Skills"is a course that focuses on the traditional cooking skills of Sichuan Province in China.It covers not only the historical and cultural background of Sichuan cuisine,but also the cooking techniques,ingredients selection,seasoning skills and dish innovation of Sichuan cuisine.Doing a good job in the teaching of"Sichuan Cuisine Cooking Skills"is of great significance to the cultivation and reserve of culinary professionals in China,and also has an important impact on students'employment competitiveness.Under the background of"new engineering education",the course reform of"Sichuan Cuisine Cooking Skills"was carried out in terms of the construction of teaching staff,teaching methods,students'participation degree and the innovation of course content,and specific reform suggestions were put forward,hoping to effectively promote the sustainable development of"Sichuan Cuisine Cooking Skills"and effectively improve the teaching quality.展开更多
Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological c...Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological conditions.In this study,we conducted experiments using four different sowing dates,the conventional sowing date 1(CS1),CS2(10 d later than CS1),DS1(30 d later than CS1),and DS2(30 d later than CS2),and three rice varieties,i.e.,Yixiangyou 2115,Fyou 498,and Chuanyou 6203.This experiment was conducted at four sites in the Sichuan Basin in 2018 and 2019 to evaluate the infuence of DS on the pasting properties of rice,which are a proxy for the eating and cooking quality(ECQ).In DS1 and DS2,the rice had a signifcantly greater amylose content(AC)but a lower protein content(PC),peak viscosity(PKV),cool paste viscosity(CPV),and hot paste viscosity(HPV)than in CS1 and CS2.Moreover,except for CS2 and DS1 in 2018,DS1 and DS2 led to 2.15-11.19%reductions in breakdown viscosity(BDV)and 23.46-108.47%increases in setback viscosity(SBV).However,the infuence of DS on rice pasting properties varied by study site and rice variety.In 2019,DS1 and DS2 led to BDV reductions of 2.35-9.33,2.61-8.61,10.03-17.78,and 2.06-8.93%,and SBV increases of 2.32-60.93,63.74-144.24,55.46-91.63,and-8.28-65.37%at the Dayi,Anzhou,Nanbu,and Shehong(except for SBV in CS2 and DS1)sites,respectively.DS resulted in greater reductions in PKV,HPV,CPV,and BDV and greater increases in the AC and SBV for Yixiangyou 2115 than for Chuanyou 6203 and Fyou 498.The correlation analysis indicated that PKV and HPV were signifcantly and positively related to the mean,maximum,and minimum temperatures after heading.These temperatures must be greater than 25.9,31.2,and 22.3℃,respectively,to increase the relative BDV and reduce the relative SBV of rice,thereby enhancing ECQ.In conclusion,DS might contribute to a signifcant deterioration in ECQ in machine-transplanted rice in the Sichuan Basin.A mean temperature above 25.9℃ after heading is required to improve the ECQ of rice.展开更多
Widespread soil acidification driven by nitrogen(N)fertilization and precipitation challenges the conventional notion of the long-term stability of soil inorganic carbon(SIC)in agroecosystems.However,the changes in SI...Widespread soil acidification driven by nitrogen(N)fertilization and precipitation challenges the conventional notion of the long-term stability of soil inorganic carbon(SIC)in agroecosystems.However,the changes in SIC with precipitation and N fertilization remain ambiguous.Based on 4,000+soil samples collected in the 1980s and 2010s and by developing machine learning models to fill the missing SIC of soil samples,this study generated 3,697 paired soil samples between the two periods and then investigated the cropland SIC change and explored its relationship with precipitation and N fertilization across the Sichuan Basin,China.The results showed an overall SIC loss,with a decline of the mean SIC by 15.73%.SIC change varied with initial soil pH and initial SIC and exhibited an exponential relationship with soil pH change,indicating the changing role of carbonates in providing acid-buffering capacity.There was a parabolical relationship between the magnitude of SIC decline and N fertilizer rates,and low N fertilizer rates contributed to a reduction in SIC loss,while SIC loss was promoted by N fertilization occurred when N fertilizing rates exceeded 250 kg ha^(-1) yr^(-1).The change in SIC showed a sinusoidal variation with precipitation,with 950 mm being the threshold controlling whether SIC increased or decreased.Meanwhile,N fertilization did not alter the sinusoidal relationship between SIC change and precipitation.In areas with rainfall<950 mm,the high N fertilizer rate did not cause SIC loss,while higher precipitation could also cause larger SIC loss in areas with lower N fertilizer rates.These results suggest that SIC dynamics are jointly driven by precipitation and N fertilization and are controlled by acid-buffering mechanisms associated with initial pH and SIC,with precipitation being the predominant driver.These findings emphasize the need for more regional soil observations and in-depth studies of SIC change and its mechanisms for accurately estimating SIC change.展开更多
The upper reaches of the Yellow River in Sichuan Province are critical area for water conservation and ecological protection in China. However, they are experiencing a range of ecological and environmental challenges,...The upper reaches of the Yellow River in Sichuan Province are critical area for water conservation and ecological protection in China. However, they are experiencing a range of ecological and environmental challenges, including grassland desertification, wetland degradation, and soil erosion, all of which pose significant threats to the environmental sustainability and overall development of the Yellow River Basin. Urbanization can lead to irreversible damage to ecosystems. Therefore, understanding the relationship between urbanization and ecosystems is crucial for fostering sustainable development in the region. With land use and meteorological data in the upper reaches of the Yellow River in Sichuan Province in 2000-2020, and using InVEST model and standardized processing methods, we analyzed the spatiotemporal evolution characteristics of urbanization and four ecosystem services: water conservation, carbon storage, habitat quality, and soil retention. Additionally, we employed the GeoDa bivariate spatial autocorrelation analysis model to reveal the spatial correlations and interactions between urbanization and ecosystems. The results reveal a significant spatial mismatch between urbanization and ecosystem services in the upper Yellow River region of Sichuan Province. While the composite urbanization index decreased from 0.0075 to 0.0042 and remained concentrated in county centers, all ecosystem services showed improvement: water conservation increased from 17.38×10^(9) mm to 23.37×10^(9) mm, carbon storage rose from 936.60 Tg to 938.42 Tg, habitat quality improved from 0.875 to 0.879, and soil retention enhanced from 13.56×10^(8) t to 17.59×10^(8) t. However, these ecological gains were mainly driven by restoration in non-urban southern areas, creating a clear spatial disconnection from urban centers and leading to persistently weak and declining coordination between systems. This spatial decoupling underscores the inadequacy of the current urbanization model in promoting regional ecological synergy. We therefore recommend implementing differentiated zoning strategies: promoting compact development coupled with ecological restoration in county centers, strictly protecting core water conservation and carbon sequestration areas in the southern key ecological zones, and enhancing soilwater conservation and ecological restoration in the vulnerable northern belt, so as to establish an ecological security framework compatible with sustainable urbanization.展开更多
The Canglangpu Formation in the JT1 well area of the Sichuan Basin exhibits strong lateral heterogeneity and complex overpressure mechanisms, leading to ambiguous pore pressure distribution characteristics. Convention...The Canglangpu Formation in the JT1 well area of the Sichuan Basin exhibits strong lateral heterogeneity and complex overpressure mechanisms, leading to ambiguous pore pressure distribution characteristics. Conventional prediction methods, such as the Equivalent Depth Method, are either inapplicable or yield unsatisfactory results (e.g., Fillippone’s method), contributing to frequent drilling incidents like gas kick, overfl ow, and lost circulation, which hinder the safe and effi cient exploration of natural gas. To address these challenges, this paper integrates lithology, physical properties, and overpressure mechanisms of the Canglangpu Formation. From a petrophysical perspective, a pore pressure prediction model independent of lithology and overpressure mechanisms was developed by combining the poroelasticity theory, linear elastic Hooke’s Law, and Biot’s eff ective stress theory, with an analysis of the relationship between carbonate rock strain, external stress, and internal pore pressure. Unlike conventional methods, the model does not rely on the establishment of a normal compaction trend line. Pre-stack seismic inversion was applied to achieve 3D pore pressure prediction for the formation. Results indicate high accuracy, with a relative error of less than 5% compared to measured data, and strong consistency with actual drilling events. The proposed method provides robust technical support for pore pressure prediction in carbonate formations and drilling geological design.展开更多
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute cour...Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.展开更多
Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and nev...Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and never-ending.It also consciously constructs a cosmic life view of the organic,homologous,isomorphic,and harmonious unity of heaven,earth,and man based on human existence and destiny with a rational thinking attitude.The life philosophy of the Huai Nan-zi offers modern people a completely new holistic view of life and medicine.Not only in China,but also in Western countries,studying its medical philosophical ideas helps us better explore the theoretical roots of TCM in the era of globalized medicine.Methods:This paper mainly uses the analysis method of literature review and chinese philosophy intellectual concepts.It employs the I Ching’s image-number logic thinking method to compare images through analogy and the holistic thinking method of the three-talent view of heaven,earth,and human to understand life consciousness.Results:This article mainly interprets medical philosophy in Huai Nan-zi through three aspects:1)The body of Taoism:heaven,earth,and humanity constitute one unity within the body of the universe;2)The spirit of Taoism:keeping the spirit inward,preserving the essence and suppressing the superficial;and 3)The mind of Taoism:the principle of life governed by the dynamics of gain and loss,prosperity and decline.Conclusion:The philosophy of life presented in the Huai Nan-zi ultimately charts a course toward a state of profound theoretical integration.Its“conscious map”does not lead to a fixed destination,but to a continuous and dynamic mode of being–a life of flourishing known in Chinese as yang sheng,the nurturing of life.The destination,therefore,is the journey itself,undertaken with unwavering cosmic awareness and harmony.This ancient text reminds us that a truly healthy life is not a fragmented pursuit of physical fitness,mental peace,or spiritual insight in isolation.Instead,it is the symphony of all three(Taoist body,spirit,and mind),orchestrated by the fundamental principles of the cosmos.By aligning our inner nature with the outer Tao,we transform our existence from a series of reactive struggles into a graceful and spontaneous free flow.In a modern world characterized by fragmentation,overstimulation,and a relentless push against natural rhythms,the Huai Nan-zi’s life consciousness map is more relevant than ever.The philosophy of Huai Nan-zi not only plays a vital role in the construction of the theoretical system of TCM in ancient East life wisdom,but also is worthwhile for Western life sciences to conduct in-depth exploration and discovery in the age of AI.展开更多
Clinically differentiating bipolarⅡdisorder(BD-Ⅱ)from major depressive disorder(MDD)remains a significant challenge in modern psychiatry.These two conditions share substantial clinical symptomatology,making accurate...Clinically differentiating bipolarⅡdisorder(BD-Ⅱ)from major depressive disorder(MDD)remains a significant challenge in modern psychiatry.These two conditions share substantial clinical symptomatology,making accurate diagnosis difficult in routine clinical practice.Misdiagnosis may lead to inappropriate treatment strategies,increased psychological and physical burdens,reduced quality of life,and impaired social functioning.Genetic overlap may partially explain the clinical similarities between MDD and BD-Ⅱ,and biomarkers along with neuroimaging techniques are receiving increasing attention as tools to aid in diagnosis.For example,electroencephalography has been shown to effectively distinguish between unipolar depression and bipolar depression;serum levels of glycogen synthase kinase-3 have also been investigated as a potential tool for differentiating between the two disorders.A comprehensive assessment integrating clinical characteristics,genetic basis research,and multimodal evaluations using neuroimaging and biomarkers through a multidisciplinary approach will help enhance clinicians'ability to distinguish between MDD and BD-Ⅱ.By improving diagnostic accuracy,more personalized and effective treatment strategies can be developed,ultimately improving patients'health outcomes and quality of life.展开更多
Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving...Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving the overall performance of CPEs due to their difficulty in achieving robust electrochemical and mechanical interfaces simultaneously.Here,by regulating the surface charge characteristics of halloysite nanotube(HNT),we propose a concept of lithium-ion dynamic interface(Li^(+)-DI)engineering in nano-charged CPE(NCCPE).Results show that the surface charge characteristics of HNTs fundamentally change the Li^(+)-DI,and thereof the mechanical and ion-conduction behaviors of the NCCPEs.Particularly,the HNTs with positively charged surface(HNTs+)lead to a higher Li^(+)transference number(0.86)than that of HNTs-(0.73),but a lower toughness(102.13 MJ m^(-3)for HNTs+and 159.69 MJ m^(-3)for HNTs-).Meanwhile,a strong interface compatibilization effect by Li^(+)is observed for especially the HNTs+-involved Li^(+)-DI,which improves the toughness by 2000%compared with the control.Moreover,HNTs+are more effective to weaken the Li^(+)-solvation strength and facilitate the formation of Li F-rich solid-electrolyte interphase of Li metal compared to HNTs-.The resultant Li|NCCPE|LiFePO4cell delivers a capacity of 144.9 m Ah g^(-1)after 400 cycles at 0.5 C and a capacity retention of 78.6%.This study provides deep insights into understanding the roles of surface charges of nanofillers in regulating the mechanical and electrochemical interfaces in ASSLMBs.展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis ...BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis and heart failure has rarely been observed in cases of pediatric patients with CH pathology.Here,we explored the etiological relationship between CH,heart failure,and refractory lactic acidosis to reflect the importance of thyroid function screening in neonates with heart disease.CASE SUMMARY A 33-day-old extremely premature female infant presented with tachypnea,respiratory distress,recurrent infections,and abdominal distension postnatal.On admission to our facility,she had cardiomegaly,hepatomegaly,and lactic acidosis(revealed on blood gas analysis),with lactate progressively rising to 25 mmol/L.Chest radiographs showed pulmonary congestion,while echocardiography revealed cardiac enlargement,left ventricular wall thickening,and pericardial effusion.Initial management aimed at correcting acidosis and treating heart failure proved ineffective.After reassessment,thyroid function tests showed significantly decreased triiodothyronine,free triiodothyronine,thyroxine,and free thyroxine levels,with a significantly increased thyroidstimulating hormone level,confirming a CH diagnosis.Levothyroxine was administered,resulting in rapid correction of lactic acidosis and gradual improvement of thyroid function and systemic symptoms,culminating in full recovery and discharge.We also reviewed the relevant literature on thyroid and cardiac dysfunctions in order to explore their deeper association.CONCLUSION This case links CH-induced heart failure with refractory lactic acidosis,urging prompt thyroid screening in affected neonates to reduce mortality.展开更多
基金2024 Sichuan Provincial Teaching Reform Project“Multidimensional Immersion and Stratified Training:Explorations in Aesthetic Education Reform in Comprehensive Universities”。
文摘Higher education increasingly emphasizes the unique role of aesthetic education in cultivating virtue and morality.From the perspective of integrating aesthetic education with teaching,this study develops an analytical framework to explore the theoretical foundations,practical pathways,and teaching mechanisms involved in interdisciplinary aesthetic education course construction at Sichuan University.Employing literature analysis and case studies,the paper systematically examines the theoretical basis of aesthetic education and its contemporary demands in higher education.Specifically,it focuses on Sichuan University’s initiatives in aesthetic education curriculum reform,covering practices such as curriculum design,faculty team development,resource coordination,and collaboration between internal and external institutions.Findings suggest that interdisciplinary aesthetic education courses enrich the content of aesthetic education in universities and enhance students’overall competence;however,these courses also face challenges like insufficient faculty and inadequate evaluation mechanisms during implementation.Consequently,this paper proposes strengthening top-level design,refining the curriculum system,enhancing faculty training,and improving evaluation mechanisms as recommendations for future improvement.This research aims to provide valuable references for aesthetic education reform in higher education in the new era,significantly contributing to interdisciplinary synergy and the comprehensive educational goal of integrating moral,intellectual,physical,aesthetic,and labor education.
基金The Innovation Fund of Postgraduate,Sichuan University of Science&Engineering(Grant Number:y2020102)。
文摘China has entered the era of post-poverty alleviation,which effectively links poverty alleviation achievements with rural revitalization strategies.In the era of post-poverty alleviation,in order to effectively promote the sustainable development of poor rural areas,local colleges and universities should actively nurture the self-development skills of the needy.Local colleges and universities should guide the transformation of ideas and concepts,scientifically optimize the allocation of poverty alleviation resources,improve the interest linkage mechanism between colleges and universities,strengthen the investigation and analysis of poverty alleviation projects,improve the convergence of assistance and practice,actively create a good spiritual and cultural environment,uphold the mission of helping cadres,attach importance to the support for the development of characteristic industries,and lastly,promote the convergence of rural revitalization strategies.
文摘Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012.
基金the Key Research Base of Humanities and Social Sciences of Higher Education in Sichuan Province,which is the Research Center for Reform and Development of Newly-Established Colleges and Universities(Project Number:XJYX2021B13)it is the result of the special project of teaching team construction of Sichuan University of Media and Communications in 2020(Sichuan University of Media and Communications[2020]No.61).
文摘Under the background of new liberal arts,in order to run a major well as well as highlight its characteristics and advantages,private colleges and universities cannot do without the construction of professional teaching teams and teaching reforms.Taking Sichuan University of Media and Communication as an example,a series of explorations and practices has been carried out from the aspects of professional team construction,personnel training objectives,professional curriculum system,professional teaching mode,and professional teaching quality,in which good results have been achieved.On this basis,a training base for journalism and communication talents serving the whole Sichuan Province and even the western region is constructed,so that the results of the project have a certain demonstration and promotion value for the construction and development of similar majors in new institutions of higher learning in Sichuan Province.
文摘The polymer science discipline at Sichuan University(SCU)was founded in 1953 by Prof.Xi Xu,one of the pioneers in polymer materials science and engineering in China and honored as the“Father of Chinese Plastics,”who was also an academician of the Chinese Academy of Sciences.Over a glorious 70-year journey,polymer science at SCU has evolved into a top-notch,globally recognized,and the largest research and teaching center in the realm of polymer science and engineering in China.On the occasion of the 70th anniversary of the establishment of the polymer science discipline at SCU,we extend our deepest gratitude to the visionary founders and every indi-vidual who has contributed to the development of this discipline.
文摘In China's Republican era(1911-1949)universities were divided into two categories,national and provincial.The president of a national university was in principle appointed by the central government,and its financial outlays provided by the treasury;while a provincial university was established by the respective province government,who bore as well its financing and management.In reality,national universities tended to develop from provincial ones,and the process of nationalization was often accompanied by a contest of strength between the central and provincial authorities.
基金supported by the funding provided by the State Key Laboratory of Hydraulics and Mountain River Engineering(SKHL2210)National Natural Science Foundation of China(42171304)+1 种基金the Sichuan Science and Technology Program(2023YFS0380)Natural Science Foundation of Jiangsu Province of China(BK20242018)。
文摘The Yellow River Basin in Sichuan Province(YRS)is undergoing severe soil erosion and exacerbated ecological vulnerability,which collectively pose formidable challenges for regional water conservation(WC)and sustainable development.While effectively enhancing WC necessitates a comprehensive understanding of its driving factors and corresponding intervention strategies,existing studies have largely neglected the spatiotemporal heterogeneity of both natural and socio-economic drivers.Therefore,this study explored the spatiotemporal heterogeneity of WC drivers in YRS using multi-scale geographically weighted regression(MGWR)and geographically and temporally weighted regression(GTWR)models from an eco-hydrological perspective.We discovered that downstream regions,which are more developed,achieved significantly better WC than upstream regions.The results also demonstrated that the influence of temperature and wind speed is consistently dominant and temporally stable due to climate stability,while the influence of vegetation shifted from negative to positive around 2010,likely indicating greater benefits from understory vegetation.Economic growth positively impacted WC in upstream regions but had a negative effect in the more developed downstream regions.These findings highlight the importance of targeted water conservation strategies,including locally appropriate revegetation,optimization of agricultural and economic structures,and the establishment of eco-compensation mechanisms for ecological conservation and sustainable development.
文摘This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.
文摘As an integral component of China’s revolutionary culture,Sichuan’s red culture,with its abundant historical resources and distinctive regional characteristics,provides high-quality educational materials for ideological and political education in higher education institutions.The integration of Sichuan’s red culture into university ideological and political education demonstrates both theoretical necessity and practical feasibility,having already yielded remarkable outcomes.This integration must adhere to the principle of unifying teacher guidance with student initiative,comprehensive coverage with focused emphasis,and cultural inheritance with innovative development,thereby fully realizing the educational value of Sichuan’s red culture in collegiate ideological and political education.
文摘"Sichuan Cuisine Cooking Skills"is a course that focuses on the traditional cooking skills of Sichuan Province in China.It covers not only the historical and cultural background of Sichuan cuisine,but also the cooking techniques,ingredients selection,seasoning skills and dish innovation of Sichuan cuisine.Doing a good job in the teaching of"Sichuan Cuisine Cooking Skills"is of great significance to the cultivation and reserve of culinary professionals in China,and also has an important impact on students'employment competitiveness.Under the background of"new engineering education",the course reform of"Sichuan Cuisine Cooking Skills"was carried out in terms of the construction of teaching staff,teaching methods,students'participation degree and the innovation of course content,and specific reform suggestions were put forward,hoping to effectively promote the sustainable development of"Sichuan Cuisine Cooking Skills"and effectively improve the teaching quality.
基金supported by the National Natural Science Foundation of China(U20A2022 and 32372217)the National Key Research and Development Program of China(2022YFD2300700)the Free Exploration Program of State Key Laboratory of Crop Gene Exploration and Utilization in Sichuan Basin,China(SKL-ZY202216)。
文摘Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological conditions.In this study,we conducted experiments using four different sowing dates,the conventional sowing date 1(CS1),CS2(10 d later than CS1),DS1(30 d later than CS1),and DS2(30 d later than CS2),and three rice varieties,i.e.,Yixiangyou 2115,Fyou 498,and Chuanyou 6203.This experiment was conducted at four sites in the Sichuan Basin in 2018 and 2019 to evaluate the infuence of DS on the pasting properties of rice,which are a proxy for the eating and cooking quality(ECQ).In DS1 and DS2,the rice had a signifcantly greater amylose content(AC)but a lower protein content(PC),peak viscosity(PKV),cool paste viscosity(CPV),and hot paste viscosity(HPV)than in CS1 and CS2.Moreover,except for CS2 and DS1 in 2018,DS1 and DS2 led to 2.15-11.19%reductions in breakdown viscosity(BDV)and 23.46-108.47%increases in setback viscosity(SBV).However,the infuence of DS on rice pasting properties varied by study site and rice variety.In 2019,DS1 and DS2 led to BDV reductions of 2.35-9.33,2.61-8.61,10.03-17.78,and 2.06-8.93%,and SBV increases of 2.32-60.93,63.74-144.24,55.46-91.63,and-8.28-65.37%at the Dayi,Anzhou,Nanbu,and Shehong(except for SBV in CS2 and DS1)sites,respectively.DS resulted in greater reductions in PKV,HPV,CPV,and BDV and greater increases in the AC and SBV for Yixiangyou 2115 than for Chuanyou 6203 and Fyou 498.The correlation analysis indicated that PKV and HPV were signifcantly and positively related to the mean,maximum,and minimum temperatures after heading.These temperatures must be greater than 25.9,31.2,and 22.3℃,respectively,to increase the relative BDV and reduce the relative SBV of rice,thereby enhancing ECQ.In conclusion,DS might contribute to a signifcant deterioration in ECQ in machine-transplanted rice in the Sichuan Basin.A mean temperature above 25.9℃ after heading is required to improve the ECQ of rice.
基金supported by the National Natural Science Foundation of China(42330707 and 41930647)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(72221002)the Science and Technology Plan of Sichuan Province,China(2022NSFSC0104).
文摘Widespread soil acidification driven by nitrogen(N)fertilization and precipitation challenges the conventional notion of the long-term stability of soil inorganic carbon(SIC)in agroecosystems.However,the changes in SIC with precipitation and N fertilization remain ambiguous.Based on 4,000+soil samples collected in the 1980s and 2010s and by developing machine learning models to fill the missing SIC of soil samples,this study generated 3,697 paired soil samples between the two periods and then investigated the cropland SIC change and explored its relationship with precipitation and N fertilization across the Sichuan Basin,China.The results showed an overall SIC loss,with a decline of the mean SIC by 15.73%.SIC change varied with initial soil pH and initial SIC and exhibited an exponential relationship with soil pH change,indicating the changing role of carbonates in providing acid-buffering capacity.There was a parabolical relationship between the magnitude of SIC decline and N fertilizer rates,and low N fertilizer rates contributed to a reduction in SIC loss,while SIC loss was promoted by N fertilization occurred when N fertilizing rates exceeded 250 kg ha^(-1) yr^(-1).The change in SIC showed a sinusoidal variation with precipitation,with 950 mm being the threshold controlling whether SIC increased or decreased.Meanwhile,N fertilization did not alter the sinusoidal relationship between SIC change and precipitation.In areas with rainfall<950 mm,the high N fertilizer rate did not cause SIC loss,while higher precipitation could also cause larger SIC loss in areas with lower N fertilizer rates.These results suggest that SIC dynamics are jointly driven by precipitation and N fertilization and are controlled by acid-buffering mechanisms associated with initial pH and SIC,with precipitation being the predominant driver.These findings emphasize the need for more regional soil observations and in-depth studies of SIC change and its mechanisms for accurately estimating SIC change.
基金supported by the funding provided by the State Key Laboratory of Hydraulics and Mountain River Engineering (SKHL2210)National Natural Science Foundation of China (42171304)the Sichuan Science and Technology Program (2023YFS0380,2023YFS0377,2023NSFSC1989)。
文摘The upper reaches of the Yellow River in Sichuan Province are critical area for water conservation and ecological protection in China. However, they are experiencing a range of ecological and environmental challenges, including grassland desertification, wetland degradation, and soil erosion, all of which pose significant threats to the environmental sustainability and overall development of the Yellow River Basin. Urbanization can lead to irreversible damage to ecosystems. Therefore, understanding the relationship between urbanization and ecosystems is crucial for fostering sustainable development in the region. With land use and meteorological data in the upper reaches of the Yellow River in Sichuan Province in 2000-2020, and using InVEST model and standardized processing methods, we analyzed the spatiotemporal evolution characteristics of urbanization and four ecosystem services: water conservation, carbon storage, habitat quality, and soil retention. Additionally, we employed the GeoDa bivariate spatial autocorrelation analysis model to reveal the spatial correlations and interactions between urbanization and ecosystems. The results reveal a significant spatial mismatch between urbanization and ecosystem services in the upper Yellow River region of Sichuan Province. While the composite urbanization index decreased from 0.0075 to 0.0042 and remained concentrated in county centers, all ecosystem services showed improvement: water conservation increased from 17.38×10^(9) mm to 23.37×10^(9) mm, carbon storage rose from 936.60 Tg to 938.42 Tg, habitat quality improved from 0.875 to 0.879, and soil retention enhanced from 13.56×10^(8) t to 17.59×10^(8) t. However, these ecological gains were mainly driven by restoration in non-urban southern areas, creating a clear spatial disconnection from urban centers and leading to persistently weak and declining coordination between systems. This spatial decoupling underscores the inadequacy of the current urbanization model in promoting regional ecological synergy. We therefore recommend implementing differentiated zoning strategies: promoting compact development coupled with ecological restoration in county centers, strictly protecting core water conservation and carbon sequestration areas in the southern key ecological zones, and enhancing soilwater conservation and ecological restoration in the vulnerable northern belt, so as to establish an ecological security framework compatible with sustainable urbanization.
基金supported by innovation consortium project of China Petroleum and Southwest Petroleum University (No.2020CX010201)Sichuan Science and Technology Program (No. 2024NSFSC0081)。
文摘The Canglangpu Formation in the JT1 well area of the Sichuan Basin exhibits strong lateral heterogeneity and complex overpressure mechanisms, leading to ambiguous pore pressure distribution characteristics. Conventional prediction methods, such as the Equivalent Depth Method, are either inapplicable or yield unsatisfactory results (e.g., Fillippone’s method), contributing to frequent drilling incidents like gas kick, overfl ow, and lost circulation, which hinder the safe and effi cient exploration of natural gas. To address these challenges, this paper integrates lithology, physical properties, and overpressure mechanisms of the Canglangpu Formation. From a petrophysical perspective, a pore pressure prediction model independent of lithology and overpressure mechanisms was developed by combining the poroelasticity theory, linear elastic Hooke’s Law, and Biot’s eff ective stress theory, with an analysis of the relationship between carbonate rock strain, external stress, and internal pore pressure. Unlike conventional methods, the model does not rely on the establishment of a normal compaction trend line. Pre-stack seismic inversion was applied to achieve 3D pore pressure prediction for the formation. Results indicate high accuracy, with a relative error of less than 5% compared to measured data, and strong consistency with actual drilling events. The proposed method provides robust technical support for pore pressure prediction in carbonate formations and drilling geological design.
基金supported by the National Key Research and Development Program of China,No.2022YFC2703101(to YC)the National Natural Science Fundation of China,No.82371422(to YC)+1 种基金the National Innovation and Entrepreneurship Training Program for College Students,No.202310611408(to XW)the 1·3·5 Project for Disciplines of Excellence Clinical Research Fund,West China Hospital,Sichuan University,No.2023HXFH032(to YC)。
文摘Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.
基金funded by the National Social Science Foundation project“Research on Chinese Life Wisdom from the Perspective of Creative Transformation and Innovative Development”(22ZDA082).
文摘Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and never-ending.It also consciously constructs a cosmic life view of the organic,homologous,isomorphic,and harmonious unity of heaven,earth,and man based on human existence and destiny with a rational thinking attitude.The life philosophy of the Huai Nan-zi offers modern people a completely new holistic view of life and medicine.Not only in China,but also in Western countries,studying its medical philosophical ideas helps us better explore the theoretical roots of TCM in the era of globalized medicine.Methods:This paper mainly uses the analysis method of literature review and chinese philosophy intellectual concepts.It employs the I Ching’s image-number logic thinking method to compare images through analogy and the holistic thinking method of the three-talent view of heaven,earth,and human to understand life consciousness.Results:This article mainly interprets medical philosophy in Huai Nan-zi through three aspects:1)The body of Taoism:heaven,earth,and humanity constitute one unity within the body of the universe;2)The spirit of Taoism:keeping the spirit inward,preserving the essence and suppressing the superficial;and 3)The mind of Taoism:the principle of life governed by the dynamics of gain and loss,prosperity and decline.Conclusion:The philosophy of life presented in the Huai Nan-zi ultimately charts a course toward a state of profound theoretical integration.Its“conscious map”does not lead to a fixed destination,but to a continuous and dynamic mode of being–a life of flourishing known in Chinese as yang sheng,the nurturing of life.The destination,therefore,is the journey itself,undertaken with unwavering cosmic awareness and harmony.This ancient text reminds us that a truly healthy life is not a fragmented pursuit of physical fitness,mental peace,or spiritual insight in isolation.Instead,it is the symphony of all three(Taoist body,spirit,and mind),orchestrated by the fundamental principles of the cosmos.By aligning our inner nature with the outer Tao,we transform our existence from a series of reactive struggles into a graceful and spontaneous free flow.In a modern world characterized by fragmentation,overstimulation,and a relentless push against natural rhythms,the Huai Nan-zi’s life consciousness map is more relevant than ever.The philosophy of Huai Nan-zi not only plays a vital role in the construction of the theoretical system of TCM in ancient East life wisdom,but also is worthwhile for Western life sciences to conduct in-depth exploration and discovery in the age of AI.
文摘Clinically differentiating bipolarⅡdisorder(BD-Ⅱ)from major depressive disorder(MDD)remains a significant challenge in modern psychiatry.These two conditions share substantial clinical symptomatology,making accurate diagnosis difficult in routine clinical practice.Misdiagnosis may lead to inappropriate treatment strategies,increased psychological and physical burdens,reduced quality of life,and impaired social functioning.Genetic overlap may partially explain the clinical similarities between MDD and BD-Ⅱ,and biomarkers along with neuroimaging techniques are receiving increasing attention as tools to aid in diagnosis.For example,electroencephalography has been shown to effectively distinguish between unipolar depression and bipolar depression;serum levels of glycogen synthase kinase-3 have also been investigated as a potential tool for differentiating between the two disorders.A comprehensive assessment integrating clinical characteristics,genetic basis research,and multimodal evaluations using neuroimaging and biomarkers through a multidisciplinary approach will help enhance clinicians'ability to distinguish between MDD and BD-Ⅱ.By improving diagnostic accuracy,more personalized and effective treatment strategies can be developed,ultimately improving patients'health outcomes and quality of life.
基金the financial support from the National Natural Science Foundation of China(52203123 and 52473248)State Key Laboratory of Polymer Materials Engineering(sklpme2024-2-04)+1 种基金the Fundamental Research Funds for the Central Universitiessponsored by the Double First-Class Construction Funds of Sichuan University。
文摘Composite polymer electrolytes(CPEs)offer a promising solution for all-solid-state lithium-metal batteries(ASSLMBs).However,conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving the overall performance of CPEs due to their difficulty in achieving robust electrochemical and mechanical interfaces simultaneously.Here,by regulating the surface charge characteristics of halloysite nanotube(HNT),we propose a concept of lithium-ion dynamic interface(Li^(+)-DI)engineering in nano-charged CPE(NCCPE).Results show that the surface charge characteristics of HNTs fundamentally change the Li^(+)-DI,and thereof the mechanical and ion-conduction behaviors of the NCCPEs.Particularly,the HNTs with positively charged surface(HNTs+)lead to a higher Li^(+)transference number(0.86)than that of HNTs-(0.73),but a lower toughness(102.13 MJ m^(-3)for HNTs+and 159.69 MJ m^(-3)for HNTs-).Meanwhile,a strong interface compatibilization effect by Li^(+)is observed for especially the HNTs+-involved Li^(+)-DI,which improves the toughness by 2000%compared with the control.Moreover,HNTs+are more effective to weaken the Li^(+)-solvation strength and facilitate the formation of Li F-rich solid-electrolyte interphase of Li metal compared to HNTs-.The resultant Li|NCCPE|LiFePO4cell delivers a capacity of 144.9 m Ah g^(-1)after 400 cycles at 0.5 C and a capacity retention of 78.6%.This study provides deep insights into understanding the roles of surface charges of nanofillers in regulating the mechanical and electrochemical interfaces in ASSLMBs.
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
文摘BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis and heart failure has rarely been observed in cases of pediatric patients with CH pathology.Here,we explored the etiological relationship between CH,heart failure,and refractory lactic acidosis to reflect the importance of thyroid function screening in neonates with heart disease.CASE SUMMARY A 33-day-old extremely premature female infant presented with tachypnea,respiratory distress,recurrent infections,and abdominal distension postnatal.On admission to our facility,she had cardiomegaly,hepatomegaly,and lactic acidosis(revealed on blood gas analysis),with lactate progressively rising to 25 mmol/L.Chest radiographs showed pulmonary congestion,while echocardiography revealed cardiac enlargement,left ventricular wall thickening,and pericardial effusion.Initial management aimed at correcting acidosis and treating heart failure proved ineffective.After reassessment,thyroid function tests showed significantly decreased triiodothyronine,free triiodothyronine,thyroxine,and free thyroxine levels,with a significantly increased thyroidstimulating hormone level,confirming a CH diagnosis.Levothyroxine was administered,resulting in rapid correction of lactic acidosis and gradual improvement of thyroid function and systemic symptoms,culminating in full recovery and discharge.We also reviewed the relevant literature on thyroid and cardiac dysfunctions in order to explore their deeper association.CONCLUSION This case links CH-induced heart failure with refractory lactic acidosis,urging prompt thyroid screening in affected neonates to reduce mortality.
