Taking the academic association of the Federation of Life Science Research and Innovation of the College of Life Science and Biotechnology of Heilongjiang Bayi Agricultural University as the research platform,it is ne...Taking the academic association of the Federation of Life Science Research and Innovation of the College of Life Science and Biotechnology of Heilongjiang Bayi Agricultural University as the research platform,it is necessary to organically combine personalized education with the cultivation of innovative and entrepreneurial ability.On the basis of unified teaching ideas,we should pay attention to the individual differences of educational objects,eliminate the disadvantages of traditional education,and break the conventional"spoon-feeding"teaching mode.It is necessary to shift from only paying attention to one-way indoctrination to paying attention to the cultivation of students'innovative quality,and to enhance students'interest in scientific research and practical ability of innovation and entrepreneurship through the rich scientific research activities of academic associations.展开更多
With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sci...With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.展开更多
In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry ou...In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.展开更多
Gordon Life Science Institute is the first Internet Research Institute ever established in the world. It is a non-profit institute. Those scientists who really dedicate themselves to science and loving science more th...Gordon Life Science Institute is the first Internet Research Institute ever established in the world. It is a non-profit institute. Those scientists who really dedicate themselves to science and loving science more than anything else can become its member. In the friendly door-opened Institute, they can maximize their time and energy to engage in their scientific creativity. They have also believed that science would be more truthful and wonderful if scientists do not have to spend a lot of time on funding application, and that great scientific findings and creations in history were often made by those who were least supported or funded but driven by interesting imagination and curiosity. Recollected in this review article is its establishing and developing processes, as well as its philosophy and accomplishments. Particularly, its productive and by-productive outcomes have covered the following five very hot topics in bioinformatics and drug development: 1) PseAAC and PseKNC;2) Disported key theory;3) Wenxiang diagram;4) Multi-label system prediction;5) 5-steps rule. Their impacts on the proteomics and genomics as well as drug development are substantially and awesome.展开更多
The impacts of coronavirus to our planet <span>are</span><span "=""><span> unprecedented;</span><i><span>i.e.</span></i><span>, </span>&...The impacts of coronavirus to our planet <span>are</span><span "=""><span> unprecedented;</span><i><span>i.e.</span></i><span>, </span></span><span>they are</span><span> going to eliminate the entire mankind. Driven by such horrible situation, some philosophical viewpoints have naturally happened. Whether the “World End” must come? If yes, when? During this waiting period, the best way to do science is via the Internet Institute, such as “Gordon Life Science Institute”, and the results thus achieved will be most rewarding.</span>展开更多
Established in 2004, Gordon Life Science Institute is the first Internet Research Institute in the world. It is a non-profit institute, a gift to science. Those scientists, who are really loving science more than anyt...Established in 2004, Gordon Life Science Institute is the first Internet Research Institute in the world. It is a non-profit institute, a gift to science. Those scientists, who are really loving science more than anything else and have shown fantastic creativity in science, can become the membership of such Institute. Their driving force is not funding but firmly belief that scientists will do much better science if they do not have to spend a lot of time for funding application, and that great scientific findings in history were often discovered by those who were without funding at all but driven by profound imagination and curiosity. Summarized in this review are also the accomplishments of the Gordon Life Science Institute and its future perspective.展开更多
With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science ...With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.展开更多
In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was...In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive development.Here, we review and summarize researches on space life sciences which were contributed by Chinese scientists.展开更多
In this review paper, the remarkable impacts of the first Internet Institute, the Gordon Life Science Institute, as well as its profound and far-reaching influence have been systematically and comprehensively presented.
With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science...With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities,to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.展开更多
The College of Life Sciences (CLS) remains one of the most prestigious—and the oldest—colleges in Zhejiang University. This special issue, which includes 16 reviews contributed by our alumni and faculties, is dedica...The College of Life Sciences (CLS) remains one of the most prestigious—and the oldest—colleges in Zhejiang University. This special issue, which includes 16 reviews contributed by our alumni and faculties, is dedicated to mark the 90th Anniversary of CLS.展开更多
Estimation of the sample position is essential for working process monitoring and management in the life science automation laboratory.Bluetooth low-energy(BLE)beacons have the advantages of low price,small size and l...Estimation of the sample position is essential for working process monitoring and management in the life science automation laboratory.Bluetooth low-energy(BLE)beacons have the advantages of low price,small size and low energy consumption,which make them a promising solution for sample position estimation in the automated laboratory.Several fingerprinting models have been proposed to achieve indoor localization with the received signal strength(RSS)data.However,most of the research depends on intensive beacon installation.Proximity estimation,which depends entirely on one beacon,is more suitable for sample position estimation in large automated laboratories.The complexity of the life science automation laboratory environment brings challenges to the traditional path loss model(PLM),which is a widely used radio wave propagation model-based proximity estimation method.In this paper,BLE sensing devices for sample position estimation are proposed.The BLE beacon-based proximity estimation is discussed in the framework of machine learning,in which the support vector regression(SVR)is utilized to model the nonlinear relationship between the RSS data and distance,and the Kalman filter is utilized to decrease the RSS data deviation.The experimental results over different environments indicate that the SVR outperforms the PLM significantly,and provides 1 m absolute errors for more than 95%of the testing samples.The Kalman filter brings benefits to stable distance predictions.Apart from proximity-based sample position estimation,the proposed framework turned out to be effective in position estimation between parallel workbenches and position estimation on an automated workstation.展开更多
Since the launch in 1950,Science China Series and Science Bulletin have published numerous significant scientific achievements,witnessing the development of science and technology in China and serving as a bridge conn...Since the launch in 1950,Science China Series and Science Bulletin have published numerous significant scientific achievements,witnessing the development of science and technology in China and serving as a bridge connecting Chinese scientists with their counterparts in the international scientific community.展开更多
The Department of Biology at Peking University was established in 1925,with Mr.Tan Xi Hong as its inaugural department head.In 1993,the department was renamed the School of Life Sciences.During the past 90 years,a ste...The Department of Biology at Peking University was established in 1925,with Mr.Tan Xi Hong as its inaugural department head.In 1993,the department was renamed the School of Life Sciences.During the past 90 years,a steady stream of students has enrolled in the department in order to explore the secrets of life and to dedicate themselves to the advancement of society.展开更多
The 2022 Nobel Prize in Chemistry was awarded to Carolyn R.Bertozzi,Morten Meldal andK.Barry Sharpless for their development of click reaction and bioorthogonal chemistry.Our understanding of life sciences has been fu...The 2022 Nobel Prize in Chemistry was awarded to Carolyn R.Bertozzi,Morten Meldal andK.Barry Sharpless for their development of click reaction and bioorthogonal chemistry.Our understanding of life sciences has been fundamentally accelerated by such novel chemistries,and to some extent,revolutionized by the emergence of new chemical tools benefited from these cutting-edge interdisciplinary explorations.In turn,the high demands of more powerful chemical tools for the sophisticated living systems have further promoted the development of new chemistry with newfunctionalities and applications.展开更多
The use of space environment to carry out life science research is of great significance.However,there are limitations in complex manipulation,research models based on mammalian and 2-dimensional cell culture experime...The use of space environment to carry out life science research is of great significance.However,there are limitations in complex manipulation,research models based on mammalian and 2-dimensional cell culture experiments,etc.Microfluidic chips possess the characteristics of integrating the relevant functions of traditional laboratories into micron-scale chips,with low energy consumption,high throughput,and automation.The application of microfluidic chips can overcome the challenges of space environments,the scarce experimental resources,and the unmanned operation problems to some extent.Moreover,microfluidic chips can realize long-term experimental operation and remote data recording and transmission.To carry out related research with microfluidic chips,the actuation and control of microfluidics are very important.In this paper,the microfluidic actuated and controlled technologies in microfluidic chips are reviewed,and then the application of microfluidic chips and microfluidic actuated and controlled systems in space life science is also briefly described.展开更多
Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and...Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and environmental sciences,modern life sciences have entered the information-rich era,the era of the 4th paradigm.The creation of Chinese information engineering infrastructure for pan-omics studies(CIEIPOS) has been long overdue as part of national scientific infrastructure,in accelerating the further development of Chinese life sciences,and translating rich data into knowledge and medical applications.By gathering facts of current status of international and Chinese bioinformatics communities in collecting,managing and utilizing biological data,the essay stresses the significance and urgency to create a 'data hub' in CIEIPOS,discusses challenges and possible solutions to integrate,query and visualize these data.Another important component of CIEIPOS,which is not part of traditional biological data centers such as NCBI and EBI,is omics informatics.Mass spectroscopy platform was taken as an example to illustrate the complexity of omics informatics.Its heavy dependency on computational power is highlighted.The demand for such power in omics studies is argued as the fundamental function to meet for CIEIPOS.Implementation outlook of CIEIPOS in hardware and network is discussed.展开更多
Life Science at Tsinghua University has a long and eventful history.The Biology Department,founded in 1926,was among the oldest and most prestigious in China.In 1952,the Biology Department,together with other natural ...Life Science at Tsinghua University has a long and eventful history.The Biology Department,founded in 1926,was among the oldest and most prestigious in China.In 1952,the Biology Department,together with other natural science departments,were eliminated from the University by order of the central government.In 1984,the Department of Biological Science and Biotechnology was re-established,with Professor Poo Mu-ming being the founding Director.In the ensuing 25 years,the Department went through rapid transformations and gained national and international recognition.In September 2009,the Department of Biological Science and Biotechnology was replaced by the School of Life Sciences.展开更多
基金Research Project of Higher Education and Teaching Reform in Heilongjiang Province(SJGY20190484)Heilongjiang Educational Science 13 th Five-Year Plan Project(GBC1317101)Graduate Education and Teaching Reform Project of Heilongjiang Bayi Agricultural University(YJG201803).
文摘Taking the academic association of the Federation of Life Science Research and Innovation of the College of Life Science and Biotechnology of Heilongjiang Bayi Agricultural University as the research platform,it is necessary to organically combine personalized education with the cultivation of innovative and entrepreneurial ability.On the basis of unified teaching ideas,we should pay attention to the individual differences of educational objects,eliminate the disadvantages of traditional education,and break the conventional"spoon-feeding"teaching mode.It is necessary to shift from only paying attention to one-way indoctrination to paying attention to the cultivation of students'innovative quality,and to enhance students'interest in scientific research and practical ability of innovation and entrepreneurship through the rich scientific research activities of academic associations.
文摘With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.
基金Supported by Space Medical Experiment Project of China Manned Space Program(HYZHXM02003)。
文摘In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.
文摘Gordon Life Science Institute is the first Internet Research Institute ever established in the world. It is a non-profit institute. Those scientists who really dedicate themselves to science and loving science more than anything else can become its member. In the friendly door-opened Institute, they can maximize their time and energy to engage in their scientific creativity. They have also believed that science would be more truthful and wonderful if scientists do not have to spend a lot of time on funding application, and that great scientific findings and creations in history were often made by those who were least supported or funded but driven by interesting imagination and curiosity. Recollected in this review article is its establishing and developing processes, as well as its philosophy and accomplishments. Particularly, its productive and by-productive outcomes have covered the following five very hot topics in bioinformatics and drug development: 1) PseAAC and PseKNC;2) Disported key theory;3) Wenxiang diagram;4) Multi-label system prediction;5) 5-steps rule. Their impacts on the proteomics and genomics as well as drug development are substantially and awesome.
文摘The impacts of coronavirus to our planet <span>are</span><span "=""><span> unprecedented;</span><i><span>i.e.</span></i><span>, </span></span><span>they are</span><span> going to eliminate the entire mankind. Driven by such horrible situation, some philosophical viewpoints have naturally happened. Whether the “World End” must come? If yes, when? During this waiting period, the best way to do science is via the Internet Institute, such as “Gordon Life Science Institute”, and the results thus achieved will be most rewarding.</span>
文摘Established in 2004, Gordon Life Science Institute is the first Internet Research Institute in the world. It is a non-profit institute, a gift to science. Those scientists, who are really loving science more than anything else and have shown fantastic creativity in science, can become the membership of such Institute. Their driving force is not funding but firmly belief that scientists will do much better science if they do not have to spend a lot of time for funding application, and that great scientific findings in history were often discovered by those who were without funding at all but driven by profound imagination and curiosity. Summarized in this review are also the accomplishments of the Gordon Life Science Institute and its future perspective.
文摘With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.
文摘In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive development.Here, we review and summarize researches on space life sciences which were contributed by Chinese scientists.
文摘In this review paper, the remarkable impacts of the first Internet Institute, the Gordon Life Science Institute, as well as its profound and far-reaching influence have been systematically and comprehensively presented.
文摘With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities,to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.
文摘The College of Life Sciences (CLS) remains one of the most prestigious—and the oldest—colleges in Zhejiang University. This special issue, which includes 16 reviews contributed by our alumni and faculties, is dedicated to mark the 90th Anniversary of CLS.
基金the Synergy Project ADAM(Autonomous Discovery of Advanced Materials)funded by the European Research Council(Grant No.856405).
文摘Estimation of the sample position is essential for working process monitoring and management in the life science automation laboratory.Bluetooth low-energy(BLE)beacons have the advantages of low price,small size and low energy consumption,which make them a promising solution for sample position estimation in the automated laboratory.Several fingerprinting models have been proposed to achieve indoor localization with the received signal strength(RSS)data.However,most of the research depends on intensive beacon installation.Proximity estimation,which depends entirely on one beacon,is more suitable for sample position estimation in large automated laboratories.The complexity of the life science automation laboratory environment brings challenges to the traditional path loss model(PLM),which is a widely used radio wave propagation model-based proximity estimation method.In this paper,BLE sensing devices for sample position estimation are proposed.The BLE beacon-based proximity estimation is discussed in the framework of machine learning,in which the support vector regression(SVR)is utilized to model the nonlinear relationship between the RSS data and distance,and the Kalman filter is utilized to decrease the RSS data deviation.The experimental results over different environments indicate that the SVR outperforms the PLM significantly,and provides 1 m absolute errors for more than 95%of the testing samples.The Kalman filter brings benefits to stable distance predictions.Apart from proximity-based sample position estimation,the proposed framework turned out to be effective in position estimation between parallel workbenches and position estimation on an automated workstation.
文摘Since the launch in 1950,Science China Series and Science Bulletin have published numerous significant scientific achievements,witnessing the development of science and technology in China and serving as a bridge connecting Chinese scientists with their counterparts in the international scientific community.
文摘The Department of Biology at Peking University was established in 1925,with Mr.Tan Xi Hong as its inaugural department head.In 1993,the department was renamed the School of Life Sciences.During the past 90 years,a steady stream of students has enrolled in the department in order to explore the secrets of life and to dedicate themselves to the advancement of society.
基金supported by the National Natural Science Foundation of China(21937001,22137001,22222701,22077004)the Ministry of Science and Technology(2019YFA0904201)the Beijing Natural Science Foundation(Z200010)。
文摘The 2022 Nobel Prize in Chemistry was awarded to Carolyn R.Bertozzi,Morten Meldal andK.Barry Sharpless for their development of click reaction and bioorthogonal chemistry.Our understanding of life sciences has been fundamentally accelerated by such novel chemistries,and to some extent,revolutionized by the emergence of new chemical tools benefited from these cutting-edge interdisciplinary explorations.In turn,the high demands of more powerful chemical tools for the sophisticated living systems have further promoted the development of new chemistry with newfunctionalities and applications.
基金supported by the Space Medical Experiment Project of China Manned Space Program(HYZHXM04001).
文摘The use of space environment to carry out life science research is of great significance.However,there are limitations in complex manipulation,research models based on mammalian and 2-dimensional cell culture experiments,etc.Microfluidic chips possess the characteristics of integrating the relevant functions of traditional laboratories into micron-scale chips,with low energy consumption,high throughput,and automation.The application of microfluidic chips can overcome the challenges of space environments,the scarce experimental resources,and the unmanned operation problems to some extent.Moreover,microfluidic chips can realize long-term experimental operation and remote data recording and transmission.To carry out related research with microfluidic chips,the actuation and control of microfluidics are very important.In this paper,the microfluidic actuated and controlled technologies in microfluidic chips are reviewed,and then the application of microfluidic chips and microfluidic actuated and controlled systems in space life science is also briefly described.
基金financial support of Taicang government,Suzhou,China
文摘Biological data,represented by the data from omics platforms,are accumulating exponentially.As some other data-intensive scientific disciplines such as high-energy physics,climatology,meteorology,geology,geography and environmental sciences,modern life sciences have entered the information-rich era,the era of the 4th paradigm.The creation of Chinese information engineering infrastructure for pan-omics studies(CIEIPOS) has been long overdue as part of national scientific infrastructure,in accelerating the further development of Chinese life sciences,and translating rich data into knowledge and medical applications.By gathering facts of current status of international and Chinese bioinformatics communities in collecting,managing and utilizing biological data,the essay stresses the significance and urgency to create a 'data hub' in CIEIPOS,discusses challenges and possible solutions to integrate,query and visualize these data.Another important component of CIEIPOS,which is not part of traditional biological data centers such as NCBI and EBI,is omics informatics.Mass spectroscopy platform was taken as an example to illustrate the complexity of omics informatics.Its heavy dependency on computational power is highlighted.The demand for such power in omics studies is argued as the fundamental function to meet for CIEIPOS.Implementation outlook of CIEIPOS in hardware and network is discussed.
文摘Life Science at Tsinghua University has a long and eventful history.The Biology Department,founded in 1926,was among the oldest and most prestigious in China.In 1952,the Biology Department,together with other natural science departments,were eliminated from the University by order of the central government.In 1984,the Department of Biological Science and Biotechnology was re-established,with Professor Poo Mu-ming being the founding Director.In the ensuing 25 years,the Department went through rapid transformations and gained national and international recognition.In September 2009,the Department of Biological Science and Biotechnology was replaced by the School of Life Sciences.
