If 2024 has taught me anything,it’s that digital is an irrefutable force for unity—a much-needed catalyst for global cooperation in an increasingly fragmented world.This truth has been on display all year long,somet...If 2024 has taught me anything,it’s that digital is an irrefutable force for unity—a much-needed catalyst for global cooperation in an increasingly fragmented world.This truth has been on display all year long,sometimes against the odds.And it’s evident in the adoption of the Pact for the Future and Global Digital Compact at the United Nations General Assembly,in the outcomes of the World Telecommunication Standardization Assembly(WTSA-24),and in the wide endorsement of the COP29 Declaration on Green Digital Action.展开更多
The InternationaL TeLecommunication Union, the United Nations speciaLized agency for information and communication technology （ICT）, has Launched a new research initiative to identify emerging and future ICT sector ...The InternationaL TeLecommunication Union, the United Nations speciaLized agency for information and communication technology （ICT）, has Launched a new research initiative to identify emerging and future ICT sector network demands, beyond 2030 and the advances expected of IMT-2020 （SG） systems. This work wiLL be carried out by the newly established ITU Focus Group on TechnoLogies for Network 2030, which is open to all interested parties.展开更多
The introduction of Intelligent and Converged Networks is the latest initiative to emerge from ITU’s burgeoning partnership with Tsinghua University,a partnership grounded in our mutual commitment to strengthening th...The introduction of Intelligent and Converged Networks is the latest initiative to emerge from ITU’s burgeoning partnership with Tsinghua University,a partnership grounded in our mutual commitment to strengthening the bonds between Academia and ITU.展开更多
This study reviews the anti-inflammatory potential of cannabidiol(CBD)in the management of type 1 diabetes(T1D).A comprehensive search was conducted across PubMed,Scopus,and ScienceDirect databases using the terms“ty...This study reviews the anti-inflammatory potential of cannabidiol(CBD)in the management of type 1 diabetes(T1D).A comprehensive search was conducted across PubMed,Scopus,and ScienceDirect databases using the terms“type 1 diabetes”,“cannabidiol”,“anti-inflammatory effect”,and“CBD”.Articles published between 2005 and 2025 were screened,and studies involving animal models that examined CBD as a therapeutic intervention for T1D and reported on its antiinflammatory effects were included.Of the 62 retrieved articles,only 6 met the predefined inclusion criteria.Although limited in number,the available studies show promising outcomes.CBD demonstrates potential as an adjuvant therapy for T1D due to its immunomodulatory and anti-inflammatory actions.Nonetheless,further research is required to establish safe and effective clinical application protocols.展开更多
As new innovation ecosystems emerge around AI,standards will be essential in bringing these ecosystems to the global scale.Our recent AI for Good Global Summit 2025 showcased our progress on AI standards in areas from...As new innovation ecosystems emerge around AI,standards will be essential in bringing these ecosystems to the global scale.Our recent AI for Good Global Summit 2025 showcased our progress on AI standards in areas from networking,multimedia,energy efficiency to healthcare,food security,road safety and disaster risk reduction.展开更多
The design of unmanned aerial vehicles(UAVs)revolves around the careful selection of materials that are both lightweight and robust.Carbon fiber-reinforced polymer(CFRP)emerged as an ideal option for wing construction...The design of unmanned aerial vehicles(UAVs)revolves around the careful selection of materials that are both lightweight and robust.Carbon fiber-reinforced polymer(CFRP)emerged as an ideal option for wing construction,with its mechanical qualities thoroughly investigated.In this study,we developed and optimized a conceptual UAV wing to withstand structural loads by establishing progressive composite stacking sequences,and we conducted a series of experimental characterizations on the resulting material.In the optimization phase,the objective was defined as weight reduction,while the Hashin damage criterion was established as the constraint for the optimization process.The optimization algorithm adaptively monitors regional damage criterion values,implementing necessary adjustments to facilitate the mitigation process in a cost-effective manner.Optimization of the analytical model using Simulia Abaqus~(TM)and a Python-based user-defined sub-routine resulted in a 34.7%reduction in the wing's structural weight after 45 iterative rounds.Then,the custom-developed optimization algorithm was compared with a genetic algorithm optimization.This comparison has demonstrated that,although the genetic algorithm explores numerous possibilities through hybridization,the custom-developed algorithm is more result-oriented and achieves optimization in a reduced number of steps.To validate the structural analysis,test specimens were fabricated from the wing's most critically loaded segment,utilizing the identical stacking sequence employed in the optimization studies.Rigorous mechanical testing revealed unexpectedly high compressive strength,while tensile and bending strengths fell within expected ranges.All observed failure loads remained within the established safety margins,thereby confirming the reliability of the analytical predictions.展开更多
The hydrodynamic performance of high-speed planing hulls has gained considerable interest,with recent advancements in computational fluid dynamics and hull design techniques enhancing the understanding of planing hull...The hydrodynamic performance of high-speed planing hulls has gained considerable interest,with recent advancements in computational fluid dynamics and hull design techniques enhancing the understanding of planing hull hydrodynamics.In this study,we conducted a numerical investigation using the Reynolds-averaged Navier-Stokes approach with overset grids to capture large motions at high speeds.This study aims to improve the hydrodynamic performances of planing hulls,specifically focusing on total resistance,trim,and sinkage.The initial Fridsma hull with a deadrise angle of 20°has been used for validation,demonstrating good agreement with measurements at different Froude numbers.Subsequently,new configurations based on the Fridsma hull have been designed by varying the deadrise angle,number of chines,and transverse steps.Our findings reveal a correlation between the deadrise angle,the number of chines,and the Froude number.As the deadrise angle increases,total resistance also increases.Additionally,a single chine yields superior results at higher Froude numbers,while multiple chines offer advantages at lower values.The introduction of transverse steps consistently increases total resistance,highlighting their role in improving planing hull performance.This research not only offers valuable insights into planing hull design but also leverages state-of-the-art numerical methods to advance the understanding of hydrodynamic behaviors at high ship speeds.展开更多
BACKGROUND Although inflammatory diseases commonly affect the pleura and pleural space,their mechanisms of action remain unclear.The presence of several mediators emphasizes the concept of pleural inflammation.Adenosi...BACKGROUND Although inflammatory diseases commonly affect the pleura and pleural space,their mechanisms of action remain unclear.The presence of several mediators emphasizes the concept of pleural inflammation.Adenosine deaminase(ADA)is an inflammatory mediator detected at increased levels in the pleural fluid.AIM To determine the role of total pleural ADA(P-ADA)levels in the diagnosis of pleural inflammatory diseases.METHODS 157 patients with inflammatory pleural effusion(exudates,n=124,79%)and noninflammatory pleural effusion(transudates,n=33,21%)were included in this observational retrospective cohort study.The P-ADA assay was tested using a kinetic technique.The performance of the model was evaluated using the area under the receiver operating characteristic(ROC)curve(AUC).The ideal cutoff value for P-ADA in pleural inflammation was determined using the Youden index in the ROC curve.RESULTS The transudates included congestive heart failure(n=26),cirrhosis of the liver with ascites(n=3),chronic renal failure(n=3),and low total protein levels(n=1).The exudate cases included tuberculosis(n=44),adenocarcinoma(n=37),simple parapneumonic effusions(n=15),complicated parapneumonic effusions/empyema(n=8),lymphoma(n=7),and other diseases(n=13).The optimal cutoff value of P-ADA was≥9.00 U/L.The diagnostic parameters as sensitivity,specificity,positive and negative predictive values,positive and negative likelihood values,odds ratio,and accuracy were 77.69(95%CI:69.22-84.75);68.75(95%CI:49.99-83.88);90.38 and 44.90(95%CI:83.03-95.29;30.67-59.77);2.48 and 0.32(95%CI:2.21-11.2;0.27-0.51);7.65(95%CI:0.78-18.34),and 75.82(95%CI:68.24-82.37),respectively(χ^(2)=29.51,P=0.00001).An AUC value of 0.8107(95%CI:0.7174-0.8754;P=0.0000)was clinically useful.The Hosmer-Lemeshow test showed excellent discrimination.CONCLUSION P-ADA biomarker has high diagnostic performance for pleural inflammatory exudates.展开更多
文摘If 2024 has taught me anything,it’s that digital is an irrefutable force for unity—a much-needed catalyst for global cooperation in an increasingly fragmented world.This truth has been on display all year long,sometimes against the odds.And it’s evident in the adoption of the Pact for the Future and Global Digital Compact at the United Nations General Assembly,in the outcomes of the World Telecommunication Standardization Assembly(WTSA-24),and in the wide endorsement of the COP29 Declaration on Green Digital Action.
文摘The InternationaL TeLecommunication Union, the United Nations speciaLized agency for information and communication technology （ICT）, has Launched a new research initiative to identify emerging and future ICT sector network demands, beyond 2030 and the advances expected of IMT-2020 （SG） systems. This work wiLL be carried out by the newly established ITU Focus Group on TechnoLogies for Network 2030, which is open to all interested parties.
文摘The introduction of Intelligent and Converged Networks is the latest initiative to emerge from ITU’s burgeoning partnership with Tsinghua University,a partnership grounded in our mutual commitment to strengthening the bonds between Academia and ITU.
文摘This study reviews the anti-inflammatory potential of cannabidiol(CBD)in the management of type 1 diabetes(T1D).A comprehensive search was conducted across PubMed,Scopus,and ScienceDirect databases using the terms“type 1 diabetes”,“cannabidiol”,“anti-inflammatory effect”,and“CBD”.Articles published between 2005 and 2025 were screened,and studies involving animal models that examined CBD as a therapeutic intervention for T1D and reported on its antiinflammatory effects were included.Of the 62 retrieved articles,only 6 met the predefined inclusion criteria.Although limited in number,the available studies show promising outcomes.CBD demonstrates potential as an adjuvant therapy for T1D due to its immunomodulatory and anti-inflammatory actions.Nonetheless,further research is required to establish safe and effective clinical application protocols.
文摘As new innovation ecosystems emerge around AI,standards will be essential in bringing these ecosystems to the global scale.Our recent AI for Good Global Summit 2025 showcased our progress on AI standards in areas from networking,multimedia,energy efficiency to healthcare,food security,road safety and disaster risk reduction.
基金supported by the Istanbul Technical University Office of Scientific Research Projects(ITUBAPSIS),under grant MYL-2022-43776。
文摘The design of unmanned aerial vehicles(UAVs)revolves around the careful selection of materials that are both lightweight and robust.Carbon fiber-reinforced polymer(CFRP)emerged as an ideal option for wing construction,with its mechanical qualities thoroughly investigated.In this study,we developed and optimized a conceptual UAV wing to withstand structural loads by establishing progressive composite stacking sequences,and we conducted a series of experimental characterizations on the resulting material.In the optimization phase,the objective was defined as weight reduction,while the Hashin damage criterion was established as the constraint for the optimization process.The optimization algorithm adaptively monitors regional damage criterion values,implementing necessary adjustments to facilitate the mitigation process in a cost-effective manner.Optimization of the analytical model using Simulia Abaqus~(TM)and a Python-based user-defined sub-routine resulted in a 34.7%reduction in the wing's structural weight after 45 iterative rounds.Then,the custom-developed optimization algorithm was compared with a genetic algorithm optimization.This comparison has demonstrated that,although the genetic algorithm explores numerous possibilities through hybridization,the custom-developed algorithm is more result-oriented and achieves optimization in a reduced number of steps.To validate the structural analysis,test specimens were fabricated from the wing's most critically loaded segment,utilizing the identical stacking sequence employed in the optimization studies.Rigorous mechanical testing revealed unexpectedly high compressive strength,while tensile and bending strengths fell within expected ranges.All observed failure loads remained within the established safety margins,thereby confirming the reliability of the analytical predictions.
基金Supported by the UK Department for Transport,as part of the UK Shipping Office for Reducing Emissions(UK SHORE)Programme and the UK Engineering and Physical Sciences Research Council(EPSRC)[grant number EP/Y024605/1].
文摘The hydrodynamic performance of high-speed planing hulls has gained considerable interest,with recent advancements in computational fluid dynamics and hull design techniques enhancing the understanding of planing hull hydrodynamics.In this study,we conducted a numerical investigation using the Reynolds-averaged Navier-Stokes approach with overset grids to capture large motions at high speeds.This study aims to improve the hydrodynamic performances of planing hulls,specifically focusing on total resistance,trim,and sinkage.The initial Fridsma hull with a deadrise angle of 20°has been used for validation,demonstrating good agreement with measurements at different Froude numbers.Subsequently,new configurations based on the Fridsma hull have been designed by varying the deadrise angle,number of chines,and transverse steps.Our findings reveal a correlation between the deadrise angle,the number of chines,and the Froude number.As the deadrise angle increases,total resistance also increases.Additionally,a single chine yields superior results at higher Froude numbers,while multiple chines offer advantages at lower values.The introduction of transverse steps consistently increases total resistance,highlighting their role in improving planing hull performance.This research not only offers valuable insights into planing hull design but also leverages state-of-the-art numerical methods to advance the understanding of hydrodynamic behaviors at high ship speeds.
文摘BACKGROUND Although inflammatory diseases commonly affect the pleura and pleural space,their mechanisms of action remain unclear.The presence of several mediators emphasizes the concept of pleural inflammation.Adenosine deaminase(ADA)is an inflammatory mediator detected at increased levels in the pleural fluid.AIM To determine the role of total pleural ADA(P-ADA)levels in the diagnosis of pleural inflammatory diseases.METHODS 157 patients with inflammatory pleural effusion(exudates,n=124,79%)and noninflammatory pleural effusion(transudates,n=33,21%)were included in this observational retrospective cohort study.The P-ADA assay was tested using a kinetic technique.The performance of the model was evaluated using the area under the receiver operating characteristic(ROC)curve(AUC).The ideal cutoff value for P-ADA in pleural inflammation was determined using the Youden index in the ROC curve.RESULTS The transudates included congestive heart failure(n=26),cirrhosis of the liver with ascites(n=3),chronic renal failure(n=3),and low total protein levels(n=1).The exudate cases included tuberculosis(n=44),adenocarcinoma(n=37),simple parapneumonic effusions(n=15),complicated parapneumonic effusions/empyema(n=8),lymphoma(n=7),and other diseases(n=13).The optimal cutoff value of P-ADA was≥9.00 U/L.The diagnostic parameters as sensitivity,specificity,positive and negative predictive values,positive and negative likelihood values,odds ratio,and accuracy were 77.69(95%CI:69.22-84.75);68.75(95%CI:49.99-83.88);90.38 and 44.90(95%CI:83.03-95.29;30.67-59.77);2.48 and 0.32(95%CI:2.21-11.2;0.27-0.51);7.65(95%CI:0.78-18.34),and 75.82(95%CI:68.24-82.37),respectively(χ^(2)=29.51,P=0.00001).An AUC value of 0.8107(95%CI:0.7174-0.8754;P=0.0000)was clinically useful.The Hosmer-Lemeshow test showed excellent discrimination.CONCLUSION P-ADA biomarker has high diagnostic performance for pleural inflammatory exudates.
