Ozone(O_(3))has become a major air pollutant worldwide,posing an alarming threat to public health.However,whether the exposure to O_(3)induces liver and lung damage remains unclear,alongside the underlying mechanisms....Ozone(O_(3))has become a major air pollutant worldwide,posing an alarming threat to public health.However,whether the exposure to O_(3)induces liver and lung damage remains unclear,alongside the underlying mechanisms.In this study,the mice were exposed to environmentally-relevant concentrations of O_(3)for 30 d,alongside the systemic analysis of the injuries in lungs and livers.The results revealed that O_(3)exposure could reduce weight gain and induce histopathological damage in both lungs and livers,accompanied by dysregulated oxidative stress-related genes and elevated proinflammatory factors.Additionally,the lung microbiome analysis demonstrated that the microbial abundance was decreased and community structure was altered,and it was indicated by the network analysis that the complexity of the microbial network was diminished.Besides,the aspartate aminotransferase(AST)activity,malondialdehyde(MDA),and Fe^(2+)levels were found to be elevated after O_(3)exposure by the hepatic profile assessment,accompanied by depleted glutathione(GSH)both in liver and plasma.These alterations were associated with a ferroptosis process in the liver,and it was confirmed by lipidomics that the most significantly impacted processes were ferroptosis-related.Additionally,multi-omics mediation analysis demonstrated that lung injury could mediate liver lipid dysregulation through lung microbiota.These findings provide novel mechanistic insights into the toxicological mechanism of O_(3)via the lung-liver axis.展开更多
Lake ecosystems are extremely sensitive to nitrogen growth,which leads to water quality degradation and ecosystem health decline.Nitrogen depositions,as one of the main sources of nitrogen in water,are expected to cha...Lake ecosystems are extremely sensitive to nitrogen growth,which leads to water quality degradation and ecosystem health decline.Nitrogen depositions,as one of the main sources of nitrogen in water,are expected to change under future climate change scenarios.However,it remains not clear how nitrogen deposition to lakes respond to future meteorological conditions.In this study,a source-oriented version of Community Multiscale Air Quality(CMAQ)Model was used to estimate nitrogen deposition to 263 lakes in 2013 and under three RCP scenarios(4.5,6.0 and 8.5)in 2046.Annual total deposition of 58.2 Gg nitrogen was predicted for all lakes,with 23.3 Gg N by wet deposition and 34.9 Gg N by dry deposition.Nitrate and ammonium in aerosol phase are the major forms of wet deposition,while NH3 and HNO_(3)in gas phase are the major forms of dry deposition.Agriculture emissions contribute to 57%of wet deposition and 44%of dry deposition.Under future meteorological conditions,wet deposition is predicted to increase by 5.5%to 16.4%,while dry deposition would decrease by 0.3%to 13.0%.Changes in wind speed,temperature,relative humidity(RH),and precipitation rates are correlated with dry and wet deposition changes.The predicted changes in deposition to lakes driven by meteorological changes can lead to significant changes in aquatic chemistry and ecosystem functions.Apart from future emission scenarios,different climate scenarios should be considered in future ecosystem health evaluation in response to nitrogen deposition.展开更多
Suicide is defined as the act of a person attempting to take their own life by causing death.Suicide is a complex phenomenon that is influenced by a multitude of factors,including psychosocial,cultural,and religious a...Suicide is defined as the act of a person attempting to take their own life by causing death.Suicide is a complex phenomenon that is influenced by a multitude of factors,including psychosocial,cultural,and religious aspects,as well as genetic,biochemical,and environmental factors.From a biochemical perspective,it is crucial to consider the communication between the endocrine,immune,and nervous systems when studying the etiology of suicide.Several pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines,hormones,and neurotransmitters.These humoral signals,when present in optimal quantities,are responsible for maintaining physiological homeostasis,including mood states.Stress elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance,thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal behavior.This review provides an integrative perspective about the neurochemical,immunological,and endocrinological disturbances associated with suicidal behavior,with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.展开更多
Urea synthesis through the simultaneous electrocatalytic reduction of N_(2)and CO_(2)molecules under ambient conditions holds great promises as a sustainable alternative to its industrial production,in which the devel...Urea synthesis through the simultaneous electrocatalytic reduction of N_(2)and CO_(2)molecules under ambient conditions holds great promises as a sustainable alternative to its industrial production,in which the development of stable,highly efficient,and highly selective catalysts to boost the chemisorption,activation,and coupling of inert N_(2)and CO_(2)molecules remains rather challenging.Herein,by means of density functional theory computations,we proposed a new class of two-dimensional nanomaterials,namely,transition-metal phosphide monolayers(TM_(2)P,TM=Ti,Fe,Zr,Mo,and W),as the potential electrocatalysts for urea production.Our results showed that these TM_(2)P materials exhibit outstanding stability and excellent metallic properties.Interestingly,the Mo_(2)P monolayer was screened out as the best catalyst for urea synthesis due to its small kinetic energy barrier(0.35 eV)for C-N coupling,low limiting potential(-0.39 V),and significant suppressing effects on the competing side reactions.The outstanding catalytic activity of the Mo_(2)P monolayer can be ascribed to its optimal adsorption strength with the key^(*)NCON species due to its moderate positive charges on the Mo active sites.Our findings not only propose a novel catalyst with high-efficiency and high-selectivity for urea production but also further widen the potential applications of metal phosphides in electrocatalysis.展开更多
Dear Colleagues,The International Council of Ophthalmology (ICO) is deeply committed to the health and safety of our communities during the COVID-19 pandemic.Unfortunately,due to escalating risks,a physical meeting of...Dear Colleagues,The International Council of Ophthalmology (ICO) is deeply committed to the health and safety of our communities during the COVID-19 pandemic.Unfortunately,due to escalating risks,a physical meeting of our international colleagues and partners at the World Ophthalmology Congress (WOC2020) in Cape Town 26-29 June,is no longer possible.While we are all disappointed that our face-to-face meeting is cancelled,the ICO remains devoted to bringing together the world’s ophthalmologists to learn the latest from one another,and to advance eye care during these extraordinarily challenging times.展开更多
Rill formation is the predominant erosion process in slope land in the Loess Plateau,China.This study was conducted to investigate rill erosion characteristics and their effects on runoff and sediment yielding process...Rill formation is the predominant erosion process in slope land in the Loess Plateau,China.This study was conducted to investigate rill erosion characteristics and their effects on runoff and sediment yielding processes under different slope gradients at a rate of 10°,15°,20°and 25°with rainfall intensity of 1.5 mm min-1 in a laboratory setting.Results revealed that mean rill depth and rill density has a positive interrelation to the slope gradient.To the contrary,width-depth ratio and distance of the longest rill to the top of the slope negatively related to slope gradient.All these suggested that increasing slope steepness could enhance rill headward erosion,vertical erosion and the fragmentation of the slope surface.Furthermore,total erosion tended to approach a stable maximum value with increasing slope,which implied that there is probably a threshold slope gradient where soil erosion begins to weaken.At the same time,the correlation analysis showed that there was a close connection between slope gradient and the variousindices of soil erosion:the correlation coefficients of slope gradient with maximal rill depth,number of rills and the distance of the longest rill from the top of the slope were 0.98,0.97 and-0.98,respectively,indicating that slope gradient is the major factor of affecting the development of rills.Furthermore,runoff was not sensitive to slope gradient and rill formation in this study.Sediment concentration,however,is positively related to slope gradient and rill formation,the sediment concentrations increased rapidly after rill initiation,especially.These results may be essential for soil loss prediction.展开更多
AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity we...AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver （FL） and 41 with nonalcoholic steatohepatitis （NASH）. METHODS： Circulating levels of Bcl-2 were detected in 84 patients with ultrasonographic findings of ＂bright liver＂ and/or hyper-transaminasemia of unknown origin and/or increase in T-glutamyl-transpeptidase （T-GT） strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups （43 with FL and 41 with NASH）. Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS： Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein （CRP） concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index （BMI） values （P ~ 0.0001） but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males （P = 0.0008）. γ-GT activity was associated with homeostatic metabolic assessment （HOMA） （P = 0.0003） and with serum ferritin （P = 0.02）. Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients pre- sented a weak negative correlation between Iobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metabolically unhealthy overweight/obese patients （MUOs） was evidenced. HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations. CONCLUSION： IvlUOs could be detected by Bcl-2 levels. By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL.展开更多
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFC3708203 and 2022YFC3704700)the National Natural Science Foundation of China(Grant Nos.22376033 and 22122601)the Major Project of Guangzhou National Laboratory(Grant No.GZNL2024A01028).
文摘Ozone(O_(3))has become a major air pollutant worldwide,posing an alarming threat to public health.However,whether the exposure to O_(3)induces liver and lung damage remains unclear,alongside the underlying mechanisms.In this study,the mice were exposed to environmentally-relevant concentrations of O_(3)for 30 d,alongside the systemic analysis of the injuries in lungs and livers.The results revealed that O_(3)exposure could reduce weight gain and induce histopathological damage in both lungs and livers,accompanied by dysregulated oxidative stress-related genes and elevated proinflammatory factors.Additionally,the lung microbiome analysis demonstrated that the microbial abundance was decreased and community structure was altered,and it was indicated by the network analysis that the complexity of the microbial network was diminished.Besides,the aspartate aminotransferase(AST)activity,malondialdehyde(MDA),and Fe^(2+)levels were found to be elevated after O_(3)exposure by the hepatic profile assessment,accompanied by depleted glutathione(GSH)both in liver and plasma.These alterations were associated with a ferroptosis process in the liver,and it was confirmed by lipidomics that the most significantly impacted processes were ferroptosis-related.Additionally,multi-omics mediation analysis demonstrated that lung injury could mediate liver lipid dysregulation through lung microbiota.These findings provide novel mechanistic insights into the toxicological mechanism of O_(3)via the lung-liver axis.
基金supported by the project of Guangzhou Institute of Geochemistry the Chinese Academy of Sciences(No.51TGC202209)Shenzhen Science and Technology Plan(Nos.KJYY20180206180737010 and 6020320003K)the National Key R&D Program of China(No.2022YFC3701105).
文摘Lake ecosystems are extremely sensitive to nitrogen growth,which leads to water quality degradation and ecosystem health decline.Nitrogen depositions,as one of the main sources of nitrogen in water,are expected to change under future climate change scenarios.However,it remains not clear how nitrogen deposition to lakes respond to future meteorological conditions.In this study,a source-oriented version of Community Multiscale Air Quality(CMAQ)Model was used to estimate nitrogen deposition to 263 lakes in 2013 and under three RCP scenarios(4.5,6.0 and 8.5)in 2046.Annual total deposition of 58.2 Gg nitrogen was predicted for all lakes,with 23.3 Gg N by wet deposition and 34.9 Gg N by dry deposition.Nitrate and ammonium in aerosol phase are the major forms of wet deposition,while NH3 and HNO_(3)in gas phase are the major forms of dry deposition.Agriculture emissions contribute to 57%of wet deposition and 44%of dry deposition.Under future meteorological conditions,wet deposition is predicted to increase by 5.5%to 16.4%,while dry deposition would decrease by 0.3%to 13.0%.Changes in wind speed,temperature,relative humidity(RH),and precipitation rates are correlated with dry and wet deposition changes.The predicted changes in deposition to lakes driven by meteorological changes can lead to significant changes in aquatic chemistry and ecosystem functions.Apart from future emission scenarios,different climate scenarios should be considered in future ecosystem health evaluation in response to nitrogen deposition.
基金Supported by CONAHCYT Project,No.CF-2023-I-2663Instituto Nacional de Psiquiatría Project,No.NC24208.0(to Pérez-Sánchez G,Pavón L,Sánchez-Huerta K,Maldonado-García JL,Chin-Chan JM,Ponce-Regalado MD,Arreola R,Contis-Montes de Oca A,and Moreno-Lafont MC).
文摘Suicide is defined as the act of a person attempting to take their own life by causing death.Suicide is a complex phenomenon that is influenced by a multitude of factors,including psychosocial,cultural,and religious aspects,as well as genetic,biochemical,and environmental factors.From a biochemical perspective,it is crucial to consider the communication between the endocrine,immune,and nervous systems when studying the etiology of suicide.Several pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines,hormones,and neurotransmitters.These humoral signals,when present in optimal quantities,are responsible for maintaining physiological homeostasis,including mood states.Stress elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance,thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal behavior.This review provides an integrative perspective about the neurochemical,immunological,and endocrinological disturbances associated with suicidal behavior,with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.
基金financially supported in China by Natural Science Funds for Distinguished Young Scholars of Heilongjiang Province(No.JC2018004)Natural Science Foundation of Heilongjiang Province of China(No.TD2020B001)in the USA by NSF-CREST Center for Innovation,Research,and Education in Environmental Nanotechnology(CIRE2N)(No.HRD-1736093)
文摘Urea synthesis through the simultaneous electrocatalytic reduction of N_(2)and CO_(2)molecules under ambient conditions holds great promises as a sustainable alternative to its industrial production,in which the development of stable,highly efficient,and highly selective catalysts to boost the chemisorption,activation,and coupling of inert N_(2)and CO_(2)molecules remains rather challenging.Herein,by means of density functional theory computations,we proposed a new class of two-dimensional nanomaterials,namely,transition-metal phosphide monolayers(TM_(2)P,TM=Ti,Fe,Zr,Mo,and W),as the potential electrocatalysts for urea production.Our results showed that these TM_(2)P materials exhibit outstanding stability and excellent metallic properties.Interestingly,the Mo_(2)P monolayer was screened out as the best catalyst for urea synthesis due to its small kinetic energy barrier(0.35 eV)for C-N coupling,low limiting potential(-0.39 V),and significant suppressing effects on the competing side reactions.The outstanding catalytic activity of the Mo_(2)P monolayer can be ascribed to its optimal adsorption strength with the key^(*)NCON species due to its moderate positive charges on the Mo active sites.Our findings not only propose a novel catalyst with high-efficiency and high-selectivity for urea production but also further widen the potential applications of metal phosphides in electrocatalysis.
基金This work was supported by the National Key R&D Program of China[grant number 2022YFC370110]the National Natural Science Foundation of China[grant numbers 42077194,42061134008,and 42377098]+1 种基金the Shanghai International Science and Technology Partnership Project[grant number 21230780200]the Shanghai General Project[grant number 23ZR1406100].
文摘Dear Colleagues,The International Council of Ophthalmology (ICO) is deeply committed to the health and safety of our communities during the COVID-19 pandemic.Unfortunately,due to escalating risks,a physical meeting of our international colleagues and partners at the World Ophthalmology Congress (WOC2020) in Cape Town 26-29 June,is no longer possible.While we are all disappointed that our face-to-face meeting is cancelled,the ICO remains devoted to bringing together the world’s ophthalmologists to learn the latest from one another,and to advance eye care during these extraordinarily challenging times.
基金Financial support for this research was provided by the National Natural Science Foundation of China(41401302)the Key Program of National Natural Science Foundation of China(41130744)+4 种基金National Natural Science Foundation of China(41271304),National Natural Science Foundation of China(41471229)Natural Science Foundation of Beijing Municipal of Education(025135303700/048)Beijing Youth Elite Project(043135336000/002)the Project of Research Base Construction of Beijing Municipal Education CommissionKey laboratory of Water Cycle and Related Land Surface Processes Foundation(201204)
文摘Rill formation is the predominant erosion process in slope land in the Loess Plateau,China.This study was conducted to investigate rill erosion characteristics and their effects on runoff and sediment yielding processes under different slope gradients at a rate of 10°,15°,20°and 25°with rainfall intensity of 1.5 mm min-1 in a laboratory setting.Results revealed that mean rill depth and rill density has a positive interrelation to the slope gradient.To the contrary,width-depth ratio and distance of the longest rill to the top of the slope negatively related to slope gradient.All these suggested that increasing slope steepness could enhance rill headward erosion,vertical erosion and the fragmentation of the slope surface.Furthermore,total erosion tended to approach a stable maximum value with increasing slope,which implied that there is probably a threshold slope gradient where soil erosion begins to weaken.At the same time,the correlation analysis showed that there was a close connection between slope gradient and the variousindices of soil erosion:the correlation coefficients of slope gradient with maximal rill depth,number of rills and the distance of the longest rill from the top of the slope were 0.98,0.97 and-0.98,respectively,indicating that slope gradient is the major factor of affecting the development of rills.Furthermore,runoff was not sensitive to slope gradient and rill formation in this study.Sediment concentration,however,is positively related to slope gradient and rill formation,the sediment concentrations increased rapidly after rill initiation,especially.These results may be essential for soil loss prediction.
文摘AIM： To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indi- ces, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver （FL） and 41 with nonalcoholic steatohepatitis （NASH）. METHODS： Circulating levels of Bcl-2 were detected in 84 patients with ultrasonographic findings of ＂bright liver＂ and/or hyper-transaminasemia of unknown origin and/or increase in T-glutamyl-transpeptidase （T-GT） strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups （43 with FL and 41 with NASH）. Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS： Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein （CRP） concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index （BMI） values （P ~ 0.0001） but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males （P = 0.0008）. γ-GT activity was associated with homeostatic metabolic assessment （HOMA） （P = 0.0003） and with serum ferritin （P = 0.02）. Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients pre- sented a weak negative correlation between Iobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metabolically unhealthy overweight/obese patients （MUOs） was evidenced. HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations. CONCLUSION： IvlUOs could be detected by Bcl-2 levels. By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL.
