Satellite communication technology has emerged as a key solution to address the challenges of data transmission in remote areas.By overcoming the limitations of traditional terrestrial communication networks,it enable...Satellite communication technology has emerged as a key solution to address the challenges of data transmission in remote areas.By overcoming the limitations of traditional terrestrial communication networks,it enables long-distance data transmission anytime and anywhere,ensuring the timely and accurate delivery of water level data,which is particularly crucial for fishway water level monitoring.To enhance the effectiveness of fishway water level monitoring,this study proposes a multi-task learning model,AS-SOMTF,designed for real-time and comprehensive prediction.The model integrates auxiliary sequences with primary input sequences to capture complex relationships and dependencies,thereby improving representational capacity.In addition,a novel timeseries embedding algorithm,AS-SOM,is introduced,which combines generative inference and pooling operations to optimize prediction efficiency for long sequences.This innovation not only ensures the timely transmission of water level data but also enhances the accuracy of real-time monitoring.Compared with traditional models such as Transformer and Long Short-Term Memory(LSTM)networks,the proposed model achieves improvements of 3.8%and 1.4%in prediction accuracy,respectively.These advancements provide more precise technical support for water level forecasting and resource management in the Diqing Tibetan Autonomous Prefecture of the Lancang River,contributing to ecosystem protection and improved operational safety.展开更多
In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better...In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.展开更多
Two new hydralazine hydrochloride-derived Schiff bases<span style="font-family:Verdana;"><span style="font-family:Verdana;">:<span style="font-family:Verdana;"> (E)...Two new hydralazine hydrochloride-derived Schiff bases<span style="font-family:Verdana;"><span style="font-family:Verdana;">:<span style="font-family:Verdana;"> (E)-1-(Phthalazin-<span style="font-family:Verdana;"> <span style="font-family:Verdana;">1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine-<span style="font-family:Verdana;"> <span style="font-family:Verdana;">3<span style="font-family:Verdana;">-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicate<span style="font-family:Verdana;"><span style="font-family:Verdana;">s<span style="font-family:Verdana;"> that the hydralazine moiety of both ligands possess<span style="font-family:Verdana;"><span style="font-family:Verdana;">es<span style="font-family:Verdana;"> the exoc<span style="font-family:Verdana;">yclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 <span style="font-family:Verdana;"><span style="font-family:Verdana;">-<span style="font-family:Verdana;"> 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> slightly high inhibition of lipid peroxidation using Vitamin C as standard. Regarding their catalase activity, both compounds show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> concentration dependent effect, but Vitamin C continued showing a higher stimulatory effect on the enzyme activity. Additionally, while PPEH showed less than 80% inhibition in the preliminary antiplasmodial assay and so was not considered for the dose-response studies, PEHP<span style="font-family:Verdana;"> displayed an inhibition percentage of 83.60% and 50% Inhibitory Concentration (IC<sub><span style="font-family:Verdana;vertical-align:sub;">50</sub><span style="font-family:Verdana;">) value of 44.13 μg/mL compared to the standard drug, artemisinin and was classified as slightly active<span style="font-family:Verdana;">.展开更多
From the ethyl acetate extract of the medicinal plant Graptophyllum glandulosum Turrill, five known compounds: Lupeol (1), Oleanolic acid (2), Chrysoeriol (3), N-methyl-isonicotinamide (4) and β-sitosterol 3-O-β-D-g...From the ethyl acetate extract of the medicinal plant Graptophyllum glandulosum Turrill, five known compounds: Lupeol (1), Oleanolic acid (2), Chrysoeriol (3), N-methyl-isonicotinamide (4) and β-sitosterol 3-O-β-D-glucopyranoside (5) were isolated. In addition, oxidation reactions carried out on lupeol (1) yielded two semi-synthetic compounds, including a previously unreported: (20R)-formyloxy-29-nor-lupan-3-one (1b) and one other well-known Lupenone (1a). The structures of natural and semi-synthetic compounds were determined by analysis of 1D-(1H, 13C), 2D-(COSY, HSQC and HMBC) NMR data in conjunction with mass spectrometry (TOFESIMS and HR-TOFESIMS) and by comparison with the reported data. The evaluation of antimicrobial activities of substrate (1) as well as semi-synthetic derivatives (1a and 1b) using broth microdilution method showed that compound 1b was the most active (16 ≤ MIC ≤ 32 μg/mL) against Escherichia coli, Staphylococcus aureus and Candida albicans compared to the starting material 1 (16 ≤ MIC ≤ 64 μg/mL) and derivative 1a (32 ≤ MIC ≤ 64 μg/mL).展开更多
目的探讨烯脂酰辅酶A水合酶短链1(enoyl-coenzyme A hydratase,short chain1,ECHS1)和细胞增殖核抗原Ki-67在结直肠癌组织中的表达及其与临床病理特征的关系。方法选择2013年1月至2016年12月秦皇岛市第一医院肿瘤科收治的50例结直肠癌...目的探讨烯脂酰辅酶A水合酶短链1(enoyl-coenzyme A hydratase,short chain1,ECHS1)和细胞增殖核抗原Ki-67在结直肠癌组织中的表达及其与临床病理特征的关系。方法选择2013年1月至2016年12月秦皇岛市第一医院肿瘤科收治的50例结直肠癌患者手术切除的组织标本,以10例癌旁组织作为对照,采用免疫组织化学SP法检测结直肠癌组织及癌旁组织中ECHS1和Ki-67的表达,并分析其与临床病理学特征的关系。结果 ECHS1和Ki-67在结直肠癌组织中的阳性表达率分别为56.0%(28/50)和62.0%(31/50),均显著高于癌旁组织中的表达,差异有显著性(P<0.05)。ECHS1和Ki-67的异常表达与结直肠癌的Dukes分期、分化程度及有无淋巴转移有关(P<0.05)。ECHS1和Ki-67的表达呈正相关关系(r=0.501,P=0.010)。结论在结直肠癌组织中ECHS1和Ki-67的表达明显升高,与Dukes分期、分化程度和淋巴转移有关,且二者具有协同作用。展开更多
In Cameroon, the Ngazi-Tina region belongs to the Adamawa-Yade domain of the Pan-African Central African Fold Belt (CAFB). It is composed of two petrographic types: quartz-monzonites (majority) and nepheline syenites....In Cameroon, the Ngazi-Tina region belongs to the Adamawa-Yade domain of the Pan-African Central African Fold Belt (CAFB). It is composed of two petrographic types: quartz-monzonites (majority) and nepheline syenites. Two morphological types, prismatic and pyramidal, were recognized in the zircon grains samples. These zircon types display internal structure</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> typical of magmatic zircons. Zircons separated from the Ngazi-Tina samples contain higher abundances of Hf (close to 8000 ppm) and moderate trace elements (Y, Th, U, Nb, Ta) and REE contents, suggesting a variable degree of magmatic evolution. The chondrite-normalized REE patterns of zircons are characterized by LREE depletion relative to HREE with positive Ce and negative Eu anomalies, typical of magmatic zircons. The high Hf content together with high Ce/Ce*, Th/U, Zr/Hf ratios suggest magma crystallization under variable oxidation and oxygen fugacity. The application of Ti-in-zircon thermometer reveals crystallization temperatures ranging from 678</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C to 811</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C and 658</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C to 768</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">C for quartz monzonites and nepheline syenites respectively. These features indicate probably a partial melting of continental crust as the source of these zircons grains and emplacement in</span></span><span style="font-family:Verdana;"> the</span><span style="font-family:Verdana;"> magmatic-arc setting.展开更多
This paper presents a detailed design of a photovoltaic (PV) system for use in the rural electrification of remote settlements that are far off from the electricity grid. Since investment in building transmission line...This paper presents a detailed design of a photovoltaic (PV) system for use in the rural electrification of remote settlements that are far off from the electricity grid. Since investment in building transmission lines from the grid to these localities is not viable, a good solution is <span>an</span><span> installation in these areas of standalone photovoltaic systems. The design process comprises the choice and dimensioning of the solar panels, the battery storage, DC-AC inverter, and mini transmission grid to the different homes. The design is for a 15 kW PV system including an economic evaluation and analysis using Hybrid Optimization of Multiple Energy Resources (HOMER) software. Data on the average monthly solar radiation and temperature w</span><span>ere</span><span> obtained from various sources, including, Photovoltaic Geographical Information System (PVGIS) for Africa. From this data the study area receives a monthly average solar insolation of 6.16 kWh/</span><span>m</span><sup><span style="vertical-align:super;">2</span></sup><span>/day with the worst month </span><span>being </span><span>August with 5.22 kWh/</span><span>m</span><sup><span style="vertical-align:super;">2</span></sup><span>/day. The total daily electrical energy consumption is estimated to be about 72.525 kWh. Simulation results using HOMER software shows that the overall capital cost of the PV system components is $122,337, a replacement cost of $12,889 and an operation and maintenance cost of $29,946 over 10years. A financial analysis of the system showed that the design was both viable and sustainable with low maintenance cost</span><span>.</span>展开更多
With the aim to produce a detailed structural map and then enhance the geological information of the south-western Cameroon, a field gravity study is carried out in the Kribi-Campo-Ma’an area (SW Cameroon). This stud...With the aim to produce a detailed structural map and then enhance the geological information of the south-western Cameroon, a field gravity study is carried out in the Kribi-Campo-Ma’an area (SW Cameroon). This study area is assumed to undergo pending active tectonics as witnessed by several earthquakes [1]. Besides, the area has been affected by some shears that gave rise to many major faults including the Kribi-Campo Fault (KCF). This N-S lineament is an active fault corresponding to the NW margin of the CC [2] [3] and related to the development of the Kribi-Campo basin. The gravity data analysis enables to highlight many deeply-seated structural features trending in the NE, NNE, N-S, NNW, NW and E-W directions in this region. The NW-SE trend is more strongly developed than the other identified trends and could have deeply affected the major NNE structure. The NNE-SSW to N-S fractures and faults which are local relays of the Kribi-Campo fault are related to the Kribi shear zone. The fairly good clustering observed on local maxima of the horizontal gradient magnitude enables to suggest that the contacts outlined have vertical to subvertical dips. However, a probable interpretation of these features is that they are vertical to subvertical faults which follow the aforementioned directions. The location of the study area in the gulf of Guinea suggests that it sustains tectonics related both to the equatorial and the south Atlantic oceans opening.展开更多
In this paper,we present a conservative semi-Lagrangian scheme designed for the numeri-cal solution of 3D hydrostatic free surface flows involving sediment transport on unstruc-tured Voronoi meshes.A high-order recons...In this paper,we present a conservative semi-Lagrangian scheme designed for the numeri-cal solution of 3D hydrostatic free surface flows involving sediment transport on unstruc-tured Voronoi meshes.A high-order reconstruction procedure is employed for obtaining a piecewise polynomial representation of the velocity field and sediment concentration within each control volume.This is subsequently exploited for the numerical integration of the Lagrangian trajectories needed for the discretization of the nonlinear convective and viscous terms.The presented method is fully conservative by construction,since the transported quantity or the vector field is integrated for each cell over the deformed vol-ume obtained at the foot of the characteristics that arises from all the vertexes defining the computational element.The semi-Lagrangian approach allows the numerical scheme to be unconditionally stable for what concerns the advection part of the governing equations.Furthermore,a semi-implicit discretization permits to relax the time step restriction due to the acoustic impedance,hence yielding a stability condition which depends only on the explicit discretization of the viscous terms.A decoupled approach is then employed for the hydrostatic fluid solver and the transport of suspended sediment,which is assumed to be passive.The accuracy and the robustness of the resulting conservative semi-Lagrangian scheme are assessed through a suite of test cases and compared against the analytical solu-tion whenever is known.The new numerical scheme can reach up to fourth order of accu-racy on general orthogonal meshes composed by Voronoi polygons.展开更多
In this article,new generalized neutrosophic soft∗b open set is introduced in neutrosophic soft bi-topological structurers(NSBTS)concerning soft points of the space.This new set is produced by making the marriage of s...In this article,new generalized neutrosophic soft∗b open set is introduced in neutrosophic soft bi-topological structurers(NSBTS)concerning soft points of the space.This new set is produced by making the marriage of soft semi-open set with soft pre-open set in neutrosophic soft topological structure.An ample of results are investigated in NSBTS on the basis of this new neutrosophic soft∗b open set.Proper examples are settled for justification of these results.The non-validity of some results is vindicated with examples.展开更多
The purpose of this work is to characterize the sediments of the Babouri-Figuil<span style="font-family:""><span style="font-family:Verdana;"> Basin from a diagenetic point of view...The purpose of this work is to characterize the sediments of the Babouri-Figuil<span style="font-family:""><span style="font-family:Verdana;"> Basin from a diagenetic point of view, the protolith context and weathering conditions, u</span><span><span style="font-family:Verdana;">sing major element geochemistry and mineralogy of the sedimentary rocks. Microscopic observations of diagenetic phenomena (on and around detrital grains of the basin), and the study of precipitation of the cement show that these sediments have undergone phenomena of compaction, dissolution, recrystallization and cementation. Cementation of quartz by silica is controlled by the rate of precipitation of silica, which is closely related to temperature than pressure. Thus, the sediments of the basin could be influenced by hydrothermalism during diagenesis, which would have inhibited their reservoir quality by generalized cementation phenomena. Geochemical features of the sediments show high contents in SiO</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;"> (47.49 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">90.79 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">), Al</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">3</span></sub><span style="font-family:Verdana;"> (2.92 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">23.18 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">), Fe</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">3</span></sub><span style="font-family:Verdana;"> (0.2 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">6.22 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">) and alkali and alkaline earth metals (>3</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">). The chemical alteration index varies between 30.92</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;"> and 95.08</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">. This variation in the CIA values reflects the variation in the proportion of feldspars and different clay minerals in these sediments. How</span></span><span style="font-family:""><span style="font-family:Verdana;">ever, the ICV calculation and the ICV versus CIA show compositional immature to mature sediments, with </span><span style="font-family:Verdana;">low to intense weathering character of these sediments. Petrographic and</span><span style="font-family:Verdana;"> geo</span><span style="font-family:Verdana;">chemical characteristics of sediments of the basin are compatible with the</span><span style="font-family:Verdana;"> composition of the granitic and gneissic surrounding bedrocks.</span></span>展开更多
Introduction: The delivery of a primipara, a woman giving birth for the first time, is challenging and may lead to complications and influence the obstetrical future of a woman. Materials and Methods: We carried out a...Introduction: The delivery of a primipara, a woman giving birth for the first time, is challenging and may lead to complications and influence the obstetrical future of a woman. Materials and Methods: We carried out a cross-sectional and analytical study at the maternity of the regional hospital annex of Ayos, a semi-rural locality in Cameroon, for the period between January 2012 and December 2020. The objective was to determine the frequency and the determinants of primipara delivery. Results: We recruited 440 cases. The frequency of primipara delivery was 31.8%. The ages of the participants ranged from 12 to 35 years with a mean age of 18.01 ± 3.52 years. Single women contributed to 95.5% of cases while 97.5% were unemployed. The delivery occurred at term in 90.2% and 98.4% of pregnancies were singleton. The delivery was vaginal in 91.6%, while caesarean delivery was done in 8.4% (8% emergency and 0.4% elective). The most frequent maternal complications were genital tract tears (15.7%), post-partum hemorrhage (12.5%) and endometritis (2.7%). The birth weight of newborns ranged from 1070 to 4500 g with a mean of 3024.5 ± 511.4 g. The single marital status, a gestational age between 37 and 42 weeks and a birth weight between 1500 g and 2499 g were significantly associated with vaginal delivery. Conclusion: The frequency of primiparous delivery was relatively high (31.8%) in the Ayos semi-rural health district of Cameroon. Major complications associated with delivery included genital tract tears, post-partum hemorrhage, cesarean section and neo-natal infection.展开更多
Few studies have compared the variability of soil properties using different types of mulches in semi-arid forests.This study evaluated the changes in physico-chemical soil properties in a semi-arid forest of Central ...Few studies have compared the variability of soil properties using different types of mulches in semi-arid forests.This study evaluated the changes in physico-chemical soil properties in a semi-arid forest of Central Eastern Spain,where straw and pine wood chips were distributed as mulch three months after a wildfire.Soils were sampled under burned and unmulched and burned and mulched plots three and nine months after the treatments.The data was processed using Principal Component Analysis(PCA)and Analytical Hierarchical Cluster Analysis(AHCA).Mulching with straw or wood chips did not have any significant effects on the texture and chemical properties of burned sites few months after the treatment.In contrast,significant changes are expected over time in organic matter,nutrients and many ions.There were no significant differences in soil properties between the two mulches.These low changes were confirmed by PCA coupled with AHCA,which did not show a clear distinction among the three soil conditions.However,a noticeable and significant variability of many of these properties over time was evident.This study shows that mulching does not degrade of soil properties in the short-term after a wildfire and after post-fire treatments,and thus helps protect semi-arid forest ecosystems against the negative impacts of high-severity fires.展开更多
Objective:To evaluate the in vitro anti-Trypanosoma cruzi（T.cruzi） activity of organic extracts prepared from halophyte species collected in the southern coast of Portugal（Algarve）,and chemically characterize the ...Objective:To evaluate the in vitro anti-Trypanosoma cruzi（T.cruzi） activity of organic extracts prepared from halophyte species collected in the southern coast of Portugal（Algarve）,and chemically characterize the most active samples.Methods:Acetone,dichloromethane and methanol extracts were prepared from 31 halophyte species and tested in vitro against trypomastigotes and intracellular amastigotes of the Tulahuen strain of T.cruzi.The most active extract was fractionated by preparative HPLC-DAD,affording 11 fractions.The most selective fraction was fully characterized by 1H-NMR.Results:From 94 samples tested,one was active,namely the root dichloromethane extract of Juncus acutus(IC50 < 20 μg/mL).This extract was fractionated by HPLC,affording 11 fractions,one of them containing only a pure compound（juncunol）,and tested for anti-parasitic activity.Fraction 8(IC50 = 4.1 μg/mL) was the most active,and was further characterized by 1H-NMR.The major compounds were phenanthrenes,9,10-dihydrophenanthrenes and benzocoumarins.Conclusion:Our results suggest that the compounds identified in fraction 8 are likely responsible for the observed anti parasitic activity.Further research is in progress aiming to isolate and identify the specific active molecules.To the best of our knowledge,this is the first report on the in vitro anti T.cruzi activity of halophyte species.展开更多
A local bivariate C1 quasi-interpolating spline operator with a four directional mesh is considered and studied. Based on the above operator we present cubature formulas for 2-D singular integrals, defined in the Hada...A local bivariate C1 quasi-interpolating spline operator with a four directional mesh is considered and studied. Based on the above operator we present cubature formulas for 2-D singular integrals, defined in the Hadamard finite part sense. Convergence results are obtained for a wide class of functions. Moreover numerical tests are given.展开更多
基金supported in part by the National Natural Science Foundation of China under Grant 62371181in part by the Changzhou Science and Technology International Cooperation Program under Grant CZ20230029The Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.RS-2024-00396797,Development of core technology for intelligent O-RAN security platform).
文摘Satellite communication technology has emerged as a key solution to address the challenges of data transmission in remote areas.By overcoming the limitations of traditional terrestrial communication networks,it enables long-distance data transmission anytime and anywhere,ensuring the timely and accurate delivery of water level data,which is particularly crucial for fishway water level monitoring.To enhance the effectiveness of fishway water level monitoring,this study proposes a multi-task learning model,AS-SOMTF,designed for real-time and comprehensive prediction.The model integrates auxiliary sequences with primary input sequences to capture complex relationships and dependencies,thereby improving representational capacity.In addition,a novel timeseries embedding algorithm,AS-SOM,is introduced,which combines generative inference and pooling operations to optimize prediction efficiency for long sequences.This innovation not only ensures the timely transmission of water level data but also enhances the accuracy of real-time monitoring.Compared with traditional models such as Transformer and Long Short-Term Memory(LSTM)networks,the proposed model achieves improvements of 3.8%and 1.4%in prediction accuracy,respectively.These advancements provide more precise technical support for water level forecasting and resource management in the Diqing Tibetan Autonomous Prefecture of the Lancang River,contributing to ecosystem protection and improved operational safety.
基金partially supported by the Natural Sciences and Engineering Research Council of Canada(2019-03907)。
文摘In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.
文摘Two new hydralazine hydrochloride-derived Schiff bases<span style="font-family:Verdana;"><span style="font-family:Verdana;">:<span style="font-family:Verdana;"> (E)-1-(Phthalazin-<span style="font-family:Verdana;"> <span style="font-family:Verdana;">1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine-<span style="font-family:Verdana;"> <span style="font-family:Verdana;">3<span style="font-family:Verdana;">-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicate<span style="font-family:Verdana;"><span style="font-family:Verdana;">s<span style="font-family:Verdana;"> that the hydralazine moiety of both ligands possess<span style="font-family:Verdana;"><span style="font-family:Verdana;">es<span style="font-family:Verdana;"> the exoc<span style="font-family:Verdana;">yclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 <span style="font-family:Verdana;"><span style="font-family:Verdana;">-<span style="font-family:Verdana;"> 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> slightly high inhibition of lipid peroxidation using Vitamin C as standard. Regarding their catalase activity, both compounds show<span style="font-family:Verdana;"><span style="font-family:Verdana;">ed<span style="font-family:Verdana;"> concentration dependent effect, but Vitamin C continued showing a higher stimulatory effect on the enzyme activity. Additionally, while PPEH showed less than 80% inhibition in the preliminary antiplasmodial assay and so was not considered for the dose-response studies, PEHP<span style="font-family:Verdana;"> displayed an inhibition percentage of 83.60% and 50% Inhibitory Concentration (IC<sub><span style="font-family:Verdana;vertical-align:sub;">50</sub><span style="font-family:Verdana;">) value of 44.13 μg/mL compared to the standard drug, artemisinin and was classified as slightly active<span style="font-family:Verdana;">.
文摘From the ethyl acetate extract of the medicinal plant Graptophyllum glandulosum Turrill, five known compounds: Lupeol (1), Oleanolic acid (2), Chrysoeriol (3), N-methyl-isonicotinamide (4) and β-sitosterol 3-O-β-D-glucopyranoside (5) were isolated. In addition, oxidation reactions carried out on lupeol (1) yielded two semi-synthetic compounds, including a previously unreported: (20R)-formyloxy-29-nor-lupan-3-one (1b) and one other well-known Lupenone (1a). The structures of natural and semi-synthetic compounds were determined by analysis of 1D-(1H, 13C), 2D-(COSY, HSQC and HMBC) NMR data in conjunction with mass spectrometry (TOFESIMS and HR-TOFESIMS) and by comparison with the reported data. The evaluation of antimicrobial activities of substrate (1) as well as semi-synthetic derivatives (1a and 1b) using broth microdilution method showed that compound 1b was the most active (16 ≤ MIC ≤ 32 μg/mL) against Escherichia coli, Staphylococcus aureus and Candida albicans compared to the starting material 1 (16 ≤ MIC ≤ 64 μg/mL) and derivative 1a (32 ≤ MIC ≤ 64 μg/mL).
文摘目的探讨烯脂酰辅酶A水合酶短链1(enoyl-coenzyme A hydratase,short chain1,ECHS1)和细胞增殖核抗原Ki-67在结直肠癌组织中的表达及其与临床病理特征的关系。方法选择2013年1月至2016年12月秦皇岛市第一医院肿瘤科收治的50例结直肠癌患者手术切除的组织标本,以10例癌旁组织作为对照,采用免疫组织化学SP法检测结直肠癌组织及癌旁组织中ECHS1和Ki-67的表达,并分析其与临床病理学特征的关系。结果 ECHS1和Ki-67在结直肠癌组织中的阳性表达率分别为56.0%(28/50)和62.0%(31/50),均显著高于癌旁组织中的表达,差异有显著性(P<0.05)。ECHS1和Ki-67的异常表达与结直肠癌的Dukes分期、分化程度及有无淋巴转移有关(P<0.05)。ECHS1和Ki-67的表达呈正相关关系(r=0.501,P=0.010)。结论在结直肠癌组织中ECHS1和Ki-67的表达明显升高,与Dukes分期、分化程度和淋巴转移有关,且二者具有协同作用。
文摘In Cameroon, the Ngazi-Tina region belongs to the Adamawa-Yade domain of the Pan-African Central African Fold Belt (CAFB). It is composed of two petrographic types: quartz-monzonites (majority) and nepheline syenites. Two morphological types, prismatic and pyramidal, were recognized in the zircon grains samples. These zircon types display internal structure</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> typical of magmatic zircons. Zircons separated from the Ngazi-Tina samples contain higher abundances of Hf (close to 8000 ppm) and moderate trace elements (Y, Th, U, Nb, Ta) and REE contents, suggesting a variable degree of magmatic evolution. The chondrite-normalized REE patterns of zircons are characterized by LREE depletion relative to HREE with positive Ce and negative Eu anomalies, typical of magmatic zircons. The high Hf content together with high Ce/Ce*, Th/U, Zr/Hf ratios suggest magma crystallization under variable oxidation and oxygen fugacity. The application of Ti-in-zircon thermometer reveals crystallization temperatures ranging from 678</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C to 811</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C and 658</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;">C to 768</span><span style="color:#4F4F4F;font-family:Verdana;">°</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">C for quartz monzonites and nepheline syenites respectively. These features indicate probably a partial melting of continental crust as the source of these zircons grains and emplacement in</span></span><span style="font-family:Verdana;"> the</span><span style="font-family:Verdana;"> magmatic-arc setting.
文摘This paper presents a detailed design of a photovoltaic (PV) system for use in the rural electrification of remote settlements that are far off from the electricity grid. Since investment in building transmission lines from the grid to these localities is not viable, a good solution is <span>an</span><span> installation in these areas of standalone photovoltaic systems. The design process comprises the choice and dimensioning of the solar panels, the battery storage, DC-AC inverter, and mini transmission grid to the different homes. The design is for a 15 kW PV system including an economic evaluation and analysis using Hybrid Optimization of Multiple Energy Resources (HOMER) software. Data on the average monthly solar radiation and temperature w</span><span>ere</span><span> obtained from various sources, including, Photovoltaic Geographical Information System (PVGIS) for Africa. From this data the study area receives a monthly average solar insolation of 6.16 kWh/</span><span>m</span><sup><span style="vertical-align:super;">2</span></sup><span>/day with the worst month </span><span>being </span><span>August with 5.22 kWh/</span><span>m</span><sup><span style="vertical-align:super;">2</span></sup><span>/day. The total daily electrical energy consumption is estimated to be about 72.525 kWh. Simulation results using HOMER software shows that the overall capital cost of the PV system components is $122,337, a replacement cost of $12,889 and an operation and maintenance cost of $29,946 over 10years. A financial analysis of the system showed that the design was both viable and sustainable with low maintenance cost</span><span>.</span>
文摘With the aim to produce a detailed structural map and then enhance the geological information of the south-western Cameroon, a field gravity study is carried out in the Kribi-Campo-Ma’an area (SW Cameroon). This study area is assumed to undergo pending active tectonics as witnessed by several earthquakes [1]. Besides, the area has been affected by some shears that gave rise to many major faults including the Kribi-Campo Fault (KCF). This N-S lineament is an active fault corresponding to the NW margin of the CC [2] [3] and related to the development of the Kribi-Campo basin. The gravity data analysis enables to highlight many deeply-seated structural features trending in the NE, NNE, N-S, NNW, NW and E-W directions in this region. The NW-SE trend is more strongly developed than the other identified trends and could have deeply affected the major NNE structure. The NNE-SSW to N-S fractures and faults which are local relays of the Kribi-Campo fault are related to the Kribi shear zone. The fairly good clustering observed on local maxima of the horizontal gradient magnitude enables to suggest that the contacts outlined have vertical to subvertical dips. However, a probable interpretation of these features is that they are vertical to subvertical faults which follow the aforementioned directions. The location of the study area in the gulf of Guinea suggests that it sustains tectonics related both to the equatorial and the south Atlantic oceans opening.
基金support of MIUR-PRIN Project 2017,No.2017KKJP4X“Innovative numerical methods for evolutionary partial differential equations and applications”.
文摘In this paper,we present a conservative semi-Lagrangian scheme designed for the numeri-cal solution of 3D hydrostatic free surface flows involving sediment transport on unstruc-tured Voronoi meshes.A high-order reconstruction procedure is employed for obtaining a piecewise polynomial representation of the velocity field and sediment concentration within each control volume.This is subsequently exploited for the numerical integration of the Lagrangian trajectories needed for the discretization of the nonlinear convective and viscous terms.The presented method is fully conservative by construction,since the transported quantity or the vector field is integrated for each cell over the deformed vol-ume obtained at the foot of the characteristics that arises from all the vertexes defining the computational element.The semi-Lagrangian approach allows the numerical scheme to be unconditionally stable for what concerns the advection part of the governing equations.Furthermore,a semi-implicit discretization permits to relax the time step restriction due to the acoustic impedance,hence yielding a stability condition which depends only on the explicit discretization of the viscous terms.A decoupled approach is then employed for the hydrostatic fluid solver and the transport of suspended sediment,which is assumed to be passive.The accuracy and the robustness of the resulting conservative semi-Lagrangian scheme are assessed through a suite of test cases and compared against the analytical solu-tion whenever is known.The new numerical scheme can reach up to fourth order of accu-racy on general orthogonal meshes composed by Voronoi polygons.
基金The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University,Abha 61413,Saudi Arabia for funding this work through research groups program under Grant No.R.G.P-2/29/42.
文摘In this article,new generalized neutrosophic soft∗b open set is introduced in neutrosophic soft bi-topological structurers(NSBTS)concerning soft points of the space.This new set is produced by making the marriage of soft semi-open set with soft pre-open set in neutrosophic soft topological structure.An ample of results are investigated in NSBTS on the basis of this new neutrosophic soft∗b open set.Proper examples are settled for justification of these results.The non-validity of some results is vindicated with examples.
文摘The purpose of this work is to characterize the sediments of the Babouri-Figuil<span style="font-family:""><span style="font-family:Verdana;"> Basin from a diagenetic point of view, the protolith context and weathering conditions, u</span><span><span style="font-family:Verdana;">sing major element geochemistry and mineralogy of the sedimentary rocks. Microscopic observations of diagenetic phenomena (on and around detrital grains of the basin), and the study of precipitation of the cement show that these sediments have undergone phenomena of compaction, dissolution, recrystallization and cementation. Cementation of quartz by silica is controlled by the rate of precipitation of silica, which is closely related to temperature than pressure. Thus, the sediments of the basin could be influenced by hydrothermalism during diagenesis, which would have inhibited their reservoir quality by generalized cementation phenomena. Geochemical features of the sediments show high contents in SiO</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;"> (47.49 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">90.79 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">), Al</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">3</span></sub><span style="font-family:Verdana;"> (2.92 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">23.18 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">), Fe</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">3</span></sub><span style="font-family:Verdana;"> (0.2 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">6.22 wt</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">) and alkali and alkaline earth metals (>3</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;">). The chemical alteration index varies between 30.92</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;"> and 95.08</span><span style="color:#4F4F4F;font-family:Verdana;">%</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">. This variation in the CIA values reflects the variation in the proportion of feldspars and different clay minerals in these sediments. How</span></span><span style="font-family:""><span style="font-family:Verdana;">ever, the ICV calculation and the ICV versus CIA show compositional immature to mature sediments, with </span><span style="font-family:Verdana;">low to intense weathering character of these sediments. Petrographic and</span><span style="font-family:Verdana;"> geo</span><span style="font-family:Verdana;">chemical characteristics of sediments of the basin are compatible with the</span><span style="font-family:Verdana;"> composition of the granitic and gneissic surrounding bedrocks.</span></span>
文摘Introduction: The delivery of a primipara, a woman giving birth for the first time, is challenging and may lead to complications and influence the obstetrical future of a woman. Materials and Methods: We carried out a cross-sectional and analytical study at the maternity of the regional hospital annex of Ayos, a semi-rural locality in Cameroon, for the period between January 2012 and December 2020. The objective was to determine the frequency and the determinants of primipara delivery. Results: We recruited 440 cases. The frequency of primipara delivery was 31.8%. The ages of the participants ranged from 12 to 35 years with a mean age of 18.01 ± 3.52 years. Single women contributed to 95.5% of cases while 97.5% were unemployed. The delivery occurred at term in 90.2% and 98.4% of pregnancies were singleton. The delivery was vaginal in 91.6%, while caesarean delivery was done in 8.4% (8% emergency and 0.4% elective). The most frequent maternal complications were genital tract tears (15.7%), post-partum hemorrhage (12.5%) and endometritis (2.7%). The birth weight of newborns ranged from 1070 to 4500 g with a mean of 3024.5 ± 511.4 g. The single marital status, a gestational age between 37 and 42 weeks and a birth weight between 1500 g and 2499 g were significantly associated with vaginal delivery. Conclusion: The frequency of primiparous delivery was relatively high (31.8%) in the Ayos semi-rural health district of Cameroon. Major complications associated with delivery included genital tract tears, post-partum hemorrhage, cesarean section and neo-natal infection.
基金funded by the Spanish Research Agency(AEI)(project code PID2021-126946OB-I00)the financial support from the EPy RIS(SOE2/P5/E0811)project funded by the European Union through the SUDOE INTERREG Program。
文摘Few studies have compared the variability of soil properties using different types of mulches in semi-arid forests.This study evaluated the changes in physico-chemical soil properties in a semi-arid forest of Central Eastern Spain,where straw and pine wood chips were distributed as mulch three months after a wildfire.Soils were sampled under burned and unmulched and burned and mulched plots three and nine months after the treatments.The data was processed using Principal Component Analysis(PCA)and Analytical Hierarchical Cluster Analysis(AHCA).Mulching with straw or wood chips did not have any significant effects on the texture and chemical properties of burned sites few months after the treatment.In contrast,significant changes are expected over time in organic matter,nutrients and many ions.There were no significant differences in soil properties between the two mulches.These low changes were confirmed by PCA coupled with AHCA,which did not show a clear distinction among the three soil conditions.However,a noticeable and significant variability of many of these properties over time was evident.This study shows that mulching does not degrade of soil properties in the short-term after a wildfire and after post-fire treatments,and thus helps protect semi-arid forest ecosystems against the negative impacts of high-severity fires.
基金supported by the Xtreme Bio(PTDC/MAR-EST/4346/2012)Ma Na Cruzi projects(bilateral project,FCT/CAPES 2358,2014/2015)+3 种基金funded by FCT–Foundation for Science and Technology and Portuguese National Budgetit also received national funds through FCT project CCMAR/Multi/04326/2013 and P3DPrograma de Descoberta e Desenvolvimento de Drogas(PROEP/CNPq/FIOCRUZ 401988/2012-0)supported by FCT Investigator Programme(IF/00049/2012)Policarpo Sales by Programa Brasil Sem Miséria/Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior(CAPES)/FIOCRUZ
文摘Objective:To evaluate the in vitro anti-Trypanosoma cruzi（T.cruzi） activity of organic extracts prepared from halophyte species collected in the southern coast of Portugal（Algarve）,and chemically characterize the most active samples.Methods:Acetone,dichloromethane and methanol extracts were prepared from 31 halophyte species and tested in vitro against trypomastigotes and intracellular amastigotes of the Tulahuen strain of T.cruzi.The most active extract was fractionated by preparative HPLC-DAD,affording 11 fractions.The most selective fraction was fully characterized by 1H-NMR.Results:From 94 samples tested,one was active,namely the root dichloromethane extract of Juncus acutus(IC50 < 20 μg/mL).This extract was fractionated by HPLC,affording 11 fractions,one of them containing only a pure compound（juncunol）,and tested for anti-parasitic activity.Fraction 8(IC50 = 4.1 μg/mL) was the most active,and was further characterized by 1H-NMR.The major compounds were phenanthrenes,9,10-dihydrophenanthrenes and benzocoumarins.Conclusion:Our results suggest that the compounds identified in fraction 8 are likely responsible for the observed anti parasitic activity.Further research is in progress aiming to isolate and identify the specific active molecules.To the best of our knowledge,this is the first report on the in vitro anti T.cruzi activity of halophyte species.
文摘A local bivariate C1 quasi-interpolating spline operator with a four directional mesh is considered and studied. Based on the above operator we present cubature formulas for 2-D singular integrals, defined in the Hadamard finite part sense. Convergence results are obtained for a wide class of functions. Moreover numerical tests are given.
