Progres in ion beam analysis at Fudan University in the recent years is briefly reviewed. Presented as examples of the research activities performed in this field are the following projects: (1) Nuclear potential reso...Progres in ion beam analysis at Fudan University in the recent years is briefly reviewed. Presented as examples of the research activities performed in this field are the following projects: (1) Nuclear potential resonance scattering of 6.25 MeV and 4.25 MeV helium ions for simultaneous compositional analysis of carbon and oxygen in a Mylar, a SnInO, and some other film samples: (2) Determination of stoichiometry of a high-temperature superconducting Y-Ba-Cu-O sample by backscattering of 8.8 MeV helium ions; (3) Backscattering and channeling analysis of multilayered structures periodically consisting of layers of pure Si and alternate layers of Ge and Si, grown on (100) Si substrates by molecular beam epitaxy: (4) Studies of surface structure of Al(100) by the use of MeV ions backscattering and channeling surface peak: and (5) MeV ion microbeam analysis and the use of PIXE method in DNA study. etc.展开更多
Particle induced X- ray emission (PIXE) and Rutherford backscattering spectrometry (RBS) have been used extensively for analytical purpose because of their quantitative accuracy, reliability, simplicity and capability...Particle induced X- ray emission (PIXE) and Rutherford backscattering spectrometry (RBS) have been used extensively for analytical purpose because of their quantitative accuracy, reliability, simplicity and capability of non- destructive and multielement analysis. When these techniques are combined with a scanning microbeam system and a data acquisition system, three dimensional distribution of elemental composition can be displayed. Samples analyzed so far at Fudan University include a microelectronic circuit and some biological and archaeological samples. The PIXE and RBS spectra and the secondary electron images have been measured.展开更多
The computed tomography was applied to setting STIM(Scanning Transmission Ion Microscopy) projections recorded at the Fudan Ion Beam Laboratory.In this work,in order to visualize the three-dimensional mass density dis...The computed tomography was applied to setting STIM(Scanning Transmission Ion Microscopy) projections recorded at the Fudan Ion Beam Laboratory.In this work,in order to visualize the three-dimensional mass density distribution in several specimens,example for a test structure of hollow gold cyliner was presented together with a detailed description of the developed system,including data reconstruction code(Tomorebuild 2) and image display software(AMIRA).Future development will allow the particle induced X-ray emission tomography for elemental analysis of micrometer-sized samples.展开更多
In this paper,we report a novel measurement system based on the development of Fudan Scanning Proton Microscopy(SPM) facility.By using Si-PIN diode(Hamamatsu S1223-01) detector,scanning transmission ion microscopy(STI...In this paper,we report a novel measurement system based on the development of Fudan Scanning Proton Microscopy(SPM) facility.By using Si-PIN diode(Hamamatsu S1223-01) detector,scanning transmission ion microscopy(STIM) measurement system has been set up.It can provide density and structural images with high probing efficiency and non-destruction by utilizing the energy loss of high energy(MeV) and focused ions penetrating through a thin sample.STIM measurement is able to map the density distribution of organic elements which mostly compose biology materials,such information can not be detected by using conventional Be-windowed Si(Li) X-ray detector in Particle Induced X-ray Emission(PIXE) technique.The spatial resolution capability of STIM is higher than PIXE technique at same accelerator status.As a result of STIM measurement,Paramecium attached on the top of Kapton tube was measured by STIM.展开更多
Active target time projection chambers are state-of-the-art tools in the field of low-energy nuclear physics and are particularly suitable for experiments using low-intensity radioactive ion beams or gamma rays.The Fu...Active target time projection chambers are state-of-the-art tools in the field of low-energy nuclear physics and are particularly suitable for experiments using low-intensity radioactive ion beams or gamma rays.The Fudan multi-purpose active target time projection chamber(fMeta-TPC)with 2048 channels was developed to studyα-clustering nuclei.This study focused on the photonuclear reaction with a laser Compton scattering gamma source,particularly for the decay of the highly excitedαcluster state.The design of fMeta-TPC is described in this paper.A comprehensive evaluation of its offline performance was conducted using an ultraviolet laser and ^(241)Amαsource.The results showed that the intrinsic angular resolution of the detector was within 0.30°,and the detector had an energy resolution of 6.85%for 3.0 MeVαparticles.The gain uniformity of the detector was approximately 10%(RMS/Mean),as tested by the ^(55)Fe X-ray source.展开更多
Quality control in disease diagnosis and treatment is critical for ensuring patient safety,optimizing resource utilization,and improving clinical outcomes.In endometrial cancer management,rigorous quality control ensu...Quality control in disease diagnosis and treatment is critical for ensuring patient safety,optimizing resource utilization,and improving clinical outcomes.In endometrial cancer management,rigorous quality control ensures accurate diagnosis through standardized protocols,reducing misdiagnosis and enabling early detection.Treatment is guided by evidence-based guidelines,fostering multi-disciplinary collaboration and minimizing unnecessary variations in care.Quality control also enhances patient safety by reducing medical errors and ensuring compliance with ethical and legal standards.By fostering transparency,professional development,and patient-centered care,it supports the sustainable advancement of healthcare systems,ultimately improving outcomes for patients and the broader medical community.This quality control of endometrial cancer was drafted by the Obstetrics and Gynecology Hospital of Fudan University based on the American Joint Committee on Cancer’s TNM staging(AJCC,8th edition,2017)and the International Federation of Obstetrics and Gynecology’s surgical pathological staging(FIGO,2009).展开更多
Polycystic ovary syndrome(PCOS),a prevalent endocrine and metabolic disorder in women of reproductive age,necessitates standardized quality control criteria for diagnosis and treatment to minimize underdiagnosis,misdi...Polycystic ovary syndrome(PCOS),a prevalent endocrine and metabolic disorder in women of reproductive age,necessitates standardized quality control criteria for diagnosis and treatment to minimize underdiagnosis,misdiagnosis,and enhance long-term outcomes.This article outlines key quality control strategies for PCOS based on the latest domestic and international guidelines,integrating clinical experience.Diagnostic standardization requires structured protocols for medical history collection,evaluation of clinical manifestations(eg,menstrual irregularities,hyperandrogenism),and auxiliary examinations(hormonal profiling,ultrasound)to prevent overdiagnosis or oversight.Unified quality control standards can improve the consistency of PCOS management,optimize reproductive and metabolic outcomes,and reduce future disease burden.By implementing these measures,healthcare systems can achieve higher diagnostic accuracy,promote evidence-based therapeutic interventions,and mitigate long-term health risks associated with PCOS.展开更多
目的探索人工智能技术在儿童专科医院智能导诊、智能预问诊及云陪诊服务中的集成应用,构建高效、精准的智慧医疗服务体系。方法融合自然语言处理与机器学习技术,设计“DS-小布医生2.0”智能系统,利用患者诊前等待时间,通过微信公众号采...目的探索人工智能技术在儿童专科医院智能导诊、智能预问诊及云陪诊服务中的集成应用,构建高效、精准的智慧医疗服务体系。方法融合自然语言处理与机器学习技术,设计“DS-小布医生2.0”智能系统,利用患者诊前等待时间,通过微信公众号采集结构化病史信息,并与医院信息系统(Hospital Information System,HIS)实时对接;同步开发云陪诊导航功能,基于室内定位技术优化院内诊疗路径规划。通过试运行数据迭代优化模型算法,建立多层级验证机制以降低信息误差。结果复旦大学附属儿科医院智能导诊上线以来,使用量达19.08万人次,“DS-小布医生2.0”运行3个月以来,使用达到14500余人次,85.17%的智能咨询集中于就诊流程和指引,人工热线相关咨询量分别下降31.32%和4.21%(P<0.05)。使用智能预问诊之后,患者就诊前平均候诊时长由(21.06±3.90)min缩短至(11.88±2.83)min(P<0.05)。运行云陪诊功能后,需要开具药品处方的患者全流程就诊时间由(149±23)min缩短至(134±20)min(P<0.05)。结论人工智能驱动的“预问诊-智能导诊-云陪诊”服务模式可优化资源配置、缩短候诊时间、提升医患交互效率,为儿科智慧门诊建设提供了可复制的技术方案。展开更多
文摘Progres in ion beam analysis at Fudan University in the recent years is briefly reviewed. Presented as examples of the research activities performed in this field are the following projects: (1) Nuclear potential resonance scattering of 6.25 MeV and 4.25 MeV helium ions for simultaneous compositional analysis of carbon and oxygen in a Mylar, a SnInO, and some other film samples: (2) Determination of stoichiometry of a high-temperature superconducting Y-Ba-Cu-O sample by backscattering of 8.8 MeV helium ions; (3) Backscattering and channeling analysis of multilayered structures periodically consisting of layers of pure Si and alternate layers of Ge and Si, grown on (100) Si substrates by molecular beam epitaxy: (4) Studies of surface structure of Al(100) by the use of MeV ions backscattering and channeling surface peak: and (5) MeV ion microbeam analysis and the use of PIXE method in DNA study. etc.
文摘Particle induced X- ray emission (PIXE) and Rutherford backscattering spectrometry (RBS) have been used extensively for analytical purpose because of their quantitative accuracy, reliability, simplicity and capability of non- destructive and multielement analysis. When these techniques are combined with a scanning microbeam system and a data acquisition system, three dimensional distribution of elemental composition can be displayed. Samples analyzed so far at Fudan University include a microelectronic circuit and some biological and archaeological samples. The PIXE and RBS spectra and the secondary electron images have been measured.
基金Supported by Chinese National Science Foundation under the Grant(No.10975034)
文摘The computed tomography was applied to setting STIM(Scanning Transmission Ion Microscopy) projections recorded at the Fudan Ion Beam Laboratory.In this work,in order to visualize the three-dimensional mass density distribution in several specimens,example for a test structure of hollow gold cyliner was presented together with a detailed description of the developed system,including data reconstruction code(Tomorebuild 2) and image display software(AMIRA).Future development will allow the particle induced X-ray emission tomography for elemental analysis of micrometer-sized samples.
基金Supported by Shanghai Synchrotron Radiation Facility project
文摘In this paper,we report a novel measurement system based on the development of Fudan Scanning Proton Microscopy(SPM) facility.By using Si-PIN diode(Hamamatsu S1223-01) detector,scanning transmission ion microscopy(STIM) measurement system has been set up.It can provide density and structural images with high probing efficiency and non-destruction by utilizing the energy loss of high energy(MeV) and focused ions penetrating through a thin sample.STIM measurement is able to map the density distribution of organic elements which mostly compose biology materials,such information can not be detected by using conventional Be-windowed Si(Li) X-ray detector in Particle Induced X-ray Emission(PIXE) technique.The spatial resolution capability of STIM is higher than PIXE technique at same accelerator status.As a result of STIM measurement,Paramecium attached on the top of Kapton tube was measured by STIM.
基金supported by the National Key R&D Program of China(Nos.2022YFA1602402,2020YFE0202001,2023YFA1606900)the National Natural Science Foundation of China(NSFC)(Nos.12235003,11835002,11925502,11705031,12275053,12147101).
文摘Active target time projection chambers are state-of-the-art tools in the field of low-energy nuclear physics and are particularly suitable for experiments using low-intensity radioactive ion beams or gamma rays.The Fudan multi-purpose active target time projection chamber(fMeta-TPC)with 2048 channels was developed to studyα-clustering nuclei.This study focused on the photonuclear reaction with a laser Compton scattering gamma source,particularly for the decay of the highly excitedαcluster state.The design of fMeta-TPC is described in this paper.A comprehensive evaluation of its offline performance was conducted using an ultraviolet laser and ^(241)Amαsource.The results showed that the intrinsic angular resolution of the detector was within 0.30°,and the detector had an energy resolution of 6.85%for 3.0 MeVαparticles.The gain uniformity of the detector was approximately 10%(RMS/Mean),as tested by the ^(55)Fe X-ray source.
基金National Natural Science Foundation of China(82273233)Natural Science Foundation of Shanghai(22ZR1408900)Clinical Research Plan of SHDC(SHDC2020CR4079)。
文摘Quality control in disease diagnosis and treatment is critical for ensuring patient safety,optimizing resource utilization,and improving clinical outcomes.In endometrial cancer management,rigorous quality control ensures accurate diagnosis through standardized protocols,reducing misdiagnosis and enabling early detection.Treatment is guided by evidence-based guidelines,fostering multi-disciplinary collaboration and minimizing unnecessary variations in care.Quality control also enhances patient safety by reducing medical errors and ensuring compliance with ethical and legal standards.By fostering transparency,professional development,and patient-centered care,it supports the sustainable advancement of healthcare systems,ultimately improving outcomes for patients and the broader medical community.This quality control of endometrial cancer was drafted by the Obstetrics and Gynecology Hospital of Fudan University based on the American Joint Committee on Cancer’s TNM staging(AJCC,8th edition,2017)and the International Federation of Obstetrics and Gynecology’s surgical pathological staging(FIGO,2009).
文摘Polycystic ovary syndrome(PCOS),a prevalent endocrine and metabolic disorder in women of reproductive age,necessitates standardized quality control criteria for diagnosis and treatment to minimize underdiagnosis,misdiagnosis,and enhance long-term outcomes.This article outlines key quality control strategies for PCOS based on the latest domestic and international guidelines,integrating clinical experience.Diagnostic standardization requires structured protocols for medical history collection,evaluation of clinical manifestations(eg,menstrual irregularities,hyperandrogenism),and auxiliary examinations(hormonal profiling,ultrasound)to prevent overdiagnosis or oversight.Unified quality control standards can improve the consistency of PCOS management,optimize reproductive and metabolic outcomes,and reduce future disease burden.By implementing these measures,healthcare systems can achieve higher diagnostic accuracy,promote evidence-based therapeutic interventions,and mitigate long-term health risks associated with PCOS.
文摘目的探索人工智能技术在儿童专科医院智能导诊、智能预问诊及云陪诊服务中的集成应用,构建高效、精准的智慧医疗服务体系。方法融合自然语言处理与机器学习技术,设计“DS-小布医生2.0”智能系统,利用患者诊前等待时间,通过微信公众号采集结构化病史信息,并与医院信息系统(Hospital Information System,HIS)实时对接;同步开发云陪诊导航功能,基于室内定位技术优化院内诊疗路径规划。通过试运行数据迭代优化模型算法,建立多层级验证机制以降低信息误差。结果复旦大学附属儿科医院智能导诊上线以来,使用量达19.08万人次,“DS-小布医生2.0”运行3个月以来,使用达到14500余人次,85.17%的智能咨询集中于就诊流程和指引,人工热线相关咨询量分别下降31.32%和4.21%(P<0.05)。使用智能预问诊之后,患者就诊前平均候诊时长由(21.06±3.90)min缩短至(11.88±2.83)min(P<0.05)。运行云陪诊功能后,需要开具药品处方的患者全流程就诊时间由(149±23)min缩短至(134±20)min(P<0.05)。结论人工智能驱动的“预问诊-智能导诊-云陪诊”服务模式可优化资源配置、缩短候诊时间、提升医患交互效率,为儿科智慧门诊建设提供了可复制的技术方案。
