The apolipoprotein E(APOE)gene,located on chromosome 19,remains the primary genetic factor associated with late-onset Alzheimer’s disease.1 In European populations,the ε4 haplotype of APOE,present in approximately 1...The apolipoprotein E(APOE)gene,located on chromosome 19,remains the primary genetic factor associated with late-onset Alzheimer’s disease.1 In European populations,the ε4 haplotype of APOE,present in approximately 14% of individuals,significantly increases Alzheimer’s disease risk,while the less common ε2 haplotype(w8%)appears to confer a protective effect.展开更多
基金support from the Rebecca L.Cooper Medical Research Foundation(No.F20231230)a Pilot Award for Global Brain Health Leaders by the Global Brain Health Institute,Alzheimer’s Association,and Alzheimer’s Society(GBHI ALZ UK-22-869,020)+13 种基金the GP2 Trainee Network,part of the Global Parkinson’s Genetics Programfunded by the Aligning Science Across Parkinson’s initiativesupported by Mexico’s National Council of Humanities Science and Technology(CONAHCYT,No.FONCICYT/50/2016)The Newton Fund through the UK Medical Research Council(No.MR/N028937/1)awarded to A.M.-E.funding from PAPIIT-UNAM(No.IG200421)funding from the NIH-NIA R01AG062588,R01AG057234,P30AG062422,P01AG019724,U19AG079774NIH-NINDS U54NS123985NIH-NIDA 75N95022C00031the Rainwater Charitable Foundationthe Bluefield Project to Cure Frontotemporal Dementiathe Alzheimer’s Associationthe Global Brain Health Institutethe French Foundationthe Mary Oakley Foundation.
文摘The apolipoprotein E(APOE)gene,located on chromosome 19,remains the primary genetic factor associated with late-onset Alzheimer’s disease.1 In European populations,the ε4 haplotype of APOE,present in approximately 14% of individuals,significantly increases Alzheimer’s disease risk,while the less common ε2 haplotype(w8%)appears to confer a protective effect.
