摘要
The apolipoprotein E(APOE)gene,located on chromosome 19,remains the primary genetic factor associated with late-onset Alzheimer’s disease.1 In European populations,the ε4 haplotype of APOE,present in approximately 14% of individuals,significantly increases Alzheimer’s disease risk,while the less common ε2 haplotype(w8%)appears to confer a protective effect.
基金
support from the Rebecca L.Cooper Medical Research Foundation(No.F20231230)
a Pilot Award for Global Brain Health Leaders by the Global Brain Health Institute,Alzheimer’s Association,and Alzheimer’s Society(GBHI ALZ UK-22-869,020)
the GP2 Trainee Network,part of the Global Parkinson’s Genetics Program
funded by the Aligning Science Across Parkinson’s initiative
supported by Mexico’s National Council of Humanities Science and Technology(CONAHCYT,No.FONCICYT/50/2016)
The Newton Fund through the UK Medical Research Council(No.MR/N028937/1)awarded to A.M.-E.
funding from PAPIIT-UNAM(No.IG200421)
funding from the NIH-NIA R01AG062588,R01AG057234,P30AG062422,P01AG019724,U19AG079774
NIH-NINDS U54NS123985
NIH-NIDA 75N95022C00031
the Rainwater Charitable Foundation
the Bluefield Project to Cure Frontotemporal Dementia
the Alzheimer’s Association
the Global Brain Health Institute
the French Foundation
the Mary Oakley Foundation.
