PCIM China, international conference and exhibition for power electronics, was held in Shanghai on March 21, 2006. PCIM is one of the most authoritative organizations and has won good reputation overseas for a long time.
AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders...AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination. METHODS:A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg,anti-HBc antibody, HBeAg and anti-HBs antibody) received 20μg of recombinant HB vaccine intramuscularly at 0,1,and 6 months.Anti HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days.A booster dose of 20μg HB vaccine was given after 6 months of the 3^(rd) vaccine dose to the 15 non- responders and anti-HBs titers were measured after i month. RESULTS:Seroprotection (anti-HBs GMT^3 10 IU/L) was achieved in 85.3 % (87/102) volunteers.The mean GMT titers of the vaccine responders was 136.1 IU/L.Of the seroprotected individuals,there were 32.4% (33/102) hyporesponders (anti- HBs titers <10-99 mIU/ml) and 52.9% (54/102) were responders (anti-HBs titers >100 IU/L).All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose. CONCLUSION:Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile.A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody titers.However,larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.展开更多
For centuries,humans’capacity to capture and depict physical space has played a central role in industrial and societal development.However,the digital revolution and the emergence of networked devices and services a...For centuries,humans’capacity to capture and depict physical space has played a central role in industrial and societal development.However,the digital revolution and the emergence of networked devices and services accelerate geospatial capture,coordination,and intelligence in unprecedented ways.Underlying the digital transformation of industry and society is the fusion of the physical and digital worlds-‘perceptality’-where geospatial perception and reality merge.This paper analyzes the myriad forces that are driving perceptality and the future of geospatial intelligence and presents real-world implications and examples of its industrial application.Applications of sensors,robotics,cameras,machine learning,encryption,cloud computing and other software,and hardware intelligence are converging,enabling new ways for organizations and their equipment to perceive and capture reality.Meanwhile,demands for performance,reliability,and security are pushing compute‘to the edge’where real-time processing and coordination are vital.Big data place new restraints on economics,as pressures abound to actually use these data,both in real-time and for longer term strategic analysis and decision-making.These challenges require orchestration between information technology(IT)and operational technology(OT)and synchronization of diverse systems,data-sets,devices,environments,workflows,and people.展开更多
文摘PCIM China, international conference and exhibition for power electronics, was held in Shanghai on March 21, 2006. PCIM is one of the most authoritative organizations and has won good reputation overseas for a long time.
文摘AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis B vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis B vaccination. METHODS:A total of 102 volunteers without markers of hepatitis B infection (negative for HBsAg,anti-HBc antibody, HBeAg and anti-HBs antibody) received 20μg of recombinant HB vaccine intramuscularly at 0,1,and 6 months.Anti HBs titers were evaluated by a quantitative Elisa kit at 90 and 210 days.A booster dose of 20μg HB vaccine was given after 6 months of the 3^(rd) vaccine dose to the 15 non- responders and anti-HBs titers were measured after i month. RESULTS:Seroprotection (anti-HBs GMT^3 10 IU/L) was achieved in 85.3 % (87/102) volunteers.The mean GMT titers of the vaccine responders was 136.1 IU/L.Of the seroprotected individuals,there were 32.4% (33/102) hyporesponders (anti- HBs titers <10-99 mIU/ml) and 52.9% (54/102) were responders (anti-HBs titers >100 IU/L).All the non-responders (15/15) responded to a single dose of the booster dose of recombinant HB vaccine and their mean anti-HBs antibody titers were more than 100.5 mIU/ml after the booster dose. CONCLUSION:Recombinant hepatitis B vaccine offers good seroprotection in the age group >40 years and has a good safety profile.A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-HBs antibody titers.However,larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.
基金supported by Hexagon AB,a global provider of information technologies for geospatial and industrial enterprises.
文摘For centuries,humans’capacity to capture and depict physical space has played a central role in industrial and societal development.However,the digital revolution and the emergence of networked devices and services accelerate geospatial capture,coordination,and intelligence in unprecedented ways.Underlying the digital transformation of industry and society is the fusion of the physical and digital worlds-‘perceptality’-where geospatial perception and reality merge.This paper analyzes the myriad forces that are driving perceptality and the future of geospatial intelligence and presents real-world implications and examples of its industrial application.Applications of sensors,robotics,cameras,machine learning,encryption,cloud computing and other software,and hardware intelligence are converging,enabling new ways for organizations and their equipment to perceive and capture reality.Meanwhile,demands for performance,reliability,and security are pushing compute‘to the edge’where real-time processing and coordination are vital.Big data place new restraints on economics,as pressures abound to actually use these data,both in real-time and for longer term strategic analysis and decision-making.These challenges require orchestration between information technology(IT)and operational technology(OT)and synchronization of diverse systems,data-sets,devices,environments,workflows,and people.
