Cardiovascular diseases are the leading cause of global mortality,accounting for 32%of deaths in 2019.Plantbased extracts,rich in bioactive compounds,have significantly contributed to modern medicine,offering therapeu...Cardiovascular diseases are the leading cause of global mortality,accounting for 32%of deaths in 2019.Plantbased extracts,rich in bioactive compounds,have significantly contributed to modern medicine,offering therapeutic potential for various diseases.However,their use is limited by possible side effects,drug interactions,and a lack of comprehensive preclinical and clinical studies.This review aims to provide an overview of the mechanisms of action,clinical evidence,and adverse effects of key bioactive compounds derived from select Mediterranean plants,integral to the Mediterranean diet:Allium sativum(diallyl trisulfide,allicin,and S-allyl[cysteine]),Crataegus monogyna(quercetin,apigenin,and chlorogenic acid),Crocus sativus(crocin and safranal),Olea europaea(oleic acid,oleuropein,hydroxytyrosol,oleocanthal,and oleacein),Salvia rosmarinus(rosmarinic acid,carnosol and carnosic acid),and Vitis vinifera(resveratrol).The review will focus on mechanisms such as antioxidant,anti-inflammatory,and vasodilatory effects,as well as the regulation of lipid metabolism,which may be relevant to conditions like atherosclerosis and hypertension.In addition to summarizing current scientific evidence,this study aims to guide future research by identifying knowledge gaps and offering recommendations for designing preclinical and clinical studies.Key areas for future exploration include the long-term safety of these compounds,the evaluation of their synergistic effects when consumed as part of the Mediterranean diet,and the need for standardized protocols in clinical settings.By expanding the scientific foundation for these traditional remedies,this review may help pave the way for their use in the development of future phytomedicines.展开更多
基金the"María Zambrano"Grant Program,(Ministry of Universities of Spain/Universitat Autònoma de Barcelona,Reference code:MZ202134)with funds from the European Union,for the support to Delgado-Hernández Rthe Final Degree Project in Biology of Anguera-Tejedor M,class 2023/2024 at the Faculty of Sciences,Autonomous University of Barcelona.
文摘Cardiovascular diseases are the leading cause of global mortality,accounting for 32%of deaths in 2019.Plantbased extracts,rich in bioactive compounds,have significantly contributed to modern medicine,offering therapeutic potential for various diseases.However,their use is limited by possible side effects,drug interactions,and a lack of comprehensive preclinical and clinical studies.This review aims to provide an overview of the mechanisms of action,clinical evidence,and adverse effects of key bioactive compounds derived from select Mediterranean plants,integral to the Mediterranean diet:Allium sativum(diallyl trisulfide,allicin,and S-allyl[cysteine]),Crataegus monogyna(quercetin,apigenin,and chlorogenic acid),Crocus sativus(crocin and safranal),Olea europaea(oleic acid,oleuropein,hydroxytyrosol,oleocanthal,and oleacein),Salvia rosmarinus(rosmarinic acid,carnosol and carnosic acid),and Vitis vinifera(resveratrol).The review will focus on mechanisms such as antioxidant,anti-inflammatory,and vasodilatory effects,as well as the regulation of lipid metabolism,which may be relevant to conditions like atherosclerosis and hypertension.In addition to summarizing current scientific evidence,this study aims to guide future research by identifying knowledge gaps and offering recommendations for designing preclinical and clinical studies.Key areas for future exploration include the long-term safety of these compounds,the evaluation of their synergistic effects when consumed as part of the Mediterranean diet,and the need for standardized protocols in clinical settings.By expanding the scientific foundation for these traditional remedies,this review may help pave the way for their use in the development of future phytomedicines.
