Cadmium(Cd)accumulation in rice grains is a complex quantitative trait.To elucidate the genetic mechanisms underlying Cd accumulation,a genome-wide association study(GWAS)was conducted over two years using Ting's ...Cadmium(Cd)accumulation in rice grains is a complex quantitative trait.To elucidate the genetic mechanisms underlying Cd accumulation,a genome-wide association study(GWAS)was conducted over two years using Ting's core collection,which consists of 150 rice landraces and more than 5.1 million single nucleotide polymorphisms(SNPs).In this study,a total of 148 SNPs were identified as significantly associated with Cd accumulation in grains.Additionally,six previously cloned genes related to Cd accumulation,i.e.,Os Cd1,Os NRAMP5,Os SRK,Os HMA1,CAL1,and Os PCS2,were detected.Moreover,four novel candidate regions were identified over the two-year period.Based on these findings,a novel gene named Os ABCG2,encoding an ABCG(WBC)transporter localized to the plasma membrane,was selected for further analysis.展开更多
基金supported by the Earmarked Fund for the R&D Program of Zhejiang Province,China(Grant No.2023C02014)the‘Three Rural and Nine Parties’Science and Technology Cooperation Program of Zhejiang Province,China(Grant No.2025SNJF045)+3 种基金the Hainan Province Science and Technology Special Fund,China(Grant No.ZDYF2022XDNY256)the Innovational Fund for Scientific and Technological Personnel of Hainan Province,China(Grant No.KJRC2023B24)the National Natural Science Foundation of China(Grant No.32472207)the Nanfan Special Project of the Chinese Academy of Agricultural Sciences(Grant Nos.YBXM2436 and YBXM2326)。
文摘Cadmium(Cd)accumulation in rice grains is a complex quantitative trait.To elucidate the genetic mechanisms underlying Cd accumulation,a genome-wide association study(GWAS)was conducted over two years using Ting's core collection,which consists of 150 rice landraces and more than 5.1 million single nucleotide polymorphisms(SNPs).In this study,a total of 148 SNPs were identified as significantly associated with Cd accumulation in grains.Additionally,six previously cloned genes related to Cd accumulation,i.e.,Os Cd1,Os NRAMP5,Os SRK,Os HMA1,CAL1,and Os PCS2,were detected.Moreover,four novel candidate regions were identified over the two-year period.Based on these findings,a novel gene named Os ABCG2,encoding an ABCG(WBC)transporter localized to the plasma membrane,was selected for further analysis.
