Objective: To determine the epidemiology and the aetiology of tinea capitis in the elderly in Turin (Italy). Methods: We prospectively collected all cases of adult tinea capitis in the Dermatology Clinic of the Univer...Objective: To determine the epidemiology and the aetiology of tinea capitis in the elderly in Turin (Italy). Methods: We prospectively collected all cases of adult tinea capitis in the Dermatology Clinic of the University of Turin from January 1997 to December 2012. Results: 13 patients (4 males and 9 females) with a mean age of 56.5 years were found to be affected by tinea capitis among a total number of 508 (2.6%). Diagnosis was made on clinical appearance and mycological examination. Culture identified M. canis in 7 patients (53.8%), T. mentagrophytes in 3 patients (23.1%), T. rubrum in 2 patients (15.4%) and T. violaceum in 1 patient (7.7%). 6 cases reported contact with animals. Treatment consisted in administration of Griseofulvin at the dose of 500 mg/d or Terbinafine at the dose of 250 mg/d for at least 8 weeks. A complete recovery was observed in 10 patients, whereas 3 of them suffered from cicatritial alopecia. Conclusion: This study wants to highlight the importance of considering tinea capitis as a differential diagnosis in elderly patients with scaly scalp lesions, even though it is considered to be rare in adults.展开更多
We report a tinea capitis caused by Microsporun Canis.A 6-year-old girl who had a history contact with dogs and cats in rural area.The girl suffered from scalp mass,pustules and itching for 2 months.There were two rou...We report a tinea capitis caused by Microsporun Canis.A 6-year-old girl who had a history contact with dogs and cats in rural area.The girl suffered from scalp mass,pustules and itching for 2 months.There were two round patches in right scalp which the several pustules scattered on it.The morphology of the colony on the culture medium,the morphological characteristics under the microscope and the results of molecular sequencing confirmed that the girl’s tinea capitis was caused by Microsporun Canis.The girl was cured with the treatment of oral administration of itraconazole and ketoconazole ointment for external use for ten days.展开更多
Objective:To determine the prevalence of infestation with head lice in primary schoolchildren in the eastern area of Bangkok,Thailand.Methods:The present study was to determine the head lice infestation(Pediculosis) l...Objective:To determine the prevalence of infestation with head lice in primary schoolchildren in the eastern area of Bangkok,Thailand.Methods:The present study was to determine the head lice infestation(Pediculosis) levels in primary schoolchildren,during May,2011 to July, 2011,A total of 3747 schoolchildren aged 5-12 years old from 12 selected primary school of Ladkrabang district,the eastern area of Bangkok were examined for head lice.Pediculosis was defined as the presence of at least on living adult,nymph and viable egg.Results:The overall head lice infestation rate was 23.32%and infestation rate was higher in girls(47.12%) than in boys(0%).The infestation rate among schoolchildren varied from 12.62%to 29.76%.The infestation rate among girls varied from 26.07%(12 years old group) to 55.89%(8 years old group).Conclusions: Pediculosis is a common public healtli problem affecting primary schoolchildren in eastern area of Bangkok and those levels are epidemic importance.展开更多
We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in China's Mainland. The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito. The ...We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in China's Mainland. The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito. The infections in the parents were mycologically confirmed to be due to Trichophyton tonsurans. Ttinea faciei in the infant was cured after two-week topical use of amorolfine cream. The mother ceased breastfeeding and took oral terbinafine for 4 weeks. No recurrence was observed in the infant during 12 months of follow-up.展开更多
Objective: To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum(C.formosum) + eucalyptus essential oil(EO), C. formosum + citrus EO, Solanum trilobatum+ eucalyptus EO, Solanum trilobatum + citrus EO, ...Objective: To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum(C.formosum) + eucalyptus essential oil(EO), C. formosum + citrus EO, Solanum trilobatum+ eucalyptus EO, Solanum trilobatum + citrus EO, Moringa oleifera + eucalyptus EO and Moringa oleifera + citrus EO] for killing all stages of Pediculus humanus capitis(Phthiraptera).Methods: A filter paper contact method was applied with three concentrations(0.05, 0.10 and 0.20 mL/cm^2) of each Thai herbal shampoo as well as permethrin pediculicide(positive control) and drinking water(negative control) against eggs, nymphs and adults of Pediculus humanus capitis. Mortality rates of the eggs were recorded after 7 days of incubation while those of nymphs and adults were recorded after 5 minutes of contact. Results: All herbal shampoos at the high concentration were highly effective against nymphs and adults, but not effective against the eggs. C. formosum + eucalyptus EO and C. formosum + citrus EO shampoos at all concentrations exhibited the highest efficacy against nymphs and adults with100% mortality rate at 5 min and LC_(50) values of 0.004 and 0.005 mL/cm^2, respectively. All formulation of Solanum trilobatum and Moringa oleifera shampoos added with eucalyptus EO showed mortality rates against nymphs at 92.0%-100.0% and 76.0%-100.0% and against adults at 84.0%-100.0% and 20.0%-32.0%, respectively. Permethrin pediculicide was not effective against the eggs, but showed 68.0%-92.0% and 28.0%-60.0% mortality rates against nymphs and adults. Conclusions: These results indicate that C. formosum + eucalyptus EO shampoo can be used as an effective nymphicide and adulticide against Pediculus humanus capitis.展开更多
Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life....Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life.These three diseases are associated with follicular occlusion.Several studies indicated topical 5-aminolevulinic acid photodynamic therapy(ALA-PDT)improved follicular occlusion besides acne treatment.So we attempted to apply ALA-PDT to medicine resistant AC,PCAS and HS.Topical ALA-PDT was applied to 10 patients with AC,seven patients with PCAS and three patients with HS for more than three sessions.All the patients completed the dermatology life quality index(DLQI)questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment.Adverse effects were recorded at each visit.The results showed 25.5%(5/20,two cases of AC and three cases of PCAS)of patients achieved excellent improvement after three sessions of PDT and another 60.0%(12/20,eight cases of AC and four cases of PCAS)of patients achieved good improvement.15.0%(3/20,three cases of HS)got poor response(<20%lesions clearance).Anotherfive cases(three cases of AC and two cases of PCAS)also achieved excellent response after 5–7 sessions of PDT.We also found that papular/nodular,cyst/abscess showed higher clearance rate than sinus/¯stula(88.5%,86.1%versus 11.1%).DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients.5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS.The e±cacy increased with more treatment sessions.展开更多
The zoophylic dermatophytes, as Trichophyton erinacei, frequently cause very inflammatory tineas in the human host. This dermatophyte is carried by some pets, particularly by the terrestrial hedgehog. Herein, we prese...The zoophylic dermatophytes, as Trichophyton erinacei, frequently cause very inflammatory tineas in the human host. This dermatophyte is carried by some pets, particularly by the terrestrial hedgehog. Herein, we present the case of a 22-year-old male student with an exudative erythematous scaly plaque on his right fifth finger for 1 month. He had a pet African hedgehog (Atelerix albiventris). KOH examination demonstrated hyphae compatible with dermatophytes. The culture revealed a white, radiated dusty colony. PCR sequencing of the region ITS1-5.8S-ITS2 identified T. erinacei. The final diagnosis was inflammatory tinea manuum due to T. erinacei. Clinical and mycological cure was achieved after treatment with oral terbinafine 250 mg/day × 1 month.展开更多
To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model.The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains.And then,high ...To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model.The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains.And then,high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals.The symptom,tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed.High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom(P<0.01),increased negative rate of strain culture(P<0.01),and improved pathological changes of tinea corporis(P<0.01).The best efficacy was observed in high dose ginkgo alcohol paste group.These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.展开更多
A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration.During that time,it had been successively misdiagnosed as psoriasis vulgaris,systemic lupus erythematosus,facial dermatitis ...A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration.During that time,it had been successively misdiagnosed as psoriasis vulgaris,systemic lupus erythematosus,facial dermatitis at other hospitals,and had been treated with agents that included acitretin and prednisone.Finally,fungi were found in the lesions by optical microscopy,and the fungal culture was positive for Microsporum gypseum,and was diagnosed as a Microsporum gypseum infection.The lesions eventually cleared completely after 8 weeks of antifungal treatment.展开更多
This prospective, open-label, single-arm investigation evaluated the performance of a multifunctional foot cream used twice daily for 8 weeks in the combined treatment of mild/moderate tinea pedis interdigitalis (TPI)...This prospective, open-label, single-arm investigation evaluated the performance of a multifunctional foot cream used twice daily for 8 weeks in the combined treatment of mild/moderate tinea pedis interdigitalis (TPI) and heel cracks, calluses and/or dry feet in 46 adult subjects. All subjects showed reductions in the severity of symptoms of both TPI (53.7% reduction) and heel cracks, calluses and/or dry feet (51.6% reduction), beginning already after 2 weeks of treatment, with reduction continuation and improvement after 4 and 8 weeks of treatment. Negative mycological cultures were obtained post-treatment in 85.7% of subjects, while 35.7% of subjects also obtained mycological cure (negative mycological culture + negative KOH test). Post-treatment questionnaires showed improved quality of life, good treatment tolerability, easy use, and that 69% of subjects would recommend the product. The results reveal that the foot cream is safe and effective in the combined treatment of TPI and heel cracks, calluses and/or dry feet.展开更多
Objective:To observe the clinical efficacy and safety of traditional Chinese medicine(TCM)detoxifying wash in the treatment of tinea versicolor with gastrointestinal dampness-heat syndrome.Methods:Ninety-three patient...Objective:To observe the clinical efficacy and safety of traditional Chinese medicine(TCM)detoxifying wash in the treatment of tinea versicolor with gastrointestinal dampness-heat syndrome.Methods:Ninety-three patients with tinea versicolor were randomly divided into observation group(48 cases)and control group(45 cases).This study was a single-blind,randomized controlled trial.The observation group was treated with external application of detoxifying wash,whereas the control group was treated with 1%bifonazole solution.Both groups received treatment for 20 days,with 10 days as one course.The clinical efficacy and adverse reactions were recorded after treatment.Results:After treatment,the observation group showed significant improvement in clinical indicators,including erythema,scales,itching,and skin greasiness.After 10 days of treatment,there was no significant difference in clinical efficacy between the two groups.After 20 days,the cure rate,effective rate,and fungal clearance rate in the observation group were higher than those of the control group,indicating superior clinical efficacy.No significant adverse reactions were observed in either group during treatment.Conclusion:Detoxifying wash is safe and effective in treating tinea versicolor with gastrointestinal dampness-heat syndrome.展开更多
Objective:Oral ivermectin has shown promise as a good option for treating pediculosis capitis(head lice).However,evidence regarding its efficacy and safety remains inconsistent in the literature.Therefore,this systema...Objective:Oral ivermectin has shown promise as a good option for treating pediculosis capitis(head lice).However,evidence regarding its efficacy and safety remains inconsistent in the literature.Therefore,this systematic review and meta-analysis was conducted to synthesize existing evidence and evaluate the efficacy and safety of oral ivermectin in treating pediculosis capitis.Methods:We systematically searched 3 major electronic databases-Medline via Ovid,Embase,and the Cochrane Central Register of Controlled Trials(CENTRAL)for clinical comparative studies on oral ivermectin for head lice from inception to May 2025.To ensure a comprehensive search,we conducted supplementary searches in Google Scholar and Semantic Scholar,scanned ResearchGate,and manually examined the reference lists of identified studies.Data were extracted and assessed by 2 independent authors.The effect size for complete head lice clearance using oral ivermectin vs.topical therapies was calculated using a fixed effect model and expressed as risk ratios(RR)with a 95%confidence interval(CI).The results from randomized controlled trials(RCTs)are emphasized owing to higher quality evidence.This systematic review and meta-analysis was registered on the International Prospective Register of Systematic Reviews with ID CRD42024565100.Results:Seven studies were included,comprising 4 RCTs and 3 non-RCTs,with a combined total of 1,316 participants.Oral ivermectin(200-400μg/kg,2 doses 1 week apart)was given to 611 patients,while 705 participants received various topical therapies,including 0.5%malathion(n=454),1.0%ivermectin(n=31),1.0%permethrin(n=60),5.0%permethrin(n=30),and d-phenothrin shampoo(n=130).The meta-analysis of RCTs indicated that oral ivermectin was superior to topical therapies in achieving complete lice clearance by day 15(RR=1.13,95%CI:1.08-1.18,P<0.05),and similar efficacy of oral ivermectin was found from non-RCTs(RR=1.39,95%CI:1.24-1.57,P<0.05).Adverse events were slightly more common in the oral ivermectin group(RR=0.88,95%CI:0.73-1.06,P>0.05)with reported serious adverse effects of seizures.Conclusion:Oral ivermectin appears to be an effective and safe option for treating pediculosis capitis.However,further high-quality research is needed to better establish its long-term safety and comparative efficacy.展开更多
Objective: To investigate the effect of Composite Divitriol Infusion (CDI) in treating tinea manum and study its antimycotic action.Methods: CDI was used to treat 139 patients with tinea manum and compared with Tinea ...Objective: To investigate the effect of Composite Divitriol Infusion (CDI) in treating tinea manum and study its antimycotic action.Methods: CDI was used to treat 139 patients with tinea manum and compared with Tinea Unguium Infusion in treating 77 cases as control. The experimental study in vivo was done, and electron microscopy (EM) was used to observe the therapeutical effect of CDI.Results: Among the 139 patients of the CDI group, 104 were cured, 21 markedly effective, 10 improved and 4 ineffective, the cure and markedly effective rate being 89.9%. The difference of effect between the CDI group and the control group was significant statistically (X 2>12.84,P < 0.005). The antimycotic action of CDI was studied in vitro. The minimum inhibitory concentration (MIC) of CDI were about 0.25% for Trichophyton rubrum and 0.5% for Trichophyton gypseum and Microsporum gypseum. Trichophyton rubrum immersed with CDI showed that the mycelia became roughened, deformed, and macroconidium became smaller under EM.Conclusion: CDI is valuable in treating tinea manum.展开更多
Introduction:Tinea of vellus hair is a rare dermatophytosis,caused by dermatophyte infection in the vellus hair.The clinical symptoms of tinea of vellus hair are more serious and the conventional topical treatment are...Introduction:Tinea of vellus hair is a rare dermatophytosis,caused by dermatophyte infection in the vellus hair.The clinical symptoms of tinea of vellus hair are more serious and the conventional topical treatment are often ineffective.Here,we report a case of tinea of vellus hair caused by Trichophyton violaceum in a child.Case presentation:A 7-year-old boy presented with a localized,scaly,and itchy erythema on his left cheek for two months.He once used a topical corticosteroid but without any clinical improvement,the erythema was progressively enlarging and spread to the left eyebrow.He denied any contact with animals.Direct microscopy found abundant spores and hyphae on the vellus hair;T.violaceum was identified by culture and PCR examination.The patient was diagnosed with tinea of vellus hair and cured after treating with oral terbinafine 125 mg/day and topical treatment for two weeks.There was no recurrence during the follow-up period.Discussion:The clinical symptoms of tinea of vellus hair are often atypical and easy to be misdiagnosed.Timely fungal examination is necessary for suspicious patients and confirmed patients should be treated with oral antifungal drugs.Conclusion:The diagnosis and treatment of tinea of vellus hair need to be paid more attention in clinical works.展开更多
文摘Objective: To determine the epidemiology and the aetiology of tinea capitis in the elderly in Turin (Italy). Methods: We prospectively collected all cases of adult tinea capitis in the Dermatology Clinic of the University of Turin from January 1997 to December 2012. Results: 13 patients (4 males and 9 females) with a mean age of 56.5 years were found to be affected by tinea capitis among a total number of 508 (2.6%). Diagnosis was made on clinical appearance and mycological examination. Culture identified M. canis in 7 patients (53.8%), T. mentagrophytes in 3 patients (23.1%), T. rubrum in 2 patients (15.4%) and T. violaceum in 1 patient (7.7%). 6 cases reported contact with animals. Treatment consisted in administration of Griseofulvin at the dose of 500 mg/d or Terbinafine at the dose of 250 mg/d for at least 8 weeks. A complete recovery was observed in 10 patients, whereas 3 of them suffered from cicatritial alopecia. Conclusion: This study wants to highlight the importance of considering tinea capitis as a differential diagnosis in elderly patients with scaly scalp lesions, even though it is considered to be rare in adults.
文摘We report a tinea capitis caused by Microsporun Canis.A 6-year-old girl who had a history contact with dogs and cats in rural area.The girl suffered from scalp mass,pustules and itching for 2 months.There were two round patches in right scalp which the several pustules scattered on it.The morphology of the colony on the culture medium,the morphological characteristics under the microscope and the results of molecular sequencing confirmed that the girl’s tinea capitis was caused by Microsporun Canis.The girl was cured with the treatment of oral administration of itraconazole and ketoconazole ointment for external use for ten days.
文摘Objective:To determine the prevalence of infestation with head lice in primary schoolchildren in the eastern area of Bangkok,Thailand.Methods:The present study was to determine the head lice infestation(Pediculosis) levels in primary schoolchildren,during May,2011 to July, 2011,A total of 3747 schoolchildren aged 5-12 years old from 12 selected primary school of Ladkrabang district,the eastern area of Bangkok were examined for head lice.Pediculosis was defined as the presence of at least on living adult,nymph and viable egg.Results:The overall head lice infestation rate was 23.32%and infestation rate was higher in girls(47.12%) than in boys(0%).The infestation rate among schoolchildren varied from 12.62%to 29.76%.The infestation rate among girls varied from 26.07%(12 years old group) to 55.89%(8 years old group).Conclusions: Pediculosis is a common public healtli problem affecting primary schoolchildren in eastern area of Bangkok and those levels are epidemic importance.
文摘We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in China's Mainland. The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito. The infections in the parents were mycologically confirmed to be due to Trichophyton tonsurans. Ttinea faciei in the infant was cured after two-week topical use of amorolfine cream. The mother ceased breastfeeding and took oral terbinafine for 4 weeks. No recurrence was observed in the infant during 12 months of follow-up.
基金supported by King Mongkut's Institute of Technology Ladkrabang,Ladkrabang,Bangkok 10520,Thailand(Grant No.2560-01-04-003)the National Research Council of Thailand(Grant for the Doctoral Degree Student Fly 2016)
文摘Objective: To evaluate the efficacy of Thai herbal shampoos [Cartoxylum formosum(C.formosum) + eucalyptus essential oil(EO), C. formosum + citrus EO, Solanum trilobatum+ eucalyptus EO, Solanum trilobatum + citrus EO, Moringa oleifera + eucalyptus EO and Moringa oleifera + citrus EO] for killing all stages of Pediculus humanus capitis(Phthiraptera).Methods: A filter paper contact method was applied with three concentrations(0.05, 0.10 and 0.20 mL/cm^2) of each Thai herbal shampoo as well as permethrin pediculicide(positive control) and drinking water(negative control) against eggs, nymphs and adults of Pediculus humanus capitis. Mortality rates of the eggs were recorded after 7 days of incubation while those of nymphs and adults were recorded after 5 minutes of contact. Results: All herbal shampoos at the high concentration were highly effective against nymphs and adults, but not effective against the eggs. C. formosum + eucalyptus EO and C. formosum + citrus EO shampoos at all concentrations exhibited the highest efficacy against nymphs and adults with100% mortality rate at 5 min and LC_(50) values of 0.004 and 0.005 mL/cm^2, respectively. All formulation of Solanum trilobatum and Moringa oleifera shampoos added with eucalyptus EO showed mortality rates against nymphs at 92.0%-100.0% and 76.0%-100.0% and against adults at 84.0%-100.0% and 20.0%-32.0%, respectively. Permethrin pediculicide was not effective against the eggs, but showed 68.0%-92.0% and 28.0%-60.0% mortality rates against nymphs and adults. Conclusions: These results indicate that C. formosum + eucalyptus EO shampoo can be used as an effective nymphicide and adulticide against Pediculus humanus capitis.
基金This work was supported by grants from the National Natural Science Foundation of China (81402585)Advanced Suitable Technology Popularization Project of Shanghai Health System (2013SY007)the Natural Science Foundation of Shanghai Municipal Commission of Health and Family Planning (20144Y0216).
文摘Acne conglobata(AC),perifolliculitis capitis abscedens et suffodiens(PCAS)and hidradenitis suppurativa(HS)are uncommon refractory chronic,inflammatory,scarring diseases but cause serious damage to the quality of life.These three diseases are associated with follicular occlusion.Several studies indicated topical 5-aminolevulinic acid photodynamic therapy(ALA-PDT)improved follicular occlusion besides acne treatment.So we attempted to apply ALA-PDT to medicine resistant AC,PCAS and HS.Topical ALA-PDT was applied to 10 patients with AC,seven patients with PCAS and three patients with HS for more than three sessions.All the patients completed the dermatology life quality index(DLQI)questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment.Adverse effects were recorded at each visit.The results showed 25.5%(5/20,two cases of AC and three cases of PCAS)of patients achieved excellent improvement after three sessions of PDT and another 60.0%(12/20,eight cases of AC and four cases of PCAS)of patients achieved good improvement.15.0%(3/20,three cases of HS)got poor response(<20%lesions clearance).Anotherfive cases(three cases of AC and two cases of PCAS)also achieved excellent response after 5–7 sessions of PDT.We also found that papular/nodular,cyst/abscess showed higher clearance rate than sinus/¯stula(88.5%,86.1%versus 11.1%).DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients.5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS.The e±cacy increased with more treatment sessions.
文摘The zoophylic dermatophytes, as Trichophyton erinacei, frequently cause very inflammatory tineas in the human host. This dermatophyte is carried by some pets, particularly by the terrestrial hedgehog. Herein, we present the case of a 22-year-old male student with an exudative erythematous scaly plaque on his right fifth finger for 1 month. He had a pet African hedgehog (Atelerix albiventris). KOH examination demonstrated hyphae compatible with dermatophytes. The culture revealed a white, radiated dusty colony. PCR sequencing of the region ITS1-5.8S-ITS2 identified T. erinacei. The final diagnosis was inflammatory tinea manuum due to T. erinacei. Clinical and mycological cure was achieved after treatment with oral terbinafine 250 mg/day × 1 month.
基金National“11th Five-Year”support program(2008BAI53B09)university science and technology innovation team(2012IRTSTHN011)Zhengzhou science and technology innovation team plan(131PCXTD612).
文摘To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model.The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains.And then,high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals.The symptom,tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed.High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom(P<0.01),increased negative rate of strain culture(P<0.01),and improved pathological changes of tinea corporis(P<0.01).The best efficacy was observed in high dose ginkgo alcohol paste group.These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.
文摘A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration.During that time,it had been successively misdiagnosed as psoriasis vulgaris,systemic lupus erythematosus,facial dermatitis at other hospitals,and had been treated with agents that included acitretin and prednisone.Finally,fungi were found in the lesions by optical microscopy,and the fungal culture was positive for Microsporum gypseum,and was diagnosed as a Microsporum gypseum infection.The lesions eventually cleared completely after 8 weeks of antifungal treatment.
文摘This prospective, open-label, single-arm investigation evaluated the performance of a multifunctional foot cream used twice daily for 8 weeks in the combined treatment of mild/moderate tinea pedis interdigitalis (TPI) and heel cracks, calluses and/or dry feet in 46 adult subjects. All subjects showed reductions in the severity of symptoms of both TPI (53.7% reduction) and heel cracks, calluses and/or dry feet (51.6% reduction), beginning already after 2 weeks of treatment, with reduction continuation and improvement after 4 and 8 weeks of treatment. Negative mycological cultures were obtained post-treatment in 85.7% of subjects, while 35.7% of subjects also obtained mycological cure (negative mycological culture + negative KOH test). Post-treatment questionnaires showed improved quality of life, good treatment tolerability, easy use, and that 69% of subjects would recommend the product. The results reveal that the foot cream is safe and effective in the combined treatment of TPI and heel cracks, calluses and/or dry feet.
基金National Natural Science Foundation of China General Project(No.82374618)Qin Chuangyuan Traditional Chinese Medicine Industry Innovation Cluster Project(L2024-QCY-ZYYJJQ-X18).
文摘Objective:To observe the clinical efficacy and safety of traditional Chinese medicine(TCM)detoxifying wash in the treatment of tinea versicolor with gastrointestinal dampness-heat syndrome.Methods:Ninety-three patients with tinea versicolor were randomly divided into observation group(48 cases)and control group(45 cases).This study was a single-blind,randomized controlled trial.The observation group was treated with external application of detoxifying wash,whereas the control group was treated with 1%bifonazole solution.Both groups received treatment for 20 days,with 10 days as one course.The clinical efficacy and adverse reactions were recorded after treatment.Results:After treatment,the observation group showed significant improvement in clinical indicators,including erythema,scales,itching,and skin greasiness.After 10 days of treatment,there was no significant difference in clinical efficacy between the two groups.After 20 days,the cure rate,effective rate,and fungal clearance rate in the observation group were higher than those of the control group,indicating superior clinical efficacy.No significant adverse reactions were observed in either group during treatment.Conclusion:Detoxifying wash is safe and effective in treating tinea versicolor with gastrointestinal dampness-heat syndrome.
文摘Objective:Oral ivermectin has shown promise as a good option for treating pediculosis capitis(head lice).However,evidence regarding its efficacy and safety remains inconsistent in the literature.Therefore,this systematic review and meta-analysis was conducted to synthesize existing evidence and evaluate the efficacy and safety of oral ivermectin in treating pediculosis capitis.Methods:We systematically searched 3 major electronic databases-Medline via Ovid,Embase,and the Cochrane Central Register of Controlled Trials(CENTRAL)for clinical comparative studies on oral ivermectin for head lice from inception to May 2025.To ensure a comprehensive search,we conducted supplementary searches in Google Scholar and Semantic Scholar,scanned ResearchGate,and manually examined the reference lists of identified studies.Data were extracted and assessed by 2 independent authors.The effect size for complete head lice clearance using oral ivermectin vs.topical therapies was calculated using a fixed effect model and expressed as risk ratios(RR)with a 95%confidence interval(CI).The results from randomized controlled trials(RCTs)are emphasized owing to higher quality evidence.This systematic review and meta-analysis was registered on the International Prospective Register of Systematic Reviews with ID CRD42024565100.Results:Seven studies were included,comprising 4 RCTs and 3 non-RCTs,with a combined total of 1,316 participants.Oral ivermectin(200-400μg/kg,2 doses 1 week apart)was given to 611 patients,while 705 participants received various topical therapies,including 0.5%malathion(n=454),1.0%ivermectin(n=31),1.0%permethrin(n=60),5.0%permethrin(n=30),and d-phenothrin shampoo(n=130).The meta-analysis of RCTs indicated that oral ivermectin was superior to topical therapies in achieving complete lice clearance by day 15(RR=1.13,95%CI:1.08-1.18,P<0.05),and similar efficacy of oral ivermectin was found from non-RCTs(RR=1.39,95%CI:1.24-1.57,P<0.05).Adverse events were slightly more common in the oral ivermectin group(RR=0.88,95%CI:0.73-1.06,P>0.05)with reported serious adverse effects of seizures.Conclusion:Oral ivermectin appears to be an effective and safe option for treating pediculosis capitis.However,further high-quality research is needed to better establish its long-term safety and comparative efficacy.
文摘Objective: To investigate the effect of Composite Divitriol Infusion (CDI) in treating tinea manum and study its antimycotic action.Methods: CDI was used to treat 139 patients with tinea manum and compared with Tinea Unguium Infusion in treating 77 cases as control. The experimental study in vivo was done, and electron microscopy (EM) was used to observe the therapeutical effect of CDI.Results: Among the 139 patients of the CDI group, 104 were cured, 21 markedly effective, 10 improved and 4 ineffective, the cure and markedly effective rate being 89.9%. The difference of effect between the CDI group and the control group was significant statistically (X 2>12.84,P < 0.005). The antimycotic action of CDI was studied in vitro. The minimum inhibitory concentration (MIC) of CDI were about 0.25% for Trichophyton rubrum and 0.5% for Trichophyton gypseum and Microsporum gypseum. Trichophyton rubrum immersed with CDI showed that the mycelia became roughened, deformed, and macroconidium became smaller under EM.Conclusion: CDI is valuable in treating tinea manum.
文摘Introduction:Tinea of vellus hair is a rare dermatophytosis,caused by dermatophyte infection in the vellus hair.The clinical symptoms of tinea of vellus hair are more serious and the conventional topical treatment are often ineffective.Here,we report a case of tinea of vellus hair caused by Trichophyton violaceum in a child.Case presentation:A 7-year-old boy presented with a localized,scaly,and itchy erythema on his left cheek for two months.He once used a topical corticosteroid but without any clinical improvement,the erythema was progressively enlarging and spread to the left eyebrow.He denied any contact with animals.Direct microscopy found abundant spores and hyphae on the vellus hair;T.violaceum was identified by culture and PCR examination.The patient was diagnosed with tinea of vellus hair and cured after treating with oral terbinafine 125 mg/day and topical treatment for two weeks.There was no recurrence during the follow-up period.Discussion:The clinical symptoms of tinea of vellus hair are often atypical and easy to be misdiagnosed.Timely fungal examination is necessary for suspicious patients and confirmed patients should be treated with oral antifungal drugs.Conclusion:The diagnosis and treatment of tinea of vellus hair need to be paid more attention in clinical works.
