The title compound, thiodiglycol dimethacrylate (TDGDMA), was synthesized from thiodiglycol and methacryloyl chloride by phase transfer catalysis reaction, and its structure was confirmed by FTIR and 1H-NMR analyses. ...The title compound, thiodiglycol dimethacrylate (TDGDMA), was synthesized from thiodiglycol and methacryloyl chloride by phase transfer catalysis reaction, and its structure was confirmed by FTIR and 1H-NMR analyses. TDGDMA possesses good polymerizability to produce a homopolymer resin with excellent transparency (T%, 90), moderate refractivity (nd20, 1.55), lower dispersivity (Abbe's number, 50.6) and higher glass transition temperature (Tg, 119°C). Through copolymerization with styrene (St) or styrene-4,4'-bismethacryloyloxydiphenylsulfone (BPSDMA), many properties of the copolymer such as refractive index, Abbe's number, strength, onset wavelength in the UV region and density were significantly modified. A copolymer resin with balanced properties between refractive index and dispersion was produced at the weight ratio of TDGDMA:St:BPSDMA (25:50:25), where nd20 and Abbe's number are 1.5815 and 36.5, respectively.展开更多
Traditional detection of thiodiglycol(TDG),a metabolic marker for sulfur mustard poisoning,requires not only professional operators,but also expensive reagents and large instruments.Herein,we developed a novel molecul...Traditional detection of thiodiglycol(TDG),a metabolic marker for sulfur mustard poisoning,requires not only professional operators,but also expensive reagents and large instruments.Herein,we developed a novel molecular imprinted polymers(MIPs)-based lateral flow assay(LFA)strategy for the quick,sensitive,and selective detection of TDG.Gold nanoparticles(Au NPs),MIPs,and metallothioneins(MTs)were respectively loaded on the conjugate pad,test line(T line)and control line(C line).After adding TDG,Au NPs on the conjugate pad reacted with TDG through the Au-S bond first.Then,under the action of capillary force,the conjugates of TDG and Au NPs were trapped by the MIPs as they traveled to the T line,and the residual Au NPs bound with the MTs on the C line,exhibiting two obvious red bands on T line and C line,respectively.In contrast,a single red band could be observed on C line without TDG.This method exhibited a wide linear range from 10.0 pg/m L to 10,000.0 ng/m L and its limit of detection(LOD)was as low as 0.41 pg/m L.This method was successfully utilized to detect TDG in human urine,presenting significant potential in the point-of-care testing of TDG in clinical samples of the sulfur mustard poisoning patients.展开更多
基金This project was supported by the Natural Science Foundation of Zhejiang Province (599103).
文摘The title compound, thiodiglycol dimethacrylate (TDGDMA), was synthesized from thiodiglycol and methacryloyl chloride by phase transfer catalysis reaction, and its structure was confirmed by FTIR and 1H-NMR analyses. TDGDMA possesses good polymerizability to produce a homopolymer resin with excellent transparency (T%, 90), moderate refractivity (nd20, 1.55), lower dispersivity (Abbe's number, 50.6) and higher glass transition temperature (Tg, 119°C). Through copolymerization with styrene (St) or styrene-4,4'-bismethacryloyloxydiphenylsulfone (BPSDMA), many properties of the copolymer such as refractive index, Abbe's number, strength, onset wavelength in the UV region and density were significantly modified. A copolymer resin with balanced properties between refractive index and dispersion was produced at the weight ratio of TDGDMA:St:BPSDMA (25:50:25), where nd20 and Abbe's number are 1.5815 and 36.5, respectively.
基金supported by the National Key Research and Development Program of China(2018YFC1602600)the National Natural Science Foundation of China(21974109)the Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX1662)
文摘Traditional detection of thiodiglycol(TDG),a metabolic marker for sulfur mustard poisoning,requires not only professional operators,but also expensive reagents and large instruments.Herein,we developed a novel molecular imprinted polymers(MIPs)-based lateral flow assay(LFA)strategy for the quick,sensitive,and selective detection of TDG.Gold nanoparticles(Au NPs),MIPs,and metallothioneins(MTs)were respectively loaded on the conjugate pad,test line(T line)and control line(C line).After adding TDG,Au NPs on the conjugate pad reacted with TDG through the Au-S bond first.Then,under the action of capillary force,the conjugates of TDG and Au NPs were trapped by the MIPs as they traveled to the T line,and the residual Au NPs bound with the MTs on the C line,exhibiting two obvious red bands on T line and C line,respectively.In contrast,a single red band could be observed on C line without TDG.This method exhibited a wide linear range from 10.0 pg/m L to 10,000.0 ng/m L and its limit of detection(LOD)was as low as 0.41 pg/m L.This method was successfully utilized to detect TDG in human urine,presenting significant potential in the point-of-care testing of TDG in clinical samples of the sulfur mustard poisoning patients.
