Dear Editor,Learning-induced expression of activity-dependent genes,especially immediate-early genes(IEGs),is required for the conversion of experience-induced neuronal activity into long-term memory[1].Neuronal Per-A...Dear Editor,Learning-induced expression of activity-dependent genes,especially immediate-early genes(IEGs),is required for the conversion of experience-induced neuronal activity into long-term memory[1].Neuronal Per-Arnt-Sim domain protein 4(Npas4)is one of the most rapidly induced IEGs,functioning as a transcription factor to regulate the activity-dependent expression of other IEGs,such as activityregulated cytoskeleton associated protein(Arc),Fos protooncogene,and early growth response 1(Egrl)[1].展开更多
基金supported by the National Key R&D Program of China(2021YFA0804900 and 2020YFA0509300)the National Natural Science Foundation of China(82125009,82330045,82071185,32100794,92149303,and 32121002)+5 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)a CAS Project for Young Scientists in Basic Research(YSBR-013)Plans for Major Provincial Science&Technology Projects(202303a07020004)the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003)Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003)USTC Research Funds of the Double First-Class Initiative.
文摘Dear Editor,Learning-induced expression of activity-dependent genes,especially immediate-early genes(IEGs),is required for the conversion of experience-induced neuronal activity into long-term memory[1].Neuronal Per-Arnt-Sim domain protein 4(Npas4)is one of the most rapidly induced IEGs,functioning as a transcription factor to regulate the activity-dependent expression of other IEGs,such as activityregulated cytoskeleton associated protein(Arc),Fos protooncogene,and early growth response 1(Egrl)[1].
