Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynam...Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynamic size and slower degradation.It is key to develop facile methods to large-scale synthesis of polymer rings with tunable compositions and microstructures.Recent progresses in large-scale synthesis of polymer rings against single-chain dynamic nanoparticles,and the example applications in synchronous enhancing toughness and strength of polymer nanocomposites are summarized.Once there is the breakthrough in rational design and effective large-scale synthesis of polymer rings and their functional derivatives,a family of cyclic functional hybrids would be available,thus providing a new paradigm in developing polymer science and engineering.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of significant,novel,and high-impact research in the fields of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provid...Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provides a systematic review of recent research progress in the chemical synthesis of biomass-based hydrocarbon fuels.It outlines the conversion pathways using feedstocks such as lipids,terpenoids,cellulose/hemicellulose,and lignin.Depending on the feedstock,various products with distinct structural characteristics can be prepared through reactions such as cyclization,condensation,and catalytic hydrogenation.Throughout the synthesis process,three key factors play a critical role:efficient catalyst development,production process optimization,and computational-chemistry-based molecular design.Finally,the article discusses future perspectives for biomass-based hydrocarbon fuel synthesis research.展开更多
The hot compression deformation behavior of Mg-6Zn-1Mn-0.5Ca(ZM61-0.5Ca)and Mg-6Zn-1Mn-2Sn-0.5Ca(ZMT612-0.5Ca)alloys was investigated at deformation temperatures ranging from 250℃to 400℃and strain rates varying from...The hot compression deformation behavior of Mg-6Zn-1Mn-0.5Ca(ZM61-0.5Ca)and Mg-6Zn-1Mn-2Sn-0.5Ca(ZMT612-0.5Ca)alloys was investigated at deformation temperatures ranging from 250℃to 400℃and strain rates varying from 0.001 s^(-1) to 1 s^(-1).The results show that the addition of Sn promotes dynamic recrystallization(DRX),and CaMgSn phases can act as nucleation sites during the compression deformation.Flow stress increases with increasing the strain rate and decreasing the temperature.Both the ZM61-0.5Ca and ZMT612-0.5Ca alloys exhibit obvious DRX characteristics.CaMgSn phases can effectively inhibit dislocation motion with the addition of Sn,thus increasing the peak fl ow stress of the alloy.The addition of Sn increases the hot deformation activation energy of the ZM61-0.5Ca alloy from 199.654 kJ/mol to 276.649 kJ/mol,thus improving the thermal stability of the alloy.For the ZMT612-0.5Ca alloy,the optimal hot deformation parameters are determined to be a deformation temperature range of 350–400℃and a strain rate range of 0.001–0.01 s^(-1).展开更多
We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as ...We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as M2,carrying two-point mutations of F97L and M242F relative to the wild-type SSCR,was constructed by site-directed mutagenesis,exhibited simultaneously improved activity toward ethyl 2′-ketopantothenate(K-PaOEt)and isopropanol,and could effectively catalyze the stereoselective reduction of K-PaOEt to(R)-PaOEt by using isopropanol as the sacrificial co-substrate to regenerate NADPH.After screening six commercially available carriers,an amino resin LXTE-700 was identified as the best solid support for the immobilization of M2 via the glutaraldehyde activation method.Upon optimization of the immobilization process and reaction conditions,the fabricated immobilized enzyme M2@amino resin demonstrated excellent recyclability and reusability,with the complete conversion of K-PaOEt to(R)-PaOEt being still realized after 12 cycles of reuse.Finally,M2@amino resin-catalyzed synthesis of(R)-PaOEt was successfully implemented in continuous-flow,accomplishing a 6.3 times higher space-time yield than that with the batch synthesis(529.2 versus 84 g L^(-1) d^(-1)).Our developed flow biocatalysis system also features an outstanding operational stability,as evidenced by the 100%conversion rate achieved after 15 consecutive days of operation.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.Th...The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.The complex was characterized by IR,^(1)H(^(13)C)NMR,elemental analysis,and powder X-ray diffraction,and the crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to the orthorhombic system with space group Iba2,and the central tin atom is in a five-coordinated trigonal bipyramidal configuration.Quantum chemistry ab initio calculations were performed to investigate the stability,molecular orbital energy,and frontier molecular orbital characteristics of the complex.Additionally,its thermal stability,electrochemical properties,and in vitro anticancer activity were evaluated.CCDC:2380308.展开更多
The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets.This review will encapsula...The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets.This review will encapsulate the key synthetic strategies for C19-hydroxylated steroids,which include indirect C–H oxidation and direct C–H oxidation in semi-synthesis as well as total synthesis.展开更多
ADPr-ATP is a natural nucleotide with three sugar rings and five pentavalent phosphorus,and can be produced through TIR-catalyzed ADP-ribosylation reactions for plant immunity.Here,we report the first total synthesis ...ADPr-ATP is a natural nucleotide with three sugar rings and five pentavalent phosphorus,and can be produced through TIR-catalyzed ADP-ribosylation reactions for plant immunity.Here,we report the first total synthesis of ADPr-ATP(1)with a total yield of 6.4%through 14 steps,featuring late-stage P(V)−N activation reaction of pyrophosphate(4)and 5′-phosphoromorpholidate(25).The protected adenosine 5′-phosphoromorpholidate(24)was prepared on the basis of a scalable to adenosine 5′′-monophosphate(2).The construction of P(V)−N bond in phosphoramidate is esteemed as a critical step as they are sufficiently stable in deprotection reactions.The chemical synthesis of ADPr-ATP can offer an appealing alternative to traditional enzymatic synthesis and fractionation methods.Furthermore,the pRib-AMP and its prodrug are also synthesized to evaluate cytotoxicity and anti-influenza activity in vitro.展开更多
Synthetic dyes,particularly azo dyes,pose significant environmental and health risks due to their persistence,toxicity,and potential carcinogenicity.Zinc oxide(ZnO)is a promising photocatalyst for wastewater remediati...Synthetic dyes,particularly azo dyes,pose significant environmental and health risks due to their persistence,toxicity,and potential carcinogenicity.Zinc oxide(ZnO)is a promising photocatalyst for wastewater remediation,but its wide bandgap and rapid charge recombination limit its practical efficacy.Furthermore,conventional doping methods often rely on hazardous chemical precursors,undermining the sustainability of the overall approach.This review introduces a novel and sustainable paradigm:the utilization of biomass-derived precursors as green reagents for the in-situ synthesis and simultaneous phosphorus-nitrogen(P-N)co-doping of ZnO nanoparticles.We critically analyze how the intrinsic biochemical composition of biomass,rich in P,N,and other heteroatoms,facilitates this one-pot,eco-friendly functionalization.This integrated strategy merges the performance enhancement offered by advanced co-doping,such as extended visible-light absorption and suppressed charge recombination,with the core principles of green chemistry and circular economy.It offers a dual benefit:creating highly effective photocatalysts for the degradation of persistent pollutants and valorizing abundant agricultural or biological waste streams.Our comprehensive evaluation goes beyond description to critically assess the underlying mechanisms,comparative efficacy,scalability challenges,and future research directions of this emerging field.This review underscores the unique contribution of biomass-mediated synthesis to advancing sustainable nanotechnology for environmental applications.展开更多
Circularly polarized luminescence perovskite nanocrystals(NCs)hold great potential in the field of information encryption,3D display and spintronics.However,the synthesis of the chiral perovskites is still confronted ...Circularly polarized luminescence perovskite nanocrystals(NCs)hold great potential in the field of information encryption,3D display and spintronics.However,the synthesis of the chiral perovskites is still confronted with various problems,such as cumbersome synthesis process,poor compatibility and limited processability,which impede their further implementation.In this study,a one-step wet-ball-milling method is proposed for the scale-up synthesis(up to 500 mL)of chiral perovskite ink,where the chiral molecule R-/S-1,2-diphenylethylenediamine(R-/S-DPEM)are introduced as chiral initiator.Chiral R-/S-DPEM molecules can endow the chirality to perovskite NCs through the strong coupling with perovskite surface.Specifically,ethyl cellulose is incorporated as passivating agents and structural supporting molecules,which can not only passivate the perovskite NCs and improve their stability,but also enable the chiral ink to possess better processability.The obtained ink is compatible with multiple substrates,which can be directly processed into various luminescent patterns by means of screen printing,writing,impregnation,laser engraving,etc.These patterns demonstrate high storage stability,flexibility and water resistance,fulfilling the requirements of a wide range of occasions in the future.This work provides a feasible solution for scalable synthesis of chiral perovskite inks,which offer promising prospects in optical anti-counterfeiting,information encryption and wearable optoelectronic devices.展开更多
The single-atom replacement strategy is a typical approach which just converts elements in lead compounds into their analogues with very small chemical changes.In this research,we implemented this strategy to modify t...The single-atom replacement strategy is a typical approach which just converts elements in lead compounds into their analogues with very small chemical changes.In this research,we implemented this strategy to modify the sulfonamide scaffold identified in our previous work,and resulting in the synthesis of 40 novel sulfonamide derivatives not previously reported in the literature.The insecticidal activities of these compounds against the Mythimna separata and Plutella xylostella were assessed.Our findings indicate that the pyridine sulfonamide structure significantly enhances insecticidal efficacy.Specifically,compound 7c exhibited LC 50 values of 0.157 and 0.256 mg/mL against the M.separata and P.xylostella,which significantly increased 97-and 41-fold compared to celangulin V,respectively.The experimental results revealed that pyridine sulfonamide analogues could serve as potential green insecticides.展开更多
This study investigated the effects of xu-argument-based continuation writing on learners’processing of source texts.Seventy-five participants were randomly assigned to three conditions:(1)continuation writing,(2)sum...This study investigated the effects of xu-argument-based continuation writing on learners’processing of source texts.Seventy-five participants were randomly assigned to three conditions:(1)continuation writing,(2)summary writing,or(3)reading comprehension.Eye-tracking data were collected during reading,measuring early(first fixation duration,first pass duration)and late(go-past time,total fixation duration)eye movements.During writing,source-text rereading was tracked via fixation counts and durations.Results showed that task type did not affect initial lexical access,as first fixation duration showed no group differences.However,both production groups exhibited significantly longer first pass durations than the reading comprehension group.Late measures revealed a gradient pattern:the continuation writing group spent significantly longer gopast time and total fixation duration than the summary writing group,which exceeded the reading comprehension group.This indicates that continuation tasks promoted deeper cognitive engagement during reading.During writing,the continuation writing group spent more time rereading the source text with higher fixation counts than the summary writing group.These findings suggest that continuation writing triggers more intensive reader-text interaction during pre-writing and enhances comprehension-production coupling through sustained attention to input during writing.This study sheds light on the cognitive mechanisms underlying the theoretical and pedagogical value of xu-argument.展开更多
Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were ...Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were isolated from the aqueous extracts of Gastrodia elata.Compounds 1 and 4 are 4-hydroxy-3-(4′-hydroxybenzyl)benzyl-substituted sulfoxide and sulfide, respectively, which are unprecedented in natural products. Compound 3 represents a rare sulfinate. Several isolates and their sulfone and disulfide analogs(10-13) were synthesized to evaluate their anti-inflammatory activity. Notably, the synthesized sulfone 10 demonstrated significant alleviation of symptoms in multiple in vivo inflammatory models.展开更多
Suancai has a lengthy history and a wide range of categories,which has some influence on the pickled diet culture around the world.Suancai production is transitioning to a large-scale,standardized production due to th...Suancai has a lengthy history and a wide range of categories,which has some influence on the pickled diet culture around the world.Suancai production is transitioning to a large-scale,standardized production due to the growth of the market.It has a unique flavor and is rich in nutrients,and its abundance of free amino acids,vitamins and phenolics has many positive effects on the human body.This review gives the types and history of suancai,as well as its impact on the world’s pickled culture.The changes in nutritional composition and flavor of suancai during fermentation are summarized.It presented the production technology and influencing factors of the northeast suancai,examined the quality and safety issues in suancai,and put forth some ideas and opinions on the standardization development of the suancai industry.It also summarized the geographic distribution and flora diversity of pickles around the world.In order to provide some knowledge and guidance for the promotion of modern industrial production in the suancai industry.展开更多
Laser micro-nano processing technologies have been developed to address challenges that are otherwise difficult to solve in industrial applications and diverse scientific fields.These technologies offer designable pat...Laser micro-nano processing technologies have been developed to address challenges that are otherwise difficult to solve in industrial applications and diverse scientific fields.These technologies offer designable patterning,arraying capabilities,three-dimensional(3D)processing,and high precision.Recent advancements in laser technologies have demonstrated their effectiveness as powerful tools for micro-nano processing of optoelectronic materials.By utilizing various laser techniques—such as laser-induced polymerization,laser ablation,laser-induced transfer,laser-directed assembly,and laser-assisted crystallization—broad applications in image sensors,displays,solar cells,lasers,anti-counterfeiting,and information encryption have been enabled.This review comprehensively summarizes recent progress in the laser micro-nano processing of optoelectronic materials,including the technologies used for preparation,patterning,arraying,and modification.These laser fabrication methods uniquely provide capabilities such as annealing,phase transitions,and ion exchange in optoelectronic materials.We also discuss the perspectives and challenges for future developments,including the advantages,disadvantages,and potential applications of different laser micro-nano processing technologies.With the rapid advancements in laser micro-nanofabrication,we foresee significant growth in advanced,high-performance optoelectronic applications.This review aims to provide researchers with insights into the current state and future prospects of laser-based micro-nano processing,encouraging further exploration and innovation in this promising field.展开更多
Peptide-and drug-protected gold nanoclusters(Au NCs)with atomic precision have attracted research attention in the last few years owing to their ultrasmall size(<2 nm),well-defined structures,tunable photoluminesce...Peptide-and drug-protected gold nanoclusters(Au NCs)with atomic precision have attracted research attention in the last few years owing to their ultrasmall size(<2 nm),well-defined structures,tunable photoluminescence from the visible to near-infrared range,water solubility,and good biocompatibility.These features,combined with low toxicity and efficient renal clearance,make such Au NCs promising candidates for biomedical use,including diagnosis,therapy,and theranostic.The incorporation of peptides or drugs into Au NCs enhances the stability,targeting specificity,cellular uptake,and prolonged circulation,enabling precise modulation of biological responses.Despite notable advances in achieving atomic precision employing complex ligands such as peptides or drugs,the synthetic methods of this new class of NCs remain a challenge.Careful control of molar ratio(Au:peptide/drug),reducing agent,temperature,and reaction time is required,because these factors directly influence the cluster size,optical properties,and in vivo performance.In this review,we highlight different synthetic approaches of atomically precise peptide-and drug-protected Au NCs,emphasizing the role of rational ligand design and reaction conditions,as well as the challenges associated with structural determination.We further discuss the optical and photoluminescence properties of peptide-protected Au NCs-the mostly explored features for biomedical applications.Finally,we conclude by outlining the current challenges,opportunities for scale-up synthesis,and future design perspectives for these emerging nanomaterials.展开更多
The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis,an original approach for the preparation of noble metal-based catalysts in this field.This method combi...The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis,an original approach for the preparation of noble metal-based catalysts in this field.This method combines high-temperature stages,such as catalytic support carburization and catalyst activation,in a single step.The innovation represents a significant advancement in utilizing cellulose as a model of waste biomass,enhancing its value,and reducing catalyst production costs.The one-pot catalysts were successfully tested in the hydrogenation reaction of sugar mixtures(L-Arabinose and D-Galactose)under mild conditions,achieving full selectivities.The research also introduces for the first time in that reaction a structural sensitivity analysis of the reaction,comparing experimental results with a theoretical model.The findings reveal a direct correlation between catalytic activity and the{0001}exposed face of hcp ruthenium nanoclusters.This discovery opens new avenues for industrial-scale catalyst development,promising substantial reductions in energy and production costs,and emphasizing the economic appeal of the process.展开更多
Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-con...Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-conjugated polymers.CMPs offer extensive versatility in synthetic approaches,enabling the synthesis of cross-linked and mesoporous structures.Advances in chemical processes,structural design,and synthesis methodologies have been developed,resulting in a diverse range of CMPs with unique configurations and properties,contributing to the fast expansion of the field.CMPs are particularly notable for their ability to enable the competitive utilization ofπ-conjugated structures within mesoporous configurations,making them valuable for investigations across various domains.They have shown considerable promise in addressing fuel and environmental challenges,demonstrated by their exceptional performance in applications such as vapor adsorption,heterogeneous catalysis,light emission,light harvesting,and energy generation.This review examines the chemical engineering principles underlying CMPs,including synthesis approaches,systemic research advancements,multifunctional investigations boundaries,potential applications,and progress in synthesis,dimensionality,and morphology studies.Specifically,it offers a comparative analysis of CMPs and linear polymeric materials,aiding in the development of functional polymers.Furthermore,this review explores the primary fundamental limitations of CMPs in fuel-related domains and discusses alternative strategies,including novel synthesis methods incorporating interactions and morphologies,to address these challenges.Ultimately,this assessment aims to provide a valuable and inspiring resource for professionals in the field of fuel management,guiding future research and development efforts.展开更多
In the future power-electronics-dominated power systems,grid-forming(GFM)converters have been regarded as important devices to actively establish frequency and voltage,so as to provide essential grid support.However,d...In the future power-electronics-dominated power systems,grid-forming(GFM)converters have been regarded as important devices to actively establish frequency and voltage,so as to provide essential grid support.However,due to their voltage source behavior and emulated swing dynamics,GFM converters may encounter low-frequency oscillations(LFOs)when connected to strong grids,which belongs to the self-stability problem of GFM converters.Moreover,GFM converters will also interact with grid-following(GFL)converters and thus impact the mid-frequency oscillations(MFOs)induced by phase-locked loops(PLLs).It has been preliminarily shown in the literature that GFM converters can help stabilize the PLL-induced MFOs,but currently,there is a lack of systematic design methods to coordinate the self-stability and stabilizing ability of GFM converters.This paper addresses this gap by revisiting the impedance model of a typical GFM converter and briefly analyze the oscillations caused by converters.Based on our analysis,we propose a frequency-partitioned synthesis design framework to enable dynamic virtual impedance(DVI)in GFM converters,aiming to enhance their self-stability and stabilizing ability simultaneously.Particularly,a self-stabilizing module is designed to ensure robust device-level damping,with control parameters auto-tuned using H∞methods.In parallel,a stabilizing module is introduced to stabilize GFL converters and enhance the system-level stability,which utilizes a perceive-and-optimize tuning strategy.Simulation results validate the effectiveness of the proposed synthesis DVI framework.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.52293472,22473096 and 22471164)。
文摘Among various architectures of polymers,end-group-free rings have attracted growing interests due to their distinct physicochemical performances over the linear counterparts which are exemplified by reduced hydrodynamic size and slower degradation.It is key to develop facile methods to large-scale synthesis of polymer rings with tunable compositions and microstructures.Recent progresses in large-scale synthesis of polymer rings against single-chain dynamic nanoparticles,and the example applications in synchronous enhancing toughness and strength of polymer nanocomposites are summarized.Once there is the breakthrough in rational design and effective large-scale synthesis of polymer rings and their functional derivatives,a family of cyclic functional hybrids would be available,thus providing a new paradigm in developing polymer science and engineering.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of significant,novel,and high-impact research in the fields of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
基金Support by National Natural Science Foundation of China(22127802,22573091)the HY Action(62402010305)。
文摘Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provides a systematic review of recent research progress in the chemical synthesis of biomass-based hydrocarbon fuels.It outlines the conversion pathways using feedstocks such as lipids,terpenoids,cellulose/hemicellulose,and lignin.Depending on the feedstock,various products with distinct structural characteristics can be prepared through reactions such as cyclization,condensation,and catalytic hydrogenation.Throughout the synthesis process,three key factors play a critical role:efficient catalyst development,production process optimization,and computational-chemistry-based molecular design.Finally,the article discusses future perspectives for biomass-based hydrocarbon fuel synthesis research.
基金Sichuan Science and Technology Program(2025ZNSFSC1341)Fundamental Research Funds for the Central Universities(J2022-090,25CAFUC04087)。
文摘The hot compression deformation behavior of Mg-6Zn-1Mn-0.5Ca(ZM61-0.5Ca)and Mg-6Zn-1Mn-2Sn-0.5Ca(ZMT612-0.5Ca)alloys was investigated at deformation temperatures ranging from 250℃to 400℃and strain rates varying from 0.001 s^(-1) to 1 s^(-1).The results show that the addition of Sn promotes dynamic recrystallization(DRX),and CaMgSn phases can act as nucleation sites during the compression deformation.Flow stress increases with increasing the strain rate and decreasing the temperature.Both the ZM61-0.5Ca and ZMT612-0.5Ca alloys exhibit obvious DRX characteristics.CaMgSn phases can effectively inhibit dislocation motion with the addition of Sn,thus increasing the peak fl ow stress of the alloy.The addition of Sn increases the hot deformation activation energy of the ZM61-0.5Ca alloy from 199.654 kJ/mol to 276.649 kJ/mol,thus improving the thermal stability of the alloy.For the ZMT612-0.5Ca alloy,the optimal hot deformation parameters are determined to be a deformation temperature range of 350–400℃and a strain rate range of 0.001–0.01 s^(-1).
基金the Science and Technology R&D Major Project of Jiangxi Province(No.20244AFI92001)the National Natural Science Foundation of China(Nos.22071033 and 21801047)for the financial supports.
文摘We report an immobilized enzyme-catalyzed batch and continuous-flow synthesis of optically pure ethyl(R)-pantothenate((R)-PaOEt),the direct precursor of d-pantothenic acid.Firstly,a ketoreductase mutant designated as M2,carrying two-point mutations of F97L and M242F relative to the wild-type SSCR,was constructed by site-directed mutagenesis,exhibited simultaneously improved activity toward ethyl 2′-ketopantothenate(K-PaOEt)and isopropanol,and could effectively catalyze the stereoselective reduction of K-PaOEt to(R)-PaOEt by using isopropanol as the sacrificial co-substrate to regenerate NADPH.After screening six commercially available carriers,an amino resin LXTE-700 was identified as the best solid support for the immobilization of M2 via the glutaraldehyde activation method.Upon optimization of the immobilization process and reaction conditions,the fabricated immobilized enzyme M2@amino resin demonstrated excellent recyclability and reusability,with the complete conversion of K-PaOEt to(R)-PaOEt being still realized after 12 cycles of reuse.Finally,M2@amino resin-catalyzed synthesis of(R)-PaOEt was successfully implemented in continuous-flow,accomplishing a 6.3 times higher space-time yield than that with the batch synthesis(529.2 versus 84 g L^(-1) d^(-1)).Our developed flow biocatalysis system also features an outstanding operational stability,as evidenced by the 100%conversion rate achieved after 15 consecutive days of operation.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.The complex was characterized by IR,^(1)H(^(13)C)NMR,elemental analysis,and powder X-ray diffraction,and the crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to the orthorhombic system with space group Iba2,and the central tin atom is in a five-coordinated trigonal bipyramidal configuration.Quantum chemistry ab initio calculations were performed to investigate the stability,molecular orbital energy,and frontier molecular orbital characteristics of the complex.Additionally,its thermal stability,electrochemical properties,and in vitro anticancer activity were evaluated.CCDC:2380308.
基金the National Natural Science Foundation of China(No.22325106)the start-up funding from Wuhan University for financial support.We thank Prof.
文摘The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets.This review will encapsulate the key synthetic strategies for C19-hydroxylated steroids,which include indirect C–H oxidation and direct C–H oxidation in semi-synthesis as well as total synthesis.
基金supported by the National Natural Science Foundation of China(Nos.82204209 and 82130103)Natural Science Foundation of Henna Province(No.242300421084).
文摘ADPr-ATP is a natural nucleotide with three sugar rings and five pentavalent phosphorus,and can be produced through TIR-catalyzed ADP-ribosylation reactions for plant immunity.Here,we report the first total synthesis of ADPr-ATP(1)with a total yield of 6.4%through 14 steps,featuring late-stage P(V)−N activation reaction of pyrophosphate(4)and 5′-phosphoromorpholidate(25).The protected adenosine 5′-phosphoromorpholidate(24)was prepared on the basis of a scalable to adenosine 5′′-monophosphate(2).The construction of P(V)−N bond in phosphoramidate is esteemed as a critical step as they are sufficiently stable in deprotection reactions.The chemical synthesis of ADPr-ATP can offer an appealing alternative to traditional enzymatic synthesis and fractionation methods.Furthermore,the pRib-AMP and its prodrug are also synthesized to evaluate cytotoxicity and anti-influenza activity in vitro.
文摘Synthetic dyes,particularly azo dyes,pose significant environmental and health risks due to their persistence,toxicity,and potential carcinogenicity.Zinc oxide(ZnO)is a promising photocatalyst for wastewater remediation,but its wide bandgap and rapid charge recombination limit its practical efficacy.Furthermore,conventional doping methods often rely on hazardous chemical precursors,undermining the sustainability of the overall approach.This review introduces a novel and sustainable paradigm:the utilization of biomass-derived precursors as green reagents for the in-situ synthesis and simultaneous phosphorus-nitrogen(P-N)co-doping of ZnO nanoparticles.We critically analyze how the intrinsic biochemical composition of biomass,rich in P,N,and other heteroatoms,facilitates this one-pot,eco-friendly functionalization.This integrated strategy merges the performance enhancement offered by advanced co-doping,such as extended visible-light absorption and suppressed charge recombination,with the core principles of green chemistry and circular economy.It offers a dual benefit:creating highly effective photocatalysts for the degradation of persistent pollutants and valorizing abundant agricultural or biological waste streams.Our comprehensive evaluation goes beyond description to critically assess the underlying mechanisms,comparative efficacy,scalability challenges,and future research directions of this emerging field.This review underscores the unique contribution of biomass-mediated synthesis to advancing sustainable nanotechnology for environmental applications.
基金supported by National Natural Science Foundation of China(Grant Nos.52572185,12204427 and 52272166)Natural Science Foundation of Henan Province of China(Grant Nos.242300421217,and 222300420299).
文摘Circularly polarized luminescence perovskite nanocrystals(NCs)hold great potential in the field of information encryption,3D display and spintronics.However,the synthesis of the chiral perovskites is still confronted with various problems,such as cumbersome synthesis process,poor compatibility and limited processability,which impede their further implementation.In this study,a one-step wet-ball-milling method is proposed for the scale-up synthesis(up to 500 mL)of chiral perovskite ink,where the chiral molecule R-/S-1,2-diphenylethylenediamine(R-/S-DPEM)are introduced as chiral initiator.Chiral R-/S-DPEM molecules can endow the chirality to perovskite NCs through the strong coupling with perovskite surface.Specifically,ethyl cellulose is incorporated as passivating agents and structural supporting molecules,which can not only passivate the perovskite NCs and improve their stability,but also enable the chiral ink to possess better processability.The obtained ink is compatible with multiple substrates,which can be directly processed into various luminescent patterns by means of screen printing,writing,impregnation,laser engraving,etc.These patterns demonstrate high storage stability,flexibility and water resistance,fulfilling the requirements of a wide range of occasions in the future.This work provides a feasible solution for scalable synthesis of chiral perovskite inks,which offer promising prospects in optical anti-counterfeiting,information encryption and wearable optoelectronic devices.
基金supported by the National Natural Science Foundation of China[Grant No.21977083].
文摘The single-atom replacement strategy is a typical approach which just converts elements in lead compounds into their analogues with very small chemical changes.In this research,we implemented this strategy to modify the sulfonamide scaffold identified in our previous work,and resulting in the synthesis of 40 novel sulfonamide derivatives not previously reported in the literature.The insecticidal activities of these compounds against the Mythimna separata and Plutella xylostella were assessed.Our findings indicate that the pyridine sulfonamide structure significantly enhances insecticidal efficacy.Specifically,compound 7c exhibited LC 50 values of 0.157 and 0.256 mg/mL against the M.separata and P.xylostella,which significantly increased 97-and 41-fold compared to celangulin V,respectively.The experimental results revealed that pyridine sulfonamide analogues could serve as potential green insecticides.
文摘This study investigated the effects of xu-argument-based continuation writing on learners’processing of source texts.Seventy-five participants were randomly assigned to three conditions:(1)continuation writing,(2)summary writing,or(3)reading comprehension.Eye-tracking data were collected during reading,measuring early(first fixation duration,first pass duration)and late(go-past time,total fixation duration)eye movements.During writing,source-text rereading was tracked via fixation counts and durations.Results showed that task type did not affect initial lexical access,as first fixation duration showed no group differences.However,both production groups exhibited significantly longer first pass durations than the reading comprehension group.Late measures revealed a gradient pattern:the continuation writing group spent significantly longer gopast time and total fixation duration than the summary writing group,which exceeded the reading comprehension group.This indicates that continuation tasks promoted deeper cognitive engagement during reading.During writing,the continuation writing group spent more time rereading the source text with higher fixation counts than the summary writing group.These findings suggest that continuation writing triggers more intensive reader-text interaction during pre-writing and enhances comprehension-production coupling through sustained attention to input during writing.This study sheds light on the cognitive mechanisms underlying the theoretical and pedagogical value of xu-argument.
基金supported by the National Natural Science Foundation of China (No. 82293680)the National Science and CAMS Innovation Fund for Medical Science (No. 2021-I2M-1-028)the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 2021-RC350-009)。
文摘Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were isolated from the aqueous extracts of Gastrodia elata.Compounds 1 and 4 are 4-hydroxy-3-(4′-hydroxybenzyl)benzyl-substituted sulfoxide and sulfide, respectively, which are unprecedented in natural products. Compound 3 represents a rare sulfinate. Several isolates and their sulfone and disulfide analogs(10-13) were synthesized to evaluate their anti-inflammatory activity. Notably, the synthesized sulfone 10 demonstrated significant alleviation of symptoms in multiple in vivo inflammatory models.
基金supported by the Foundation of National Dairy Technology Innovation Center(2022-Open Funding Project-12)Foundation of National Dairy Technology Innovation Center(2022-Scientific Research-9)+2 种基金Key Project of National Dairy Innovation Research Center of Inner Mongolia(2021-National Dairy Innovation Research Center-8)Key Projects of Research Operating Expenses of Provincial Research Institutes in Heilongjiang Province(CZKYF2021-2-B017)Key Project of Natural Science Foundation of Heilongjiang Province(ZD2022C007).
文摘Suancai has a lengthy history and a wide range of categories,which has some influence on the pickled diet culture around the world.Suancai production is transitioning to a large-scale,standardized production due to the growth of the market.It has a unique flavor and is rich in nutrients,and its abundance of free amino acids,vitamins and phenolics has many positive effects on the human body.This review gives the types and history of suancai,as well as its impact on the world’s pickled culture.The changes in nutritional composition and flavor of suancai during fermentation are summarized.It presented the production technology and influencing factors of the northeast suancai,examined the quality and safety issues in suancai,and put forth some ideas and opinions on the standardization development of the suancai industry.It also summarized the geographic distribution and flora diversity of pickles around the world.In order to provide some knowledge and guidance for the promotion of modern industrial production in the suancai industry.
基金supported by the National Key Research and Development Program of ChinaNational Natural Science Foundation of China(NSFC)Jilin Province Science and Technology Development Plan Project under Grants 2020YFA0715000,62075081,and 20220402011GH。
文摘Laser micro-nano processing technologies have been developed to address challenges that are otherwise difficult to solve in industrial applications and diverse scientific fields.These technologies offer designable patterning,arraying capabilities,three-dimensional(3D)processing,and high precision.Recent advancements in laser technologies have demonstrated their effectiveness as powerful tools for micro-nano processing of optoelectronic materials.By utilizing various laser techniques—such as laser-induced polymerization,laser ablation,laser-induced transfer,laser-directed assembly,and laser-assisted crystallization—broad applications in image sensors,displays,solar cells,lasers,anti-counterfeiting,and information encryption have been enabled.This review comprehensively summarizes recent progress in the laser micro-nano processing of optoelectronic materials,including the technologies used for preparation,patterning,arraying,and modification.These laser fabrication methods uniquely provide capabilities such as annealing,phase transitions,and ion exchange in optoelectronic materials.We also discuss the perspectives and challenges for future developments,including the advantages,disadvantages,and potential applications of different laser micro-nano processing technologies.With the rapid advancements in laser micro-nanofabrication,we foresee significant growth in advanced,high-performance optoelectronic applications.This review aims to provide researchers with insights into the current state and future prospects of laser-based micro-nano processing,encouraging further exploration and innovation in this promising field.
基金RGM is grateful to CNPq for the PDE fellowship(200437/2025-9),MTM acknowledges CNPq research scholarship(314470/2023-9)FAPESP fundings(2022/01825-22025/063196).
文摘Peptide-and drug-protected gold nanoclusters(Au NCs)with atomic precision have attracted research attention in the last few years owing to their ultrasmall size(<2 nm),well-defined structures,tunable photoluminescence from the visible to near-infrared range,water solubility,and good biocompatibility.These features,combined with low toxicity and efficient renal clearance,make such Au NCs promising candidates for biomedical use,including diagnosis,therapy,and theranostic.The incorporation of peptides or drugs into Au NCs enhances the stability,targeting specificity,cellular uptake,and prolonged circulation,enabling precise modulation of biological responses.Despite notable advances in achieving atomic precision employing complex ligands such as peptides or drugs,the synthetic methods of this new class of NCs remain a challenge.Careful control of molar ratio(Au:peptide/drug),reducing agent,temperature,and reaction time is required,because these factors directly influence the cluster size,optical properties,and in vivo performance.In this review,we highlight different synthetic approaches of atomically precise peptide-and drug-protected Au NCs,emphasizing the role of rational ligand design and reaction conditions,as well as the challenges associated with structural determination.We further discuss the optical and photoluminescence properties of peptide-protected Au NCs-the mostly explored features for biomedical applications.Finally,we conclude by outlining the current challenges,opportunities for scale-up synthesis,and future design perspectives for these emerging nanomaterials.
基金support for this work was obtained from Spanish Ministerio de Ciencia e Innovación(No.MCIN/AEI(10.13039/501100011033)/FEDER Funds una manera de hacer Europa)Project PID2020-113809RB-C32 and Junta de Andalucía via Consejería de EconómTransformación ica,Industria,Conocimiento y Universidades and its PAIDI 2020 program(No.P18-RT-3405)all co-financed by FEDER funds from the European Union.
文摘The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis,an original approach for the preparation of noble metal-based catalysts in this field.This method combines high-temperature stages,such as catalytic support carburization and catalyst activation,in a single step.The innovation represents a significant advancement in utilizing cellulose as a model of waste biomass,enhancing its value,and reducing catalyst production costs.The one-pot catalysts were successfully tested in the hydrogenation reaction of sugar mixtures(L-Arabinose and D-Galactose)under mild conditions,achieving full selectivities.The research also introduces for the first time in that reaction a structural sensitivity analysis of the reaction,comparing experimental results with a theoretical model.The findings reveal a direct correlation between catalytic activity and the{0001}exposed face of hcp ruthenium nanoclusters.This discovery opens new avenues for industrial-scale catalyst development,promising substantial reductions in energy and production costs,and emphasizing the economic appeal of the process.
基金supported by the King Khalid University,Abha,Saudi Arabiathe Deanship of Scientific Research at King Khalid University for funding this work through Large Groups Project under grant number(R.G.P.2/335/46)the Guangdong Office of Research Projects at the Provincial University(No.2024KCXTD064)。
文摘Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-conjugated polymers.CMPs offer extensive versatility in synthetic approaches,enabling the synthesis of cross-linked and mesoporous structures.Advances in chemical processes,structural design,and synthesis methodologies have been developed,resulting in a diverse range of CMPs with unique configurations and properties,contributing to the fast expansion of the field.CMPs are particularly notable for their ability to enable the competitive utilization ofπ-conjugated structures within mesoporous configurations,making them valuable for investigations across various domains.They have shown considerable promise in addressing fuel and environmental challenges,demonstrated by their exceptional performance in applications such as vapor adsorption,heterogeneous catalysis,light emission,light harvesting,and energy generation.This review examines the chemical engineering principles underlying CMPs,including synthesis approaches,systemic research advancements,multifunctional investigations boundaries,potential applications,and progress in synthesis,dimensionality,and morphology studies.Specifically,it offers a comparative analysis of CMPs and linear polymeric materials,aiding in the development of functional polymers.Furthermore,this review explores the primary fundamental limitations of CMPs in fuel-related domains and discusses alternative strategies,including novel synthesis methods incorporating interactions and morphologies,to address these challenges.Ultimately,this assessment aims to provide a valuable and inspiring resource for professionals in the field of fuel management,guiding future research and development efforts.
基金supported by National Natural Science Foundation of China(U24B6008,U22B6008)State Grid Zhejiang Electric Power Co.,Ltd.Science,and Technology Project(B311DS240015).
文摘In the future power-electronics-dominated power systems,grid-forming(GFM)converters have been regarded as important devices to actively establish frequency and voltage,so as to provide essential grid support.However,due to their voltage source behavior and emulated swing dynamics,GFM converters may encounter low-frequency oscillations(LFOs)when connected to strong grids,which belongs to the self-stability problem of GFM converters.Moreover,GFM converters will also interact with grid-following(GFL)converters and thus impact the mid-frequency oscillations(MFOs)induced by phase-locked loops(PLLs).It has been preliminarily shown in the literature that GFM converters can help stabilize the PLL-induced MFOs,but currently,there is a lack of systematic design methods to coordinate the self-stability and stabilizing ability of GFM converters.This paper addresses this gap by revisiting the impedance model of a typical GFM converter and briefly analyze the oscillations caused by converters.Based on our analysis,we propose a frequency-partitioned synthesis design framework to enable dynamic virtual impedance(DVI)in GFM converters,aiming to enhance their self-stability and stabilizing ability simultaneously.Particularly,a self-stabilizing module is designed to ensure robust device-level damping,with control parameters auto-tuned using H∞methods.In parallel,a stabilizing module is introduced to stabilize GFL converters and enhance the system-level stability,which utilizes a perceive-and-optimize tuning strategy.Simulation results validate the effectiveness of the proposed synthesis DVI framework.
