Purpose–This study aims to investigate the fatigue behavior and failure modes of bolted lap joints using Modified Tensile Specimens(MTS)under various cyclic load conditions.Emphasis is placed on identifying the relat...Purpose–This study aims to investigate the fatigue behavior and failure modes of bolted lap joints using Modified Tensile Specimens(MTS)under various cyclic load conditions.Emphasis is placed on identifying the relationship between load amplitude,fatigue life,and damage progression in low-carbon steel assemblies.Design/methodology/approach–An experimental approach was adopted using MTS specimens fabricated from St 1203 cold-rolled steel,joined with Grade 8.8 M4 bolts.Cyclic fatigue tests were conducted under zerobased loading at seven distinct force levels.Fracture surfaces were visually analyzed to identify dominant failure mechanisms.Findings–The results revealed a strong inverse correlation between applied cyclic load and fatigue life.Three distinct failure modes were identified:bolt shear at high loads(5.4 kN),interface cracking and slippage at moderate loads(4.9–5.1 kN),and plate tearing or stable fatigue behavior at lower loads(54.1 kN).The results highlight a progressive transition in failure mechanisms,from bolt shear at high loads to plate tearing and interface cracking at lower loads,providing essential insights for fatigue-resistant bolted joint design.Originality/value–This study offers original insights into the fatigue behavior of bolted lap joints using MTS,a relatively underexplored configuration in fatigue assessment.By experimentally evaluating failure modes under varied cyclic load levels,the authors uncover critical transitions in damage mechanisms—from bolt shear to interface cracking and plate tearing—depending on the applied load.Unlike many existing studies focused on numerical modeling or bonded joints alone,this work provides empirical data rooted in real-world fastening conditions using cold-rolled low-carbon steel.展开更多
BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.How...BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.However,the uneven development of healthcare in China,especially in eastern and western China,creates challenges for sharing a standardized diagnostic process.AIM To optimize the process of ESD specimen sampling,embedding and slide production,and to provide complete and accurate pathological reports.METHODS We established a practical process of specimen sampling,created standardized reporting templates,and trained pathologists from neighboring hospitals and those in the western region.A training effectiveness survey was conducted,and the collected data were assessed by the corresponding percentages.RESULTS A total of 111 valid feedback forms have been received,among which 58%of the participants obtained photographs during specimen collection,whereas the percentage increased to 79%after training.Only 58%and 62%of the respondents ensured the mucosal tissue strips were flat and their order remained unchanged;after training,these two proportions increased to 95%and 92%,respectively.Approximately half the participants measured the depth of the submucosal infiltration,which significantly increased to 95%after training.The percentage of pathologists who did not evaluate lymphovascular invasion effectively reduced.Only 22%of the participants had fixed clinic-pathological meetings before training,which increased to 49%after training.The number of participants who had a thorough understanding of endoscopic diagnosis also significantly increased.CONCLUSION There have been significant improvements in the process of specimen collection,section quality,and pathology reporting in trained hospitals.Therefore,our study provides valuable insights for others facing similar challenges.展开更多
The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term out...The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term outcomes.A retrospective comparative analysis was performed on 120 patients who underwent laparoscopic radical excision for rectal cancer from June 2017 to June 2021.Patients were categorized into two groups:Group RIES(n=58),which received the novel RIES technique,and Group AIES(n=62),which underwent the conventional abdominal incision for specimen extraction.Short-term outcomes,such as postoperative pelvic sepsis,temporary ileus,anastomotic leakage,and anastomotic stricture,were meticulously recorded.Longterm efficacy was evaluated through the 3-year overall survival(OS),disease-free survival(DFS),and local recurrence rate(LRR).The RIES group demonstrated a 3-year OS,DFS,and LRR of 86.2%,77.6%,and 8.6%,respectively,with a low incidence of short-term complications.Comparatively,the AIES group showed a 3-year OS,DFS,and LRR of 83.9%,74.2%,and 19.4%,respectively,with slightly higher rates of postoperative complications.Statistical analysis using the Student's t-test,the chi-square(χ^(2))test revealed no significant differences in the primary outcomes between the two groups,and suggested the noninferiority of the RIES technique.The study suggests that the RIES technique is a safe,feasible,and potentially functional and oncological superior approach to rectal cancer treatment,without compromising clinical efficacy.Further research is warranted to validate thesefindings in a larger,multicenter,and randomized controlled trial.展开更多
The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geo...The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geometrically induced stress gradients in the test region.Experimental data on CCF life and strain responses of ZSGH4169 alloy are acquired under different CCF loads.The Maximum Strain within Each(MSE)CCF cycle is demonstrated to be independent of the Low-Cycle Fatigue(LCF)loads and High-Cycle Fatigue(HCF)stress amplitudes,but exhibits a correlation with the Cycle Ratio of HCF/LCF(Rf).The growth law of MSE changes from linear to logarithmic as Rfdecreases.Strain amplitudes in the dwell stage,observed unaffected by Rf,are quantified as a function of LCF nominal stresses and HCF stress amplitudes.However,under a defined CCF load,strain amplitudes in the dwell stage remain constant.Strain peaks in the dwell stage in a single CCF cycle decrease in a power function with increasing HCF cycles.展开更多
文摘Purpose–This study aims to investigate the fatigue behavior and failure modes of bolted lap joints using Modified Tensile Specimens(MTS)under various cyclic load conditions.Emphasis is placed on identifying the relationship between load amplitude,fatigue life,and damage progression in low-carbon steel assemblies.Design/methodology/approach–An experimental approach was adopted using MTS specimens fabricated from St 1203 cold-rolled steel,joined with Grade 8.8 M4 bolts.Cyclic fatigue tests were conducted under zerobased loading at seven distinct force levels.Fracture surfaces were visually analyzed to identify dominant failure mechanisms.Findings–The results revealed a strong inverse correlation between applied cyclic load and fatigue life.Three distinct failure modes were identified:bolt shear at high loads(5.4 kN),interface cracking and slippage at moderate loads(4.9–5.1 kN),and plate tearing or stable fatigue behavior at lower loads(54.1 kN).The results highlight a progressive transition in failure mechanisms,from bolt shear at high loads to plate tearing and interface cracking at lower loads,providing essential insights for fatigue-resistant bolted joint design.Originality/value–This study offers original insights into the fatigue behavior of bolted lap joints using MTS,a relatively underexplored configuration in fatigue assessment.By experimentally evaluating failure modes under varied cyclic load levels,the authors uncover critical transitions in damage mechanisms—from bolt shear to interface cracking and plate tearing—depending on the applied load.Unlike many existing studies focused on numerical modeling or bonded joints alone,this work provides empirical data rooted in real-world fastening conditions using cold-rolled low-carbon steel.
基金Supported by the Medical Education Research Project from Nanjing Drum Tower Hospital,No.2021-7the Clinical Trials Fund from Nanjing Drum Tower Hospital,No.2022-YXZX-XH-04National Natural Science Foundation of China,No.82203063.
文摘BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.However,the uneven development of healthcare in China,especially in eastern and western China,creates challenges for sharing a standardized diagnostic process.AIM To optimize the process of ESD specimen sampling,embedding and slide production,and to provide complete and accurate pathological reports.METHODS We established a practical process of specimen sampling,created standardized reporting templates,and trained pathologists from neighboring hospitals and those in the western region.A training effectiveness survey was conducted,and the collected data were assessed by the corresponding percentages.RESULTS A total of 111 valid feedback forms have been received,among which 58%of the participants obtained photographs during specimen collection,whereas the percentage increased to 79%after training.Only 58%and 62%of the respondents ensured the mucosal tissue strips were flat and their order remained unchanged;after training,these two proportions increased to 95%and 92%,respectively.Approximately half the participants measured the depth of the submucosal infiltration,which significantly increased to 95%after training.The percentage of pathologists who did not evaluate lymphovascular invasion effectively reduced.Only 22%of the participants had fixed clinic-pathological meetings before training,which increased to 49%after training.The number of participants who had a thorough understanding of endoscopic diagnosis also significantly increased.CONCLUSION There have been significant improvements in the process of specimen collection,section quality,and pathology reporting in trained hospitals.Therefore,our study provides valuable insights for others facing similar challenges.
文摘The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term outcomes.A retrospective comparative analysis was performed on 120 patients who underwent laparoscopic radical excision for rectal cancer from June 2017 to June 2021.Patients were categorized into two groups:Group RIES(n=58),which received the novel RIES technique,and Group AIES(n=62),which underwent the conventional abdominal incision for specimen extraction.Short-term outcomes,such as postoperative pelvic sepsis,temporary ileus,anastomotic leakage,and anastomotic stricture,were meticulously recorded.Longterm efficacy was evaluated through the 3-year overall survival(OS),disease-free survival(DFS),and local recurrence rate(LRR).The RIES group demonstrated a 3-year OS,DFS,and LRR of 86.2%,77.6%,and 8.6%,respectively,with a low incidence of short-term complications.Comparatively,the AIES group showed a 3-year OS,DFS,and LRR of 83.9%,74.2%,and 19.4%,respectively,with slightly higher rates of postoperative complications.Statistical analysis using the Student's t-test,the chi-square(χ^(2))test revealed no significant differences in the primary outcomes between the two groups,and suggested the noninferiority of the RIES technique.The study suggests that the RIES technique is a safe,feasible,and potentially functional and oncological superior approach to rectal cancer treatment,without compromising clinical efficacy.Further research is warranted to validate thesefindings in a larger,multicenter,and randomized controlled trial.
基金co-supported by the National Natural Science Foundation of China(51805017)National Science and Technology Project(J2017-IV-0012-0049)+1 种基金National Science and Technology Project,China(J2019-IV-0007-0075)the Fundamental Research Funds for the Central Universities,China(JKF-20240036).
文摘The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geometrically induced stress gradients in the test region.Experimental data on CCF life and strain responses of ZSGH4169 alloy are acquired under different CCF loads.The Maximum Strain within Each(MSE)CCF cycle is demonstrated to be independent of the Low-Cycle Fatigue(LCF)loads and High-Cycle Fatigue(HCF)stress amplitudes,but exhibits a correlation with the Cycle Ratio of HCF/LCF(Rf).The growth law of MSE changes from linear to logarithmic as Rfdecreases.Strain amplitudes in the dwell stage,observed unaffected by Rf,are quantified as a function of LCF nominal stresses and HCF stress amplitudes.However,under a defined CCF load,strain amplitudes in the dwell stage remain constant.Strain peaks in the dwell stage in a single CCF cycle decrease in a power function with increasing HCF cycles.
