Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various f...Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.展开更多
Background:Acupuncture has shown potential therapeutic benefits for individuals with simple obesity.However,some researchers argue that some of the effectiveness of acupuncture may be due to the placebo response.Objec...Background:Acupuncture has shown potential therapeutic benefits for individuals with simple obesity.However,some researchers argue that some of the effectiveness of acupuncture may be due to the placebo response.Objective:To understand the placebo response of acupuncture treatment in simple obesity,a systematic review and meta-analysis was designed based on the comparison between sham acupuncture before and after treatment.Search strategy:Eight databases(Pub Med,Web of Science,Cochrane Library,Embase,China National Knowledge Infrastructure,Wanfang Database,China Biology Medicine Database,and Chinese Scientific Journals Database)were searched from inception to August 1,2023.The Me SH search terms comprised obesity and acupuncture.Inclusion criteria:Randomized controlled trials(RCTs)using sham or placebo acupuncture as a control in treating obesity were enrolled.Data extraction and analysis:Two researchers independently extracted data,and the results were crosschecked after completion.Each RCT’s detailed sham/placebo acupuncture treatment protocol was assessed according to the SHam Acupuncture REporting guidelines.The revised Cochrane risk-of-bias tool for randomized trials and the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)system were used to determine the risk of bias and quality of evidence,respectively.Body mass index(BMI)was defined as the primary outcome.Anthropometric parameters and laboratory test parameters related to obesity were defined as secondary outcomes.We used standardized mean difference(SMD)with 95%confidence interval(CI)to calculate treatment effects of outcomes.Results:Fifteen RCTs with a total of 1250 patients were included.The BMI significantly decreased after treatment in the sham acupuncture group compared to baseline(SMD 0.37,95%CI 0.09–0.66;I2=81%,random model;P<0.01).Treatment duration(P=0.02)and other interventions significantly impacted the placebo response rate(P=0.00).Conclusion:The placebo response of sham acupuncture was strong in the RCTs for simple obesity,and the effect sizes differed between various outcomes.The treatment duration and other interventions emerged as potential influencing factors for the placebo response of sham acupuncture.展开更多
Mg alloy often undergoes shear deformation during industrial processing.While its anisotropy and tension-compression asymmetry have been thoroughly studied under uniaxial loading,the understanding for shear loading is...Mg alloy often undergoes shear deformation during industrial processing.While its anisotropy and tension-compression asymmetry have been thoroughly studied under uniaxial loading,the understanding for shear loading is still lacking.This study employed a rolled AZ31B plate with typical basal texture to investigate the shear behaviors.Positive and negative simple shear experiments were performed at different angles in the transverse plane,whereby the visco-plastic self-consistent model was calibrated to reveal the deformation mechanisms and predict the mechanical responses at various orientations.Positive-negative shear asymmetry is present because extension twinning preferentially operates in one shear direction but is suppressed in the opposite direction.Simple shear induces multiple twin variants,thus impedes twin growth and slows the consumption of matrix,as compared to in-plane compression.For slip dominated simple shear,the interaction between loading-induced rigid body rotation and slip-induced crystal rotation produces distinct hardening behaviors,namely orthogonally asymmetric mechanical responses at complementary loading angles,which is largely absent in uniaxial loading.Finally,simulation results verify that positive-negative shear asymmetry appears only when the deviatoric normal stress on the sheet plane is non-zero.Positive-negative shear asymmetry persists except for the conditions of shear plane parallel to sheet plane,or shear direction parallel or perpendicular to rolling direction.展开更多
Background:Radical prostatectomy has long been the treatment of choice for men with clinically significant prostate cancer(PCa)in those with concurrent significant lower urinary tract symptoms(LUTS).For men who meet t...Background:Radical prostatectomy has long been the treatment of choice for men with clinically significant prostate cancer(PCa)in those with concurrent significant lower urinary tract symptoms(LUTS).For men who meet this description with marked prostatomegaly,we present a multi-institutional proof of concept study describing an alternative pathway of robotic simple prostatectomy(RASP)followed by external beam radiation therapy(EBRT)for the treatment of clinically significant prostate cancer.Methods:A retrospective study was performed of 17 patients with PCa who underwent RASP followed by EBRT at two institutions from 2015–2023.Demographic,peri-operative,and post-radiation treatment functional outcomes are reported.Results:No postoperative or post-EBRT complications were reported for any of the 17 patients who underwent RASP followed by EBRT during a median follow-up time of 12 months.The median time from RASP to EBRT was 9 months.Median prostate size was 135 g(IQR 110–165).13(76.5%)patients received a pre-EBRT rectal spacer.Median IPSS score preoperatively improved at 90 days post-RASP(13.5 vs.2.5;IQR 10.8–15.2),and this benefit was sustained post-EBRT with a median IPSS at 3 vs.12 months(4 vs.0;IQR 0–5).There was no statistically significant difference between postoperative IPSS and post-EBRT IPSS at 3(p=0.677)or 12(p=0.627)months.In all 14 patients with localized disease and PSA data,none had recurrence during the study period.Conclusions:A subset of patients with clinically significant prostate cancer have marked prostatomegaly and LUTS.We report an alternative treatment approach for patients unwilling to undergo radical prostatectomy.We found robotic simple prostatectomy followed by definitive radiation to be feasible and safe.展开更多
Transparent sand is a special material to realize visualization of concealed work in geotechnical engineering. To investigate the dynamic characteristics of transparent sand, a series of undrained cyclic simple shear ...Transparent sand is a special material to realize visualization of concealed work in geotechnical engineering. To investigate the dynamic characteristics of transparent sand, a series of undrained cyclic simple shear tests were conducted on the saturated transparent sand composed of fused quartz and refractive index-matched oil mixture. The results reveal that an increase in the initial shear stress ratio significantly affects the shape of the hysteresis loop, particularly resulting in more pronounced asymmetrical accumulation. Factors such as lower relative density, higher cyclic stress ratios and higher initial shear stress ratio have been shown to accelerate cyclic deformation, cyclic pore water pressure and stiffness degradation. The cyclic liquefaction resistance curves decrease as the initial shear stress ratio increases or as relative density decreases. Booker model and power law function model were applied to predict the pore water pressure for transparent sand. Both models yielded excellent fits for their respective condition, indicating a similar dynamic liquefaction pattern to that of natural sands. Finally, transparent sand displays similar dynamic characteristics in terms of cyclic liquefaction resistance and Kα correction factor. These comparisons indicate that transparent sand can serve as an effective means to mimic many natural sands in dynamic model tests.展开更多
Objective:Thulium fiber laser enucleation of the prostate(ThuFLEP)and robot-assisted simple prostatectomy(RASP)are two options for treating large benign prostatic hyperplasia.The most appropriate technique remains a m...Objective:Thulium fiber laser enucleation of the prostate(ThuFLEP)and robot-assisted simple prostatectomy(RASP)are two options for treating large benign prostatic hyperplasia.The most appropriate technique remains a matter of debate.We evaluated the efficacy and safety of ThuFLEP compared to RASP.Methods:Between January 2020 and December 2023,all patients who underwent either RASP or ThuFLEP for a prostate volume>80 mL were retrospectively included.The surgical procedure choice was left to the surgeon’s and patient’s discretion.Preoperative patient evaluation included the assessment of functional parameters.The groups were compared.Results:A total of 234 patients were included:106(45%)underwent RASP and 128(55%)underwent ThuFLEP.The mean operative time was shorter in the ThuFLEP group compared to the RASP group(106.4 with standard deviation[SD]46.1 min vs.123.2[SD 32.8]min,p=0.012).The mean lengths of catheterization and stay were significantly longer in the RASP group(5.0[SD 3.9]days vs.1.7[SD 2.0]days,p=0.009[catheterization]and 4.9[SD 3.0]days vs.1.9[SD 1.8]days,p=0.009[stay]).The overall complication rate was significantly higher in the ThuFLEP group(12%vs.2.8%in the RASP group,p=0.022).However,we did not observe significant differences in major complications(Clavien-Dindo≥3)between the two groups(four[3.1%]in the ThuFLEP group vs.one[0.94%]in the RASP group,p=0.073).At 3 months,the rate of stress urinary incontinence was 4.7%after ThuFLEP and 1.9%after RASP(p=0.2).Finally,the quality of life score and maximum urinary flow were comparable between the ThuFLEP and RASP groups,but the International Prostate Symptom Score at 3 months postoperatively was lower in the RASP group(p=0.012).Conclusion:Both ThuFLEP and RASP are safe techniques with comparable functional outcomes for large benign prostatic hyperplasia.ThuFLEP allows a reduction in catheterization and hospitalization durations but presents more complications compared to RASP.展开更多
BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measu...BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measured using Life’s Essential 8(LE8)and Life’s Simple 7(LS7),and the prevalence of MAFLD.METHODS This cross-sectional study had a sample of 2234 individuals,representing approximately 120 million individuals in the United States.Baseline parameters were compared between the LE8 and LS7 groups.Logistic regression models were used to evaluate the relationship between LE8,LS7,and MAFLD,while taking into account confounding factors.The investigation employed restricted cubic splines to investigate non-linear associations.Subgroup analyses and sensitivity studies were performed to evaluate the strength and reliability of the results.RESULTS Higher LE8 and LS7 scores were significantly associated with a decreased risk of MAFLD,even after controlling for demographic,socioeconomic,and clinical variables.This association demonstrated a non-linear pattern,with the most dramatic risk reduction observed at higher CVH levels.Individual CVH components,notably healthy behaviors and factors,exhibited strong relationships with MAFLD.Subgroup analyses indicated consistent relationships across several demographics.Sensitivity tests utilizing other MAFLD definitions validated the robustness of the findings.CONCLUSION Higher adherence to CVH criteria,as indicated by LE8 and LS7 scores,is associated with a significantly lower risk of MAFLD.These results emphasize the need to advance CVH to control and avoid MAFLD.展开更多
Over an algebraically closed field of characteristic p>2,based on the results on the representation theory of special linear Lie algebra sl(2),restricted simple modules L(λ) of the Schrodinger algebra S(1)are dete...Over an algebraically closed field of characteristic p>2,based on the results on the representation theory of special linear Lie algebra sl(2),restricted simple modules L(λ) of the Schrodinger algebra S(1)are determined,and all derivations of S(1)on L(λ)are also obtained.As an application,the first cohomology of S(1)with the coefficient in L(λ)is determined.展开更多
BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic treatment.CASE SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lip...BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic treatment.CASE SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lips requested orthodontic camouflage.The treatment plan consisted of extracting the right upper third molar,right lower third molar,left lower second molar,and left upper third molar and moving the maxillary dentition distally using a convenient method involving microimplant nail anchors,push springs,long arm traction hooks,and elastic traction chains.After 52 months of treatment,her overbite and overjet were normal,and her facial profile was favorable.CONCLUSION This method can be used for distal movement of the maxillary dentition and to correct severe skeletal class II malocclusion in adults.展开更多
Photocatalytic and photoinduced silyl radicals cascade cyclization procedures for the green and simple preparation of fused tetracyclic skeleton silylated indolo[2,1-a]isoquinoline-6(5H)-ones from 2-aryl-N-acryloyl in...Photocatalytic and photoinduced silyl radicals cascade cyclization procedures for the green and simple preparation of fused tetracyclic skeleton silylated indolo[2,1-a]isoquinoline-6(5H)-ones from 2-aryl-N-acryloyl indoles with hydrosilanes are developed.The photocatalytic reaction is carried out with 9,10-dicyanoanthracene(DCA)as an organophotocatalyst and 3-acetoxyquinuclidine as hydrogen atom transfer(HAT)catalyst at room temperature under metal-and oxidant-free conditions.The keys to the success of photoredox-catalytic conversion include(1)the reductive quenching of DCA^(*)[E_(1/2)(*P/P^(-))=+1.97 V vs.SCE in MeCN]by 3-acetoxyquinuclidine(E_(p)=+1.22 V vs.SCE in MeCN),and(2)the thermodynamic feasibility of hydrogen atom abstraction from hydridic Si-H bond by electrophilic N^(+·).Particularly,the simple photoinduced cascade cyclization using(TMS)3SiH with 2-aryl-N-acryloyl indoles was exploited via an electron-donor-acceptor(EDA)complex under visible light irradiation.展开更多
This manuscript presents a dataset detailing a method for purifying monomers. Purification plays a crucial role in every chemical process, as it leads to an improvement in product quality through the removal of impuri...This manuscript presents a dataset detailing a method for purifying monomers. Purification plays a crucial role in every chemical process, as it leads to an improvement in product quality through the removal of impurities. The primary method for monomer purification, like acrylonitrile (AN), is the distillation technique. However, this technique is unsafe and hard to set up or handle. A straightforward, risk-free, low-cost method like the column technique resolves these issues. A simple column technique demonstrated the successful execution of purifying AN. Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) analyses confirmed that AN was successfully purified, with purity reaching 99.8%. FTIR spectra revealed changes in the position and intensity of the stretching vibration peaks after purification. Also, the functional groups of the inhibitor monomethyl ether of hydroquinone (MeHQ) were undetected after purification. Furthermore, after purification, NMR spectra revealed the absence of aromatic protons and carbons associated with MeHQ. In conclusion, the column technique is a successful and inexpensive way to purify AN monomers. This makes it useful for a wide range of applications, especially in polymerization reactions where MeHQ needs to be removed to prevent self-polymerization during the initiation process.展开更多
We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that t...We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that the heat kernel in higher dimensions converges rapidly. We also compute the constants involved in the estimate for the 1-dimensional heat kernel. Furthermore, we discuss the general case of on-diagonal estimates for the heat kernel.展开更多
文摘Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.
基金supported by grants from the National Natural Science Foundation of China(82405192)the Capital’s Funds for Health Improvement and Research(CFH 2022-2-20213,CFH 2022-1-2021)+1 种基金the project of"Friendship Seed Plan"Talent Project of Beijing Friendship Hospital,Capital Medical University(YYZZ202333)Beijing key project of major disease by Chinese medicine and Western medicine(Fatty liver,No.2023BJSZDYNJBXTGG-017)。
文摘Background:Acupuncture has shown potential therapeutic benefits for individuals with simple obesity.However,some researchers argue that some of the effectiveness of acupuncture may be due to the placebo response.Objective:To understand the placebo response of acupuncture treatment in simple obesity,a systematic review and meta-analysis was designed based on the comparison between sham acupuncture before and after treatment.Search strategy:Eight databases(Pub Med,Web of Science,Cochrane Library,Embase,China National Knowledge Infrastructure,Wanfang Database,China Biology Medicine Database,and Chinese Scientific Journals Database)were searched from inception to August 1,2023.The Me SH search terms comprised obesity and acupuncture.Inclusion criteria:Randomized controlled trials(RCTs)using sham or placebo acupuncture as a control in treating obesity were enrolled.Data extraction and analysis:Two researchers independently extracted data,and the results were crosschecked after completion.Each RCT’s detailed sham/placebo acupuncture treatment protocol was assessed according to the SHam Acupuncture REporting guidelines.The revised Cochrane risk-of-bias tool for randomized trials and the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)system were used to determine the risk of bias and quality of evidence,respectively.Body mass index(BMI)was defined as the primary outcome.Anthropometric parameters and laboratory test parameters related to obesity were defined as secondary outcomes.We used standardized mean difference(SMD)with 95%confidence interval(CI)to calculate treatment effects of outcomes.Results:Fifteen RCTs with a total of 1250 patients were included.The BMI significantly decreased after treatment in the sham acupuncture group compared to baseline(SMD 0.37,95%CI 0.09–0.66;I2=81%,random model;P<0.01).Treatment duration(P=0.02)and other interventions significantly impacted the placebo response rate(P=0.00).Conclusion:The placebo response of sham acupuncture was strong in the RCTs for simple obesity,and the effect sizes differed between various outcomes.The treatment duration and other interventions emerged as potential influencing factors for the placebo response of sham acupuncture.
基金supports of the National Key Research and Development Program of China(Grant No.2023YFB3710900)the National Natural Science Foundation of China(Grant Nos.52071211 and 52071208)。
文摘Mg alloy often undergoes shear deformation during industrial processing.While its anisotropy and tension-compression asymmetry have been thoroughly studied under uniaxial loading,the understanding for shear loading is still lacking.This study employed a rolled AZ31B plate with typical basal texture to investigate the shear behaviors.Positive and negative simple shear experiments were performed at different angles in the transverse plane,whereby the visco-plastic self-consistent model was calibrated to reveal the deformation mechanisms and predict the mechanical responses at various orientations.Positive-negative shear asymmetry is present because extension twinning preferentially operates in one shear direction but is suppressed in the opposite direction.Simple shear induces multiple twin variants,thus impedes twin growth and slows the consumption of matrix,as compared to in-plane compression.For slip dominated simple shear,the interaction between loading-induced rigid body rotation and slip-induced crystal rotation produces distinct hardening behaviors,namely orthogonally asymmetric mechanical responses at complementary loading angles,which is largely absent in uniaxial loading.Finally,simulation results verify that positive-negative shear asymmetry appears only when the deviatoric normal stress on the sheet plane is non-zero.Positive-negative shear asymmetry persists except for the conditions of shear plane parallel to sheet plane,or shear direction parallel or perpendicular to rolling direction.
文摘Background:Radical prostatectomy has long been the treatment of choice for men with clinically significant prostate cancer(PCa)in those with concurrent significant lower urinary tract symptoms(LUTS).For men who meet this description with marked prostatomegaly,we present a multi-institutional proof of concept study describing an alternative pathway of robotic simple prostatectomy(RASP)followed by external beam radiation therapy(EBRT)for the treatment of clinically significant prostate cancer.Methods:A retrospective study was performed of 17 patients with PCa who underwent RASP followed by EBRT at two institutions from 2015–2023.Demographic,peri-operative,and post-radiation treatment functional outcomes are reported.Results:No postoperative or post-EBRT complications were reported for any of the 17 patients who underwent RASP followed by EBRT during a median follow-up time of 12 months.The median time from RASP to EBRT was 9 months.Median prostate size was 135 g(IQR 110–165).13(76.5%)patients received a pre-EBRT rectal spacer.Median IPSS score preoperatively improved at 90 days post-RASP(13.5 vs.2.5;IQR 10.8–15.2),and this benefit was sustained post-EBRT with a median IPSS at 3 vs.12 months(4 vs.0;IQR 0–5).There was no statistically significant difference between postoperative IPSS and post-EBRT IPSS at 3(p=0.677)or 12(p=0.627)months.In all 14 patients with localized disease and PSA data,none had recurrence during the study period.Conclusions:A subset of patients with clinically significant prostate cancer have marked prostatomegaly and LUTS.We report an alternative treatment approach for patients unwilling to undergo radical prostatectomy.We found robotic simple prostatectomy followed by definitive radiation to be feasible and safe.
基金Project(U2268213) supported by the National Natural Science Foundation of ChinaProject(2024YFHZ0121) supported by the Sichuan Science and Technology Program,China。
文摘Transparent sand is a special material to realize visualization of concealed work in geotechnical engineering. To investigate the dynamic characteristics of transparent sand, a series of undrained cyclic simple shear tests were conducted on the saturated transparent sand composed of fused quartz and refractive index-matched oil mixture. The results reveal that an increase in the initial shear stress ratio significantly affects the shape of the hysteresis loop, particularly resulting in more pronounced asymmetrical accumulation. Factors such as lower relative density, higher cyclic stress ratios and higher initial shear stress ratio have been shown to accelerate cyclic deformation, cyclic pore water pressure and stiffness degradation. The cyclic liquefaction resistance curves decrease as the initial shear stress ratio increases or as relative density decreases. Booker model and power law function model were applied to predict the pore water pressure for transparent sand. Both models yielded excellent fits for their respective condition, indicating a similar dynamic liquefaction pattern to that of natural sands. Finally, transparent sand displays similar dynamic characteristics in terms of cyclic liquefaction resistance and Kα correction factor. These comparisons indicate that transparent sand can serve as an effective means to mimic many natural sands in dynamic model tests.
文摘Objective:Thulium fiber laser enucleation of the prostate(ThuFLEP)and robot-assisted simple prostatectomy(RASP)are two options for treating large benign prostatic hyperplasia.The most appropriate technique remains a matter of debate.We evaluated the efficacy and safety of ThuFLEP compared to RASP.Methods:Between January 2020 and December 2023,all patients who underwent either RASP or ThuFLEP for a prostate volume>80 mL were retrospectively included.The surgical procedure choice was left to the surgeon’s and patient’s discretion.Preoperative patient evaluation included the assessment of functional parameters.The groups were compared.Results:A total of 234 patients were included:106(45%)underwent RASP and 128(55%)underwent ThuFLEP.The mean operative time was shorter in the ThuFLEP group compared to the RASP group(106.4 with standard deviation[SD]46.1 min vs.123.2[SD 32.8]min,p=0.012).The mean lengths of catheterization and stay were significantly longer in the RASP group(5.0[SD 3.9]days vs.1.7[SD 2.0]days,p=0.009[catheterization]and 4.9[SD 3.0]days vs.1.9[SD 1.8]days,p=0.009[stay]).The overall complication rate was significantly higher in the ThuFLEP group(12%vs.2.8%in the RASP group,p=0.022).However,we did not observe significant differences in major complications(Clavien-Dindo≥3)between the two groups(four[3.1%]in the ThuFLEP group vs.one[0.94%]in the RASP group,p=0.073).At 3 months,the rate of stress urinary incontinence was 4.7%after ThuFLEP and 1.9%after RASP(p=0.2).Finally,the quality of life score and maximum urinary flow were comparable between the ThuFLEP and RASP groups,but the International Prostate Symptom Score at 3 months postoperatively was lower in the RASP group(p=0.012).Conclusion:Both ThuFLEP and RASP are safe techniques with comparable functional outcomes for large benign prostatic hyperplasia.ThuFLEP allows a reduction in catheterization and hospitalization durations but presents more complications compared to RASP.
基金Supported by The Science Foundation of 925th Hospital,No.2023[3]and No.2022[3/4]The Guizhou Provincial Health Commission Science and Technology Fund,No.gzwkj2023-135。
文摘BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measured using Life’s Essential 8(LE8)and Life’s Simple 7(LS7),and the prevalence of MAFLD.METHODS This cross-sectional study had a sample of 2234 individuals,representing approximately 120 million individuals in the United States.Baseline parameters were compared between the LE8 and LS7 groups.Logistic regression models were used to evaluate the relationship between LE8,LS7,and MAFLD,while taking into account confounding factors.The investigation employed restricted cubic splines to investigate non-linear associations.Subgroup analyses and sensitivity studies were performed to evaluate the strength and reliability of the results.RESULTS Higher LE8 and LS7 scores were significantly associated with a decreased risk of MAFLD,even after controlling for demographic,socioeconomic,and clinical variables.This association demonstrated a non-linear pattern,with the most dramatic risk reduction observed at higher CVH levels.Individual CVH components,notably healthy behaviors and factors,exhibited strong relationships with MAFLD.Subgroup analyses indicated consistent relationships across several demographics.Sensitivity tests utilizing other MAFLD definitions validated the robustness of the findings.CONCLUSION Higher adherence to CVH criteria,as indicated by LE8 and LS7 scores,is associated with a significantly lower risk of MAFLD.These results emphasize the need to advance CVH to control and avoid MAFLD.
文摘Over an algebraically closed field of characteristic p>2,based on the results on the representation theory of special linear Lie algebra sl(2),restricted simple modules L(λ) of the Schrodinger algebra S(1)are determined,and all derivations of S(1)on L(λ)are also obtained.As an application,the first cohomology of S(1)with the coefficient in L(λ)is determined.
基金Supported by Medical Science Research Project Plan by Health Commission of the Hebei Province,No.20220063.
文摘BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic treatment.CASE SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lips requested orthodontic camouflage.The treatment plan consisted of extracting the right upper third molar,right lower third molar,left lower second molar,and left upper third molar and moving the maxillary dentition distally using a convenient method involving microimplant nail anchors,push springs,long arm traction hooks,and elastic traction chains.After 52 months of treatment,her overbite and overjet were normal,and her facial profile was favorable.CONCLUSION This method can be used for distal movement of the maxillary dentition and to correct severe skeletal class II malocclusion in adults.
基金the Tianshan Talents Program for Leading Talents in Science and Technology Innovation(No.2022TSYCLJ0016)the National Natural Science Foundation of China(Nos.21961037 and 22201241)+3 种基金the Program for Tianshan Innovative Research Team of Xinjiang Uygur Autonomous Region(No.2021D14011)the Graduate Innovation Project of Xinjiang Uygur Autonomous Region(No.XJ2021G036)the Key Program of Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01D06)the Natural Science Foundation of Xinjiang Uygur Autonomous Region(Nos.2021D01E10 and 2022E01042).
文摘Photocatalytic and photoinduced silyl radicals cascade cyclization procedures for the green and simple preparation of fused tetracyclic skeleton silylated indolo[2,1-a]isoquinoline-6(5H)-ones from 2-aryl-N-acryloyl indoles with hydrosilanes are developed.The photocatalytic reaction is carried out with 9,10-dicyanoanthracene(DCA)as an organophotocatalyst and 3-acetoxyquinuclidine as hydrogen atom transfer(HAT)catalyst at room temperature under metal-and oxidant-free conditions.The keys to the success of photoredox-catalytic conversion include(1)the reductive quenching of DCA^(*)[E_(1/2)(*P/P^(-))=+1.97 V vs.SCE in MeCN]by 3-acetoxyquinuclidine(E_(p)=+1.22 V vs.SCE in MeCN),and(2)the thermodynamic feasibility of hydrogen atom abstraction from hydridic Si-H bond by electrophilic N^(+·).Particularly,the simple photoinduced cascade cyclization using(TMS)3SiH with 2-aryl-N-acryloyl indoles was exploited via an electron-donor-acceptor(EDA)complex under visible light irradiation.
文摘This manuscript presents a dataset detailing a method for purifying monomers. Purification plays a crucial role in every chemical process, as it leads to an improvement in product quality through the removal of impurities. The primary method for monomer purification, like acrylonitrile (AN), is the distillation technique. However, this technique is unsafe and hard to set up or handle. A straightforward, risk-free, low-cost method like the column technique resolves these issues. A simple column technique demonstrated the successful execution of purifying AN. Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) analyses confirmed that AN was successfully purified, with purity reaching 99.8%. FTIR spectra revealed changes in the position and intensity of the stretching vibration peaks after purification. Also, the functional groups of the inhibitor monomethyl ether of hydroquinone (MeHQ) were undetected after purification. Furthermore, after purification, NMR spectra revealed the absence of aromatic protons and carbons associated with MeHQ. In conclusion, the column technique is a successful and inexpensive way to purify AN monomers. This makes it useful for a wide range of applications, especially in polymerization reactions where MeHQ needs to be removed to prevent self-polymerization during the initiation process.
文摘We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that the heat kernel in higher dimensions converges rapidly. We also compute the constants involved in the estimate for the 1-dimensional heat kernel. Furthermore, we discuss the general case of on-diagonal estimates for the heat kernel.
