Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by cognitive decline.The pathological hallmarks of AD include the deposition of b-amyloid(Ab)plaques,hyperphosphorylation of tau protei...Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by cognitive decline.The pathological hallmarks of AD include the deposition of b-amyloid(Ab)plaques,hyperphosphorylation of tau protein,synaptic loss,and reactive astrogliosis in the brain[1].As there is still no effective therapy for AD,the development of novel treatment strategies is imperative.展开更多
Homeostasis is essential for the maintenance of health,and how it is maintained is the focus of attention in homeostatic medicine.As a natural dietary nutrient,nitrate is critical in regulating homeostasis.This articl...Homeostasis is essential for the maintenance of health,and how it is maintained is the focus of attention in homeostatic medicine.As a natural dietary nutrient,nitrate is critical in regulating homeostasis.This article summarizes nitrate's cognitive his-tory,sources,and metabolism.It discusses the relationship and possible mechanism between nitrate and organism homeostasis from three aspects:flora homeostasis,inflammation-immunity homeostasis,and energy metabolism homeostasis,as well as the clinical application scenarios of nitrate as a promising new generation of drugs,including preventing and treating multi-system diseases,reducing organism injury,improving exercise ability,regulating glucose and lipid metabolism,and assisting tumor treatment.An increased understanding of nitrate's impact on body home-ostasis could foster a new research concept for its application in disease prevention and treatment.展开更多
基金supported by the National Natural Science Foundation of China(82030031,91649124,and 92049201)Beijing Municipal Science&Technology Commission(Z181100001718208)+8 种基金Chinese Academy of Medical Sciences Research Unit(2019–12M-5-031)Beijing Municipality Government grants(Beijing Laboratory of Oral HealthPXM2021_014226_000041Beijing Scholar ProgramPXM2021_014226_000021)Beijing Municipal Education Commission(119207020201)Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201)Scientific Research Common Program of Beijing Municipal Commission of Education(KM202110025009)Beijing Municipal Natural Science Foundation(7232071)Scientific Research Key Program of Beijing Municipal Commission of Education(KZ202110025032)the STI2030-Major Project(2021ZD0201100 Task 1-2021ZD0201101).
文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by cognitive decline.The pathological hallmarks of AD include the deposition of b-amyloid(Ab)plaques,hyperphosphorylation of tau protein,synaptic loss,and reactive astrogliosis in the brain[1].As there is still no effective therapy for AD,the development of novel treatment strategies is imperative.
基金supported by the National Natural Science Foundation of China(92049201,82030031,81991504,92149301,L2224038,82001067,and 82170951)National Key Research and Development Program(2022YFA1104401)+9 种基金Beijing Municipal Govermment(Beijing Laboratory of Oral Health,PXM2021_014226_000041Beijing Scholar Program,PXM2020_014226_000005 and PXM2021_014226_000020)Beijing Municipal Science and Technology Commission(Z181100001718208)Beijing Municipal Education Commission(119207020201)Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201)Research Unit of Tooth Development and Regeneration,Chinese Academy of Medical Sciences(2019-12M-5-031)Beijing Advanced Innovation Center for Big Data-based Precision Medicine(PXM2021_014226_000026)Beijing Municipal Colleges and Universities High Level Talents Introduction and Cultivate Project-Beijing Great Wall Scholar Program(CIT&TCD 20180332)Scientific Research Common Program of Beijing Municipal Commission of Education(KM202110025009)Beijing Municipal Natural Science Foundation(7232071 and 7222079).
文摘Homeostasis is essential for the maintenance of health,and how it is maintained is the focus of attention in homeostatic medicine.As a natural dietary nutrient,nitrate is critical in regulating homeostasis.This article summarizes nitrate's cognitive his-tory,sources,and metabolism.It discusses the relationship and possible mechanism between nitrate and organism homeostasis from three aspects:flora homeostasis,inflammation-immunity homeostasis,and energy metabolism homeostasis,as well as the clinical application scenarios of nitrate as a promising new generation of drugs,including preventing and treating multi-system diseases,reducing organism injury,improving exercise ability,regulating glucose and lipid metabolism,and assisting tumor treatment.An increased understanding of nitrate's impact on body home-ostasis could foster a new research concept for its application in disease prevention and treatment.
