摘要
Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by cognitive decline.The pathological hallmarks of AD include the deposition of b-amyloid(Ab)plaques,hyperphosphorylation of tau protein,synaptic loss,and reactive astrogliosis in the brain[1].As there is still no effective therapy for AD,the development of novel treatment strategies is imperative.
基金
supported by the National Natural Science Foundation of China(82030031,91649124,and 92049201)
Beijing Municipal Science&Technology Commission(Z181100001718208)
Chinese Academy of Medical Sciences Research Unit(2019–12M-5-031)
Beijing Municipality Government grants(Beijing Laboratory of Oral HealthPXM2021_014226_000041
Beijing Scholar ProgramPXM2021_014226_000021)
Beijing Municipal Education Commission(119207020201)
Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201)
Scientific Research Common Program of Beijing Municipal Commission of Education(KM202110025009)
Beijing Municipal Natural Science Foundation(7232071)
Scientific Research Key Program of Beijing Municipal Commission of Education(KZ202110025032)
the STI2030-Major Project(2021ZD0201100 Task 1-2021ZD0201101).
