Bolting steel angles at the bottom ends of columns provides a rapid and efficient method for repairing damaged structures,while also offering a viable approach to restore their potential bearing capacity.To validate t...Bolting steel angles at the bottom ends of columns provides a rapid and efficient method for repairing damaged structures,while also offering a viable approach to restore their potential bearing capacity.To validate the suitability of specific strengthening strategies,particularly the utilization of bolted steel angles,three reinforced concrete frame specimens were subjected to hysteresis testing.These specimens all featured RC columns strengthened with steel angle ends.Additionally,one control specimen without steel angle ends was included in the testing.The hysteresis effects of bolting steel angles were discussed in terms of typical failure mode,hysteresis and skeleton curves,stiffness degradation and energy dissipation.The experimental results revealed that the three specimens that had bolted steel angles exhibited ductile failure behavior.Through analysis of hysteresis and skeleton curves,it was observed that the frame demonstrated distinct plasticity,maintaining sufficient load-bearing capacity even after yielding and exhibiting superior displacement ductility performance.Considering equivalent viscous damping,the energy dissipation capacity of the RC frame increased linearly with drift and remained largely unaffected by structural damage.Therefore,bolting steel angles at specified cross-sections proved to be a viable technique for structural repair and restoration.展开更多
A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners spac...A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.展开更多
Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in...Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the ＂free mode＂ assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.展开更多
A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient mod...A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient module of output and input pressure of the moving ending model and neglected ending moving model are made on the frequency response. It is revealed that the moving ending of pipeline influences largely the quotient amplitude of output and input pressure, and the peak value of frequency resonance increases with the increase of pipeline’s length.展开更多
Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided int...Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided into three study groups. A standard transverse diaphysial fracture in the femurs of the same side of all subjects under anesthesia was created and the fracture were fixed intramedullarily. While preserving the structural integrity of the sciatic nerve in the first group, neurectomy to the nerve in the second group was performed. In the third group, following the sciatic nerve cut, the proximal end of the nerve were interposed the fracture line. After a 28-day observational period, the callus formation in the subjects was examined radiologically, biomechanically and histopathologically. Results: Among all groups, the third group subjects showed significant increase in radiological area measurements when they are compared to the second group rats. There was no significant difference in biomechanical measurements of fractured femurs of the three groups. In histopathological evaluations, it was observed that denervation had increased the thickness of the cartilage and the number of the chondrocytes and osteoclasts significantly but decreased the number of fibroblasts compared to the control group. In addition to the denervation nerve ending interpositioning increased the bone thickness and the number of the osteoblasts but decreased the number of the osteoclasts significantly. Conclusions: While radiological observations exhibit that nerve ending interpositioning has resulted more hypertrophic callus formation, histopathological evaluations led us to that denervation created partial (immature) callus formation and nerve ending interpositioning demonstrated larger but immature callus formation.展开更多
The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his uni...The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his unique narrative skills,and his unexpected and reasonable ending,O.Henry got a high reputation.His execllent technique of writng is more obvious for the irony of reality and the return of human nature.The O.Henry-style ending opened up the pluralistic development of later realistic literature.The highly critical ending of its turning point also promotes the practical significance of the reaction of world literature to society.展开更多
As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22＇s （1961） position in American literature remains secure. Yet its ending has been held as unconvincing ...As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22＇s （1961） position in American literature remains secure. Yet its ending has been held as unconvincing ever since its publication. Taking the overall structure, tone, and the theme of the novel into consideration, this paper aims to prove the credibility of this controversial part. It consists of five sections apart from an introduction and a conclusion. Section One provides general information on the life and works of Joseph Heller. Section Two traces the impact of existentialism and the generation of black humor to clarify the literary position of Catch-22. Section Three brings out the disputative opinions on the ending part. Sections Four and Five, try to prove Yossarian＇s final desertion a natural and convincing ending from different perspectives： Section Four analyses how Yossarian gains an entropic vision of the cosmos; section Five studies his existential vision of physical life and searches for the immediate factors that propel Yossarian＇s desertion. Section five also explains the ending＇s change in tone and structure. The conclusion summarizes the paper and points out the social significance of the novel.展开更多
The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transport...The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter （DAT）, the diffusion of DA and its metabolism by mono-amine oxidase （MAO） and cate- chol-O-methyl transferase （COMT）. DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis （Popolo et al., 2004; Reimer et al., 2013） and neuroregeneration （Hoglinger et al., 2004; Yang et al., 2008）. These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.展开更多
The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conven...The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conventions to pursue independence and freedom.Undoubtedly,Sarah is an independent woman ahead of her times.This paper is attempted to interpret the last ending of The French Lieutenant's woman written by John Fowles,thus finding relevant evidence to support this interpretation that Sarah has finally got her freedom which is not allowed against the Victorian background.展开更多
A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, b...A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, but they are costly or difficult to apply for thick plates. This study proposes a new, simple approach that reduces these flat areas. This approach includes moving the bottom roll slightly along the feeding direction and adjusting the bottom roll location. Sensitivity analyses were performed using a developed 3D dynamic FE （finite element） model of an asymmetrical roll-bending process in the Ansys/LS-Dyna software package. Simulations were validated by experiments run on an instrumented roll-bending machine. The FE results indicate that this new approach not only minimizes the flat areas but also reduces the forming forces.展开更多
OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-perf...OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.展开更多
Acceptor-donor-acceptor(A-D-A)type molecules,of which the novel non-fused azacyclic end-group pyrazoli-nones were modified with chlorine substitution on the phenyl ring,were synthesized.The non-fused azacyclic end-gro...Acceptor-donor-acceptor(A-D-A)type molecules,of which the novel non-fused azacyclic end-group pyrazoli-nones were modified with chlorine substitution on the phenyl ring,were synthesized.The non-fused azacyclic end-group py-razolinones have the advantages of simple synthesis steps,low cost and environmental friendliness,compared to the classical end-group dicyanomethyleneindianone.The properties of the synthesized A-D-A type molecules with non-fused azacyclic end groups were characterized by theoretical calculation,UV-vis absorption,cyclic voltammetry,X-ray diffraction and space charge limited current.It is shown that the strong UV-vis absorptions of the synthesized A-D-A type molecules are located in the wavelength range of 500~700 nm,with a moderate band gap of nearly 1.7 eV.At the same time,the influence of end-group chlorination on the properties of A-D-A type molecules was compared and explored.It is proven that this kind of A-D-A type molecule with non-fused azacyclic end groups has the potential to be applied as interfacial modified layer of the active layer in perovskite solar cell devices.展开更多
BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,t...at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,the satellite entered into sun-synchronous circular orbit after separating with the rocket.展开更多
Liver transplantation(LT)has made significant progress in the treatment of end stage liver disease(ESLD).However,many patients still die from disease progression while awaiting transplantation.As the number of patient...Liver transplantation(LT)has made significant progress in the treatment of end stage liver disease(ESLD).However,many patients still die from disease progression while awaiting transplantation.As the number of patients on LT waiting lists is increasing,and the organ shortage crisis is obvious,various efforts have been made to increase the pool of available liver grafts[1].In addition to living donor liver transplantation(LDLT),improving the utilization rate of extended criteria donor(ECD)livers is an important way.However,under traditional cold storage,ECD livers are usually associated with a higher risk of ischemic biliary disease,early allograft dysfunction(EAD)or even primary nonfunction(PNF).The frequently described definition in the literature for ECD grafts generally includes elderly,steatotic,long cold ischemia time(CIT),grafts obtained from donation after circulatory death(DCD),split liver grafts,donors with increased risk of infectious disease transmission and prolonged donor intensive care unit stay[2].展开更多
基金National Key R&D Program of China under Grant No.2023YFC3805100Technologies R&D Project of China Construction First Group Corporation Limited under Grant No.PT-2022-09National Natural Science Foundation of China under Grant No.52178126。
文摘Bolting steel angles at the bottom ends of columns provides a rapid and efficient method for repairing damaged structures,while also offering a viable approach to restore their potential bearing capacity.To validate the suitability of specific strengthening strategies,particularly the utilization of bolted steel angles,three reinforced concrete frame specimens were subjected to hysteresis testing.These specimens all featured RC columns strengthened with steel angle ends.Additionally,one control specimen without steel angle ends was included in the testing.The hysteresis effects of bolting steel angles were discussed in terms of typical failure mode,hysteresis and skeleton curves,stiffness degradation and energy dissipation.The experimental results revealed that the three specimens that had bolted steel angles exhibited ductile failure behavior.Through analysis of hysteresis and skeleton curves,it was observed that the frame demonstrated distinct plasticity,maintaining sufficient load-bearing capacity even after yielding and exhibiting superior displacement ductility performance.Considering equivalent viscous damping,the energy dissipation capacity of the RC frame increased linearly with drift and remained largely unaffected by structural damage.Therefore,bolting steel angles at specified cross-sections proved to be a viable technique for structural repair and restoration.
文摘A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.
文摘Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the ＂free mode＂ assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.
文摘A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient module of output and input pressure of the moving ending model and neglected ending moving model are made on the frequency response. It is revealed that the moving ending of pipeline influences largely the quotient amplitude of output and input pressure, and the peak value of frequency resonance increases with the increase of pipeline’s length.
文摘Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided into three study groups. A standard transverse diaphysial fracture in the femurs of the same side of all subjects under anesthesia was created and the fracture were fixed intramedullarily. While preserving the structural integrity of the sciatic nerve in the first group, neurectomy to the nerve in the second group was performed. In the third group, following the sciatic nerve cut, the proximal end of the nerve were interposed the fracture line. After a 28-day observational period, the callus formation in the subjects was examined radiologically, biomechanically and histopathologically. Results: Among all groups, the third group subjects showed significant increase in radiological area measurements when they are compared to the second group rats. There was no significant difference in biomechanical measurements of fractured femurs of the three groups. In histopathological evaluations, it was observed that denervation had increased the thickness of the cartilage and the number of the chondrocytes and osteoclasts significantly but decreased the number of fibroblasts compared to the control group. In addition to the denervation nerve ending interpositioning increased the bone thickness and the number of the osteoblasts but decreased the number of the osteoclasts significantly. Conclusions: While radiological observations exhibit that nerve ending interpositioning has resulted more hypertrophic callus formation, histopathological evaluations led us to that denervation created partial (immature) callus formation and nerve ending interpositioning demonstrated larger but immature callus formation.
文摘The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his unique narrative skills,and his unexpected and reasonable ending,O.Henry got a high reputation.His execllent technique of writng is more obvious for the irony of reality and the return of human nature.The O.Henry-style ending opened up the pluralistic development of later realistic literature.The highly critical ending of its turning point also promotes the practical significance of the reaction of world literature to society.
文摘As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22＇s （1961） position in American literature remains secure. Yet its ending has been held as unconvincing ever since its publication. Taking the overall structure, tone, and the theme of the novel into consideration, this paper aims to prove the credibility of this controversial part. It consists of five sections apart from an introduction and a conclusion. Section One provides general information on the life and works of Joseph Heller. Section Two traces the impact of existentialism and the generation of black humor to clarify the literary position of Catch-22. Section Three brings out the disputative opinions on the ending part. Sections Four and Five, try to prove Yossarian＇s final desertion a natural and convincing ending from different perspectives： Section Four analyses how Yossarian gains an entropic vision of the cosmos; section Five studies his existential vision of physical life and searches for the immediate factors that propel Yossarian＇s desertion. Section five also explains the ending＇s change in tone and structure. The conclusion summarizes the paper and points out the social significance of the novel.
文摘The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter （DAT）, the diffusion of DA and its metabolism by mono-amine oxidase （MAO） and cate- chol-O-methyl transferase （COMT）. DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis （Popolo et al., 2004; Reimer et al., 2013） and neuroregeneration （Hoglinger et al., 2004; Yang et al., 2008）. These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.
文摘The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conventions to pursue independence and freedom.Undoubtedly,Sarah is an independent woman ahead of her times.This paper is attempted to interpret the last ending of The French Lieutenant's woman written by John Fowles,thus finding relevant evidence to support this interpretation that Sarah has finally got her freedom which is not allowed against the Victorian background.
文摘A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, but they are costly or difficult to apply for thick plates. This study proposes a new, simple approach that reduces these flat areas. This approach includes moving the bottom roll slightly along the feeding direction and adjusting the bottom roll location. Sensitivity analyses were performed using a developed 3D dynamic FE （finite element） model of an asymmetrical roll-bending process in the Ansys/LS-Dyna software package. Simulations were validated by experiments run on an instrumented roll-bending machine. The FE results indicate that this new approach not only minimizes the flat areas but also reduces the forming forces.
基金the Guangdong Provincial Basic and Applied Basic Research Project:Mechanistic Study on the Regulation of Inflammatory Microenvironment and Improvement of Ulcerative Colitis by Lingnan Traditional Medicine Ficus Pandurata Hance through Wilms'Tumor 1-associating Protein-Mediated RNA Methyltransferase Promoting Toll Like Receptor 4 m6A Modification(2023A1515011699)the Zhongshan Medical Research Project:Mechanistic Study on the Action of Xiahuo Pingwei San in the Treatment of Ulcerative Colitis(2022A020446)。
文摘OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.
文摘Acceptor-donor-acceptor(A-D-A)type molecules,of which the novel non-fused azacyclic end-group pyrazoli-nones were modified with chlorine substitution on the phenyl ring,were synthesized.The non-fused azacyclic end-group py-razolinones have the advantages of simple synthesis steps,low cost and environmental friendliness,compared to the classical end-group dicyanomethyleneindianone.The properties of the synthesized A-D-A type molecules with non-fused azacyclic end groups were characterized by theoretical calculation,UV-vis absorption,cyclic voltammetry,X-ray diffraction and space charge limited current.It is shown that the strong UV-vis absorptions of the synthesized A-D-A type molecules are located in the wavelength range of 500~700 nm,with a moderate band gap of nearly 1.7 eV.At the same time,the influence of end-group chlorination on the properties of A-D-A type molecules was compared and explored.It is proven that this kind of A-D-A type molecule with non-fused azacyclic end groups has the potential to be applied as interfacial modified layer of the active layer in perovskite solar cell devices.
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
文摘at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,the satellite entered into sun-synchronous circular orbit after separating with the rocket.
文摘Liver transplantation(LT)has made significant progress in the treatment of end stage liver disease(ESLD).However,many patients still die from disease progression while awaiting transplantation.As the number of patients on LT waiting lists is increasing,and the organ shortage crisis is obvious,various efforts have been made to increase the pool of available liver grafts[1].In addition to living donor liver transplantation(LDLT),improving the utilization rate of extended criteria donor(ECD)livers is an important way.However,under traditional cold storage,ECD livers are usually associated with a higher risk of ischemic biliary disease,early allograft dysfunction(EAD)or even primary nonfunction(PNF).The frequently described definition in the literature for ECD grafts generally includes elderly,steatotic,long cold ischemia time(CIT),grafts obtained from donation after circulatory death(DCD),split liver grafts,donors with increased risk of infectious disease transmission and prolonged donor intensive care unit stay[2].
