The present article covers a simple approach to detect and subsequently identify in vivo metabolites of brodimoprim, using high performance liquid chromatography coupled to ion trap mass spectrometer（LC/ESI-MS）, whi...The present article covers a simple approach to detect and subsequently identify in vivo metabolites of brodimoprim, using high performance liquid chromatography coupled to ion trap mass spectrometer（LC/ESI-MS）, which is based on a data-dependent acquisition of isotope ions and result verified by full scan mass spectrum. The distinguished advantage of data-dependent scan is rapidness because it requires minimum sample preparation, and all the necessary data can be obtained in one chromatographic run. In addition, it is highly sensitive and selective, allowing detection of trace metabolites even in the presence of complex biomatrix. As a result, four phase-Ⅰ（M1--M4） and four Phase-Ⅱ（M5--M8） metabolites of brodimoprim were identified in urine after the oral administration of hrodimoprim to Wistar rats. Their chemical structures were proposed based on the interpretation of their CID fragmentation characterizations and the metabolic pathway was exhibited in this article.展开更多
This paper demonstrates an experiment on the generation of 3D virtual geographic environment on the basis of experimental flight laser scanning data by a set of algorithms and methods that were developed to automatica...This paper demonstrates an experiment on the generation of 3D virtual geographic environment on the basis of experimental flight laser scanning data by a set of algorithms and methods that were developed to automatically interpret range images for extracting geo-spatial features and then to reconstruct geo-objects. The algorithms and methods for the interpretation and modeling of laser scanner data include triangulated-irregular-network (TIN)-based range image interpolation; mathematical-morphology (MM)-based range image filtering, feature extraction and range image segmentation, feature generalization and optimization, 3D objects reconstruction and modeling; computer-graphics (CG)-based visualization and animation of geographic virtual reality environment.展开更多
The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surf...The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surface shape”for short) data is analysed. This technique in- cludes these concrete methods and principles such as data smoothing, fitting, reconstructing ,elimi- nating and so on. The example and result about computer processing of 3- D surface shape data are given .展开更多
This study cross-validates existing urban maps using point cloud models to update GIS related data. The model, as-built 3D data, is created to integrate with maps in an architectural CAD platform. The clouds are refer...This study cross-validates existing urban maps using point cloud models to update GIS related data. The model, as-built 3D data, is created to integrate with maps in an architectural CAD platform. The clouds are referred by existing vector maps to verify inconsistency and to update 3D spatial relationships between subjects and environment. The cloud model shows its top reference hierarchy as the updated data for topographic-derived urban maps.展开更多
基金the National Natural Science Foundation of China(Nos.30630075 and 20675056)Natural Science Founda-tion of Tianjin City,China(No.07JCYBJC01600)
文摘The present article covers a simple approach to detect and subsequently identify in vivo metabolites of brodimoprim, using high performance liquid chromatography coupled to ion trap mass spectrometer（LC/ESI-MS）, which is based on a data-dependent acquisition of isotope ions and result verified by full scan mass spectrum. The distinguished advantage of data-dependent scan is rapidness because it requires minimum sample preparation, and all the necessary data can be obtained in one chromatographic run. In addition, it is highly sensitive and selective, allowing detection of trace metabolites even in the presence of complex biomatrix. As a result, four phase-Ⅰ（M1--M4） and four Phase-Ⅱ（M5--M8） metabolites of brodimoprim were identified in urine after the oral administration of hrodimoprim to Wistar rats. Their chemical structures were proposed based on the interpretation of their CID fragmentation characterizations and the metabolic pathway was exhibited in this article.
文摘This paper demonstrates an experiment on the generation of 3D virtual geographic environment on the basis of experimental flight laser scanning data by a set of algorithms and methods that were developed to automatically interpret range images for extracting geo-spatial features and then to reconstruct geo-objects. The algorithms and methods for the interpretation and modeling of laser scanner data include triangulated-irregular-network (TIN)-based range image interpolation; mathematical-morphology (MM)-based range image filtering, feature extraction and range image segmentation, feature generalization and optimization, 3D objects reconstruction and modeling; computer-graphics (CG)-based visualization and animation of geographic virtual reality environment.
文摘The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surface shape”for short) data is analysed. This technique in- cludes these concrete methods and principles such as data smoothing, fitting, reconstructing ,elimi- nating and so on. The example and result about computer processing of 3- D surface shape data are given .
文摘This study cross-validates existing urban maps using point cloud models to update GIS related data. The model, as-built 3D data, is created to integrate with maps in an architectural CAD platform. The clouds are referred by existing vector maps to verify inconsistency and to update 3D spatial relationships between subjects and environment. The cloud model shows its top reference hierarchy as the updated data for topographic-derived urban maps.
