Background:To confirm that the four constitutions of the Korean medicine is closely related to the intestinal flora,and explore the influence of specific intestinal microbes on these four populations.Methods:We collec...Background:To confirm that the four constitutions of the Korean medicine is closely related to the intestinal flora,and explore the influence of specific intestinal microbes on these four populations.Methods:We collect stool samples of four different physiques of the Taeeum,Soeum,Taeyang,and Shaoyang.Based on 16S rDNA amplicon sequencing,SPSS 18.0 statistical software and GraphPad Prism 8.0 mapping software,the body weight,body mass index,cholesterol and intestinal microcommunity composition of the four groups were analyzed and compared.Results:The results found that the body weight and body mass index of the Taeeum group were significantly higher than the Shaoyang group and the Soeum group,the body weight,cholesterol and body mass index of the Taeyang group were significantly higher than the Soeum Group.In the analysis of gut microbiota,the richness and diversity of intestinal microorganisms and the abundance ratio of posterior firmicutes to bacteroides were all different in the four populations,and there were 24 gut microbiota with significant differences(P<0.05).Among them,the abundance of[Eubacterium]coprostanoligenes group of Taeyang people,Taeeum people,Shaoyang people,and Soeum people were 3.71,9.62,9.36 and 9.33,respectively.Conclusion:[Eubacterium]coprostanoligenes group may be related to the differences in cholesterol content of the four populations.Similarly,the firmicutes/bacteroidetes abundance ratio may also be related to the differences in body weight,blood glucose and blood lipid among the four groups.展开更多
OBJECTIVE:To investigated the characteristics of patients with functional dyspepsia(FD)in terms of Sasang constitutional medicine.METHODS:A total of 116 patients with FD were recruited based on diagnosis by gastroscop...OBJECTIVE:To investigated the characteristics of patients with functional dyspepsia(FD)in terms of Sasang constitutional medicine.METHODS:A total of 116 patients with FD were recruited based on diagnosis by gastroscopy and symptomatic measurements.The distributions of Sasang constitutions and six syndromes in terms of TKM theory in the patients was compared with those from 1423 healthy subjects.RESULTS:The distribution of Sasang constitutions for the patients with FD significantly differed from that for healthy subjects,especially among women;36.7%vs 45.6%for Taeumin,28.9%vs 33.9%for Soumin,and 34.4%vs 20.4%for Soyangin.Our results assumed a high prevalence in Soyangin women(around 1.7 folds),and Soumin(45.2%),inparticular,had a high prevalence of"deficiency and coldness of spleen and stomach"compared with Taeumin(14.9%)and Soyangin types(15.7%).CONCLUSION:This study identified a trend for the frequency of FD and the Sasang constitutions.The findings may provide new ideas for the study of prevention and management of FD.展开更多
基金supported by the National Natural Science Foundation of China(No.81660834).
文摘Background:To confirm that the four constitutions of the Korean medicine is closely related to the intestinal flora,and explore the influence of specific intestinal microbes on these four populations.Methods:We collect stool samples of four different physiques of the Taeeum,Soeum,Taeyang,and Shaoyang.Based on 16S rDNA amplicon sequencing,SPSS 18.0 statistical software and GraphPad Prism 8.0 mapping software,the body weight,body mass index,cholesterol and intestinal microcommunity composition of the four groups were analyzed and compared.Results:The results found that the body weight and body mass index of the Taeeum group were significantly higher than the Shaoyang group and the Soeum group,the body weight,cholesterol and body mass index of the Taeyang group were significantly higher than the Soeum Group.In the analysis of gut microbiota,the richness and diversity of intestinal microorganisms and the abundance ratio of posterior firmicutes to bacteroides were all different in the four populations,and there were 24 gut microbiota with significant differences(P<0.05).Among them,the abundance of[Eubacterium]coprostanoligenes group of Taeyang people,Taeeum people,Shaoyang people,and Soeum people were 3.71,9.62,9.36 and 9.33,respectively.Conclusion:[Eubacterium]coprostanoligenes group may be related to the differences in cholesterol content of the four populations.Similarly,the firmicutes/bacteroidetes abundance ratio may also be related to the differences in body weight,blood glucose and blood lipid among the four groups.
基金Supported by the a National Research Foundation of Korea(NRF)Grant funded by the Ministry of Science,ICT&Future Planning(No.2006-2005173)
文摘OBJECTIVE:To investigated the characteristics of patients with functional dyspepsia(FD)in terms of Sasang constitutional medicine.METHODS:A total of 116 patients with FD were recruited based on diagnosis by gastroscopy and symptomatic measurements.The distributions of Sasang constitutions and six syndromes in terms of TKM theory in the patients was compared with those from 1423 healthy subjects.RESULTS:The distribution of Sasang constitutions for the patients with FD significantly differed from that for healthy subjects,especially among women;36.7%vs 45.6%for Taeumin,28.9%vs 33.9%for Soumin,and 34.4%vs 20.4%for Soyangin.Our results assumed a high prevalence in Soyangin women(around 1.7 folds),and Soumin(45.2%),inparticular,had a high prevalence of"deficiency and coldness of spleen and stomach"compared with Taeumin(14.9%)and Soyangin types(15.7%).CONCLUSION:This study identified a trend for the frequency of FD and the Sasang constitutions.The findings may provide new ideas for the study of prevention and management of FD.
