目的总结羟基-α-山椒素的药理学作用及其作用机制,探讨其多靶点治疗潜力。方法采用计算机检索PubMed,Web of Science,中国知网(CNKI)等数据库,筛选有关花椒及其化学成分的药理学作用及其作用机制研究的文献,系统分析其化学成分羟基-α...目的总结羟基-α-山椒素的药理学作用及其作用机制,探讨其多靶点治疗潜力。方法采用计算机检索PubMed,Web of Science,中国知网(CNKI)等数据库,筛选有关花椒及其化学成分的药理学作用及其作用机制研究的文献,系统分析其化学成分羟基-α-山椒素在疾病模型中的药物效应学特征与分子机制。结果花椒的化学成分羟基-α-山椒素在多种疾病的治疗中展现出了显著的药理学作用,如改善阿尔茨海默病模型中的认知能力和神经退行性病变,调节血糖、改善胰岛素抵抗、减少糖尿病并发症,减轻体质量、抗肥胖,调血脂、改善非酒精性脂肪性肝病,抗炎、抗氧化,改善术后肠梗阻和心肌损伤,局部麻醉,抗肿瘤,镇痛,杀虫等。结论花椒的化学成分羟基-α-山椒素具有治疗多种疾病的潜在价值。该研究为花椒资源的深度开发提供了理论依据,也为进一步探索花椒中其他活性成分的药理学作用及其作用机制提供了研究思路。展开更多
As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green pri...As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total size of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarZhuye Huajiao’ was a triploid. We identified a Zanthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome size of Z. armatum. Metabolomic analysis of the Zanthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of Zanthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.展开更多
文摘目的总结羟基-α-山椒素的药理学作用及其作用机制,探讨其多靶点治疗潜力。方法采用计算机检索PubMed,Web of Science,中国知网(CNKI)等数据库,筛选有关花椒及其化学成分的药理学作用及其作用机制研究的文献,系统分析其化学成分羟基-α-山椒素在疾病模型中的药物效应学特征与分子机制。结果花椒的化学成分羟基-α-山椒素在多种疾病的治疗中展现出了显著的药理学作用,如改善阿尔茨海默病模型中的认知能力和神经退行性病变,调节血糖、改善胰岛素抵抗、减少糖尿病并发症,减轻体质量、抗肥胖,调血脂、改善非酒精性脂肪性肝病,抗炎、抗氧化,改善术后肠梗阻和心肌损伤,局部麻醉,抗肿瘤,镇痛,杀虫等。结论花椒的化学成分羟基-α-山椒素具有治疗多种疾病的潜在价值。该研究为花椒资源的深度开发提供了理论依据,也为进一步探索花椒中其他活性成分的药理学作用及其作用机制提供了研究思路。
基金supported by the Projects for Innovative Research Groups of Chongqing Universities (Grant No.CXQT21028)Chongqing talent program for Zexiong Chen+2 种基金Scientific Technological Research Program of Chongqing Municipal Education Commission (Grant No.KJZD-K201901303)National Natural Science Foundation of China (Grant No.31925034)National Key Research and Development Project (Grant No.2019YFD1001200)。
文摘As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total size of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarZhuye Huajiao’ was a triploid. We identified a Zanthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome size of Z. armatum. Metabolomic analysis of the Zanthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of Zanthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.
