In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces nove...In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces novel realization of a sensor that us-es a polymer optical multi-mode fiber to sense pulse wave bio-signal from a wrist by analyzing the specklegram mea-sured at the output of the fiber.Applying machine learning techniques over the pulse wave signal allowed medical diag-nostics and recognizing different gestures with accuracy rate of 95%.展开更多
Ferroptosis is a novel form of cell death driven by oxidative damage,and is implicated in various pathological conditions,including neurodegenerative diseases,retinal damage,and ischemia-reperfusion injury of organs.I...Ferroptosis is a novel form of cell death driven by oxidative damage,and is implicated in various pathological conditions,including neurodegenerative diseases,retinal damage,and ischemia-reperfusion injury of organs.Inhibiting ferroptosis has shown great promise as a therapeutic strategy for these diseases,underscoring the urgent need to develop effective ferroptosis inhibitors.Although Ferrostatin-1(Fer-1)is a potent ferroptosis inhibitor,its susceptibility to oxidation and metabolic inactivation limits its clinical utility.In this study,the accumulation of peroxides and the resulting oxidative damage in the cellular microenvironment during ferroptosis were utilized to design Ferrostatin-1 prodrugs with reactive oxygen species-responsive features.This approach led to the development of a series of ferroptosis inhibitors that were capable of recognizing oxidative damage in diseased areas,allowing for targeted release and improved stability.The novel compounds demonstrated significant inhibitory effects and selectivity against RSL-3-induced ferroptosis in HK-2 cells,with compound a1 exhibiting an EC50 of 15.4�0.7μM,outperforming Fer-1.These compounds effectively identify the oxidative microenvironment associated with ferroptosis,enabling the targeted release of Fer-1,which prevents lipid peroxide accumulation and inhibits ferroptosis.This strategy holds promise for treating diseases related to ferroptosis,offering a targeted and intelligent therapeutic approach.展开更多
Chinese Physics Letters (CPL) is a peer-reviewed, international and multidisciplinary journal sponsored by the Chinese Physical Society (CPS) and Institute of Physics, CAS,and hosted online by IOP Publishing Ltd. Laun...Chinese Physics Letters (CPL) is a peer-reviewed, international and multidisciplinary journal sponsored by the Chinese Physical Society (CPS) and Institute of Physics, CAS,and hosted online by IOP Publishing Ltd. Launched in 1984 as the flagship journal of CPS, CPL has become one of the most prestigious periodicals published in China, and been among the good choices for worldwide physicists to disseminate their most important breakthroughs. Nowadays it is dedicated to build an internationally recognized platform for researchers to publish original research works in all the branches of fundamental,applied, and interdisciplinary physics.展开更多
I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised us...I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.展开更多
食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架...食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架,引入了“一般公认安全”(generally recognized as safe,GRAS)物质的定义。美国食用香料与萃取物制造者协会专家小组基于严格的科学标准对风味成分进行评估,并通过GRAS清单发布结果。该体系不仅在美国国内广泛应用,还对国际组织和其他国家的监管体系产生了深远影响。相比之下,中国的食品风味配料监管体系也在不断完善,形成了以国家市场监督管理总局为主导的多部门协同监管模式,以国家标准和法规为基础,强调政府的主导作用。通过对比分析,揭示中美两国在食品风味配料监管体系上的差异,并提出了对我国监管体系优化的建议,旨在推动食品行业的安全、有序发展。展开更多
文摘In a recent study,Prof.Rui Min and collaborators published their paper in the journal of Opto-Electronic Science that is entitled"Smart photonic wristband for pulse wave monitoring".The paper introduces novel realization of a sensor that us-es a polymer optical multi-mode fiber to sense pulse wave bio-signal from a wrist by analyzing the specklegram mea-sured at the output of the fiber.Applying machine learning techniques over the pulse wave signal allowed medical diag-nostics and recognizing different gestures with accuracy rate of 95%.
基金supported by the Natural Science Foundation of Liaoning Province(2023-MSBA-020)the Fundamental Research Funds for Central Universities(DUT24MS020)Science and Technology Innovation Fund of Dalian(2022JJ13SN073).
文摘Ferroptosis is a novel form of cell death driven by oxidative damage,and is implicated in various pathological conditions,including neurodegenerative diseases,retinal damage,and ischemia-reperfusion injury of organs.Inhibiting ferroptosis has shown great promise as a therapeutic strategy for these diseases,underscoring the urgent need to develop effective ferroptosis inhibitors.Although Ferrostatin-1(Fer-1)is a potent ferroptosis inhibitor,its susceptibility to oxidation and metabolic inactivation limits its clinical utility.In this study,the accumulation of peroxides and the resulting oxidative damage in the cellular microenvironment during ferroptosis were utilized to design Ferrostatin-1 prodrugs with reactive oxygen species-responsive features.This approach led to the development of a series of ferroptosis inhibitors that were capable of recognizing oxidative damage in diseased areas,allowing for targeted release and improved stability.The novel compounds demonstrated significant inhibitory effects and selectivity against RSL-3-induced ferroptosis in HK-2 cells,with compound a1 exhibiting an EC50 of 15.4�0.7μM,outperforming Fer-1.These compounds effectively identify the oxidative microenvironment associated with ferroptosis,enabling the targeted release of Fer-1,which prevents lipid peroxide accumulation and inhibits ferroptosis.This strategy holds promise for treating diseases related to ferroptosis,offering a targeted and intelligent therapeutic approach.
文摘Chinese Physics Letters (CPL) is a peer-reviewed, international and multidisciplinary journal sponsored by the Chinese Physical Society (CPS) and Institute of Physics, CAS,and hosted online by IOP Publishing Ltd. Launched in 1984 as the flagship journal of CPS, CPL has become one of the most prestigious periodicals published in China, and been among the good choices for worldwide physicists to disseminate their most important breakthroughs. Nowadays it is dedicated to build an internationally recognized platform for researchers to publish original research works in all the branches of fundamental,applied, and interdisciplinary physics.
文摘I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.
文摘食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架,引入了“一般公认安全”(generally recognized as safe,GRAS)物质的定义。美国食用香料与萃取物制造者协会专家小组基于严格的科学标准对风味成分进行评估,并通过GRAS清单发布结果。该体系不仅在美国国内广泛应用,还对国际组织和其他国家的监管体系产生了深远影响。相比之下,中国的食品风味配料监管体系也在不断完善,形成了以国家市场监督管理总局为主导的多部门协同监管模式,以国家标准和法规为基础,强调政府的主导作用。通过对比分析,揭示中美两国在食品风味配料监管体系上的差异,并提出了对我国监管体系优化的建议,旨在推动食品行业的安全、有序发展。
