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基于UCP1通路探讨黄连-吴茱萸药对对小鼠棕色脂肪细胞的影响
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作者 付晓 杨明翰 葛亮 《中国民族民间医药》 2025年第8期40-45,共6页
目的:通过检测不同配比黄连-吴茱萸药对对成熟的小鼠棕色脂肪细胞中解偶联蛋白(UCP1)基因表达和蛋白表达的影响,探索中药寒热药性的分子生物学本质。方法:诱导小鼠原代前棕色脂肪细胞,待分化为成熟的棕色脂肪细胞,油红O染色鉴定并观察... 目的:通过检测不同配比黄连-吴茱萸药对对成熟的小鼠棕色脂肪细胞中解偶联蛋白(UCP1)基因表达和蛋白表达的影响,探索中药寒热药性的分子生物学本质。方法:诱导小鼠原代前棕色脂肪细胞,待分化为成熟的棕色脂肪细胞,油红O染色鉴定并观察细胞形态变化。用荧光定量PCR技术和Western blot技术研究不同配比黄连-吴茱萸药对(左金丸、反左金丸、痞满方)以及单味中药及单体(黄连、吴茱萸、黄连素、吴茱萸碱)对成熟棕色脂肪细胞中UCP1在基因和蛋白表达层面的影响。结果:不同配比的“连-萸”药对会使UCP1、PGC-1α蛋白和基因相对表达量发生变化,偏寒性“连-萸”药对(左金丸、痞满方、黄连)会使UCP1、PGC-1α蛋白和基因相对表达量下降(P<0.05),偏热性“连-萸”药对(反左金丸、吴茱萸)会使UCP1、PGC-1α蛋白和基因相对表达量上升(P<0.05)。结论:具有寒热偏性的中药药对可以通过调节UCP1、PGC-1α蛋白和基因相对表达来影响能量代谢。在分子水平上解释中药寒热药性的科学本质。 展开更多
关键词 黄连-吴茱萸药对 寒热性中药 能量代谢 ucp1 PGC-1Α 基因蛋白表达
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基于UCP2/TXNIP/NLRP3通路探讨菟丝子总黄酮对CUMS小鼠抗抑郁的作用机制
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作者 宋安东 李国花 +5 位作者 袁博 贾孟辉 李占涛 王晓丽 王龙 付慧玲 《中国实验方剂学杂志》 北大核心 2025年第21期109-119,共11页
目的:探讨菟丝子总黄酮对慢性不可预知温和应激(CUMS)模型小鼠的抗抑郁作用及机制研究。方法:选取50只雄性4周龄ICR小鼠,随机分为空白组、CUMS模型组、菟丝子组(10.2 g·kg^(-1)·d^(-1))、帕罗西汀组(2.6 mg·kg^(-1)·... 目的:探讨菟丝子总黄酮对慢性不可预知温和应激(CUMS)模型小鼠的抗抑郁作用及机制研究。方法:选取50只雄性4周龄ICR小鼠,随机分为空白组、CUMS模型组、菟丝子组(10.2 g·kg^(-1)·d^(-1))、帕罗西汀组(2.6 mg·kg^(-1)·d^(-1))及总黄酮组(173.2 mg·kg^(-1)·d^(-1)),每组10只。除空白组外,其余各组全程持续进行CUMS造模。造模4周后进行行为学评估,随后模型组给予蒸馏水(10 mL·kg^(-1)·d^(-1)),其余治疗组给药,连续灌胃4周,灌胃容积为10 mL·kg^(-1)。通过糖水偏好实验、强迫游泳及悬尾实验评估抑郁样行为改变。苏木素-伊红(HE)染色观察海马神经元形态。原位末端标记法(TUNEL)染色观察小鼠脑组织细胞凋亡情况。酶联免疫吸附测定法(ELISA)检测海马炎症因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及神经递质5-羟色胺(5-HT)、多巴胺(DA)、脑源性神经营养因子(BDNF)水平,2′,7′-二氯二氢荧光素二乙酸酯(DCFH-DA)荧光探针法测定活性氧(ROS)含量。实时荧光定量聚合酶链式反应(Real-time PCR)检测炎症小体相关蛋白NOD样受体蛋白3(NLRP3)、凋亡相关微粒蛋白(ASC)、胱天蛋白酶-1(Caspase-1)、IL-1β、诱导型一氧化氮合酶(iNOS)mRNA表达,蛋白免疫印迹法(Western blot)检测NLRP3、ASC、Caspase-1、线粒体解偶联蛋白2(UCP2)及硫氧还蛋白互作蛋白(TXNIP)蛋白表达水平。结果:与空白组比较,CUMS模型组小鼠体质量显著下降(P<0.01),糖水偏好率显著下降(P<0.01),强迫游泳和悬尾实验静止时间显著延长(P<0.01);海马CA3区细胞密度降低、排列紊乱并伴有核固缩,脑组织细胞可见凋亡细胞增加;炎症因子IL-1β、IL-6、TNF-α水平显著升高(P<0.01),神经递质5-HT、DA、BDNF含量显著减少(P<0.01);ROS显著升高(P<0.01);NLRP3、ASC、Caspase-1、IL-1β、iNOS mRNA表达显著上调(P<0.01);UCP2蛋白表达显著降低(P<0.01),NLRP3、ASC、Caspase-1及TXNIP蛋白水平显著升高(P<0.01)。与模型组比较,各给药组小鼠糖水偏好率显著回升(P<0.01),强迫游泳和悬尾静止时间显著缩短(P<0.01);海马CA3区神经元结构修复;大脑组织细胞凋亡数目减少;炎症因子IL-1β、IL-6、TNF-α水平显著下降(P<0.01);神经递质5-HT、DA及BDNF含量恢复(P<0.01);ROS蓄积显著减轻(P<0.01);NLRP3、ASC、Caspase-1、IL-1β、iNOS mRNA表达显著降低(P<0.01);UCP2蛋白表达显著上调(P<0.01),NLRP3、ASC、Caspase-1及TXNIP蛋白水平显著降低(P<0.01)。总黄酮可显著改善抑郁样行为,其效果优于菟丝子干预。总黄酮对海马神经元结构修复及神经递质稳态调节作用更为突出,同时能有效抑制炎症因子的释放,下调NLRP3、ASC、Caspase-1、TXNIP蛋白表达并激活UCP2通路。结论:菟丝子总黄酮可通过调控小鼠海马UCP2/TXNIP/NLRP3信号通路,抑制炎症小体激活、减少氧化损伤并恢复神经递质含量,从而协同缓解神经元凋亡并促进海马细胞排列及形态结构的恢复,其比菟丝子水煎剂有更显著的抗抑郁作用。 展开更多
关键词 菟丝子 总黄酮 抑郁症 线粒体解偶联蛋白2(ucp2)/硫氧还蛋白互作蛋白(TXNIP)/NOD样受体蛋白3(NLRP3)通路 氧化应激-炎症轴
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基于语料库工具Wmatrix对Incoterms和UCP文本特征的研究与比较
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作者 李梦实 《语言与文化研究》 2025年第1期15-19,共5页
本文以语料库自动赋码软件Wmatrix为工具,以Incoterms的三个修订版和整合后的两个UCP修订版为语料,从语义域、词性分布和关键词三个角度探讨了它们的文体特征及异同,结果发现:1)从语义域角度看,两种文本都有将各方的权利和义务明晰化的... 本文以语料库自动赋码软件Wmatrix为工具,以Incoterms的三个修订版和整合后的两个UCP修订版为语料,从语义域、词性分布和关键词三个角度探讨了它们的文体特征及异同,结果发现:1)从语义域角度看,两种文本都有将各方的权利和义务明晰化的倾向。但是Incoterms在规定中突出的是对贸易双方的约束;而UCP文本则更强调对买方一方的要求;2)从词性特征看,Incoterms在功能上更偏向于表达型文本的特征;而UCP文本在功能上则更偏向于信息型文本的特征;3)对两份语料关键词分布特征的统计结果,也进一步证实了以上两个结论。 展开更多
关键词 国际贸易术语解释通则 商业跟单信用证统一惯例 语义域 词性特征
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On Waring-Goldbach Problem for Two Squares, Two Cubes and Two Fifth Powers
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作者 LI Jinjiang ZHAO Chenyang +1 位作者 LIU Zishun ZHANG Min 《数学进展》 北大核心 2025年第4期735-748,共14页
Let Pr denote an almost-prime with at most r prime factors,counted according to multiplicity.In this paper,it is proved that,for every sufficiently large even integer N,the equation N=x^(2)+p_(2)^(2)+p_(3)^(3)+p_(4)^(... Let Pr denote an almost-prime with at most r prime factors,counted according to multiplicity.In this paper,it is proved that,for every sufficiently large even integer N,the equation N=x^(2)+p_(2)^(2)+p_(3)^(3)+p_(4)^(3)+p_(5)^(5)+_6^(5)is solvable with being an almost-prime P_(6) and the other variables primes.This result constitutes an enhancement upon the previous result of Hooley[Recent Progress in Analytic Number Theory,Vol.1(Durham,1979),London:Academic Press,1981,127-191]. 展开更多
关键词 Waring-Goldbach problem Hardy-Littlewood method almost-prime sieve method
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On the Divisor Problem with Congruence Conditions
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作者 JIA Lirui ZHAI Wenguang CAI Tianxin 《数学进展》 北大核心 2025年第1期1-17,共17页
Let d(n;r_(1),q_(1),r_(2),q_(2))be the number of factorization n=n_(1)n_(2)satisfying n_i≡r_i(mod q_i)(i=1,2)andΔ(x;r_(1),q_(1),r_(2),q_(2))be the error term of the summatory function of d(n;r_(1),q_(1),r_(2),q_(2))... Let d(n;r_(1),q_(1),r_(2),q_(2))be the number of factorization n=n_(1)n_(2)satisfying n_i≡r_i(mod q_i)(i=1,2)andΔ(x;r_(1),q_(1),r_(2),q_(2))be the error term of the summatory function of d(n;r_(1),q_(1),r_(2),q_(2)).Suppose x≥(q_(1)q_(2))^(1+ε),1≤r_i≤q_i,and(r_i,q_i)=1(i=1,2).This paper studies the power moments and sign changes ofΔ(x;r_(1),q_(1),r_(2),q_(2)).We prove that for sufficiently large constant C,Δ(q_(1)q_(2)x:r_(1),q_(1),r_(2),q_(2))changes sign in the interval[T,T+C√T]for any large T.Meanwhile,we show that for small constants c and c,there exist infinitely many subintervals of length c√log^(-7)T in[T,2T]where±Δ(q_(1)q_(2)x:r_(1),q_(1),r_(2),q_(2))>cx^(1/4)always holds. 展开更多
关键词 divisor problem sign change congruence condition
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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis
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作者 Zhi-Wei Fu Yue-Jing Li +3 位作者 Ran Yu Rui-Qing Guo Li-Xia Gao Sheng-Xia Zhao 《World Journal of Psychiatry》 SCIE 2025年第1期128-136,共9页
BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current statu... BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children. 展开更多
关键词 Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect
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Efficacy of School-Based Interventions to Manage Psychosocial Problems of an Adolescent: A Clinical Case Study
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作者 Dua Fatima Afzaal Farhan Hashmi 《Open Journal of Medical Psychology》 2025年第1期19-31,共13页
This case study explores the efficacy of school-based intervention to address psychosocial challenges faced by an 11-year-old adolescent. The case study aimed to decrease the agression and acting out behavior as resul... This case study explores the efficacy of school-based intervention to address psychosocial challenges faced by an 11-year-old adolescent. The case study aimed to decrease the agression and acting out behavior as result of being victimized at school by the peers. The aim was to assess and manage the child’s aggressive behavior and academic underperformance which played a significant role in the child’s low self-esteem and emotional regulation. A comprehensive assessment was conducted to rule out the difficulties and a multi-faceted intervention strategy was utilized including anger management and structured activity scheduling that helped that child to improve his academic performance as well as to learn to manage his emotional expression. Throughout 16 sessions, the intervention targeted key behavioural indicators such as emotional expression, and aggression;post-assessment results demonstrated a 22% improvement in the child’s behavioral and academic challenges. The findings suggest that a multi-faceted therapeutic approach can be effective in addressing complex issues of aggression and academic underperformance in children, highlighting the importance of integrated psychological and educational interventions. 展开更多
关键词 AGGRESSION School-Related problems BULLYING VICTIMIZATION Cognitive-Behavioral Therapy
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Programming guide for solving constraint satisfaction problems with tensor networks
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作者 Xuanzhao Gao Xiaofeng Li Jinguo Liu 《Chinese Physics B》 2025年第5期71-90,共20页
Constraint satisfaction problems(CSPs)are a class of problems that are ubiquitous in science and engineering.They feature a collection of constraints specified over subsets of variables.A CSP can be solved either dire... Constraint satisfaction problems(CSPs)are a class of problems that are ubiquitous in science and engineering.They feature a collection of constraints specified over subsets of variables.A CSP can be solved either directly or by reducing it to other problems.This paper introduces the Julia ecosystem for solving and analyzing CSPs with a focus on the programming practices.We introduce some important CSPs and show how these problems are reduced to each other.We also show how to transform CSPs into tensor networks,how to optimize the tensor network contraction orders,and how to extract the solution space properties by contracting the tensor networks with generic element types.Examples are given,which include computing the entropy constant,analyzing the overlap gap property,and the reduction between CSPs. 展开更多
关键词 tensor networks constraint satisfaction problems problem reductions Julia
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Direct and Inverse Problems for a Third-order Differential Operator with Anti-periodic Boundary Conditions and a Non-local Potential
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作者 ZHANG Mingming LIU Yixuan 《数学理论与应用》 2025年第1期62-80,共19页
This paper focuses on the direct and inverse problems for a third-order self-adjoint differential operator with non-local potential and anti-periodic boundary conditions.Firstly,we obtain the expressions for the chara... This paper focuses on the direct and inverse problems for a third-order self-adjoint differential operator with non-local potential and anti-periodic boundary conditions.Firstly,we obtain the expressions for the characteristic function and resolvent of this third-order differential operator.Secondly,by using the expression for the resolvent of the operator,we prove that the spectrum for this operator consists of simple eigenvalues and a finite number of eigenvalues with multiplicity 2.Finally,we solve the inverse problem for this operator,which states that the non-local potential function can be reconstructed from four spectra.Specially,we prove the Ambarzumyan theorem and indicate that odd or even potential functions can be reconstructed by three spectra. 展开更多
关键词 Direct problem Inverse problem Non-local potential Anti-periodic boundary condition
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On the Riemann-Hilbert problem for the reverse space-time nonlocal Hirota equation with step-like initial data
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作者 Bei-Bei Hu Ling Zhang +1 位作者 Zu-Yi Shen Ji Lin 《Communications in Theoretical Physics》 2025年第2期30-38,共9页
In this paper,we use the Riemann-Hilbert(RH)method to investigate the Cauchy problem of the reverse space-time nonlocal Hirota equation with step-like initial data:q(z,0)=o(1)as z→-∞and q(z,0)=δ+o(1)as z→∞,where... In this paper,we use the Riemann-Hilbert(RH)method to investigate the Cauchy problem of the reverse space-time nonlocal Hirota equation with step-like initial data:q(z,0)=o(1)as z→-∞and q(z,0)=δ+o(1)as z→∞,whereδis an arbitrary positive constant.We show that the solution of the Cauchy problem can be determined by the solution of the corresponding matrix RH problem established on the plane of complex spectral parameterλ.As an example,we construct an exact solution of the reverse space-time nonlocal Hirota equation in a special case via this RH problem. 展开更多
关键词 nonlocal Hirota equation Cauchy problem Riemann-Hilbert problem step-like initial data
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Study on Current Situation,Existing Problems and Countermeasures of Soybean Cultivation
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作者 Huajun SUN 《Agricultural Biotechnology》 2025年第1期9-12,18,共5页
As one of the world's three major food crops and an important economic and oil crop,soybean plays a crucial role in ensuring food safety.In recent years,there are many problems in soybean cultivation,production an... As one of the world's three major food crops and an important economic and oil crop,soybean plays a crucial role in ensuring food safety.In recent years,there are many problems in soybean cultivation,production and processing.In view of this situation,this paper comprehensively expounded and decomposed the cultivation situation,existing problems,specific countermeasures and conclusions,so as to re-recognize them.This study provides reference materials for the sustainable and healthy development of the soybean industry. 展开更多
关键词 SOYBEAN Cultivation situation problemS COUNTERMEASURE
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Solve the Word Problems of Maths
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作者 杨哲 《疯狂英语(双语世界)》 2025年第3期44-46,68,共4页
1.The price of a desk is 10 times the price of a chair.The desk costs 288 yuan more than the chair.How much does one desk and one chair cost?2.A and B start from two different places and walk toward each other.After 4... 1.The price of a desk is 10 times the price of a chair.The desk costs 288 yuan more than the chair.How much does one desk and one chair cost?2.A and B start from two different places and walk toward each other.After 4 hours,they meet at a point that is 4 kilometres away from the midpoint between their starting points.A walks faster than B.How many more kilometres per hour does A walk than B? 展开更多
关键词 COST DISTANCE word problems MATHS PRICE SPEED
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A neural network based on novel equivalent model for linear complementarity problems
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作者 KE Yi-fen XIE Ya-jun +1 位作者 ZHANG Huai MA Chang-feng 《Applied Mathematics(A Journal of Chinese Universities)》 2025年第2期311-326,共16页
A family of neural networks is proposed to solve linear complementarity problems(LCP).The neural networks are constructed from the novel equivalent model of LCP,which is reformulated by utilizing the modulus and smoot... A family of neural networks is proposed to solve linear complementarity problems(LCP).The neural networks are constructed from the novel equivalent model of LCP,which is reformulated by utilizing the modulus and smoothing technologies.Some important properties of the proposed novel equivalent model are summarized.In addition,the stability properties of the proposed steepest descent-based neural networks for LCP are analyzed.In order to illustrate the theoretical results,we provide some numerical simulations and compare the proposed neural networks with existing neural networks based on the NCP-functions.Numerical results indicate that the performance of the proposed neural networks is effective and robust. 展开更多
关键词 linear complementarity problem neural network MODULUS STABILITY
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Problems and Coping Strategies of Mechanical Drawing Courses in Vocational Colleges
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作者 Jinru Ma 《Journal of Contemporary Educational Research》 2025年第5期122-127,共6页
With the economic and social development of the country,vocational education is playing an increasingly significant role in cultivating highly skilled talents.However,the mechanical drawing courses in vocational colle... With the economic and social development of the country,vocational education is playing an increasingly significant role in cultivating highly skilled talents.However,the mechanical drawing courses in vocational colleges still face numerous challenges in the teaching process,such as outdated textbook content,inadequate practical resources,weak teaching staff,and low student interest.This paper aims to explore these issues and propose corresponding coping strategies.The findings of this study not only provide specific improvement suggestions for vocational colleges but also emphasize the importance of these strategies in enhancing students’comprehensive abilities and promoting the development of vocational education.By addressing these challenges,this paper contributes to the enhancement of teaching quality and the overall advancement of vocational skills education. 展开更多
关键词 Mechanical Drawing courses Mechanical drawing problemS STRATEGIES
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Decomposition for Large-Scale Optimization Problems:An Overview
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作者 Thai Doan CHUONG Chen LIU Xinghuo YU 《Artificial Intelligence Science and Engineering》 2025年第3期157-174,共18页
Formalizing complex processes and phenomena of a real-world problem may require a large number of variables and constraints,resulting in what is termed a large-scale optimization problem.Nowadays,such large-scale opti... Formalizing complex processes and phenomena of a real-world problem may require a large number of variables and constraints,resulting in what is termed a large-scale optimization problem.Nowadays,such large-scale optimization problems are solved using computing machines,leading to an enormous computational time being required,which may delay deriving timely solutions.Decomposition methods,which partition a large-scale optimization problem into lower-dimensional subproblems,represent a key approach to addressing time-efficiency issues.There has been significant progress in both applied mathematics and emerging artificial intelligence approaches on this front.This work aims at providing an overview of the decomposition methods from both the mathematics and computer science points of view.We also remark on the state-of-the-art developments and recent applications of the decomposition methods,and discuss the future research and development perspectives. 展开更多
关键词 decomposition methods nonlinear optimization large-scale problems computational intelligence
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THREE INERTIAL ACCELERATION ALGORITHMS FOR SOLVING NON-MONOTONE EQUILIBRIUM PROBLEMS IN HILBERT SPACES
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作者 Yonghong YAO Olaniyi S.IYIOLA Yekini SHEHU 《Acta Mathematica Scientia》 2025年第4期1674-1700,共27页
Several results on iterative methods for equilibrium problems have been proposed and studied in the literature.Most of these results are obtained when the associated bifunction of the equilibrium problem is either a m... Several results on iterative methods for equilibrium problems have been proposed and studied in the literature.Most of these results are obtained when the associated bifunction of the equilibrium problem is either a monotone or pseudomonotone operator.Results on iterative methods for equilibrium problems without monotonicity conditions on the bifunction are still few in the literature.In this paper,we study equilibrium problems for which the underlined bifunction is not assumed any form of monotonicity.We propose two weakly convergent iterative algorithms and one strongly convergent algorithm.We obtain our convergence results without assuming either monotonicity or pseudomonotonicity condition on the bifunction.Our proposed algorithms are tested numerically to be more efficient and faster than some few available algorithms for equilibrium problems without monotonicity in the literature. 展开更多
关键词 equilibrium problem nonmonotone bifunction weak convergence strong convergence
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Algorithm and Application in Vehicle Routing Problem: A Review
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作者 Zhenyu Chen 《Journal of Electronic Research and Application》 2025年第2期166-174,共9页
This paper systematically reviews the latest research developments in Vehicle Routing Problems(VRP).It examines classical VRP models and their classifications across different dimensions,including load capacity,operat... This paper systematically reviews the latest research developments in Vehicle Routing Problems(VRP).It examines classical VRP models and their classifications across different dimensions,including load capacity,operational characteristics,optimization objectives,vehicle types,and time constraints.Based on literature retrieval results from the Web of Science database,the paper analyzes the current state and trends in VRP research,providing detailed explanations of VRP models and algorithms applied to various scenarios in recent years.Additionally,the article discusses limitations in existing research and provides perspectives on future development trends in VRP research.This review offers researchers in the VRP field a comprehensive overview while identifying future research directions. 展开更多
关键词 Vehicle routing problem VRP Delivery route optimization Logistics planning
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Pilot Study of a School-Based Parenting Intervention:Prevention of Emotional and Behavioral Problems among Chinese Children
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作者 Jin Peng Jiabei He Na Li 《International Journal of Mental Health Promotion》 2025年第7期953-977,共25页
Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parent... Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parenting interventions remain scarcely investigated as preventive public health strategies.This pilot study evaluated a school-based intervention for preventing CEBP.Methods:We employed a quasi-experimental design with propensity score matching(PSM)to select 28 families(intervention:n=13;control:n=15)from two matched urban primary schools.Quantitative data from seven validated scales were analyzed using t-tests and ANCOVA.Qualitative insights were derived from 10 semi-structured interviews via thematic analysis.Results:Compared to the control group,the intervention group demonstrated significantly greater improvements in CEBP(p=0.020,Cohen’s d=0.92),parental adjustment(p=0.031,Cohen’s d=0.80),parenting confidence(p=0.003,Cohen’s d=1.04),and parentchild relationships(p=0.001,Cohen’s d=1.46).Non-significant effects were observed for parenting style,parental relationship,and parenting conflict(p>0.05).Qualitative analysis corroborated these findings and further identified contributing factors for non-significant outcomes,including challengeswithmeasurement adaptability and inconsistent co-parenting practices.Conclusions:This pilot study suggests that an authoritative parenting style may be effective and culturally adaptable in China.Positive parenting interventions appear to mitigate CEBP by reducing risk factors and enhancing protective factors.However,improving parental relationships and parenting conflict may require targeted strategies.Given the pilot nature of this PSM-matched study(n=28),the findings should be interpreted as exploratory and used primarily for intervention refinement. 展开更多
关键词 Parenting intervention CHILDREN SCHOOL-BASED China emotional and behavioral problems
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Bioinspired Discrete Two-Stage Surrogate-Assisted Algorithm for Large-Scale Traveling Salesman Problem
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作者 Ai-Qing Tian Hong-Xia Lv +2 位作者 Xiao-Yang Wang Jeng-Shyang Pan Václav Snášel 《Journal of Bionic Engineering》 2025年第4期1926-1939,共14页
The Traveling Salesman Problem(TSP)is a well-known NP-Hard problem,particularly challenging for conventional solving methods due to the curse of dimensionality in high-dimensional instances.This paper proposes a novel... The Traveling Salesman Problem(TSP)is a well-known NP-Hard problem,particularly challenging for conventional solving methods due to the curse of dimensionality in high-dimensional instances.This paper proposes a novel Double-stage Surrogate-assisted Pigeon-inspired Optimization algorithm(DOSA-PIO)to address this issue.DOSA-PIO integrates the ordering points to identify the clustering structure method for data clustering and employs a local surrogate model to assist the evolution of the Pigeon-inspired Optimization(PIO)algorithm.This combination enhances the algorithm’s ability to explore the solution space and converge to optimal solutions more effectively.Additionally,two novel approaches are introduced to extend the generalizability of continuous algorithms for solving discrete problems,enabling the adaptation of continuous optimization techniques to the discrete nature of TSP.Extensive experiments using benchmark functions and high-dimensional TSP instances demonstrate that DOSA-PIO significantly outperforms comparative algorithms in various dimensions(10D,20D,30D,50D,and 100D).The proposed algorithm provides superior solutions compared to traditional methods,highlighting its potential for solving high-dimensional TSPs.By leveraging advanced data clustering techniques and surrogate-assisted optimization,DOSA-PIO offers an effective solution for high-dimensional TSP instances,with experimental results confirming its superior performance and potential for practical applications in complex optimization problems. 展开更多
关键词 Traveling salesman problems Pigeon-inspired optimization Surrogate-assisted evolutionary Swarm intelligence
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The Relationship between Parental Phubbing and Problem Behaviors in Preschool Children
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作者 Qiulan Gu Mei Zhao 《International Journal of Mental Health Promotion》 2025年第5期607-623,共17页
With the widespread adoption of smartphones,parental phubbing behaviors have become increasingly prevalent,potentially affecting preschool children’s development.Current research primarily focuses on adolescent popul... With the widespread adoption of smartphones,parental phubbing behaviors have become increasingly prevalent,potentially affecting preschool children’s development.Current research primarily focuses on adolescent populations,while the mechanisms through which parental phubbing and authoritarian parenting style influence preschool children’s behavioral problems within the Chinese cultural context remain to be explored.Our investigation seeks to examine the factors contributing to behavioral difficulties among children of preschool age and provide theoretical guidance for prevention.Methods In our research,we utilized a convenience sampling approach to collect data from parents whose children(n=612)were between 3 and 7 years of age.The questionnaire distribution was facilitated via the Wenjuanxing online survey platform.Research instruments included the Parental Phubbing Scale,Parent-Child Relationship Scale,Authoritarian Parenting Style Scale,and Conners Child Behavior Rating Scale.For analytical procedures,we employed SPSS 24.0 to generate descriptive statistics and correlation analysis.Chain mediation effects were examined via Process macro,while significance assessment of the mediating effects relied on the Bootstrap method for constructing 95%confidence intervals.Results A statistically significant positive association was observed between parental phubbing and behavioral problems exhibited by children(r=0.251,p<0.001).Parental phubbing exhibited a significant direct effect on children’s behavioral problems(β=0.088,p<0.001).Analysis of sequential mediation demonstrated that authoritarian parenting style together with parent-child conflict functioned as significant intermediary variables in the relationship between parental phubbing and children’s problem behaviors(β=0.163,p<0.001),with these indirect pathways constituting 64.94%of the total effect.Conclusion Parental phubbing significantly contributes to behavioral problems in preschool children.Parents should monitor their media use,improve their parenting approach,and enhance parent-child relationships to reduce behavioral problems in preschool children. 展开更多
关键词 Parental phubbing authoritarian parenting style parent-child conflict child problem behaviors
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