At present,artificial intelligence(AI)technologies are deeply integrated into all scenarios of teaching,research,and student development in higher education.Intelligent teaching systems,research data processing tools,...At present,artificial intelligence(AI)technologies are deeply integrated into all scenarios of teaching,research,and student development in higher education.Intelligent teaching systems,research data processing tools,and AI platforms for student management are gradually becoming important aids to educational activities.This transformation disrupts the traditional framework of university teachers’responsibilities:fundamental tasks in knowledge transmission are diverted,repetitive work in research is replaced,and some managerial functions in student development are covered.Consequently,the boundaries of teachers’responsibilities are increasingly blurred,and the substitution effect has led to role anxiety and confusion about professional positioning.Clarifying the specific impact of AI on teachers’responsibilities,identifying the replaceable and irreplaceable domains,and exploring effective paths for fulfilling responsibilities are key to resolving teachers’role-identity crisis,promoting the implementation of“human-AI collaborative”education models,and ensuring the high-quality digital development of higher education.展开更多
Through analyzing the cases of Xiao Zhijun and the Yulin maternal jumping incident,the authors found significant disputes between the requests for non-indicated cesarean section and medical risk prevention,as well as ...Through analyzing the cases of Xiao Zhijun and the Yulin maternal jumping incident,the authors found significant disputes between the requests for non-indicated cesarean section and medical risk prevention,as well as between the psychology of avoiding childbirth pain and surgical responsibility.Currently,based on people’s current awareness and the responsibility orientation of expert opinions in disputes,medical institutions tend to satisfy family members’surgical requirements after fulfilling their obligation to fully inform about risks,to reduce the risk of losing disputes.This phenomenon actually reflects the contradiction between the demands of patients’families and the responsibilities of medical staff in medical decision-making.To balance the responsibilities of medical staff and the demands of patients’families,the authors believe that multiple governance paths need to be constructed:first,optimizing the level of medical staff’s communication;second,strengthening medical risk science popularization relying on modern information technology to improve patients’risk cognition ability;and third,raising society’s correct understanding of cesarean section through multiple channels.These measures can help to enhance patients’trust in hospital diagnosis and treatment results and promote harmonious development of doctor-patient relationships.展开更多
The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this ...The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this study,we investigated the role of Oryza sativa AUXIN RESPONSE FACTOR 13(OsARF13),a transcription factor involved in callus-related processes.We observed that OsARF13 expression is significantly higher in japonica rice callus than in indica rice callus.This differential expression might be associated with an allelic variation in the promoter region of OsARF13,where a deletion commonly found in indica rice corresponds to the loss of a conserved auxin-responsive element(AuxRE)motif.To functionally characterize OsARF13,we generated CRISPR/Cas9-mediated knockout mutants.These mutants exhibited a substantial reduction in callus fresh weight,demonstrating that OsARF13 is required for efficient callus induction.Transcriptome analysis of the osarf13 mutant further showed that OsARF13 influences the expression of genes involved in hormone signal transduction and stress responses.Our findings suggest that OsARF13 is a key component of the regulatory network governing callus induction and that natural variation in its promoter might provide a potential explanation for the differential regenerative capacity between japonica and indica rice subspecies.展开更多
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to enviro...Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon entry into oral biofilms are reviewed.Supra-gingival biofilms are characterized by acidic pH,the presence of bacterial enzymes,and the development of hypoxia in deeper layers.Sub-gingival biofilms are slightly alkaline,with hypoxia occurring over their entire depth.Upon entering biofilms,negatively charged,pH-and/or hypoxia-responsive nanocarriers become positively charged.This charge reversal leads to electrostatic double-layer attraction between positively charged nanocarriers towards negatively charged,waterfilled channel walls in biofilms,enhancing their accumulation in a biofilm.Degradation of bacterial enzyme-responsive nanocarriers causes in-biofilm release of antimicrobial cargo,yielding higher local antimicrobial concentrations than can be achieved through their direct,oral administration without harming soft tissues.Enhanced antibiofilm activity after in-biofilm antimicrobial release from biofilm-responsive micelles and liposomes has been demonstrated in vitro towards single-species Streptococcus mutans and Staphylococcus aureus biofilms or in vivo using specific-pathogen-free rodents inoculated with selected pathogens.This preferential antibacterial activity regulated the microbial composition of ex vivo human oral biofilm towards a more healthy microbiome composition.Although clinical confirmation is limited,the potential benefits of stimuli-responsive,antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration are worth further investigation towards clinical translation.展开更多
With the increasing penetration of variable renewable energy,flexible resources are highly needed to hedge the growing uncertainty,and variability in the power system.Demand response has served as a cost-effective typ...With the increasing penetration of variable renewable energy,flexible resources are highly needed to hedge the growing uncertainty,and variability in the power system.Demand response has served as a cost-effective type of flexible resource in recent years.In order to balance the uncertainty of the system,it is crucial to assess how much flexibility demand response programs can provide.Thus,forecasting demand response potential is important for the operation of the bulk system.This paper proposes a modeling approach that can characterize the multi-timescale flexibility of demand response so that not only the power potential but also temporal-coupling characteristics can be considered.Furthermore,a day-ahead demand response potential forecasting method is proposed using deep convolutional generative adversarial networks.The proposed forecasting method is tested using data from 170 users in Pecan Street Dataport.The results show that the proposed method can forecast the multi-timescale flexibility of demand response with high accuracy.展开更多
The interplay between gut microbiota and host health has attracted significant interest in the animal science community.Maintaining gut microbiota homeostasis by supplementing probiotics to treat clinical conditions l...The interplay between gut microbiota and host health has attracted significant interest in the animal science community.Maintaining gut microbiota homeostasis by supplementing probiotics to treat clinical conditions like calf diarrhea is an emerging area of research nowadays because of increased concerns regarding antimicrobial resistance(AMR)and drug residues in animal products.Probiotics reduce the incidence of calf diarrhea by increasing the gut microbiota diversity and richness with more commensal bacteria such as Lactobacillus and Bifidobacterium that produce antimicrobial compounds,as well as modulating the immune response by increasing cytokines,Interleukin-2(IL-2),IL-4,IL-6,IL-10,and reducing tumor necrosis factor-α(TNF-α),by increasing production of antibodies,especially immunoglobulin E(Ig E),also Ig G,differentiating naive Th lymphocytes(Tho)into Th1,hence stimulate innate immunity and prime the adaptive immune response.Specific probiotic strains of bacteria and yeast(Saccharomyces cerevisiae)derived probiotics maintain the integrity of the intestinal barrier.In this review,data are being organized to address the role of probiotics in treating calf diarrhea by modulating gut microbiota and stimulating an immune response against notorious pathogens,to present animal and veterinary scientists and nutritionists with a new concept to treat infectious diseases from the perspective of the gut microbiota,increasing animal health,performance,and welfare.In conclusion,health status and gut microbiome are strongly interlinked.Research data indicated a significant reduction in the incidence of diarrhea after probiotic administration.If interrelations between probiotics and existing gut microbiota are explored more quantitatively,novel antibiotic substitutes can emerge in the future.展开更多
Reinforced concrete(RC)columns are often subjected to off-central explosion due to the uncertainty of blast locations.However,few studies have focused on the dynamic response of RC columns under offcentral explosions....Reinforced concrete(RC)columns are often subjected to off-central explosion due to the uncertainty of blast locations.However,few studies have focused on the dynamic response of RC columns under offcentral explosions.A field blast experiment was conducted under close-in explosion with varying detonation offset distances(0 m,0.5 m,and 1 m),the overpressure load and dynamic responses of the full-scale RC columns were measured.Compared with the centrally detonated condition,a relative offset distance of 1.67 decreases the maximum and residual deflections of the RC column by 16.8%and 21.4%,respectively,while increasing the maximum and residual support rotations by 24.7%and 17.8%.Based on the experimental results,a theoretical model was proposed that considers the detonation location and charge mass,boundary conditions,axial compression ratio and material properties.The theoretical model exhibited good agreement with the experimental results,with prediction errors below 10%for both maximum and residual deflection.The effects of parameters were analyzed,and it indicated that an increase in offset distance results in decreased maximum and residual deflections but an increased support angle,thereby exacerbating damage.Higher axial load ratio,span-depth ratio,and longitudinal reinforcement ratio reduce both deflections and support angle.Additionally,a rapid method to predict the maximum and residual deflection of RC columns under off-central blast loading was also proposed based on the Generalized Regression Neural Network(GRNN).Eleven features which related to the RC column properties and the blast characteristics were used in the training process of GRNN,and accurate predictions were achieved with prediction errors within 20%.This study fills the gap in predicting the dynamic response of RC columns under off-central explosion,providing valuable references for blast-resistant design.展开更多
With the continuous progress of automatic driving technology,automatic driving technology standards are gradually affecting the determination of criminal responsibility for traffic accidents in China.At present,the ch...With the continuous progress of automatic driving technology,automatic driving technology standards are gradually affecting the determination of criminal responsibility for traffic accidents in China.At present,the characteristics and tendency of China's automatic driving technology standards present the situation of high policy relevance coexisting with low normative binding,professionalism coexist with barriers,forefront coexist with ambiguity.Therefore,challenges are presented both theoretically and practically on the determination of criminal responsibility based on automatic driving technology standard..In this regard,the misunderstanding should be clarified in theory:The legal order under the automatic driving technology standard has constitutionality and systematic,and there is a balance between the frontier of automatic driving technology development and the lagging of criminal law.The automatic driving technology risk level system should be built to clarify the boundary of the effectiveness of criminal law norms,seeking fora breakthrough in the application of the establishment of a comprehensive judgment system of the risks and accidents and the system of evidence to prove the system,which clarifies the determination of criminal responsibility under the automatic driving technology standard.This essay hopes to pursue breakthroughs in the application-to establish a comprehensive judgment system of risks and accidents as well as an evidence proof system,so as to clarify the determination of criminal responsibility under automatic driving technology standards.展开更多
Near-infrared(NIR)light-responsive shape memory polymers(SMPs)show great promise for biomedical applications,but conventional photothermal agents suffer from high cost,complex preparation,or poor biocompatibility,whil...Near-infrared(NIR)light-responsive shape memory polymers(SMPs)show great promise for biomedical applications,but conventional photothermal agents suffer from high cost,complex preparation,or poor biocompatibility,while lignin-based alternatives exhibit insufficient photothermal conversion efficiency.Herein,we developed a novel strategy to enhance photothermal performance of lignin through sequential demethylation modification and Fe^(3+)complexation for constructing NIR light responsive SMPs.Dealkaline lignin(DL)was first demethylated using iodocyclohexane to produce demethylated lignin(DDL)with increased catechol content,which was then incorporated into polycaprolactone-based polyurethane synthesis followed by Fe^(3+)complexation.Results showed that DDL-Fe^(3+)complexes have significantly enhanced photothermal conversion performance,and the resulting PU-DDL+Fe^(3+)polyurethane with 0.5 wt%DDL content demonstrated a temperature increases of 39.8℃under 0.33 W·cm-2808 nm NIR irradiation.This excellent photothermal performance enables the shape-fixed PU-DDL+Fe^(3+)polyurethane to rapidly recover to its initial shape under NIR light irradiation.Additionally,PU-DDL+Fe^(3+)polyurethane exhibits good mechanical properties and biocompatibility,demonstrating significant biomedical application potential.展开更多
Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful...Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful regulators of gene expression and are thus involved in diverse biological processes.Recent studies have demonstrated that several lncRNAs play critical roles in DNA repair.Nonetheless,the relationship between DNA damage-responsive lncRNAs and chemoresistance remains poorly defined.In this study,we established four different DNA damage models triggered by cisplatin(DDP),H2O2,neocarzinostatin(NCS)or ultraviolet(UV)irradiation and identified a specific upregu-lated lncRNA(lnc-DUSP6)involved in the cisplatin-induced DNA damage response.Furthermore,loss-or gain-of-function experiments confirmed that lnc-DUSP6 enhanced DNA repair and cell survival under cisplatin treatment,thus promoting cisplatin resistance.Mechanistically,an RNA immunoprecipitation(RIP)assay revealed that lnc-DUSP6 directly interacts with DUSP6(Dual Specificity Phosphatase 6),which is closely associated with cisplatin sensitivity.Additionally,overexpression of DUSP6 significantly rescued the effects of lnc-DUSP6 silencing on DNA repair and cell survival under cisplatin treatment.O-verall,our results show the effect and underlying mechanism of lnc-DUSP6 in cisplatin resistance:lnc-DUSP6 promotes cisplatin-induced DNA damage repair and cisplatin resistance by stabilizing DUSP6,which is highly clinically important for enhancing the efficacy of cisplatin for cancers.展开更多
Solvents in crystalline materials typically exist either as structural components that stabilize the framework or as adsorbed vips that modulate properties,yet achieving their orthogonal coexistence within a single ...Solvents in crystalline materials typically exist either as structural components that stabilize the framework or as adsorbed vips that modulate properties,yet achieving their orthogonal coexistence within a single system remains challenging.This study proposes a natural mineral-inspired solvent hierarchy strategy that enables the concurrent achievement of framework stability and dynamic responsiveness in hydrogen-bonded organic frameworks(HOFs)through the orthogonal integration of structural and adsorbed solvents.We have validated the feasibility of this solvent hierarchy approach based on four model systems with progressively increasing stability and dynamism:(1)unstable HOFs containing only adsorbed solvents,(2)unstable HOFs with low-binding-energy structural solvents,(3)stable HOFs incorporating strong-fitted structural solvents,and(4)stable HOFs with structural solvents and dynamically adjustable adsorption solvents.Crystallographic and theoretical analyses reveal that the superior stability of structural solvents originates from the high-electron-density oxygen of the DMSO S═O bond,which acts as a strong hydrogen-bond acceptor,forming stable N─H…O═S bonds with amine groups.The host’s aggregation-induced emission(AIE)characteristics allow real-time optical monitoring of reversible single-crystal-to-single-crystal transformations without compromising structural integrity,demonstrating promising applications for visual water content and water leakage detection.This work not only establishes a new paradigm in solvent engineering for developing smart crystalline materials but also expands the design possibilities for functional porous frameworks.展开更多
I come from Slovenia,a small but ambitious country from Central Europe.I study at the Faculty of Electrical Engineering at the University of Ljublgana.I have the privilege of being one of the first young ambassadors o...I come from Slovenia,a small but ambitious country from Central Europe.I study at the Faculty of Electrical Engineering at the University of Ljublgana.I have the privilege of being one of the first young ambassadors of standardization not only in Slovenia but of this generation across the entire world.展开更多
In coal mines,dynamic disasters such as rock bursts seriously threaten the safety of mining activities.Exploring the dynamic behaviors and disaster characteristics in the impact failure process of coal serves as the b...In coal mines,dynamic disasters such as rock bursts seriously threaten the safety of mining activities.Exploring the dynamic behaviors and disaster characteristics in the impact failure process of coal serves as the basis and prerequisite for monitoring and warning rock bursts.In this context,impact failure tests of coal were carried out under different axial static loads and impact velocities to analyze the dynamic behaviors and acoustic emission(AE)response characteristics of coal.The results show that the dynamic behaviors of coal under combined dynamic and static loads are significantly different from those under static loads,and the stress-strain curve displays double peaks without an obvious compaction stage.As the axial static load grows,the dynamic strength and peak strain both have a quadratic function with the axial static load.When the coal damage intensifies instantaneously,the AE count and energy parameters both witness pulse-like increases and reach their peak values.The damage effect of axial static loads on coal,though limited,has an extreme point.In contrast,the impact velocity can strengthen the response of AE signals and has linear function relationships with the peak values of AE count and energy.This plays a leading role in the damage to samples and sets a critical point for coal failure and fracture.Compared with the analysis results of stress and strain,the responses of AE signals are more accurate and reliable.Based on AE response characteristics,the damage evolution process of coal under the combined dynamic and static loads can be identified more accurately to reveal the moment corresponding to coal damage and the characteristics of coal failure.The research results are conducive to the further application of AE monitoring methods to early warning of rock burst disasters in coal mining sites.展开更多
Objective:To explore the relationship between anesthetic depth and surgical stress response in minimally invasive cardiothoracic surgery.Methods:A total of 89 patients who underwent thoracoscopic minimally invasive ca...Objective:To explore the relationship between anesthetic depth and surgical stress response in minimally invasive cardiothoracic surgery.Methods:A total of 89 patients who underwent thoracoscopic minimally invasive cardiothoracic surgery in our hospital from June 2024 to December 2024 were selected as the research objects.They were divided into the light anesthesia group(n=45)and the deep anesthesia group(n=44).The vital signs at different intraoperative nodes and perioperative stress status of the two groups were compared.Results:Before lesion resection and after surgery,the mean arterial pressure and heart rate of the deep anesthesia group were lower than those of the light anesthesia group,with statistically significant differences.Conclusion:In thoracoscopic minimally invasive cardiothoracic surgery,deep anesthesia can effectively control the patient’s surgical stress response,but the postoperative awakening time is longer;patients under light anesthesia have a shorter awakening time,but the intraoperative stress response is obvious.展开更多
Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has...Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.展开更多
BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary app...BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.展开更多
Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could in...Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could induce tinnitus.There are no standardized objective tests for tinnitus assessment because of its multifaceted nature.Hence,the current study aimed to explore the effect of Tinnitus on Latency and Amplitude of the Auditory Middle Latency Response in Audiological Attendees.The study recruited 50 individuals(25 normals and 25 individuals with tinnitus)who underwent audiological evaluations like Pure tone audiometry,immittance,pitch and loudness matching,THI and middle latency response.The IHS program was used to record MLR,which was obtained using tone burst stimuli of 500 Hz,1 KHz,2 KHz,and 4 KHz at a rate of 7.1/s with a constant duration of 5 ms,for a total of 1500 sweeps.As a covariate,pure tone thresholds were one of the variabilities that were addressed by ANCOVA.The amplitude of the Pa component varied significantly between the tinnitus and control groups,according to the MLR data and no other components of MLR reached that significance.Furthermore,there was no discernible variation in the latency or amplitude of MLR among any of the other components.The latency of the waveforms increased as the stimulus frequency increased.Karl Pearson correlation coefficient showed no significant correlation between THI scores and any of the outcome measures except for Pa amplitude.As the Pa component of MLR showed maximum changes between controls and individuals with tinnitus,the Pa component could be considered a potential tool for identifying neurophysiological changes related to tinnitus.展开更多
Zinc oxide(ZnO)films,as representative piezoelectric semiconductors,have garnered considerable interest in ultrasonic testing.Current research challenges include maintaining the consistency of continuous c-axis orient...Zinc oxide(ZnO)films,as representative piezoelectric semiconductors,have garnered considerable interest in ultrasonic testing.Current research challenges include maintaining the consistency of continuous c-axis orientation and determining the fundamental link between the electrical structure and piezoelectric response.Accordingly,we have proposed ZnO films incorporated with an orientation-inducing layer(OIL),utilizing orientation induction and rapid deposition technology to regulate the growth structure of the ZnO films.Furthermore,the influence of the competitive mechanism between the film growth and lateral diffusion on the film's growth structure has been investigated.Piezoelectric force microscopy(PFM)analysis demonstrated the regulation and enhancement of ZnO piezoelectric polarization by the OIL.The enhancement mechanism of OIL on film performance was revealed via experimental examination of the film structure,morphology,crystallization orientation,oxygen vacancies,carrier concentration,band structure,and density of states based on density functional theory(DFT).Benefiting from the superior electromechanical response of the ZnO OIL sensor,characterized by fast response recovery times of 2.4 ms/7.7 ms and a sensitivity of 1.09 V/N,the device has successfully demonstrated practical applications in both motion pressure detection and bolt axial force measurement.These findings provide new insights into the ultrasonic detection for aerospace applications of ZnO OIL piezoelectric devices and demonstrate significant potential for health monitoring in connection systems.展开更多
Excessive blasting-induced vibration during drilling-and-blasting excavation of deep tunnels can trigger geological hazards and compromise the stability of both the rock mass and support structures.This study focused ...Excessive blasting-induced vibration during drilling-and-blasting excavation of deep tunnels can trigger geological hazards and compromise the stability of both the rock mass and support structures.This study focused on the deep double-line Sejila Mountain tunnel to systematically analyze the spatial response of blasting-induced vibration and to develop a prediction model through field tests and numerical simulations.The results revealed that the presence of a cross passage significantly altered propagation paths and the spatial distribution of blasting-induced vibration velocity.The peak particle velocity(PPV)at the cross-passage corner was amplified by approximately 1.92 times due to wave reflection and geometric focusing.Blasting-induced vibration waves attenuated non-uniformly across the tunnel cross-section,where PPV on the blast-face side was 1.54–6.56 times higher than that on the opposite side.We propose an improved PPV attenuation model that accounts for the propagation path effect.This model significantly improved fitting accuracy and resolved anomalous parameter(k and a)estimates in traditional equations,thereby improving prediction reliability.Furthermore,based on the observed spatial distribution of blasting-induced vibration,optimal monitoring point placement and targeted vibration control measures for tunnel blasting were discussed.These findings provide a scientific basis for designing blasting schemes and vibration mitigation strategies in deep tunnels.展开更多
Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline...Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline that converts standard medical images into high-dimensional quantitative data,offers a non-invasive and reproducible means to capture tumor phenotype,heterogeneity,and treatment-induced changes.This review provides a comprehensive overview of recent advances in radiomics for breast cancer NAC,emphasizing the roles in predicting a pathologic complete response(pCR),monitoring early therapeutic efficacy,and quantifying intratumoral heterogeneity.Among imaging modalities,magnetic resonance imaging(MRI)-based radiomics,particularly utilizing dynamic contrast-enhanced and diffusion-weighted sequences,demonstrates robust predictive performance for the pCR,with multi-center studies reporting area under the curve(AUC)values>0.80.Longitudinal and delta-radiomics approaches further enhance early response evaluation by tracking temporal alterations in imaging features that precede measurable morphologic regression.Radiomic assessment of tumor heterogeneity,especially in triple-negative breast cancer(TNBC),reveals strong associations with immune infiltration,metabolic reprogramming,and therapeutic resistance,providing mechanistic insight into radiomic biomarkers.Integrative multi-omics frameworks,combining radiomics with genomics,transcriptomics and pathomics,are increasingly elucidating the biological underpinnings of imaging phenotypes,improving both model interpretability and clinical relevance.Despite these advances,widespread clinical adoption of radiomics is limited by methodologic variability,lack of standardization,and insufficient external validation.Future efforts should focus on harmonized imaging protocols,explainable artificial intelligence,and prospective multi-center trials to translate radiomics into a clinically actionable tool.Collectively,radiomics represents a transformative approach for individualized response prediction and dynamic treatment optimization in precision breast cancer management(Figure 1).展开更多
文摘At present,artificial intelligence(AI)technologies are deeply integrated into all scenarios of teaching,research,and student development in higher education.Intelligent teaching systems,research data processing tools,and AI platforms for student management are gradually becoming important aids to educational activities.This transformation disrupts the traditional framework of university teachers’responsibilities:fundamental tasks in knowledge transmission are diverted,repetitive work in research is replaced,and some managerial functions in student development are covered.Consequently,the boundaries of teachers’responsibilities are increasingly blurred,and the substitution effect has led to role anxiety and confusion about professional positioning.Clarifying the specific impact of AI on teachers’responsibilities,identifying the replaceable and irreplaceable domains,and exploring effective paths for fulfilling responsibilities are key to resolving teachers’role-identity crisis,promoting the implementation of“human-AI collaborative”education models,and ensuring the high-quality digital development of higher education.
文摘Through analyzing the cases of Xiao Zhijun and the Yulin maternal jumping incident,the authors found significant disputes between the requests for non-indicated cesarean section and medical risk prevention,as well as between the psychology of avoiding childbirth pain and surgical responsibility.Currently,based on people’s current awareness and the responsibility orientation of expert opinions in disputes,medical institutions tend to satisfy family members’surgical requirements after fulfilling their obligation to fully inform about risks,to reduce the risk of losing disputes.This phenomenon actually reflects the contradiction between the demands of patients’families and the responsibilities of medical staff in medical decision-making.To balance the responsibilities of medical staff and the demands of patients’families,the authors believe that multiple governance paths need to be constructed:first,optimizing the level of medical staff’s communication;second,strengthening medical risk science popularization relying on modern information technology to improve patients’risk cognition ability;and third,raising society’s correct understanding of cesarean section through multiple channels.These measures can help to enhance patients’trust in hospital diagnosis and treatment results and promote harmonious development of doctor-patient relationships.
基金supported by the National Natural Science Foundation of China(Grant Nos.32201834 and 32201814)the Hainan Provincial Natural Science Foundation of China(Grant No.324RC530)+1 种基金the Hainan Provincial‘Nanhai NewStar’Science and Technology Innovation Platform Project,China(Grant No.NHXXRCXM-202362)the Research Startup Funding from Hainan Institute of Zhejiang University,China(Grant No.0201-6602-A12202).
文摘The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this study,we investigated the role of Oryza sativa AUXIN RESPONSE FACTOR 13(OsARF13),a transcription factor involved in callus-related processes.We observed that OsARF13 expression is significantly higher in japonica rice callus than in indica rice callus.This differential expression might be associated with an allelic variation in the promoter region of OsARF13,where a deletion commonly found in indica rice corresponds to the loss of a conserved auxin-responsive element(AuxRE)motif.To functionally characterize OsARF13,we generated CRISPR/Cas9-mediated knockout mutants.These mutants exhibited a substantial reduction in callus fresh weight,demonstrating that OsARF13 is required for efficient callus induction.Transcriptome analysis of the osarf13 mutant further showed that OsARF13 influences the expression of genes involved in hormone signal transduction and stress responses.Our findings suggest that OsARF13 is a key component of the regulatory network governing callus induction and that natural variation in its promoter might provide a potential explanation for the differential regenerative capacity between japonica and indica rice subspecies.
基金supported by the National Science Fund for Excellent Young Scholars (32322044)the CQMU Program for Youth Innovation in Future Medicine (W0077)+1 种基金the Program for Scientific and Technological Innovation Leader of Chongqing (CQYC20220303655)the Young Scientists Fund of the National Natural Science Foundation of China (82301144)。
文摘Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials.Here,nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon entry into oral biofilms are reviewed.Supra-gingival biofilms are characterized by acidic pH,the presence of bacterial enzymes,and the development of hypoxia in deeper layers.Sub-gingival biofilms are slightly alkaline,with hypoxia occurring over their entire depth.Upon entering biofilms,negatively charged,pH-and/or hypoxia-responsive nanocarriers become positively charged.This charge reversal leads to electrostatic double-layer attraction between positively charged nanocarriers towards negatively charged,waterfilled channel walls in biofilms,enhancing their accumulation in a biofilm.Degradation of bacterial enzyme-responsive nanocarriers causes in-biofilm release of antimicrobial cargo,yielding higher local antimicrobial concentrations than can be achieved through their direct,oral administration without harming soft tissues.Enhanced antibiofilm activity after in-biofilm antimicrobial release from biofilm-responsive micelles and liposomes has been demonstrated in vitro towards single-species Streptococcus mutans and Staphylococcus aureus biofilms or in vivo using specific-pathogen-free rodents inoculated with selected pathogens.This preferential antibacterial activity regulated the microbial composition of ex vivo human oral biofilm towards a more healthy microbiome composition.Although clinical confirmation is limited,the potential benefits of stimuli-responsive,antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration are worth further investigation towards clinical translation.
基金supported by the National Key R&D Program of China(No.2021YFB2401200)National Natural Science Foundation of China(72242105)Organized Research Support Program,Department of Electrical Engineering,Tsinghua University.
文摘With the increasing penetration of variable renewable energy,flexible resources are highly needed to hedge the growing uncertainty,and variability in the power system.Demand response has served as a cost-effective type of flexible resource in recent years.In order to balance the uncertainty of the system,it is crucial to assess how much flexibility demand response programs can provide.Thus,forecasting demand response potential is important for the operation of the bulk system.This paper proposes a modeling approach that can characterize the multi-timescale flexibility of demand response so that not only the power potential but also temporal-coupling characteristics can be considered.Furthermore,a day-ahead demand response potential forecasting method is proposed using deep convolutional generative adversarial networks.The proposed forecasting method is tested using data from 170 users in Pecan Street Dataport.The results show that the proposed method can forecast the multi-timescale flexibility of demand response with high accuracy.
基金financial support from the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20230718)。
文摘The interplay between gut microbiota and host health has attracted significant interest in the animal science community.Maintaining gut microbiota homeostasis by supplementing probiotics to treat clinical conditions like calf diarrhea is an emerging area of research nowadays because of increased concerns regarding antimicrobial resistance(AMR)and drug residues in animal products.Probiotics reduce the incidence of calf diarrhea by increasing the gut microbiota diversity and richness with more commensal bacteria such as Lactobacillus and Bifidobacterium that produce antimicrobial compounds,as well as modulating the immune response by increasing cytokines,Interleukin-2(IL-2),IL-4,IL-6,IL-10,and reducing tumor necrosis factor-α(TNF-α),by increasing production of antibodies,especially immunoglobulin E(Ig E),also Ig G,differentiating naive Th lymphocytes(Tho)into Th1,hence stimulate innate immunity and prime the adaptive immune response.Specific probiotic strains of bacteria and yeast(Saccharomyces cerevisiae)derived probiotics maintain the integrity of the intestinal barrier.In this review,data are being organized to address the role of probiotics in treating calf diarrhea by modulating gut microbiota and stimulating an immune response against notorious pathogens,to present animal and veterinary scientists and nutritionists with a new concept to treat infectious diseases from the perspective of the gut microbiota,increasing animal health,performance,and welfare.In conclusion,health status and gut microbiome are strongly interlinked.Research data indicated a significant reduction in the incidence of diarrhea after probiotic administration.If interrelations between probiotics and existing gut microbiota are explored more quantitatively,novel antibiotic substitutes can emerge in the future.
基金financially supported by the National Natural Science Foundation of China(Grants No.12472399)。
文摘Reinforced concrete(RC)columns are often subjected to off-central explosion due to the uncertainty of blast locations.However,few studies have focused on the dynamic response of RC columns under offcentral explosions.A field blast experiment was conducted under close-in explosion with varying detonation offset distances(0 m,0.5 m,and 1 m),the overpressure load and dynamic responses of the full-scale RC columns were measured.Compared with the centrally detonated condition,a relative offset distance of 1.67 decreases the maximum and residual deflections of the RC column by 16.8%and 21.4%,respectively,while increasing the maximum and residual support rotations by 24.7%and 17.8%.Based on the experimental results,a theoretical model was proposed that considers the detonation location and charge mass,boundary conditions,axial compression ratio and material properties.The theoretical model exhibited good agreement with the experimental results,with prediction errors below 10%for both maximum and residual deflection.The effects of parameters were analyzed,and it indicated that an increase in offset distance results in decreased maximum and residual deflections but an increased support angle,thereby exacerbating damage.Higher axial load ratio,span-depth ratio,and longitudinal reinforcement ratio reduce both deflections and support angle.Additionally,a rapid method to predict the maximum and residual deflection of RC columns under off-central blast loading was also proposed based on the Generalized Regression Neural Network(GRNN).Eleven features which related to the RC column properties and the blast characteristics were used in the training process of GRNN,and accurate predictions were achieved with prediction errors within 20%.This study fills the gap in predicting the dynamic response of RC columns under off-central explosion,providing valuable references for blast-resistant design.
基金The National Social Science Foundation Youth Project of China:Research on the collaborative govemance path of administrative law and criminal law against dangerous driving behaviors in the digital-intelligent society(25CFX108)。
文摘With the continuous progress of automatic driving technology,automatic driving technology standards are gradually affecting the determination of criminal responsibility for traffic accidents in China.At present,the characteristics and tendency of China's automatic driving technology standards present the situation of high policy relevance coexisting with low normative binding,professionalism coexist with barriers,forefront coexist with ambiguity.Therefore,challenges are presented both theoretically and practically on the determination of criminal responsibility based on automatic driving technology standard..In this regard,the misunderstanding should be clarified in theory:The legal order under the automatic driving technology standard has constitutionality and systematic,and there is a balance between the frontier of automatic driving technology development and the lagging of criminal law.The automatic driving technology risk level system should be built to clarify the boundary of the effectiveness of criminal law norms,seeking fora breakthrough in the application of the establishment of a comprehensive judgment system of the risks and accidents and the system of evidence to prove the system,which clarifies the determination of criminal responsibility under the automatic driving technology standard.This essay hopes to pursue breakthroughs in the application-to establish a comprehensive judgment system of risks and accidents as well as an evidence proof system,so as to clarify the determination of criminal responsibility under automatic driving technology standards.
基金supported by the National Natural Science Foundation of China(Nos.51603005,52403186 and 52573150)Fujian Provincial Natural Science Foundation of China(No.2024J011447)+1 种基金Natural Science Foundation of Xiamen,China(No.3502Z20227305)the Postdoctoral Fellowship Program of CPSF(No.GZC20240095)。
文摘Near-infrared(NIR)light-responsive shape memory polymers(SMPs)show great promise for biomedical applications,but conventional photothermal agents suffer from high cost,complex preparation,or poor biocompatibility,while lignin-based alternatives exhibit insufficient photothermal conversion efficiency.Herein,we developed a novel strategy to enhance photothermal performance of lignin through sequential demethylation modification and Fe^(3+)complexation for constructing NIR light responsive SMPs.Dealkaline lignin(DL)was first demethylated using iodocyclohexane to produce demethylated lignin(DDL)with increased catechol content,which was then incorporated into polycaprolactone-based polyurethane synthesis followed by Fe^(3+)complexation.Results showed that DDL-Fe^(3+)complexes have significantly enhanced photothermal conversion performance,and the resulting PU-DDL+Fe^(3+)polyurethane with 0.5 wt%DDL content demonstrated a temperature increases of 39.8℃under 0.33 W·cm-2808 nm NIR irradiation.This excellent photothermal performance enables the shape-fixed PU-DDL+Fe^(3+)polyurethane to rapidly recover to its initial shape under NIR light irradiation.Additionally,PU-DDL+Fe^(3+)polyurethane exhibits good mechanical properties and biocompatibility,demonstrating significant biomedical application potential.
基金Supported by the National Natural Science Foundation of China(No.82071571)the Natural Science Foundation of Guangdong Province(No.2021A1515010601)+3 种基金Guangdong Provincial Basic and Applied Basic Research Foundation-Dongguan Joint Fund(No.2024A1515140121)the“Climbing”Program of Guangdong Province(No.pdjh2021b0226)the Innovation and Entrepreneurship Program for College Students(No.GDMU2022038,202310571038,ZZDC002,S202510571041)Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project(No.JDXM2024039,JDXM2025046)。
文摘Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful regulators of gene expression and are thus involved in diverse biological processes.Recent studies have demonstrated that several lncRNAs play critical roles in DNA repair.Nonetheless,the relationship between DNA damage-responsive lncRNAs and chemoresistance remains poorly defined.In this study,we established four different DNA damage models triggered by cisplatin(DDP),H2O2,neocarzinostatin(NCS)or ultraviolet(UV)irradiation and identified a specific upregu-lated lncRNA(lnc-DUSP6)involved in the cisplatin-induced DNA damage response.Furthermore,loss-or gain-of-function experiments confirmed that lnc-DUSP6 enhanced DNA repair and cell survival under cisplatin treatment,thus promoting cisplatin resistance.Mechanistically,an RNA immunoprecipitation(RIP)assay revealed that lnc-DUSP6 directly interacts with DUSP6(Dual Specificity Phosphatase 6),which is closely associated with cisplatin sensitivity.Additionally,overexpression of DUSP6 significantly rescued the effects of lnc-DUSP6 silencing on DNA repair and cell survival under cisplatin treatment.O-verall,our results show the effect and underlying mechanism of lnc-DUSP6 in cisplatin resistance:lnc-DUSP6 promotes cisplatin-induced DNA damage repair and cisplatin resistance by stabilizing DUSP6,which is highly clinically important for enhancing the efficacy of cisplatin for cancers.
基金supported by the National Natural Science Foundation of China(22375002)the Anhui Provincial Natural Science Foundation(2308085Y10).
文摘Solvents in crystalline materials typically exist either as structural components that stabilize the framework or as adsorbed vips that modulate properties,yet achieving their orthogonal coexistence within a single system remains challenging.This study proposes a natural mineral-inspired solvent hierarchy strategy that enables the concurrent achievement of framework stability and dynamic responsiveness in hydrogen-bonded organic frameworks(HOFs)through the orthogonal integration of structural and adsorbed solvents.We have validated the feasibility of this solvent hierarchy approach based on four model systems with progressively increasing stability and dynamism:(1)unstable HOFs containing only adsorbed solvents,(2)unstable HOFs with low-binding-energy structural solvents,(3)stable HOFs incorporating strong-fitted structural solvents,and(4)stable HOFs with structural solvents and dynamically adjustable adsorption solvents.Crystallographic and theoretical analyses reveal that the superior stability of structural solvents originates from the high-electron-density oxygen of the DMSO S═O bond,which acts as a strong hydrogen-bond acceptor,forming stable N─H…O═S bonds with amine groups.The host’s aggregation-induced emission(AIE)characteristics allow real-time optical monitoring of reversible single-crystal-to-single-crystal transformations without compromising structural integrity,demonstrating promising applications for visual water content and water leakage detection.This work not only establishes a new paradigm in solvent engineering for developing smart crystalline materials but also expands the design possibilities for functional porous frameworks.
文摘I come from Slovenia,a small but ambitious country from Central Europe.I study at the Faculty of Electrical Engineering at the University of Ljublgana.I have the privilege of being one of the first young ambassadors of standardization not only in Slovenia but of this generation across the entire world.
基金Open Fund of State Key Laboratory of Coal Mine Disaster Dynamics and Control,Grant/Award Number:2011DA105287-FW202306Postgraduate Research&Practice Innovation Program of Jiangsu Province,Grant/Award Number:KYCX24_2925+4 种基金Fundamental Research Program of Xuzhou,Grant/Award Number:KC23017National Natural Science Foundation of China,Grant/Award Number:52104234Fundamental Research Funds for the Central Universities,Grant/Award Number:2024-10962National Science Foundation for Young Scientists of Jiangsu Province,Grant/Award Number:BK20200657Graduate Innovation Program of China University of Mining and Technology,Grant/Award Number:2024WLKXJ152。
文摘In coal mines,dynamic disasters such as rock bursts seriously threaten the safety of mining activities.Exploring the dynamic behaviors and disaster characteristics in the impact failure process of coal serves as the basis and prerequisite for monitoring and warning rock bursts.In this context,impact failure tests of coal were carried out under different axial static loads and impact velocities to analyze the dynamic behaviors and acoustic emission(AE)response characteristics of coal.The results show that the dynamic behaviors of coal under combined dynamic and static loads are significantly different from those under static loads,and the stress-strain curve displays double peaks without an obvious compaction stage.As the axial static load grows,the dynamic strength and peak strain both have a quadratic function with the axial static load.When the coal damage intensifies instantaneously,the AE count and energy parameters both witness pulse-like increases and reach their peak values.The damage effect of axial static loads on coal,though limited,has an extreme point.In contrast,the impact velocity can strengthen the response of AE signals and has linear function relationships with the peak values of AE count and energy.This plays a leading role in the damage to samples and sets a critical point for coal failure and fracture.Compared with the analysis results of stress and strain,the responses of AE signals are more accurate and reliable.Based on AE response characteristics,the damage evolution process of coal under the combined dynamic and static loads can be identified more accurately to reveal the moment corresponding to coal damage and the characteristics of coal failure.The research results are conducive to the further application of AE monitoring methods to early warning of rock burst disasters in coal mining sites.
文摘Objective:To explore the relationship between anesthetic depth and surgical stress response in minimally invasive cardiothoracic surgery.Methods:A total of 89 patients who underwent thoracoscopic minimally invasive cardiothoracic surgery in our hospital from June 2024 to December 2024 were selected as the research objects.They were divided into the light anesthesia group(n=45)and the deep anesthesia group(n=44).The vital signs at different intraoperative nodes and perioperative stress status of the two groups were compared.Results:Before lesion resection and after surgery,the mean arterial pressure and heart rate of the deep anesthesia group were lower than those of the light anesthesia group,with statistically significant differences.Conclusion:In thoracoscopic minimally invasive cardiothoracic surgery,deep anesthesia can effectively control the patient’s surgical stress response,but the postoperative awakening time is longer;patients under light anesthesia have a shorter awakening time,but the intraoperative stress response is obvious.
基金supported by the Natural Science Foundation of Guangdong Province,China (No.2025A1515011654)the National Natural Science Foundation of China (No.22090053)+3 种基金the Fundamental Research Funds for National Universities,China University of Geosciences (Wuhan)support from the program of China Scholarships Council (No.202406410155)Young Elite Scientists Sponsorship Program by CAST-Doctoral Student Special Plansupport from the S&T Special Program of Huzhou (No.2024GZ07)。
文摘Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.
文摘BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.
文摘Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could induce tinnitus.There are no standardized objective tests for tinnitus assessment because of its multifaceted nature.Hence,the current study aimed to explore the effect of Tinnitus on Latency and Amplitude of the Auditory Middle Latency Response in Audiological Attendees.The study recruited 50 individuals(25 normals and 25 individuals with tinnitus)who underwent audiological evaluations like Pure tone audiometry,immittance,pitch and loudness matching,THI and middle latency response.The IHS program was used to record MLR,which was obtained using tone burst stimuli of 500 Hz,1 KHz,2 KHz,and 4 KHz at a rate of 7.1/s with a constant duration of 5 ms,for a total of 1500 sweeps.As a covariate,pure tone thresholds were one of the variabilities that were addressed by ANCOVA.The amplitude of the Pa component varied significantly between the tinnitus and control groups,according to the MLR data and no other components of MLR reached that significance.Furthermore,there was no discernible variation in the latency or amplitude of MLR among any of the other components.The latency of the waveforms increased as the stimulus frequency increased.Karl Pearson correlation coefficient showed no significant correlation between THI scores and any of the outcome measures except for Pa amplitude.As the Pa component of MLR showed maximum changes between controls and individuals with tinnitus,the Pa component could be considered a potential tool for identifying neurophysiological changes related to tinnitus.
基金supported by startup funding from Huazhong University of Science and Technology.
文摘Zinc oxide(ZnO)films,as representative piezoelectric semiconductors,have garnered considerable interest in ultrasonic testing.Current research challenges include maintaining the consistency of continuous c-axis orientation and determining the fundamental link between the electrical structure and piezoelectric response.Accordingly,we have proposed ZnO films incorporated with an orientation-inducing layer(OIL),utilizing orientation induction and rapid deposition technology to regulate the growth structure of the ZnO films.Furthermore,the influence of the competitive mechanism between the film growth and lateral diffusion on the film's growth structure has been investigated.Piezoelectric force microscopy(PFM)analysis demonstrated the regulation and enhancement of ZnO piezoelectric polarization by the OIL.The enhancement mechanism of OIL on film performance was revealed via experimental examination of the film structure,morphology,crystallization orientation,oxygen vacancies,carrier concentration,band structure,and density of states based on density functional theory(DFT).Benefiting from the superior electromechanical response of the ZnO OIL sensor,characterized by fast response recovery times of 2.4 ms/7.7 ms and a sensitivity of 1.09 V/N,the device has successfully demonstrated practical applications in both motion pressure detection and bolt axial force measurement.These findings provide new insights into the ultrasonic detection for aerospace applications of ZnO OIL piezoelectric devices and demonstrate significant potential for health monitoring in connection systems.
基金financially supported by the National Natural Science Foundation of China(Nos.42577209 and U22A20239)the Key R&D Program of Hunan Province(No.2024WK2004)the Key Technologies for Accurate Diagnosis and Intelligent Prevention and Control of Slope Hazards in Open pit Mines,181 Major R&D projects of Metallurgical Corporation of China Ltd。
文摘Excessive blasting-induced vibration during drilling-and-blasting excavation of deep tunnels can trigger geological hazards and compromise the stability of both the rock mass and support structures.This study focused on the deep double-line Sejila Mountain tunnel to systematically analyze the spatial response of blasting-induced vibration and to develop a prediction model through field tests and numerical simulations.The results revealed that the presence of a cross passage significantly altered propagation paths and the spatial distribution of blasting-induced vibration velocity.The peak particle velocity(PPV)at the cross-passage corner was amplified by approximately 1.92 times due to wave reflection and geometric focusing.Blasting-induced vibration waves attenuated non-uniformly across the tunnel cross-section,where PPV on the blast-face side was 1.54–6.56 times higher than that on the opposite side.We propose an improved PPV attenuation model that accounts for the propagation path effect.This model significantly improved fitting accuracy and resolved anomalous parameter(k and a)estimates in traditional equations,thereby improving prediction reliability.Furthermore,based on the observed spatial distribution of blasting-induced vibration,optimal monitoring point placement and targeted vibration control measures for tunnel blasting were discussed.These findings provide a scientific basis for designing blasting schemes and vibration mitigation strategies in deep tunnels.
基金supported by grants from National Science and Technology Major Project(Grant No.2025ZD0544000)National Natural Science Foundation of China(Grant No.82171898)+2 种基金Deng Feng Project of High-level Hospital Construction(Grant No.DFJHBF202109)Beijing Science and Technology Innovation Medical Development Foundation(Grant No.KC2023-JX-0270-09)Development Center for Medical Science&Technology National Health commission of the People’s Republic of China(Grant No.WKZX2025RL0130)。
文摘Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline that converts standard medical images into high-dimensional quantitative data,offers a non-invasive and reproducible means to capture tumor phenotype,heterogeneity,and treatment-induced changes.This review provides a comprehensive overview of recent advances in radiomics for breast cancer NAC,emphasizing the roles in predicting a pathologic complete response(pCR),monitoring early therapeutic efficacy,and quantifying intratumoral heterogeneity.Among imaging modalities,magnetic resonance imaging(MRI)-based radiomics,particularly utilizing dynamic contrast-enhanced and diffusion-weighted sequences,demonstrates robust predictive performance for the pCR,with multi-center studies reporting area under the curve(AUC)values>0.80.Longitudinal and delta-radiomics approaches further enhance early response evaluation by tracking temporal alterations in imaging features that precede measurable morphologic regression.Radiomic assessment of tumor heterogeneity,especially in triple-negative breast cancer(TNBC),reveals strong associations with immune infiltration,metabolic reprogramming,and therapeutic resistance,providing mechanistic insight into radiomic biomarkers.Integrative multi-omics frameworks,combining radiomics with genomics,transcriptomics and pathomics,are increasingly elucidating the biological underpinnings of imaging phenotypes,improving both model interpretability and clinical relevance.Despite these advances,widespread clinical adoption of radiomics is limited by methodologic variability,lack of standardization,and insufficient external validation.Future efforts should focus on harmonized imaging protocols,explainable artificial intelligence,and prospective multi-center trials to translate radiomics into a clinically actionable tool.Collectively,radiomics represents a transformative approach for individualized response prediction and dynamic treatment optimization in precision breast cancer management(Figure 1).
