The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementa...The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementation of the progressive talent training model featuring the integration of industry and education and work-study alternation is conducive to carrying out talent cultivation activities,improving the effectiveness of professional talent development,and effectively meeting the needs of market development.From the perspective of Meizhou Hakka cuisine cooking talents,this paper analyzes the problems existing in the implementation of the industry-education integration and work-study alternation model,and puts forward specific practical strategies for talent cultivation.The purpose is to enhance the training effect of Hakka cuisine cooking talents and provide reference for the subsequent optimization of professional teaching.展开更多
Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in...Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in June followed by floods in July.The 2024 event was the most severe since 1981.This study demonstrates that such compound extreme events are closely linked to anomalous subseasonal evolution of large-scale atmospheric circulation.During the drought phase,the East Asian subtropical westerly jet(EAJ)shifts southward,and the western Pacific subtropical high(WPSH)exhibits anomalous strengthening with its western ridge line displaced southward.The flood phase is characterized by acceleration of the EAJ,westward extension of the WPSH,and enhanced southwestern moisture transport from the western Pacific.Beyond these typical features,the 2024 early summer circulation exhibited unique characteristics:Anomalous northeastward intensification of the WPSH facilitated merged moisture influx from both the Indian Ocean and the western Pacific along the southeast pathway into the HHHRB in July,resulting in the highest net moisture inflow at the southern boundary of the HHHRB since 1981.The synergistic effects of multiple factors primarily explain the exceptionally intense DFAA event in 2024.展开更多
Single-pixel imaging(SPI)enables efficient sensing in challenging conditions.However,the requirement for numerous samplings constrains its practicality.We address the challenge of high-quality SPI reconstruction at ul...Single-pixel imaging(SPI)enables efficient sensing in challenging conditions.However,the requirement for numerous samplings constrains its practicality.We address the challenge of high-quality SPI reconstruction at ultra-low sampling rates.We develop an alternative optimization with physics and a data-driven diffusion network(APD-Net).It features alternative optimization driven by the learned task-agnostic natural image prior and the task-specific physics prior.During the training stage,APD-Net harnesses the power of diffusion models to capture data-driven statistics of natural signals.In the inference stage,the physics prior is introduced as corrective guidance to ensure consistency between the physics imaging model and the natural image probability distribution.Through alternative optimization,APD-Net reconstructs data-efficient,high-fidelity images that are statistically and physically compliant.To accelerate reconstruction,initializing images with the inverse SPI physical model reduces the need for reconstruction inference from 100 to 30 steps.Through both numerical simulations and real prototype experiments,APD-Net achieves high-quality,full-color reconstructions of complex natural images at a low sampling rate of 1%.In addition,APD-Net’s tuning-free nature ensures robustness across various imaging setups and sampling rates.Our research offers a broadly applicable approach for various applications,including but not limited to medical imaging and industrial inspection.展开更多
As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-int...As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-interaction benefits and clear business models.Consequently,assessing the value of grid-alternative energy storage in the systemtransition has become critically important.Considering the performance characteristics of storage,we propose a value assessment frame-work for grid-alternative energy storage,quantifying its non-wires-alternative effects from both cost and benefit perspectives.Building on this,we developed a collaborative planning model for energy storage and transmission grids,aimed at maximizing the economic benefits of storage systems while balancing investment and operational costs.The model considers regional grid interconnections and their interactions with system operation.By participating in system operations,grid-alternative energy storage not only maximizes its own economic benefits but also generates social welfare transfer effects.Furthermore,based on multi-regional interconnected planning,grid-alternative energy storage can reduce system costs by approximately 35%,with the most significant changes observed in generation costs.Multi-regional coordinated planning significantly enhances the sys-tem’s flexibility in regulation.However,when the load factor of interconnection lines between regions remains constant,system operational flexibility tends to decrease,leading to a roughly 28.9%increase in storage investment.Additionally,under regional coordinated planning,the greater the disparity in wind power integration across interconnected regions,the more noticeable the reduction in system costs.展开更多
The ring-opening alternating copolymerization(ROAC)of 3,4-dihydrocoumarin(DHC)/epoxides has been successfully developed using an imidazolium salt of 1-ethyl-3-methylimidazolium chloride(EMIMCl)as a catalyst.The result...The ring-opening alternating copolymerization(ROAC)of 3,4-dihydrocoumarin(DHC)/epoxides has been successfully developed using an imidazolium salt of 1-ethyl-3-methylimidazolium chloride(EMIMCl)as a catalyst.The resulting copolymer has a molecular weight of 13.7kg·mol^(-1),a narrow molecular weight distribution of 1.03 and a strictly alternating structure.The MALDI-TOF MS characterization and DFT calculations including electrostatic potential(ESP),hydrogen-atom abstraction(HAA),independent gradient model based on hirshfeld partition(IGMH)and atoms-in-molecules(AIM)analysis were used to investigate the metal-free catalytic process.The synergistic effect of anions and cations of EMIMCl for ROAC of DHC and epoxides was demonstrated.This study provides a metal-free catalytic system for the facile synthesis of alternating polyesters from DHC.展开更多
The results of the study of the effect of partial substitution of Fe by Mn in the La Fe_(11.2-x)Mn_(x)Co_(0.7)Si_(1.1)system on magnetization,specific heat,magnetostriction and magnetocaloric effect are presented.Dire...The results of the study of the effect of partial substitution of Fe by Mn in the La Fe_(11.2-x)Mn_(x)Co_(0.7)Si_(1.1)system on magnetization,specific heat,magnetostriction and magnetocaloric effect are presented.Direct measurements of the adiabatic temperature change(ΔT_(ad))were carried out in alternating magnetic fields(AMF)using the magnetic field modulation method.Partial substitution of Fe atoms by Mn atoms leads to a shift in the Curie temperature(T_(C))towards lower temperatures without a noticeable deterioration in magnetic properties.A correlation was found between the structural component of the magnetocaloric effect and the stability of the frequency of theΔT_(ad)in the AMFs—an increase in the manganese concentration leads to a decrease in magnetostriction and to a lower dependence ofΔT_(ad)on the frequency of the magnetic field.Estimates of the specific cooling power Q_(C)as a function of the frequency of the AMF showed that the highest value of Q_(C)at f=20 Hz in a magnetic field of 12k Oe is 26.3 W g^(-1)and is observed for the composition with x=0.1.This value is higher than that of Gd,for which,under the same conditions,Q_(C)=21.6 W g^(-1).All the samples studied show stability of the value ofΔT_(ad)without any sign of deterioration of the effect up to 60,000cycles of switching on/off of the magnetic field of 12 k Oe.The discovered frequency and cyclic stability ofΔT_(ad)of the studied samples increase their prospects for application in magnetic cooling technology.展开更多
Background With the global expansion of aquaculture and the increasing demand for fish meal,identifying appropriate and sustainable alternative protein sources for aquafeeds has become essential.Single-cell protein(SC...Background With the global expansion of aquaculture and the increasing demand for fish meal,identifying appropriate and sustainable alternative protein sources for aquafeeds has become essential.Single-cell protein(SCP),derived from methanotrophic bacteria,presents a promising alternative by converting methane into protein,potentially addressing both the need for alternative protein sources and reducing industrial greenhouse gas emissions.This study aimed to evaluate the effects of different levels of SCP inclusion(0%,25%,50%,and 75%fish meal replacement)on the health,gene expression,and gut microbiome of yellowtail kingfish(YTK,Seriola lalandi)following a 35-day growth trial.Results The study found that SCP inclusion at the highest level of fishmeal replacement(75%)induced a mild inflammatory response in the hindgut of the fish.However,micromorphological assessments of the hindgut,serum biochemistry,and gene expression analyses revealed no significant detrimental effects from SCP replacement.Notably,there were indications of improved lipid digestibility with SCP.Furthermore,SCP inclusion significantly enhanced microbial richness and altered the composition of the gut microbiome,introducing beneficial bacterial taxa that may contribute to improved gut health and resilience.Conclusions This study highlights SCP as a viable and sustainable alternative to fish meal in YTK diets.The findings suggest that SCP can be included in YTK diets without adverse health effects at moderate levels and may even offer benefits in terms of lipid digestibility and gut microbiome diversity.These results contribute to the advancement of more sustainable aquaculture practices.展开更多
The 2025 U.S.-China Trade War has intensified the vulnerability of China's oil supply chain due to heavy reliance on soybean imports,posing serious challenges to food security.This study examines soybean dependenc...The 2025 U.S.-China Trade War has intensified the vulnerability of China's oil supply chain due to heavy reliance on soybean imports,posing serious challenges to food security.This study examines soybean dependency risks and evaluates substitution strategies through diversified oilseed use,including palm-based alternatives.Findings show that high reciprocal tariffs caused a 75%drop in U.S.soybean exports to China.Palm oil,with high yield efficiency and cost-effectiveness,offers a viable supplement to fill supply chain gaps.Promoting oil palm cultivation through northward expansion and cooperation with Belt and Road countries is recommended.Additionally,multi-omics,gene editing,tissue culture,and precision agriculture are crucial to address technical bottlenecks.The study concludes that palm and soybean oils will form a complementary system,and that policy and technology investments are essential to strengthen China's oilseed supply chain resilience and sustainability.展开更多
The number of newborns born with diseases is increasing recently.Thyroid hormones(THs)are closely related to the growth and development of the newborn in the mother's womb and to the carriage of related diseases a...The number of newborns born with diseases is increasing recently.Thyroid hormones(THs)are closely related to the growth and development of the newborn in the mother's womb and to the carriage of related diseases after birth.Environmental endocrine-disrupting compounds(EDCs)have been proven to harm THs in newborns.Phthalates(PAEs),a typical class of EDCs,are commonly used in toys,childcare materials,and food contact materials,which have been closely connected with neonatal thyroid dysfunction and thyroid-related diseases.As restrictions on PAEs becomemore stringent in neonatal field,numerous PAE alternatives are emerging.Associations between exposure to PAEs and their alternatives and dysfunctions in THs have been explored.Hence,we summarized the body burdens and regional characteristics of PAEs and their alternatives in neonatal urine,cord blood,and meconium.Subsequently,the influences of PAEs and their alternatives on thyroid dysfunction,prematurity,low birth weight,fetal growth restriction,respiratory dysfunction,immune disorders,neurological disorders,and reproductive disorders in newborns were evaluated.Furthermore,we scrutinized the effects of PAEs and their alternatives on the neonatal thyroid from signaling,substance transport,and hormone production to explore the underlying mechanisms of action on neonatal thyroid and thyroid-related disorders.As the declining global trends of healthy newborns and the potential impacts of PAEs and their alternatives on thyroid function,a more comprehensive study is needed to discuss their effects on newborns and their underlying mechanisms.This review facilitates attention to the effects of PAEs and their alternatives on thyroid and thyroid-related disorders in newborns.展开更多
The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting th...The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting the phase transition rate in PB-1 was established by adjusting the crystallization,nucleation,and growth temperatures.Nevertheless,low-molecular-weight PB-1(LMWPB-1)faces challenges because this method requires a low crystallization temperature,which is difficult to achieve during extrusion processing.In this study,we attempted to increase the phase transition rate in PB-1 by changing the annealing temperature after processing rather than the crystallization temperature in the classical scheme.The results indicated that regardless of low-or high-molecular-weight PB-1,repeated annealing between 0 and 90℃could also promote formⅡto formⅠphase transition.The initial content of formⅠincreased with the heating and cooling cycles.The half-time of the phase transition(t_(1/2))was also shortened after heating/cooling.After 100 heating/cooling cycles,t_(1/2) was reduced to one-quarter of that without annealing,which had almost the same effect as the crystallization temperature at 25℃in promoting the phase transition.This study indicates that annealing after processing is also an important factor affecting the phase transition of PB-1,and should receive sufficient attention.展开更多
Heat stress is a major threat to maize(Zea mays L.)production worldwide.Heat shock transcription factors(HSFs)play vital roles in plant responses to heat stress.However,the molecular and genetic mechanisms underlying ...Heat stress is a major threat to maize(Zea mays L.)production worldwide.Heat shock transcription factors(HSFs)play vital roles in plant responses to heat stress.However,the molecular and genetic mechanisms underlying HSF-meditated thermotolerance in maize remain largely unexplored.In this study,we demonstrate that the alternative splicing of ZmHsf23 modulates heat stress tolerance in maize.Hsf23 produced two functional transcripts,Hsf23L and Hsf23S,which differ by the presence of a cryptic mini-exon in Hsf23L that is spliced out in Hsf23S.Both transcripts were strongly induced by heat stress.Mutants lacking Hsf23L alone(hsf23l)or both Hsf23L and Hsf23S(hsf23l23s)exhibited increased susceptibility to heat stress,whereas overexpression of Hsf23S enhanced heat stress tolerance in maize.Subsequently,we found that Hsf23S positively regulates heat stress tolerance by directly activating the transcription of three sHSP genes(Hsp16.9,Hsp17.2,and Hsp18a)and TIL1 gene.In addition,Hsf23L physically interacted with Hsf23S and enhanced the transcriptional activation of Hsf23S on the sHSPs and TIL1 promoters.Notably,genetic analysis suggested that co-overexpression of Hsf23L and Hsf23S further improves heat tolerance of the transgenic plants.Taken together,these results reveal two splicing variants of ZmHsf23 cooperatively regulate maize heat tolerance,thus highlighting potential value of ZmHsf23 in breeding heat-tolerant maize varieties.展开更多
Over the past century,advancements in chemistry have significantly propelled human innovation,enhancing both industrial and consumer products.However,this rapid progression has resulted in chemical pollution increasin...Over the past century,advancements in chemistry have significantly propelled human innovation,enhancing both industrial and consumer products.However,this rapid progression has resulted in chemical pollution increasingly surpassing planetary boundaries,as production and release rates have outpaced our monitoring capabilities.To catalyze more impactful efforts,this study transitions from traditional chemical assessment to inverse chemical design,introducing a generative graph latent diffusion model aimed at discovering safer alternatives.In a case study on the design of green solvents for cyclohexane/benzene extraction distillation,we constructed a design database encompassing functional,environmental hazards,and process constraints.Virtual screening of previous design dataset revealed distinct trade-off trends between these design requirements.Based on the screening outcomes,an unconstrained generative model was developed,which covered a broader chemical space and demonstrated superior capabilities for structural interpolation and extrapolation.To further optimize molecular generation towards desired properties,a multi-objective latent diffusion method was applied,yielding 19 candidate molecules.Of these,7 were identified in PubChem as the most viable green solvent candidates,while the remaining 12 as potential novel candidates.Overall,this study effectively designed green solvent candidates for safer and more sustainable industrial production,setting a promising precedent for the development of environmentally friendly alternatives in other areas of chemical research.展开更多
The predominant causal agent of poplar leaf blight is the pathogenic fungus Alternaria alternata (Fr.) Keissl., which exhibits host specificity toward Populus species. To elucidate the molecular response mechanisms of...The predominant causal agent of poplar leaf blight is the pathogenic fungus Alternaria alternata (Fr.) Keissl., which exhibits host specificity toward Populus species. To elucidate the molecular response mechanisms of A. alternata under fludioxonil fungicide stress, the fungus was cultured at the half-maximal effective concentration (EC₅₀) of fludioxonil. Transcriptomic and metabolomic profiles were analyzed using mycelia harvested under these conditions. Comparative analysis revealed 1,001 differentially expressed genes (DEGs) in the resistant strain (RS) relative to the wild-type strain (WT), comprising 628 upregulated and 373 downregulated genes. Concurrently, 524 differentially accumulated metabolites (DAMs) were identified, with 336 upregulated and 188 downregulated metabolites. KEGG pathway enrichment demonstrated pronounced upregulation in glycerophospholipid metabolism, α-linolenic acid metabolism, nucleic acid biosynthesis, and glycosylation processes. Conversely, arachidonic acid and galactose metabolism pathways were suppressed. Significant downregulation was observed in phosphatidylinositol signaling, aflatoxin biosynthesis, and cutin/suberin/wax biosynthesis pathways. Transcriptomic profiling further indicated that upregulated DEGs were predominantly associated with amino sugar/nucleotide sugar metabolism, ABC transporters, aflatoxin biosynthesis, and purine metabolism, while downregulated DEGs were enriched in N-glycan biosynthesis, endoplasmic reticulum protein processing, steroid biosynthesis, and riboflavin metabolism. Fludioxonil exerted substantial inhibitory effects on fungal growth, pathogenicity, and metabolic activity. Mechanistically, A. alternata counteracted fungicide-induced stress through modulation of its antioxidant defense system. This integrative multi-omics study delineates the dynamic gene expression and metabolic reprogramming in A. alternata under fludioxonil exposure, providing novel insights into potential molecular targets and informing the development of next-generation fungicidal strategies for phytopathogen control.展开更多
Moistube irrigation is a newly-developed irrigation technique that utilizes a semipermeable membrane to release water slowly and continuously into the plant root zone.Alternate Moistube Irrigation(AMI)is a combination...Moistube irrigation is a newly-developed irrigation technique that utilizes a semipermeable membrane to release water slowly and continuously into the plant root zone.Alternate Moistube Irrigation(AMI)is a combination of alternative irrigation and moistube irrigation.In order to investigate the effects of AMI on plant growth,greenhouse experiments were conducted on spinach(Spinacia oleracea)and water spinach(Ipomoea aquatica)plants at different time.We measured soil water content at a depth of 20 cm in the planting boxes,and also determined seed emergence rate,plant height,largest leaf area,fresh weight per plant,yield,and irrigation water productivity(IWP)for both spinach and water spinach.The results showed that the AMI treatments had significantly higher soil water content than the conventional surface irrigation control(CK).The emergence rates of spinach and water spinach were significantly higher in the AMI treatments than in the CK,and the plant height,largest leaf area,and fresh weight during the middle and late stages of spinach and water spinach growth were also significantly higher than those of the CK.Both spinach and water spinach grew well and produced high yield with high IWP under AMI with a high water head pressure of 1.5 m at tube spacing of 20 or 30 cm.We found that AMI with a suitable combination of head pressure and tube spacing can promote plant growth and increase yield and IWP under controlled conditions.展开更多
Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.Howeve...Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.However,the mechanisms of hypoxia-promoted tumor progression remain elusive.Methods:Alternative splicing of diacylglycerol kinase gamma(DGKG)-Δexon13 was amplified and verified by PCR-Sanger sequencing.The functions of DGKG and DGKG-Δexon13 were analyzed by Cell counting kit-8(CCK-8),Transwell,Matrigeltranswell experiments,and in vivo orthotropic GBM animal models.Transcriptome analyses were done to find out the regulated genes.Results:In this study,we found that a new transcript DGKG-Δexon13 was generated in GBM under hypoxia via alternative splicing.Moreover,the results of CCK-8,Transwell,and Matrigel-transwell experiments showed that the proliferation,migration,and invasion abilities of U87-MG and T98G were decreased after DGKG knockdown.Compared to wild-type DGKG,DGKG-Δexon13 overexpression significantly promoted cellular proliferation,migration,and invasion abilities in GBM.Furthermore,in vivo,orthotropic GBM animal models analysis showed that the tumor volumes were much smaller in the DGKG knockdown group.However,the tumor sizes in the DGKG and DGKG-Δexon13 rescue groups were restored,especially in the DGKG-Δexon13 group.Transcriptome analysis revealed that MORC1,KLHDC7B,ATP1A2,INHBE,TMEM119,and FGD3 were altered significantly when DGKG was knocked down.IL-16,CCN2,and EFNB3 were specifically regulated by DGKG-Δexon13.Conclusions:Our study found that hypoxia-induced alternative splicing transcript DGKG-Δexon13 promotes GBM proliferation and infiltration,which might provide a new potential target for the clinical treatment and diagnosis of GBM.展开更多
Background:The use of complementary and alternative medicine(CAM)is common among individuals with underlying chronic illnesses.Objective:This systematic review and meta-analysis investigated the global prevalence and ...Background:The use of complementary and alternative medicine(CAM)is common among individuals with underlying chronic illnesses.Objective:This systematic review and meta-analysis investigated the global prevalence and patterns of CAM use among individuals with chronic kidney disease(CKD).Search strategy:PubMed,Embase,and Cumulative Index to Nursing and Allied Health Literature Plus were searched from inception until 26th February 2024.Inclusion criteria:Original articles reporting the use of at least one type of CAM among individuals aged above 18 years old and at all stages of CKD or undergoing any form of kidney replacement therapy.Data extraction and analysis:Two independent reviewers performed the literature screening.The data were extracted from the included studies by one reviewer and cross-checked by another.Discrepancies were resolved by discussion and consensus among two reviewers.Primary information included prevalence of CAM use,types of CAM used,reasons for CAM use,factors associated with CAM use,and disclosure to healthcare providers.Meta-analyses were performed to determine the pooled prevalence of CAM use and non-disclosure of CAM using a random effect model.Results:Forty-one studies were included in this systematic review and meta-analysis.The pooled prevalence of CAM use was 43%(95%confidence interval:34%,51%),I2=99.46%.The reasons for CAM use included treatment of underlying comorbidities,complications or symptoms,maintenance of general health,and treatment of CKD.Nutritional approaches were the most common CAM modality,with 412different herbal and dietary supplements reported;psychological and physical approaches included massage therapy,relaxation techniques,and mind–body practices;and other complementary health approaches such as homeopathy,traditional Chinese medicine,and Ayurvedic medicine were also frequently reported.Factors associated with CAM use included sociodemographic characteristics such as older age,female gender,or higher income;disease or therapy factors such as not having diabetes,relying on hemodialysis,or poor adherence to medication;and patient or internal factors such as positive attitude towards CAM and perceived safety of CAM.About 66%(61%,72%)of CAM users did not disclose the use of CAM to their healthcare providers.Conclusion:CAM use is prevalent among individuals with CKD,and healthcare providers should communicate openly and effectively to emphasize the rational use of CAM to avoid potential harm.展开更多
This review aims to identify the assets and limitations of Dabema(Piptadeniastrum africanum)as a sustainable alternative to traditional timber species for furniture and construction applications.Dabema is characterize...This review aims to identify the assets and limitations of Dabema(Piptadeniastrum africanum)as a sustainable alternative to traditional timber species for furniture and construction applications.Dabema is characterized by its high density and dimensional stability,meeting ASTM(American Society for Testing and Materials)standards for mechanical strength,which is essential for promoting its use.However,its limited availability in trade and ingrained habits of use are obstacles to its widespread commercialization.In addition,thermal and oleothermal treatments have shown great potential for improving the characteristics of this wood,although they require ongoing optimization and rigorous environmental assessment.Consequently,increased awareness of the benefits of Dabema is decisive to encourage its sustainable adoption in modern economies.This could help to diversify forest resources and encourage more sustainable building practices,taking advantage of Dabema’s unique properties while mitigating environmental sustainability concerns.展开更多
BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 ...BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 Hz)play an essential role in supporting working memory operations.Theta-band transcranial alternating current stimulation(tACS)offers a potential mechanism for working memory enhancement through direct modulation of these fundamental neural oscillations.Nevertheless,current empirical evidence shows substantial variability in the observed effects of theta-tACS across studies.AIM To conduct a systematic review and meta-analysis evaluating the effects of thetatACS on working memory performance in healthy adults.METHODS A systematic literature search was performed on PubMed,EMBASE,and Web of Science up to March 10,2025.Effect sizes were computed using Hedges’g with 95%confidence intervals(CIs),with separate meta-analyses for all included studies and for distinct working memory paradigms[n-back and delayed matchto-sample(DMTS)tasks]to examine potential task-specific effects.Subgroup analyses and meta-regression were performed to evaluate the influence of key moderating variables.RESULTS The systematic review included 21 studies(67 effect sizes).Initial meta-analysis showed theta-tACS moderately improved working memory(Hedges’g=0.405,95%CI:0.212-0.598).However,this effect became nonsignificant after correcting for publication bias(trim-and-fill adjusted Hedges’g=0.082,95%CI:-0.052 to 0.217).Task-specific analyses revealed significant benefits in n-back tasks(Hedges’g=0.463,95%CI:0.193-0.733)but not in DMTS tasks(Hedges’g=0.257,95%CI:-0.186 to 0.553).Moderator analyses showed that performance in n-back tasks was influenced by stimulation frequency(P=0.001),concurrent status(P=0.014),task modality(P=0.005),and duration(P=0.013),whereas only the region of targeted stimulation(P=0.012)moderated DMTS tasks.CONCLUSION Theta-tACS enhances working memory in healthy adults,with effects modulated by the task type and protocol parameters,offering dual implications for cognitive enhancement and clinical interventions.展开更多
Agricultural production(especially intensive rice production)is a primary income source for over 2.0×10^(7) people in the Vietnamese Mekong River Delta.However,adverse climate change impacts,socio-economic change...Agricultural production(especially intensive rice production)is a primary income source for over 2.0×10^(7) people in the Vietnamese Mekong River Delta.However,adverse climate change impacts,socio-economic change,and high dependence on farm inputs for intensive production constrain the longer-term sustainability of rice systems.Government and agribusiness actors are encouraging more farmers to grow non-rice crops and supporting the upscaling of alternative crops to paddy rice.We used a qualitative approach to investigate the value chain characteristics,as well as constraints and opportunities of alternative crops via two case studies(baby corn and honeydew melon)in An Giang and Hau Giang provinces,Vietnam.Data collection involved focus group discussions with local farmers and interviews with farmers and industry experts.Thematic analysis was used to compile the findings,and the results were validated with local government staff.The baby corn value chain featured on-going and stable market demand(including value-addition)and better vertical coordination(e.g.,written contracts and financial support).The honeydew melon value chain featured positive relationships between farmers and traders despite less-developed vertical coordination.There are opportunities for value chain engagement through product quality certification,value-addition,and accessing high-value domestic and export markets.However,farmers require crop-specific and generic support from private and public sectors.Increased labour requirements and limited access to finance and credit limit value chain participation.Upscaling and marketing alternative crops can enhance farmer profitability and support non-farming agricultural business establishment,economic growth,and community development.Efficient value chains will be critical to ensure the adoption of alternative crops and development of crop-specific agribusiness models.These findings can inform policy-makers and change facilitators in designing targeted interventions to support the adoption of alternative crops in the study area as well as in Vietnam and globally.展开更多
基金2025 Meizhou Municipal Planning Project of Philosophy and Social Sciences(Project No.:mzsklx2025101)。
文摘The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementation of the progressive talent training model featuring the integration of industry and education and work-study alternation is conducive to carrying out talent cultivation activities,improving the effectiveness of professional talent development,and effectively meeting the needs of market development.From the perspective of Meizhou Hakka cuisine cooking talents,this paper analyzes the problems existing in the implementation of the industry-education integration and work-study alternation model,and puts forward specific practical strategies for talent cultivation.The purpose is to enhance the training effect of Hakka cuisine cooking talents and provide reference for the subsequent optimization of professional teaching.
基金supported by the National Natural Science Foundation of China[grant numbers U2142207 and U2342205]the National Key R&D Program of China[grant number 2024YFC3013100]China Meteorological Administration(CMA)Youth Innovation Team[CMA2024QN06].
文摘Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in June followed by floods in July.The 2024 event was the most severe since 1981.This study demonstrates that such compound extreme events are closely linked to anomalous subseasonal evolution of large-scale atmospheric circulation.During the drought phase,the East Asian subtropical westerly jet(EAJ)shifts southward,and the western Pacific subtropical high(WPSH)exhibits anomalous strengthening with its western ridge line displaced southward.The flood phase is characterized by acceleration of the EAJ,westward extension of the WPSH,and enhanced southwestern moisture transport from the western Pacific.Beyond these typical features,the 2024 early summer circulation exhibited unique characteristics:Anomalous northeastward intensification of the WPSH facilitated merged moisture influx from both the Indian Ocean and the western Pacific along the southeast pathway into the HHHRB in July,resulting in the highest net moisture inflow at the southern boundary of the HHHRB since 1981.The synergistic effects of multiple factors primarily explain the exceptionally intense DFAA event in 2024.
基金upported by the National Natural Science Foundation of China(Grant No.62305184)the Major Key Project of Pengcheng Laboratory(Grant No.PCL2024A1)+1 种基金the Basic and Applied Basic Research Foundation of Guangdong Province(Grant No.2023A1515012932)the Science,Technology and Innovation Commission of Shenzhen Municipality(Grant No.WDZC20220818100259004).
文摘Single-pixel imaging(SPI)enables efficient sensing in challenging conditions.However,the requirement for numerous samplings constrains its practicality.We address the challenge of high-quality SPI reconstruction at ultra-low sampling rates.We develop an alternative optimization with physics and a data-driven diffusion network(APD-Net).It features alternative optimization driven by the learned task-agnostic natural image prior and the task-specific physics prior.During the training stage,APD-Net harnesses the power of diffusion models to capture data-driven statistics of natural signals.In the inference stage,the physics prior is introduced as corrective guidance to ensure consistency between the physics imaging model and the natural image probability distribution.Through alternative optimization,APD-Net reconstructs data-efficient,high-fidelity images that are statistically and physically compliant.To accelerate reconstruction,initializing images with the inverse SPI physical model reduces the need for reconstruction inference from 100 to 30 steps.Through both numerical simulations and real prototype experiments,APD-Net achieves high-quality,full-color reconstructions of complex natural images at a low sampling rate of 1%.In addition,APD-Net’s tuning-free nature ensures robustness across various imaging setups and sampling rates.Our research offers a broadly applicable approach for various applications,including but not limited to medical imaging and industrial inspection.
基金funded by the Technology Project of State Grid Jibei Electric Power Supply Co.,Ltd.(Grant Number:52018F240001).
文摘As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-interaction benefits and clear business models.Consequently,assessing the value of grid-alternative energy storage in the systemtransition has become critically important.Considering the performance characteristics of storage,we propose a value assessment frame-work for grid-alternative energy storage,quantifying its non-wires-alternative effects from both cost and benefit perspectives.Building on this,we developed a collaborative planning model for energy storage and transmission grids,aimed at maximizing the economic benefits of storage systems while balancing investment and operational costs.The model considers regional grid interconnections and their interactions with system operation.By participating in system operations,grid-alternative energy storage not only maximizes its own economic benefits but also generates social welfare transfer effects.Furthermore,based on multi-regional interconnected planning,grid-alternative energy storage can reduce system costs by approximately 35%,with the most significant changes observed in generation costs.Multi-regional coordinated planning significantly enhances the sys-tem’s flexibility in regulation.However,when the load factor of interconnection lines between regions remains constant,system operational flexibility tends to decrease,leading to a roughly 28.9%increase in storage investment.Additionally,under regional coordinated planning,the greater the disparity in wind power integration across interconnected regions,the more noticeable the reduction in system costs.
基金financially supported by the National Natural Science Foundation of China(No.22161040)Natural Science Foundation of Gansu(No.24JRRA125)Science Research Project of Northwest Normal University(No.NWNU-LKZD2021-3)。
文摘The ring-opening alternating copolymerization(ROAC)of 3,4-dihydrocoumarin(DHC)/epoxides has been successfully developed using an imidazolium salt of 1-ethyl-3-methylimidazolium chloride(EMIMCl)as a catalyst.The resulting copolymer has a molecular weight of 13.7kg·mol^(-1),a narrow molecular weight distribution of 1.03 and a strictly alternating structure.The MALDI-TOF MS characterization and DFT calculations including electrostatic potential(ESP),hydrogen-atom abstraction(HAA),independent gradient model based on hirshfeld partition(IGMH)and atoms-in-molecules(AIM)analysis were used to investigate the metal-free catalytic process.The synergistic effect of anions and cations of EMIMCl for ROAC of DHC and epoxides was demonstrated.This study provides a metal-free catalytic system for the facile synthesis of alternating polyesters from DHC.
基金financially supported by Russian Science Foundation(No.24-43-00156,https://rscf.ru/en/project/24-43-00156/)the National Natural Science Foundation of China(No.52171169)the State Key Laboratory for Advanced Metals and Materials(No.2023-ZD01)。
文摘The results of the study of the effect of partial substitution of Fe by Mn in the La Fe_(11.2-x)Mn_(x)Co_(0.7)Si_(1.1)system on magnetization,specific heat,magnetostriction and magnetocaloric effect are presented.Direct measurements of the adiabatic temperature change(ΔT_(ad))were carried out in alternating magnetic fields(AMF)using the magnetic field modulation method.Partial substitution of Fe atoms by Mn atoms leads to a shift in the Curie temperature(T_(C))towards lower temperatures without a noticeable deterioration in magnetic properties.A correlation was found between the structural component of the magnetocaloric effect and the stability of the frequency of theΔT_(ad)in the AMFs—an increase in the manganese concentration leads to a decrease in magnetostriction and to a lower dependence ofΔT_(ad)on the frequency of the magnetic field.Estimates of the specific cooling power Q_(C)as a function of the frequency of the AMF showed that the highest value of Q_(C)at f=20 Hz in a magnetic field of 12k Oe is 26.3 W g^(-1)and is observed for the composition with x=0.1.This value is higher than that of Gd,for which,under the same conditions,Q_(C)=21.6 W g^(-1).All the samples studied show stability of the value ofΔT_(ad)without any sign of deterioration of the effect up to 60,000cycles of switching on/off of the magnetic field of 12 k Oe.The discovered frequency and cyclic stability ofΔT_(ad)of the studied samples increase their prospects for application in magnetic cooling technology.
基金Fisheries Research Development Corporation,Grant/Award Number:2017-030.
文摘Background With the global expansion of aquaculture and the increasing demand for fish meal,identifying appropriate and sustainable alternative protein sources for aquafeeds has become essential.Single-cell protein(SCP),derived from methanotrophic bacteria,presents a promising alternative by converting methane into protein,potentially addressing both the need for alternative protein sources and reducing industrial greenhouse gas emissions.This study aimed to evaluate the effects of different levels of SCP inclusion(0%,25%,50%,and 75%fish meal replacement)on the health,gene expression,and gut microbiome of yellowtail kingfish(YTK,Seriola lalandi)following a 35-day growth trial.Results The study found that SCP inclusion at the highest level of fishmeal replacement(75%)induced a mild inflammatory response in the hindgut of the fish.However,micromorphological assessments of the hindgut,serum biochemistry,and gene expression analyses revealed no significant detrimental effects from SCP replacement.Notably,there were indications of improved lipid digestibility with SCP.Furthermore,SCP inclusion significantly enhanced microbial richness and altered the composition of the gut microbiome,introducing beneficial bacterial taxa that may contribute to improved gut health and resilience.Conclusions This study highlights SCP as a viable and sustainable alternative to fish meal in YTK diets.The findings suggest that SCP can be included in YTK diets without adverse health effects at moderate levels and may even offer benefits in terms of lipid digestibility and gut microbiome diversity.These results contribute to the advancement of more sustainable aquaculture practices.
基金financially sponsored by Hainan Provincial Natural Science Foundation(324QN360)Project of Sanya Yazhou Bay Sci-ence and Technology City(SCKJ-JYRC-2024-35).
文摘The 2025 U.S.-China Trade War has intensified the vulnerability of China's oil supply chain due to heavy reliance on soybean imports,posing serious challenges to food security.This study examines soybean dependency risks and evaluates substitution strategies through diversified oilseed use,including palm-based alternatives.Findings show that high reciprocal tariffs caused a 75%drop in U.S.soybean exports to China.Palm oil,with high yield efficiency and cost-effectiveness,offers a viable supplement to fill supply chain gaps.Promoting oil palm cultivation through northward expansion and cooperation with Belt and Road countries is recommended.Additionally,multi-omics,gene editing,tissue culture,and precision agriculture are crucial to address technical bottlenecks.The study concludes that palm and soybean oils will form a complementary system,and that policy and technology investments are essential to strengthen China's oilseed supply chain resilience and sustainability.
基金supported by the National Natural Science Foundation of China(No.22225605)the National Key Research and Development Program of China(No.2023YFC3706600)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750200).
文摘The number of newborns born with diseases is increasing recently.Thyroid hormones(THs)are closely related to the growth and development of the newborn in the mother's womb and to the carriage of related diseases after birth.Environmental endocrine-disrupting compounds(EDCs)have been proven to harm THs in newborns.Phthalates(PAEs),a typical class of EDCs,are commonly used in toys,childcare materials,and food contact materials,which have been closely connected with neonatal thyroid dysfunction and thyroid-related diseases.As restrictions on PAEs becomemore stringent in neonatal field,numerous PAE alternatives are emerging.Associations between exposure to PAEs and their alternatives and dysfunctions in THs have been explored.Hence,we summarized the body burdens and regional characteristics of PAEs and their alternatives in neonatal urine,cord blood,and meconium.Subsequently,the influences of PAEs and their alternatives on thyroid dysfunction,prematurity,low birth weight,fetal growth restriction,respiratory dysfunction,immune disorders,neurological disorders,and reproductive disorders in newborns were evaluated.Furthermore,we scrutinized the effects of PAEs and their alternatives on the neonatal thyroid from signaling,substance transport,and hormone production to explore the underlying mechanisms of action on neonatal thyroid and thyroid-related disorders.As the declining global trends of healthy newborns and the potential impacts of PAEs and their alternatives on thyroid function,a more comprehensive study is needed to discuss their effects on newborns and their underlying mechanisms.This review facilitates attention to the effects of PAEs and their alternatives on thyroid and thyroid-related disorders in newborns.
基金financially supported by the National Natural Science Foundation of China(No.22175183)。
文摘The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting the phase transition rate in PB-1 was established by adjusting the crystallization,nucleation,and growth temperatures.Nevertheless,low-molecular-weight PB-1(LMWPB-1)faces challenges because this method requires a low crystallization temperature,which is difficult to achieve during extrusion processing.In this study,we attempted to increase the phase transition rate in PB-1 by changing the annealing temperature after processing rather than the crystallization temperature in the classical scheme.The results indicated that regardless of low-or high-molecular-weight PB-1,repeated annealing between 0 and 90℃could also promote formⅡto formⅠphase transition.The initial content of formⅠincreased with the heating and cooling cycles.The half-time of the phase transition(t_(1/2))was also shortened after heating/cooling.After 100 heating/cooling cycles,t_(1/2) was reduced to one-quarter of that without annealing,which had almost the same effect as the crystallization temperature at 25℃in promoting the phase transition.This study indicates that annealing after processing is also an important factor affecting the phase transition of PB-1,and should receive sufficient attention.
基金supported by the National Key Research and Development Program of China(2021YFF1000301)the National Natural Science Foundation of China(31771805)。
文摘Heat stress is a major threat to maize(Zea mays L.)production worldwide.Heat shock transcription factors(HSFs)play vital roles in plant responses to heat stress.However,the molecular and genetic mechanisms underlying HSF-meditated thermotolerance in maize remain largely unexplored.In this study,we demonstrate that the alternative splicing of ZmHsf23 modulates heat stress tolerance in maize.Hsf23 produced two functional transcripts,Hsf23L and Hsf23S,which differ by the presence of a cryptic mini-exon in Hsf23L that is spliced out in Hsf23S.Both transcripts were strongly induced by heat stress.Mutants lacking Hsf23L alone(hsf23l)or both Hsf23L and Hsf23S(hsf23l23s)exhibited increased susceptibility to heat stress,whereas overexpression of Hsf23S enhanced heat stress tolerance in maize.Subsequently,we found that Hsf23S positively regulates heat stress tolerance by directly activating the transcription of three sHSP genes(Hsp16.9,Hsp17.2,and Hsp18a)and TIL1 gene.In addition,Hsf23L physically interacted with Hsf23S and enhanced the transcriptional activation of Hsf23S on the sHSPs and TIL1 promoters.Notably,genetic analysis suggested that co-overexpression of Hsf23L and Hsf23S further improves heat tolerance of the transgenic plants.Taken together,these results reveal two splicing variants of ZmHsf23 cooperatively regulate maize heat tolerance,thus highlighting potential value of ZmHsf23 in breeding heat-tolerant maize varieties.
基金supported by Shanghai Science and Technology Commission Project(No.21DZ1201502)Shanghai Municipal Bureau of Ecology and Environment(Shanghai Environ-mental Science[2023]No.40)+1 种基金the Interdisciplinary Joint Research Project of Tongji University(No.2022-4-YB-12)Shanghai Science and Technology Commission Project(No.22DZ2200200).
文摘Over the past century,advancements in chemistry have significantly propelled human innovation,enhancing both industrial and consumer products.However,this rapid progression has resulted in chemical pollution increasingly surpassing planetary boundaries,as production and release rates have outpaced our monitoring capabilities.To catalyze more impactful efforts,this study transitions from traditional chemical assessment to inverse chemical design,introducing a generative graph latent diffusion model aimed at discovering safer alternatives.In a case study on the design of green solvents for cyclohexane/benzene extraction distillation,we constructed a design database encompassing functional,environmental hazards,and process constraints.Virtual screening of previous design dataset revealed distinct trade-off trends between these design requirements.Based on the screening outcomes,an unconstrained generative model was developed,which covered a broader chemical space and demonstrated superior capabilities for structural interpolation and extrapolation.To further optimize molecular generation towards desired properties,a multi-objective latent diffusion method was applied,yielding 19 candidate molecules.Of these,7 were identified in PubChem as the most viable green solvent candidates,while the remaining 12 as potential novel candidates.Overall,this study effectively designed green solvent candidates for safer and more sustainable industrial production,setting a promising precedent for the development of environmentally friendly alternatives in other areas of chemical research.
基金supported by the Northeast Asia Biodiversity Research Center(grant number 411147021003).
文摘The predominant causal agent of poplar leaf blight is the pathogenic fungus Alternaria alternata (Fr.) Keissl., which exhibits host specificity toward Populus species. To elucidate the molecular response mechanisms of A. alternata under fludioxonil fungicide stress, the fungus was cultured at the half-maximal effective concentration (EC₅₀) of fludioxonil. Transcriptomic and metabolomic profiles were analyzed using mycelia harvested under these conditions. Comparative analysis revealed 1,001 differentially expressed genes (DEGs) in the resistant strain (RS) relative to the wild-type strain (WT), comprising 628 upregulated and 373 downregulated genes. Concurrently, 524 differentially accumulated metabolites (DAMs) were identified, with 336 upregulated and 188 downregulated metabolites. KEGG pathway enrichment demonstrated pronounced upregulation in glycerophospholipid metabolism, α-linolenic acid metabolism, nucleic acid biosynthesis, and glycosylation processes. Conversely, arachidonic acid and galactose metabolism pathways were suppressed. Significant downregulation was observed in phosphatidylinositol signaling, aflatoxin biosynthesis, and cutin/suberin/wax biosynthesis pathways. Transcriptomic profiling further indicated that upregulated DEGs were predominantly associated with amino sugar/nucleotide sugar metabolism, ABC transporters, aflatoxin biosynthesis, and purine metabolism, while downregulated DEGs were enriched in N-glycan biosynthesis, endoplasmic reticulum protein processing, steroid biosynthesis, and riboflavin metabolism. Fludioxonil exerted substantial inhibitory effects on fungal growth, pathogenicity, and metabolic activity. Mechanistically, A. alternata counteracted fungicide-induced stress through modulation of its antioxidant defense system. This integrative multi-omics study delineates the dynamic gene expression and metabolic reprogramming in A. alternata under fludioxonil exposure, providing novel insights into potential molecular targets and informing the development of next-generation fungicidal strategies for phytopathogen control.
基金Supported by Key Research and Development Program of Shanxi Province(202302140601009).
文摘Moistube irrigation is a newly-developed irrigation technique that utilizes a semipermeable membrane to release water slowly and continuously into the plant root zone.Alternate Moistube Irrigation(AMI)is a combination of alternative irrigation and moistube irrigation.In order to investigate the effects of AMI on plant growth,greenhouse experiments were conducted on spinach(Spinacia oleracea)and water spinach(Ipomoea aquatica)plants at different time.We measured soil water content at a depth of 20 cm in the planting boxes,and also determined seed emergence rate,plant height,largest leaf area,fresh weight per plant,yield,and irrigation water productivity(IWP)for both spinach and water spinach.The results showed that the AMI treatments had significantly higher soil water content than the conventional surface irrigation control(CK).The emergence rates of spinach and water spinach were significantly higher in the AMI treatments than in the CK,and the plant height,largest leaf area,and fresh weight during the middle and late stages of spinach and water spinach growth were also significantly higher than those of the CK.Both spinach and water spinach grew well and produced high yield with high IWP under AMI with a high water head pressure of 1.5 m at tube spacing of 20 or 30 cm.We found that AMI with a suitable combination of head pressure and tube spacing can promote plant growth and increase yield and IWP under controlled conditions.
基金funded by Guizhou Province Science and Technology Plan Project Qiankehe Foundation-ZK[2023]General 360,362Science and Technology Fund project of Guizhou Provincial Health Commission(gzwkj-2022-09,gzwkj-2023-035)+1 种基金National Natural Science Foundation Cultivation Project of Guizhou Medical University(21NSFCP14,gyfynsfc-2022-25)The PhD Scientific Research Launch Fund Project of the Affiliated Hospital of Guizhou Medical University(gyfybsky-2022-02).
文摘Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.However,the mechanisms of hypoxia-promoted tumor progression remain elusive.Methods:Alternative splicing of diacylglycerol kinase gamma(DGKG)-Δexon13 was amplified and verified by PCR-Sanger sequencing.The functions of DGKG and DGKG-Δexon13 were analyzed by Cell counting kit-8(CCK-8),Transwell,Matrigeltranswell experiments,and in vivo orthotropic GBM animal models.Transcriptome analyses were done to find out the regulated genes.Results:In this study,we found that a new transcript DGKG-Δexon13 was generated in GBM under hypoxia via alternative splicing.Moreover,the results of CCK-8,Transwell,and Matrigel-transwell experiments showed that the proliferation,migration,and invasion abilities of U87-MG and T98G were decreased after DGKG knockdown.Compared to wild-type DGKG,DGKG-Δexon13 overexpression significantly promoted cellular proliferation,migration,and invasion abilities in GBM.Furthermore,in vivo,orthotropic GBM animal models analysis showed that the tumor volumes were much smaller in the DGKG knockdown group.However,the tumor sizes in the DGKG and DGKG-Δexon13 rescue groups were restored,especially in the DGKG-Δexon13 group.Transcriptome analysis revealed that MORC1,KLHDC7B,ATP1A2,INHBE,TMEM119,and FGD3 were altered significantly when DGKG was knocked down.IL-16,CCN2,and EFNB3 were specifically regulated by DGKG-Δexon13.Conclusions:Our study found that hypoxia-induced alternative splicing transcript DGKG-Δexon13 promotes GBM proliferation and infiltration,which might provide a new potential target for the clinical treatment and diagnosis of GBM.
文摘Background:The use of complementary and alternative medicine(CAM)is common among individuals with underlying chronic illnesses.Objective:This systematic review and meta-analysis investigated the global prevalence and patterns of CAM use among individuals with chronic kidney disease(CKD).Search strategy:PubMed,Embase,and Cumulative Index to Nursing and Allied Health Literature Plus were searched from inception until 26th February 2024.Inclusion criteria:Original articles reporting the use of at least one type of CAM among individuals aged above 18 years old and at all stages of CKD or undergoing any form of kidney replacement therapy.Data extraction and analysis:Two independent reviewers performed the literature screening.The data were extracted from the included studies by one reviewer and cross-checked by another.Discrepancies were resolved by discussion and consensus among two reviewers.Primary information included prevalence of CAM use,types of CAM used,reasons for CAM use,factors associated with CAM use,and disclosure to healthcare providers.Meta-analyses were performed to determine the pooled prevalence of CAM use and non-disclosure of CAM using a random effect model.Results:Forty-one studies were included in this systematic review and meta-analysis.The pooled prevalence of CAM use was 43%(95%confidence interval:34%,51%),I2=99.46%.The reasons for CAM use included treatment of underlying comorbidities,complications or symptoms,maintenance of general health,and treatment of CKD.Nutritional approaches were the most common CAM modality,with 412different herbal and dietary supplements reported;psychological and physical approaches included massage therapy,relaxation techniques,and mind–body practices;and other complementary health approaches such as homeopathy,traditional Chinese medicine,and Ayurvedic medicine were also frequently reported.Factors associated with CAM use included sociodemographic characteristics such as older age,female gender,or higher income;disease or therapy factors such as not having diabetes,relying on hemodialysis,or poor adherence to medication;and patient or internal factors such as positive attitude towards CAM and perceived safety of CAM.About 66%(61%,72%)of CAM users did not disclose the use of CAM to their healthcare providers.Conclusion:CAM use is prevalent among individuals with CKD,and healthcare providers should communicate openly and effectively to emphasize the rational use of CAM to avoid potential harm.
文摘This review aims to identify the assets and limitations of Dabema(Piptadeniastrum africanum)as a sustainable alternative to traditional timber species for furniture and construction applications.Dabema is characterized by its high density and dimensional stability,meeting ASTM(American Society for Testing and Materials)standards for mechanical strength,which is essential for promoting its use.However,its limited availability in trade and ingrained habits of use are obstacles to its widespread commercialization.In addition,thermal and oleothermal treatments have shown great potential for improving the characteristics of this wood,although they require ongoing optimization and rigorous environmental assessment.Consequently,increased awareness of the benefits of Dabema is decisive to encourage its sustainable adoption in modern economies.This could help to diversify forest resources and encourage more sustainable building practices,taking advantage of Dabema’s unique properties while mitigating environmental sustainability concerns.
基金Supported by Shanghai Municipal Health Commission’s Special Clinical Research Project for the Hygiene Industry,No.20244Y0041Youth Initiation Fund of Naval Medical University,No.2023QN028 and No.2023QN030。
文摘BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 Hz)play an essential role in supporting working memory operations.Theta-band transcranial alternating current stimulation(tACS)offers a potential mechanism for working memory enhancement through direct modulation of these fundamental neural oscillations.Nevertheless,current empirical evidence shows substantial variability in the observed effects of theta-tACS across studies.AIM To conduct a systematic review and meta-analysis evaluating the effects of thetatACS on working memory performance in healthy adults.METHODS A systematic literature search was performed on PubMed,EMBASE,and Web of Science up to March 10,2025.Effect sizes were computed using Hedges’g with 95%confidence intervals(CIs),with separate meta-analyses for all included studies and for distinct working memory paradigms[n-back and delayed matchto-sample(DMTS)tasks]to examine potential task-specific effects.Subgroup analyses and meta-regression were performed to evaluate the influence of key moderating variables.RESULTS The systematic review included 21 studies(67 effect sizes).Initial meta-analysis showed theta-tACS moderately improved working memory(Hedges’g=0.405,95%CI:0.212-0.598).However,this effect became nonsignificant after correcting for publication bias(trim-and-fill adjusted Hedges’g=0.082,95%CI:-0.052 to 0.217).Task-specific analyses revealed significant benefits in n-back tasks(Hedges’g=0.463,95%CI:0.193-0.733)but not in DMTS tasks(Hedges’g=0.257,95%CI:-0.186 to 0.553).Moderator analyses showed that performance in n-back tasks was influenced by stimulation frequency(P=0.001),concurrent status(P=0.014),task modality(P=0.005),and duration(P=0.013),whereas only the region of targeted stimulation(P=0.012)moderated DMTS tasks.CONCLUSION Theta-tACS enhances working memory in healthy adults,with effects modulated by the task type and protocol parameters,offering dual implications for cognitive enhancement and clinical interventions.
基金funded by the 2022-2023 Australian Centre for International Agricultural Research(ACIAR)Alumni Research Support Facility(ARSF)programme:“Farmers’adaptive capacity and agricultural transformation in the Vietnamese Mekong Delta:understanding and supporting value chain engagement”the ACIAR-funded project“Farmer options for crops under saline conditions(FOCUS)in the Mekong River Delta,Vietnam”(SLaM/2018/144)to this study.
文摘Agricultural production(especially intensive rice production)is a primary income source for over 2.0×10^(7) people in the Vietnamese Mekong River Delta.However,adverse climate change impacts,socio-economic change,and high dependence on farm inputs for intensive production constrain the longer-term sustainability of rice systems.Government and agribusiness actors are encouraging more farmers to grow non-rice crops and supporting the upscaling of alternative crops to paddy rice.We used a qualitative approach to investigate the value chain characteristics,as well as constraints and opportunities of alternative crops via two case studies(baby corn and honeydew melon)in An Giang and Hau Giang provinces,Vietnam.Data collection involved focus group discussions with local farmers and interviews with farmers and industry experts.Thematic analysis was used to compile the findings,and the results were validated with local government staff.The baby corn value chain featured on-going and stable market demand(including value-addition)and better vertical coordination(e.g.,written contracts and financial support).The honeydew melon value chain featured positive relationships between farmers and traders despite less-developed vertical coordination.There are opportunities for value chain engagement through product quality certification,value-addition,and accessing high-value domestic and export markets.However,farmers require crop-specific and generic support from private and public sectors.Increased labour requirements and limited access to finance and credit limit value chain participation.Upscaling and marketing alternative crops can enhance farmer profitability and support non-farming agricultural business establishment,economic growth,and community development.Efficient value chains will be critical to ensure the adoption of alternative crops and development of crop-specific agribusiness models.These findings can inform policy-makers and change facilitators in designing targeted interventions to support the adoption of alternative crops in the study area as well as in Vietnam and globally.
