AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV betwe...AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV between January 2014 and August 2021 were retrospectively reviewed.Corneal keratometry parameters were measured using IOLMaster or a handheld keratometer.Differences in CA between the affected and fellow eyes were analyzed in 52 unilateral PFV patients with available examination data.RESULTS:Totally 133 patients diagnosed with PFV were retrospectively reviewed.The male-to-female ratio was 73/60.Median age at surgery was 38.03mo(interquartile range 58.27mo).Among the PFV patients,32(24.06%)had anterior PFV,2(1.50%)had posterior PFV,and 99(74.44%)had combined anterior-posterior PFV.Mild combined PFV was the most common subtype.In unilateral PFV cases,the mean CA in the affected eye was 2.29±1.11 D,and 59.62%(31 eyes)had CA≥2.0 D.The mean CA in the affected eyes was significantly higher than in the fellow eyes(1.37±0.77 D;P<0.001).Among PFV-affected eyes with CA≥2.0 D,the steepest corneal meridian was vertically oriented in 30 cases(96.77%),while only 1 case(3.23%)had the steepest meridian oriented horizontally.CONCLUSION:In children with unilateral PFV,CA is significantly higher in the affected eyes than in the fellow eyes,and the steepest corneal meridian was predominantly oriented vertically.展开更多
Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of ima...Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of imaging[1].Among numerous persistent luminescence materials,lanthanide-doped fluoride nanoparticles have shown tunable persistent luminescence across the UV-vis-NIR spectrum(200-1700 nm)under X-ray excitation and adjustable size,promising significant applications in deep-tissue imaging[2,3],security encryption,and data storage[4].In particular,those exhibiting NIR-II luminescence(1000-1700 nm)provide key advantages such as deeper tissue penetration,higher contrast,and minimal interference from biological autofluorescence.However,challenges such as low brightness and rapid signal decay,especially in the NIR-II region,limit their effectiveness in long-term monitoring,including tumor theranostics[5].Traditional approaches like size control and surface passivation yield only marginal improvements,underscoring the need for next-generation nanoparticles with superior NIR-II brightness.展开更多
Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a ra...Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a rare phenomenon.In the general population,the incidence of this condition is reported to be between 0.3%and 2.1%.[1]While this anatomical variation is often asymptomatic and discovered incidentally,it becomes relevant in certain clinical scenarios.Indeed,the presence of a PLSVC and double superior vena cava can pose challenges as incorrect positioning and result in failure.展开更多
Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algo...Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.展开更多
Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmenta...Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.展开更多
Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent lumine...Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent luminescent material applications.At present,YAGG:Ce^(3+),Cr^(3+)powders exhibit good persistent performance,but their persistent performance of ceramics still needs to be further improved to meet the new requirements.In this work,(Y_(0.998)Ce_(0.002))_(3)(Al_(1-x)Cr_(x))_(2)Ga_(3)O_(12) ceramics with different Cr^(3+)doping concentrations were prepared by solid-state reaction,including air pre-sintering,hot isostatic pressing(HIP)post-treatment and air annealing,to investigate the effects of Cr^(3+)doping concentration on the microstructure,optical properties and persistent performance of the ceramics.The results showed that as the doping concentration of Cr^(3+)increased from 0.025%to 0.2%(in atom),no significant effect of Cr^(3+)concentration on the morphology of pre-sintered ceramics or HIP post-treatment ceramics was observed,but the in-line transmittance gradually increased while the persistent performance gradually decreased.Among them,YAGG:Ce^(3+),Cr^(3+)ceramics doped with 0.025%Cr^(3+)showed the strongest initial luminescence intensity exceeding 6055 mcd/m^(2) and a persistent time of 1030 min after air pre-sintering combined with HIP post-treatment and air annealing.By optimizing the Cr^(3+)doping concentration and the fabrication process,the persistent luminescence(PersL)performance of the YAGG:Ce^(3+),Cr^(3+)ceramics was obviously improved.展开更多
In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide r...In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide radiation quantum energy range of 0.62–3.1 eV both at T=4.2 K and at T=77 K.Common features of the PPC spectra for all structures were revealed,and their relation to the presence of a CdTe cap layer in all structures and the appropriate cadmium fraction in the CdHgTe barrier layers was shown.One of the features was associated with the presence of a deep level in the CdTe layer.In addition,the oscillatory behavior of the PPC spectra in the region from 0.8–1.1 eV to 1.2–1.5 eV was observed.It is associated with the cascade emission of longitudinal optical phonons in CdHgTe barrier.展开更多
BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum ...BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum months,with notably high incidence rates even one year after childbirth.Persistent PPD has been associated with poor developmental outcomes in infants,highlighting the need for continued monitoring and support during this critical period.Understanding the broader impacts of persistent PPD is essential for developing effective interventions to improve maternal and infant well-being.AIM To explore the impact of persistent PPD on infant developmental behavior and maternal self-efficacy.METHODS We recruited 60 postpartum women who experienced persistent depression after childbirth in our hospital from January 2020 to December 2024 as the research subjects.The study collected basic characteristics of both infants and mothers,analyzed the self-efficacy of the mothers and the developmental behaviors of the infants,and conducted a correlation analysis to examine the relationship between postpartum persistent depression in mothers and the developmental behaviors and self-efficacy of infants.The Bootstrap method was used to verify the significance of the mediating effect.RESULTS The basic characteristics of infants and mothers show that 53.33%are male,58.33%are born via vaginal delivery,88.33%have a normal body mass index,51.67%are aged between 25 and 29 years,70%are non-agricultural workers,51.67%have a per capita household income over 4000 yuan,96.67%are full-term births,and 58.33%of the fathers are aged between 26 and 32 years.In terms of infant development behavior,the gross motor skills score is relatively low(38.44±12.15).Regarding maternal self-efficacy,the skill score(45.68±5.49)and mental activity score(46.37±3.72)are both at a low level.Correlation analysis reveals that postpartum persistent depression is significantly negatively correlated with maternal self-efficacy and infant development behavior(β=-0.439,-0.657,P<0.001),while self-efficacy is positively correlated with infant development behavior(β=0.728,P<0.001).The path coefficient and Bootstrap method test indicate that self-efficacy acts as a mediator between postpartum persistent depression and infant development behavior,accounting for 54.80%of the effect(P<0.05),while the direct effect of postpartum persistent depression on infant development behavior is 45.20%(P<0.05).CONCLUSION Persistent PPD significantly negatively impacts infant developmental outcomes,with maternal self-efficacy serving as a partial mediator.These findings suggest that interventions targeting both depressive symptoms and selfenhancement may effectively promote infant health development.展开更多
The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these s...The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.展开更多
Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security...Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security threats.Programmable switches provide line-rate packet processing to meet the requirements of high-speed network environments,yet they are fundamentally limited in computational and memory resources.Accurate and memoryefficient persistent flow detection on programmable switches is therefore essential.However,existing approaches often rely on fixed-window sketches or multiple sketches instances,which either suffer from insufficient temporal precision or incur substantial memory overhead,making them ineffective on programmable switches.To address these challenges,we propose SP-Sketch,an innovative sliding-window-based sketch that leverages a probabilistic update mechanism to emulate slot expiration without maintaining multiple sketch instances.This innovative design significantly reduces memory consumption while preserving high detection accuracy across multiple time intervals.We provide rigorous theoretical analyses of the estimation errors,deriving precise error bounds for the proposed method,and validate our approach through comprehensive implementations on both P4 hardware switches(with Intel Tofino ASIC)and software switches(i.e.,BMv2).Experimental evaluations using real-world traffic traces demonstrate that SP-Sketch outperforms traditional methods,improving accuracy by up to 20%over baseline sliding window approaches and enhancing recall by 5%compared to non-sliding alternatives.Furthermore,SP-Sketch achieves a significant reduction in memory utilization,reducing memory consumption by up to 65%compared to traditional methods,while maintaining a robust capability to accurately track persistent flow behavior over extended time periods.展开更多
Scintillator is a key material for the development of X-ray detectors,which has a promising application in medical imaging,security inspection and industrial non-injury detection.The majority of scintillators currentl...Scintillator is a key material for the development of X-ray detectors,which has a promising application in medical imaging,security inspection and industrial non-injury detection.The majority of scintillators currently used in imaging are real-time imaging scintillators,which can cause ionization radiation damage to biological subjects or detection equipment during the imaging process and require complex,highly sensitive detection systems.Therefore,exploring stable,environmentally friendly scintillator materials that can achieve delayed imaging is of significance in the field of imaging.Herein,we devel-oped an X-ray time-lapse imaging scintillator,Sr_(2)Al_(6)O_(11):Dy^(3+)phosphor,which generates stable traps by X-ray irradiation,thus endowing it with excellent persistent luminescence and information storage properties(>42 d).Moreover,traps constructed by X-ray can be repeatedly refilled(>40 times)under UV light and carriers are released in theform of mechanical or thermal excitation when refilling is complete.By constructing the traps in the phosphor during X-ray excitation and using it for repetitive imaging,the detection limit is 74.78 nGy/s,and the spatial imaging resolution is as high as 16 lp/mm.This discovery providesa new idea for the development oftime-delayed X-ray scintillator.展开更多
Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy....Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy.This multicenter,non-inferiority,single-blinded randomized controlled trial aimed to compare the differences in efficacy between warm needling(WN)therapy and loratadine(LO)in improving AR symptoms and quality of life.Methods:A total of 98 patients with persistent AR(PAR)were randomly divided into two groups in a 1:1 ratio:treatment group receiving WN therapy at Dazhui(GV14)and normal acupuncture at other acupoints for 12 sessions in 4 weeks and control group receiving LO at a dosage of 10 mg/day for oral administration.The study duration was 28 weeks(4-week treatment period with a 24-week follow-up).The primary outcome was the mean change in the Total Nasal Symptom Score(TNSS)from baseline to week 28,and the secondary outcomes included the Total Non-Nasal Symptom Score(TNNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)score.Statistical analyses were conducted us-ing SPSS22.0.Both intention-to-treat and treatment compliance analyses were performed to analyze all outcomes.Results:After intervention,TNSS scores improved from baseline to week 28 by 5.18(95%confidence interval[CI]:3.91,6.45;P<0.001)in the WN group and 4.59(95%CI 3.28,5.89;P<0.001)in the LO group,but the changes did not differ between the groups(P=0.515).The margin by 95%CI(−1.20,2.38)was not reached,indicating non-inferiority.WN therapy resulted in clinical improvements in TNNSS,with a significant difference com pared with LO treatment(f=5.466,P=0.021).WN therapy also resulted in clinical improvements in RQLQ scores,with a significant difference compared with LO(f=9.222,P=0.003).Conclusions:WN therapy demonstrated comparable efficacy to oral LO in improving nasal symptoms of PAR.However,it showed superior effects in alleviating concomitant nasal symptoms and enhancing patients’quality of life.展开更多
Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are i...Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are involved in numerous physiological processes.However,research on the effects of PFOA on epigenetic modifications is still limited.In this study,we systematically investigated the alterations in epigenetic modifications in both DNA and RNA from the heart,liver,spleen,lung,kidney,and brain of C57BL/6N mice following exposure to PFOA at doses of 0,0.5,and 5 mg kg^(-1)d^(-1),utilizing liquid chromatography-tandem mass spectrometry(LC-MS/MS).The results indicated that exposure to PFOA inhibited weight gain in mice,and significant changes were observed in the organ coefficients of the liver,spleen,lungs,and heart in the high PFOA exposure group.Modifications in DNA and RNA exhibited tissue specificity.Orthogonal partial least squares discriminant analysis revealed that the control group and the high PFOA exposure group clustered well,suggesting that PFOA exposure significantly impacts epigenetic modifications in DNA and RNA.Specifically,PFOA exposure significantly affected the levels of 5-hydroxymethylcytosine(5hmC)in genomic DNA in the heart,lung,kidney,and liver tissues.For RNA modifications,significant changes were observed,with the levels of 12,13,10,6,12,and 14 modifications in the heart,liver,spleen,lung,kidney,and brain,respectively,altered in response to PFOA exposure.Our study highlights the significance of PFOA exposure in altering DNA and RNA modifications,providing a new perspective on understanding the toxicology of PFOA from an epigenetic standpoint.展开更多
Background Persistent pulmonary hypertension(PPHN)of the newborn is one of the major contributors to neonatal mortality.Current conventional treatments for PPHN primarily encompass mechanical ventilation,inhaled nitri...Background Persistent pulmonary hypertension(PPHN)of the newborn is one of the major contributors to neonatal mortality.Current conventional treatments for PPHN primarily encompass mechanical ventilation,inhaled nitric oxide(iNO),sildenafil,and magnesium sulfate.In confirmed cases of neonatal respiratory distress syndrome,pulmonary surfactant(PS)can be considered as a potential treatment option;However,the optimal dosage and administration frequency of PS remain subjects of ongoing debate.This study aimed to assess the efficacy of early repeated endotracheal PS administration combined with iNO therapy in the management of newborns with PPHN.Methods Twenty-three neonates with PPHN received iNO alongside foundational treatments,including anti-infection therapy,mechanical ventilation,acidosis correction,and blood pressure stabilization.The observation group(n=13)received endotracheal instillation of PS three times,with each administration spaced six hours apart;The control group(n=10)received endotracheal instillation of PS once.Parameters compared included blood gas indices,oxygenation index(OI),alveolar-arterial oxygen partial pressure difference(PA-aDO,),pulmonary artery systolic pressure(PAP),and N-terminal pro-brain natriuretic peptide(NT-pro-BNP).Mechanical ventilation duration,oxygen therapy time,hospitalization length,and survival outcomes were recorded and compared between groups.Results The blood gas parameters,OI,and PA-aDO,showed no significant differences between the two groups of children before treatment(P>0.05).By 24-hour post-treatment,both groups exhibited significant increases in partial pressure of oxygen(PaO,)and potential of hydrogen(PH)levels,alongside significant decreases in lactate,partial pressure of carbon dioxide(PaCO,),OI,and PA-aDO2,with statistically significant differences(P<0.05).By 48-hour post-treatment,the observation group demonstrated significantly better improvements in blood gas parameters,OI,and PA-aDO,compared to the control group,and these differences were statistically significant(P<0.05).There was no statistically significant difference in PAP and NT-pro-BNP levels between the two groups before treatment(P>0.05).After treatment,both groups showed significant decreases in PAP and NT-pro-BNP levels(P<0.05),with a more pronounced reduction observed in the observation group(P<0.05).The observation group had significantly shorter durations of mechanical ventilation and oxygen therapy compared to the control group,with statistically significant differences(P<0.05).Additionally,the observation group exhibited a shorter total hospital stay and a lower mortality rate than the control group,though these differences were not statistically significant(P>0.05).Conclusions Early consecutive multiple doses of PS combined with iNO,compared to a single dose,better improves respiratory function indices,maintains stability,reduces pulmonary artery pressure,enhances cardiac function,shortens ventilator dependency,and increases cure rates in PPHN neonates.This approach is particularly suitable for severe PPHN cases,especially those with underlying pulmonary conditions.展开更多
Persistent Luminescence(PersL)materials,which use traps to store energy and emit photons over a long period,have found important applications in the fields of optical information storage,security labeling,and biologic...Persistent Luminescence(PersL)materials,which use traps to store energy and emit photons over a long period,have found important applications in the fields of optical information storage,security labeling,and biological imaging.The trap depth is a crucial factor determining the performance of these materials;however,achieving the desired trap depth with high precision remains a great challenge.Here,we provide double perovskite phosphors(Cs_(2)SnCl_(6)-Cs_(2)ZrCl_(6)-Cs_(2)HfCl_(6)series)with highly compatible crystal structures,enabling continuous and precise tuning of trap depth over an ultra-wide range of 0.11-1.25 eV.By incorporating W4+as the luminescent centers,these phosphors exhibit outstanding near-infrared(NIR)PersL performance at approximately 900 nm and a lasting emission duration exceeding 10 h.The underlying mechanism of PersL is elucidated,and the wide-range tunability of trap depth is attributed to the universal applicability of band-gap engineering in the entire material system.Furthermore,we demonstrate the practical application of these materials by designing a flexible detector plate for X-ray imaging.The detector plate exhibits a storage time of more than 1 week,a detection limit of 0.83μGyair·s^(-1)in the near-infrared region,and real-time and delay-time imaging resolutions of 14.2 lp·mm^(-1)and 2.5 lp·mm^(-1),respectively.These attributes demonstrate strong potential for X-ray luminescence extension imaging.展开更多
Ce^(3+),due to its broadband emission,has the potential to serve as a donor ion for energy transfer to achieve the possible efficient tunable multi-emission in materials.However,current related research primarily focu...Ce^(3+),due to its broadband emission,has the potential to serve as a donor ion for energy transfer to achieve the possible efficient tunable multi-emission in materials.However,current related research primarily focuses on photoluminescent(PL)phosphors,while studies on achieving tunable long persistent luminescence(LPL),particularly in glass materials,are insufficient.In this work,Ce-Tb codoped boroaluminate glass was synthesized using a high-temperature melting method under a reducing atmosphere.Under the influence of oxygen vacancy traps induced during the reduction of Ce^(4+)to Ce^(3+),glass samples exhibit an obvious LPL with a broadband center wavelength at 420 nm and a narrowband center wavelength at 547 nm,which correspond well to Ce^(3+)ions'd-f transitions and Tb^(3+)ions'f-f transitions,respectively.A reasonable Ce^(3+)doping amount achieves the optimal trap depth and concentration to enhance LPL intensity and duration.Additionally,it improves the PL intensity of Tb^(3+)by enhancing the energy transfer from Ce^(3+)to Tb^(3+),thereby enabling the glass to exhibit variable LPL colo rs ranging from blue to cyan.Finally,based on the PL and LPL characteristics of the samples,a dynamic encryption anticounterfeiting application is described.展开更多
Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and...Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and thereby are attributed to socio‐psychological reasons and treated by psychological interventions,such as cognitive behavior treatment.However,it is not ideal to rationalize and manage the PPS lack of pathophysiological explanation relying on psychological approaches.The entrenched disease‐centered biomedical mode limits the perception of PPS.Traditional medicine is a unique methodology of medicine independent from biomedical mode.Traditional Chinese medicine(TCM),achieved knowledge of health and disease from extensive observation and developed theoretical framework based on ancient mathematics using the principles of ancient naive materialism and dialectical materialism,has amassed extensive experience in symptom management.Particularly,the system of body constitution in TCM serves a reference model of evidence‐based integration of traditional and modern medicine in healthcare,and offers a promising approach for managing PPS.Nine types of body constitution were identified and validated through a series of scientific research.Individuals with a specific type of body constitution tend to present a corresponding cluster of symptoms,physical signs,disease susceptibility and prognosis.Adjustment of unhealthy constitution helps the symptom control and disease management.Standardized protocol of body constitution classification was established as an industry standard,and that of body constitution adjustment was compiled as clinical guidelines for quality control.Taken together,such evidence‐based integration of traditional medicine with modern medicine provides new avenues for managing PPS effectively.展开更多
It is with profound respect and gratitude that we dedicate this special issue of the Journal of Environmental Sciences to the memory of Professor Chuanyong Jing,whose outstanding contributions to environmental science...It is with profound respect and gratitude that we dedicate this special issue of the Journal of Environmental Sciences to the memory of Professor Chuanyong Jing,whose outstanding contributions to environmental sciences have advanced the field and continue to resonate with both academia and the broader environmental community.展开更多
Persistent infection with high-risk human papillomavirus(HR-HPV)is the core pathogenic factor of cervical cancer(CC).Although HPV vaccination is an effective primary prevention method for CC,the global vaccination rat...Persistent infection with high-risk human papillomavirus(HR-HPV)is the core pathogenic factor of cervical cancer(CC).Although HPV vaccination is an effective primary prevention method for CC,the global vaccination rate is generally insufficient(target population vaccination rate in China<5%),far from meeting the requirements for herd immunity(80%)and the WHO target(90%).However,only about 10% of HR-HPV infections progress to persistent infections.Therefore,identifying and intervening in the“HR-HPV persistent infection”population can systematically narrow the scope of prevention and control,reduce prevention and control costs,and provide a new path for low-income countries to explore suitable prevention and control models for CC.Based on this understanding,the team has pioneered a systematic method for identifying HR-HPV persistent infections and a tiered intervention system based on drug classification,which has achieved good results in both basic research and clinical observations.This article will summarize the current research status of“HR-HPV persistent infection”in relation to CIN and CC,as well as the team’s relevant concepts and research results,to provide a reference for the identification and intervention of“HR-HPV persistent infection.”展开更多
We present a grid-growth method to reconstruct 3D rock joints with arbitrary joint roughness and persistence.In the first step of this workflow,the joint model is divided into uniform grids.Then by adjusting the posit...We present a grid-growth method to reconstruct 3D rock joints with arbitrary joint roughness and persistence.In the first step of this workflow,the joint model is divided into uniform grids.Then by adjusting the positions of the grids,the joint morphology can be modified to construct models with desired joint roughness and persistence.Accordingly,numerous joint models with different joint roughness and persistence were built.The effects of relevant parameters(such as the number,height,slope of asperities,and the number,area of rock bridges)on the joint roughness coefficient(JRC)and joint persistence were investigated.Finally,an artificially split joint was reconstructed using the method,and the method's accuracy was evaluated by comparing the JRC of the models with that of the artificially split joint.The results showed that the proposed method can effectively control the JRC of joint models by adjusting the number,height,and slope of asperities.The method can also modify the joint persistence of joint models by adjusting the number and area of rock bridges.Additionally,the JRC of models obtained by our method agrees with that of the artificially split surface.Overall,the method demonstrated high accuracy for 3D rock joint reconstruction.展开更多
基金Supported by the National Natural Science Foundation of China(No.82070942,No.81970780,No.81770907,No.81670835).
文摘AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV between January 2014 and August 2021 were retrospectively reviewed.Corneal keratometry parameters were measured using IOLMaster or a handheld keratometer.Differences in CA between the affected and fellow eyes were analyzed in 52 unilateral PFV patients with available examination data.RESULTS:Totally 133 patients diagnosed with PFV were retrospectively reviewed.The male-to-female ratio was 73/60.Median age at surgery was 38.03mo(interquartile range 58.27mo).Among the PFV patients,32(24.06%)had anterior PFV,2(1.50%)had posterior PFV,and 99(74.44%)had combined anterior-posterior PFV.Mild combined PFV was the most common subtype.In unilateral PFV cases,the mean CA in the affected eye was 2.29±1.11 D,and 59.62%(31 eyes)had CA≥2.0 D.The mean CA in the affected eyes was significantly higher than in the fellow eyes(1.37±0.77 D;P<0.001).Among PFV-affected eyes with CA≥2.0 D,the steepest corneal meridian was vertically oriented in 30 cases(96.77%),while only 1 case(3.23%)had the steepest meridian oriented horizontally.CONCLUSION:In children with unilateral PFV,CA is significantly higher in the affected eyes than in the fellow eyes,and the steepest corneal meridian was predominantly oriented vertically.
基金supported by the Major Research Plan of the National Natural Science Foundation of China(No.92361202)National Natural Science Foundation of China(No.12204481).
文摘Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of imaging[1].Among numerous persistent luminescence materials,lanthanide-doped fluoride nanoparticles have shown tunable persistent luminescence across the UV-vis-NIR spectrum(200-1700 nm)under X-ray excitation and adjustable size,promising significant applications in deep-tissue imaging[2,3],security encryption,and data storage[4].In particular,those exhibiting NIR-II luminescence(1000-1700 nm)provide key advantages such as deeper tissue penetration,higher contrast,and minimal interference from biological autofluorescence.However,challenges such as low brightness and rapid signal decay,especially in the NIR-II region,limit their effectiveness in long-term monitoring,including tumor theranostics[5].Traditional approaches like size control and surface passivation yield only marginal improvements,underscoring the need for next-generation nanoparticles with superior NIR-II brightness.
文摘Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a rare phenomenon.In the general population,the incidence of this condition is reported to be between 0.3%and 2.1%.[1]While this anatomical variation is often asymptomatic and discovered incidentally,it becomes relevant in certain clinical scenarios.Indeed,the presence of a PLSVC and double superior vena cava can pose challenges as incorrect positioning and result in failure.
文摘Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.
基金supported by the National Natural Science Foundation of China(Nos.42077299,and U21A20290)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750400)the Ordos Key Research and Development Program(No.YF20240037).
文摘Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.
基金National Key R&D Program of China(2023YFB3506600)。
文摘Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent luminescent material applications.At present,YAGG:Ce^(3+),Cr^(3+)powders exhibit good persistent performance,but their persistent performance of ceramics still needs to be further improved to meet the new requirements.In this work,(Y_(0.998)Ce_(0.002))_(3)(Al_(1-x)Cr_(x))_(2)Ga_(3)O_(12) ceramics with different Cr^(3+)doping concentrations were prepared by solid-state reaction,including air pre-sintering,hot isostatic pressing(HIP)post-treatment and air annealing,to investigate the effects of Cr^(3+)doping concentration on the microstructure,optical properties and persistent performance of the ceramics.The results showed that as the doping concentration of Cr^(3+)increased from 0.025%to 0.2%(in atom),no significant effect of Cr^(3+)concentration on the morphology of pre-sintered ceramics or HIP post-treatment ceramics was observed,but the in-line transmittance gradually increased while the persistent performance gradually decreased.Among them,YAGG:Ce^(3+),Cr^(3+)ceramics doped with 0.025%Cr^(3+)showed the strongest initial luminescence intensity exceeding 6055 mcd/m^(2) and a persistent time of 1030 min after air pre-sintering combined with HIP post-treatment and air annealing.By optimizing the Cr^(3+)doping concentration and the fabrication process,the persistent luminescence(PersL)performance of the YAGG:Ce^(3+),Cr^(3+)ceramics was obviously improved.
基金supported by the Russian Science Foundation (Grant No. 22-12-00298)supported by the Center of Excellence "Center of Photonics" funded by the Ministry of Science and Higher Education of the Russian Federation, Contract #075-15-2022-316the Theoretical Physics and Mathematics Advancement Foundation "BASIS" scholarship for the support.
文摘In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide radiation quantum energy range of 0.62–3.1 eV both at T=4.2 K and at T=77 K.Common features of the PPC spectra for all structures were revealed,and their relation to the presence of a CdTe cap layer in all structures and the appropriate cadmium fraction in the CdHgTe barrier layers was shown.One of the features was associated with the presence of a deep level in the CdTe layer.In addition,the oscillatory behavior of the PPC spectra in the region from 0.8–1.1 eV to 1.2–1.5 eV was observed.It is associated with the cascade emission of longitudinal optical phonons in CdHgTe barrier.
基金Supported by the Key Medical Research Project of Hebei Province in 2020,No.20201360.
文摘BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum months,with notably high incidence rates even one year after childbirth.Persistent PPD has been associated with poor developmental outcomes in infants,highlighting the need for continued monitoring and support during this critical period.Understanding the broader impacts of persistent PPD is essential for developing effective interventions to improve maternal and infant well-being.AIM To explore the impact of persistent PPD on infant developmental behavior and maternal self-efficacy.METHODS We recruited 60 postpartum women who experienced persistent depression after childbirth in our hospital from January 2020 to December 2024 as the research subjects.The study collected basic characteristics of both infants and mothers,analyzed the self-efficacy of the mothers and the developmental behaviors of the infants,and conducted a correlation analysis to examine the relationship between postpartum persistent depression in mothers and the developmental behaviors and self-efficacy of infants.The Bootstrap method was used to verify the significance of the mediating effect.RESULTS The basic characteristics of infants and mothers show that 53.33%are male,58.33%are born via vaginal delivery,88.33%have a normal body mass index,51.67%are aged between 25 and 29 years,70%are non-agricultural workers,51.67%have a per capita household income over 4000 yuan,96.67%are full-term births,and 58.33%of the fathers are aged between 26 and 32 years.In terms of infant development behavior,the gross motor skills score is relatively low(38.44±12.15).Regarding maternal self-efficacy,the skill score(45.68±5.49)and mental activity score(46.37±3.72)are both at a low level.Correlation analysis reveals that postpartum persistent depression is significantly negatively correlated with maternal self-efficacy and infant development behavior(β=-0.439,-0.657,P<0.001),while self-efficacy is positively correlated with infant development behavior(β=0.728,P<0.001).The path coefficient and Bootstrap method test indicate that self-efficacy acts as a mediator between postpartum persistent depression and infant development behavior,accounting for 54.80%of the effect(P<0.05),while the direct effect of postpartum persistent depression on infant development behavior is 45.20%(P<0.05).CONCLUSION Persistent PPD significantly negatively impacts infant developmental outcomes,with maternal self-efficacy serving as a partial mediator.These findings suggest that interventions targeting both depressive symptoms and selfenhancement may effectively promote infant health development.
基金supported by grants from the National Key R&D Program of China(grant number 2021YFD1400900)the National Natural Science Foundation of China(grant numbers U1905201,32171805)+6 种基金the Forestry Key Program of Science and Technology in Fujian Province(grant number 2021FKJ03)the Natural Science Foundation of Fujian Province,China(grant number 2021J01056)the Forestry Programs of Science and Technology in Fujian Province[grant number Mincaizhi(2020)601]the Science and Technology Program of Fujian Province(grant number 2018N5002)the Forestry Science Research Project of Fujian Forestry Department[grant number Minlinke(2017)03]the National Major Emergency Science and Technology Program of China(grant number ZD202001)the Forestry Peak Discipline Construction Project of Fujian Agriculture and Forestry University(grant numbers 72202200205,71201800720).
文摘The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.
基金supported by the National Undergraduate Innovation and Entrepreneurship Training Program of China(Project No.202510559076)at Jinan University,a nationwide initiative administered by the Ministry of Educationthe National Natural Science Foundation of China(NSFC)under Grant No.62172189.
文摘Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security threats.Programmable switches provide line-rate packet processing to meet the requirements of high-speed network environments,yet they are fundamentally limited in computational and memory resources.Accurate and memoryefficient persistent flow detection on programmable switches is therefore essential.However,existing approaches often rely on fixed-window sketches or multiple sketches instances,which either suffer from insufficient temporal precision or incur substantial memory overhead,making them ineffective on programmable switches.To address these challenges,we propose SP-Sketch,an innovative sliding-window-based sketch that leverages a probabilistic update mechanism to emulate slot expiration without maintaining multiple sketch instances.This innovative design significantly reduces memory consumption while preserving high detection accuracy across multiple time intervals.We provide rigorous theoretical analyses of the estimation errors,deriving precise error bounds for the proposed method,and validate our approach through comprehensive implementations on both P4 hardware switches(with Intel Tofino ASIC)and software switches(i.e.,BMv2).Experimental evaluations using real-world traffic traces demonstrate that SP-Sketch outperforms traditional methods,improving accuracy by up to 20%over baseline sliding window approaches and enhancing recall by 5%compared to non-sliding alternatives.Furthermore,SP-Sketch achieves a significant reduction in memory utilization,reducing memory consumption by up to 65%compared to traditional methods,while maintaining a robust capability to accurately track persistent flow behavior over extended time periods.
基金the National Natural Science Foundation of China(12364044)Yunnan Major Scientific and Technological Projects(202202AG050004,202202AG050016,202302AQ370003)+1 种基金the International Joint Innovation Platform of Yunnan Province(202203AP140004)the Outstanding Youth Project of Yunnan Province Applied Basic Research Project(202401AV070012).
文摘Scintillator is a key material for the development of X-ray detectors,which has a promising application in medical imaging,security inspection and industrial non-injury detection.The majority of scintillators currently used in imaging are real-time imaging scintillators,which can cause ionization radiation damage to biological subjects or detection equipment during the imaging process and require complex,highly sensitive detection systems.Therefore,exploring stable,environmentally friendly scintillator materials that can achieve delayed imaging is of significance in the field of imaging.Herein,we devel-oped an X-ray time-lapse imaging scintillator,Sr_(2)Al_(6)O_(11):Dy^(3+)phosphor,which generates stable traps by X-ray irradiation,thus endowing it with excellent persistent luminescence and information storage properties(>42 d).Moreover,traps constructed by X-ray can be repeatedly refilled(>40 times)under UV light and carriers are released in theform of mechanical or thermal excitation when refilling is complete.By constructing the traps in the phosphor during X-ray excitation and using it for repetitive imaging,the detection limit is 74.78 nGy/s,and the spatial imaging resolution is as high as 16 lp/mm.This discovery providesa new idea for the development oftime-delayed X-ray scintillator.
基金Supported by Beijing Municipal Science&Technology Commission Program:Z151100004015117Shenzhen Science and Technology Plan Project:JCYJ20210324120804012Shenzhen Luohu District Soft Science Research Plan project:LX202202128。
文摘Objective:Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis(AR),it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy.This multicenter,non-inferiority,single-blinded randomized controlled trial aimed to compare the differences in efficacy between warm needling(WN)therapy and loratadine(LO)in improving AR symptoms and quality of life.Methods:A total of 98 patients with persistent AR(PAR)were randomly divided into two groups in a 1:1 ratio:treatment group receiving WN therapy at Dazhui(GV14)and normal acupuncture at other acupoints for 12 sessions in 4 weeks and control group receiving LO at a dosage of 10 mg/day for oral administration.The study duration was 28 weeks(4-week treatment period with a 24-week follow-up).The primary outcome was the mean change in the Total Nasal Symptom Score(TNSS)from baseline to week 28,and the secondary outcomes included the Total Non-Nasal Symptom Score(TNNSS)and the Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)score.Statistical analyses were conducted us-ing SPSS22.0.Both intention-to-treat and treatment compliance analyses were performed to analyze all outcomes.Results:After intervention,TNSS scores improved from baseline to week 28 by 5.18(95%confidence interval[CI]:3.91,6.45;P<0.001)in the WN group and 4.59(95%CI 3.28,5.89;P<0.001)in the LO group,but the changes did not differ between the groups(P=0.515).The margin by 95%CI(−1.20,2.38)was not reached,indicating non-inferiority.WN therapy resulted in clinical improvements in TNNSS,with a significant difference com pared with LO treatment(f=5.466,P=0.021).WN therapy also resulted in clinical improvements in RQLQ scores,with a significant difference compared with LO(f=9.222,P=0.003).Conclusions:WN therapy demonstrated comparable efficacy to oral LO in improving nasal symptoms of PAR.However,it showed superior effects in alleviating concomitant nasal symptoms and enhancing patients’quality of life.
基金supported by the National Key R&D Program of China(Nos.2022YFA0806600,2022YFC3400700)the Fundamental Research Funds for the Central Universities(No.2042024kf1045)+2 种基金the National Natural Science Foundation of China(No.22277093)the Key Research and Development Project of Hubei Province(No.2023BCB094)the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(No.JCRCGW-2022008)。
文摘Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are involved in numerous physiological processes.However,research on the effects of PFOA on epigenetic modifications is still limited.In this study,we systematically investigated the alterations in epigenetic modifications in both DNA and RNA from the heart,liver,spleen,lung,kidney,and brain of C57BL/6N mice following exposure to PFOA at doses of 0,0.5,and 5 mg kg^(-1)d^(-1),utilizing liquid chromatography-tandem mass spectrometry(LC-MS/MS).The results indicated that exposure to PFOA inhibited weight gain in mice,and significant changes were observed in the organ coefficients of the liver,spleen,lungs,and heart in the high PFOA exposure group.Modifications in DNA and RNA exhibited tissue specificity.Orthogonal partial least squares discriminant analysis revealed that the control group and the high PFOA exposure group clustered well,suggesting that PFOA exposure significantly impacts epigenetic modifications in DNA and RNA.Specifically,PFOA exposure significantly affected the levels of 5-hydroxymethylcytosine(5hmC)in genomic DNA in the heart,lung,kidney,and liver tissues.For RNA modifications,significant changes were observed,with the levels of 12,13,10,6,12,and 14 modifications in the heart,liver,spleen,lung,kidney,and brain,respectively,altered in response to PFOA exposure.Our study highlights the significance of PFOA exposure in altering DNA and RNA modifications,providing a new perspective on understanding the toxicology of PFOA from an epigenetic standpoint.
文摘Background Persistent pulmonary hypertension(PPHN)of the newborn is one of the major contributors to neonatal mortality.Current conventional treatments for PPHN primarily encompass mechanical ventilation,inhaled nitric oxide(iNO),sildenafil,and magnesium sulfate.In confirmed cases of neonatal respiratory distress syndrome,pulmonary surfactant(PS)can be considered as a potential treatment option;However,the optimal dosage and administration frequency of PS remain subjects of ongoing debate.This study aimed to assess the efficacy of early repeated endotracheal PS administration combined with iNO therapy in the management of newborns with PPHN.Methods Twenty-three neonates with PPHN received iNO alongside foundational treatments,including anti-infection therapy,mechanical ventilation,acidosis correction,and blood pressure stabilization.The observation group(n=13)received endotracheal instillation of PS three times,with each administration spaced six hours apart;The control group(n=10)received endotracheal instillation of PS once.Parameters compared included blood gas indices,oxygenation index(OI),alveolar-arterial oxygen partial pressure difference(PA-aDO,),pulmonary artery systolic pressure(PAP),and N-terminal pro-brain natriuretic peptide(NT-pro-BNP).Mechanical ventilation duration,oxygen therapy time,hospitalization length,and survival outcomes were recorded and compared between groups.Results The blood gas parameters,OI,and PA-aDO,showed no significant differences between the two groups of children before treatment(P>0.05).By 24-hour post-treatment,both groups exhibited significant increases in partial pressure of oxygen(PaO,)and potential of hydrogen(PH)levels,alongside significant decreases in lactate,partial pressure of carbon dioxide(PaCO,),OI,and PA-aDO2,with statistically significant differences(P<0.05).By 48-hour post-treatment,the observation group demonstrated significantly better improvements in blood gas parameters,OI,and PA-aDO,compared to the control group,and these differences were statistically significant(P<0.05).There was no statistically significant difference in PAP and NT-pro-BNP levels between the two groups before treatment(P>0.05).After treatment,both groups showed significant decreases in PAP and NT-pro-BNP levels(P<0.05),with a more pronounced reduction observed in the observation group(P<0.05).The observation group had significantly shorter durations of mechanical ventilation and oxygen therapy compared to the control group,with statistically significant differences(P<0.05).Additionally,the observation group exhibited a shorter total hospital stay and a lower mortality rate than the control group,though these differences were not statistically significant(P>0.05).Conclusions Early consecutive multiple doses of PS combined with iNO,compared to a single dose,better improves respiratory function indices,maintains stability,reduces pulmonary artery pressure,enhances cardiac function,shortens ventilator dependency,and increases cure rates in PPHN neonates.This approach is particularly suitable for severe PPHN cases,especially those with underlying pulmonary conditions.
基金supported by the National Natural Science Foundation of China(Nos.52172156,12474412)the Natural Science Foundation of Fujian Province(No.2023J06005)+2 种基金the Natural Science Foundation of Guangdong Province(No.2024A1515011197)the Fundamental Research Funds for the Central Universities(No.20720240057)The DFT calculations in this work was done with the assistance of the Intelligent Computing Center of Tan Kah Kee Innovation Laboratory(IKKEM).
文摘Persistent Luminescence(PersL)materials,which use traps to store energy and emit photons over a long period,have found important applications in the fields of optical information storage,security labeling,and biological imaging.The trap depth is a crucial factor determining the performance of these materials;however,achieving the desired trap depth with high precision remains a great challenge.Here,we provide double perovskite phosphors(Cs_(2)SnCl_(6)-Cs_(2)ZrCl_(6)-Cs_(2)HfCl_(6)series)with highly compatible crystal structures,enabling continuous and precise tuning of trap depth over an ultra-wide range of 0.11-1.25 eV.By incorporating W4+as the luminescent centers,these phosphors exhibit outstanding near-infrared(NIR)PersL performance at approximately 900 nm and a lasting emission duration exceeding 10 h.The underlying mechanism of PersL is elucidated,and the wide-range tunability of trap depth is attributed to the universal applicability of band-gap engineering in the entire material system.Furthermore,we demonstrate the practical application of these materials by designing a flexible detector plate for X-ray imaging.The detector plate exhibits a storage time of more than 1 week,a detection limit of 0.83μGyair·s^(-1)in the near-infrared region,and real-time and delay-time imaging resolutions of 14.2 lp·mm^(-1)and 2.5 lp·mm^(-1),respectively.These attributes demonstrate strong potential for X-ray luminescence extension imaging.
基金Project supported by the Department of Science and Technology of Zhejiang Province,China(2024C01192)。
文摘Ce^(3+),due to its broadband emission,has the potential to serve as a donor ion for energy transfer to achieve the possible efficient tunable multi-emission in materials.However,current related research primarily focuses on photoluminescent(PL)phosphors,while studies on achieving tunable long persistent luminescence(LPL),particularly in glass materials,are insufficient.In this work,Ce-Tb codoped boroaluminate glass was synthesized using a high-temperature melting method under a reducing atmosphere.Under the influence of oxygen vacancy traps induced during the reduction of Ce^(4+)to Ce^(3+),glass samples exhibit an obvious LPL with a broadband center wavelength at 420 nm and a narrowband center wavelength at 547 nm,which correspond well to Ce^(3+)ions'd-f transitions and Tb^(3+)ions'f-f transitions,respectively.A reasonable Ce^(3+)doping amount achieves the optimal trap depth and concentration to enhance LPL intensity and duration.Additionally,it improves the PL intensity of Tb^(3+)by enhancing the energy transfer from Ce^(3+)to Tb^(3+),thereby enabling the glass to exhibit variable LPL colo rs ranging from blue to cyan.Finally,based on the PL and LPL characteristics of the samples,a dynamic encryption anticounterfeiting application is described.
基金the Natural Science Foundation of Beijing(L232118)the National Natural Science Foundation of China(T2341006)+1 种基金the Beijing University of Chinese Medicine Basic Research Operating Funds(2023‐JYB‐JBZD‐023the High‐Level Key Discipline of National Administration of Traditional Chinese Medicine—Traditional Chinese Constitutional Medicine(zyyzdxk‐2023251).
文摘Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and thereby are attributed to socio‐psychological reasons and treated by psychological interventions,such as cognitive behavior treatment.However,it is not ideal to rationalize and manage the PPS lack of pathophysiological explanation relying on psychological approaches.The entrenched disease‐centered biomedical mode limits the perception of PPS.Traditional medicine is a unique methodology of medicine independent from biomedical mode.Traditional Chinese medicine(TCM),achieved knowledge of health and disease from extensive observation and developed theoretical framework based on ancient mathematics using the principles of ancient naive materialism and dialectical materialism,has amassed extensive experience in symptom management.Particularly,the system of body constitution in TCM serves a reference model of evidence‐based integration of traditional and modern medicine in healthcare,and offers a promising approach for managing PPS.Nine types of body constitution were identified and validated through a series of scientific research.Individuals with a specific type of body constitution tend to present a corresponding cluster of symptoms,physical signs,disease susceptibility and prognosis.Adjustment of unhealthy constitution helps the symptom control and disease management.Standardized protocol of body constitution classification was established as an industry standard,and that of body constitution adjustment was compiled as clinical guidelines for quality control.Taken together,such evidence‐based integration of traditional medicine with modern medicine provides new avenues for managing PPS effectively.
文摘It is with profound respect and gratitude that we dedicate this special issue of the Journal of Environmental Sciences to the memory of Professor Chuanyong Jing,whose outstanding contributions to environmental sciences have advanced the field and continue to resonate with both academia and the broader environmental community.
基金Guizhou Provincial Health Commission(Project No.:gzwkj2023-429)。
文摘Persistent infection with high-risk human papillomavirus(HR-HPV)is the core pathogenic factor of cervical cancer(CC).Although HPV vaccination is an effective primary prevention method for CC,the global vaccination rate is generally insufficient(target population vaccination rate in China<5%),far from meeting the requirements for herd immunity(80%)and the WHO target(90%).However,only about 10% of HR-HPV infections progress to persistent infections.Therefore,identifying and intervening in the“HR-HPV persistent infection”population can systematically narrow the scope of prevention and control,reduce prevention and control costs,and provide a new path for low-income countries to explore suitable prevention and control models for CC.Based on this understanding,the team has pioneered a systematic method for identifying HR-HPV persistent infections and a tiered intervention system based on drug classification,which has achieved good results in both basic research and clinical observations.This article will summarize the current research status of“HR-HPV persistent infection”in relation to CIN and CC,as well as the team’s relevant concepts and research results,to provide a reference for the identification and intervention of“HR-HPV persistent infection.”
基金supported by the National Natural Science Foundation of China(Nos.12172019 and 42477210).
文摘We present a grid-growth method to reconstruct 3D rock joints with arbitrary joint roughness and persistence.In the first step of this workflow,the joint model is divided into uniform grids.Then by adjusting the positions of the grids,the joint morphology can be modified to construct models with desired joint roughness and persistence.Accordingly,numerous joint models with different joint roughness and persistence were built.The effects of relevant parameters(such as the number,height,slope of asperities,and the number,area of rock bridges)on the joint roughness coefficient(JRC)and joint persistence were investigated.Finally,an artificially split joint was reconstructed using the method,and the method's accuracy was evaluated by comparing the JRC of the models with that of the artificially split joint.The results showed that the proposed method can effectively control the JRC of joint models by adjusting the number,height,and slope of asperities.The method can also modify the joint persistence of joint models by adjusting the number and area of rock bridges.Additionally,the JRC of models obtained by our method agrees with that of the artificially split surface.Overall,the method demonstrated high accuracy for 3D rock joint reconstruction.
