The effect of oxygen partial pressure （Po2） during the channel layer deposition on bias stability of amorphous indium-gallium-zinc oxide （a-IGZO） thin film transistors （TFTs） is investigated. As Po2 increases fr...The effect of oxygen partial pressure （Po2） during the channel layer deposition on bias stability of amorphous indium-gallium-zinc oxide （a-IGZO） thin film transistors （TFTs） is investigated. As Po2 increases from 10% to 30%, it is found that the device shows enhanced bias stress stability with significantly reduced threshold voltage drift under positive gate bias stress. Based on the x-ray photoelectron spectroscopy measurement, the concentration of oxygen vacancies （Or） within the a-IGZO layer is suppressed by increasing Po2. Meanwhile, the low-frequency noise analysis indicates that the average trap density near the channel/dielectric interface continuously drops with increasing Po2. Therefore, the improved interface quality with increasing Po2 during the channel layer deposition can be attributed to the reduction of interface Ov-related defects, which agrees with the enhanced bias stress stability of the a-IGZO TFTs.展开更多
Hippocampal volume loss is an important biomarker in distinguishing subjects with Alzheimer＇s disease （AD） and its measurement in magnetic resonance images （MRI） is influenced by partial volume effects （PVE）. T...Hippocampal volume loss is an important biomarker in distinguishing subjects with Alzheimer＇s disease （AD） and its measurement in magnetic resonance images （MRI） is influenced by partial volume effects （PVE）. This paper describes a post-processing approach to quantify PVE for correction of the hippocampal volume by using a spatial fuzzyC-means （SFCM） method. The algorithm is evaluated on a dataset of 20 T1-weighted MRI scans sampled at two different resolutions. The corrected volumes for left and right hippocampus （HC） which are 23% and 18% for the low resolution and 6% and 5% for the high resolution datasets, respectively are lower than hippocampal volume results from manual segmentation. Results show the importance of applying this technique in AD detection with low resolution datasets.展开更多
The effect of salt solutions(NaCl,Na2SO4 and CaCl2) on the conformational properties of partially hydrolyzed polyacrylamide(HPAM) was investigated by using static laser light scattering(SLLS).The special interaction b...The effect of salt solutions(NaCl,Na2SO4 and CaCl2) on the conformational properties of partially hydrolyzed polyacrylamide(HPAM) was investigated by using static laser light scattering(SLLS).The special interaction between CaCl2 solution and HPAM was also researched.Experimental results show that the chain structure of HPAM is interrelated with the charge density,the kind and the concentration of salt solutions.The mean-square radius of gyration(Rz) and the second virial coefficient(A2) of HPAM decrease with increasing concentration of salt solutions,and the salt effect tends towards the maximum when the concentration of salt solution is increased to some amount.展开更多
To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1]...To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim of this study was to analyse the impact of terlipressin ver-展开更多
Magnetic resonance elastography (MRE) allows the quantitative assessment of the stiffness of tissues based on the tissue response to oscillatory shear stress. Shear wave displacements of the tissues are encoded as pha...Magnetic resonance elastography (MRE) allows the quantitative assessment of the stiffness of tissues based on the tissue response to oscillatory shear stress. Shear wave displacements of the tissues are encoded as phase shifts and converted to stiffness (elastogram). Generally, a partial volume effect occurs when different materials are encompassed on the same voxel. In MRE, however, the partial volume effect occurs even if the voxel is filled with the same materials because wave displacements due to vibrations are spatially distributed. The purpose of this study was to investigate how the partial volume effect can affect the phase shift and the elastogram in MRE. We assumed that the partial volume effect appears only in the slice thickness direction and performed a simulation and MRE experiment with various slice thicknesses (1 - 19 mm), two types of imaging plane (coronal and axial) and two types of vibration frequency (100 and 200 Hz). The results of the simulation and the MRE experiment were similar, and indicated that the phase shift and the elastogram changed variously depending on the slice thickness, the wave pattern and the vibration frequency, even if the voxel was filled with the same material. To reduce the partial volume effect, it is necessary to perform the MRE under the following conditions: Use a wave pattern which barely causes this artefact, a smaller voxel size and a lower vibration frequency.展开更多
The variation of the magnetic properties of the nanocrystalline alloys for the partial substitution of V for Nb with crystallizing treatment temperature and time was investigated. The variation law of the magnetic pro...The variation of the magnetic properties of the nanocrystalline alloys for the partial substitution of V for Nb with crystallizing treatment temperature and time was investigated. The variation law of the magnetic properties with the annealing temperature and time is essentially the same. The magnetic properties of the Fe-based nanocrystalline alloys for the partial substitution of V for Nb reduce, and the crystallizing treatment temperature of the alloys increases. The optimum properties of Fe74Cu1Nb3Si13B9 nanocrystalline alloys crystallized at 550℃x60 min are μ0=9.2xl0^4, μm=54.8xl0^4, Hc=1.14 A/m and Bs=1.26 T. The best properties for Fe74Cu1Nb3Si13B9 alloys annealed at 560℃x60 min are μ0=8.79x10^4, μm=50.18xl0^4, Hc=1.26 A/m and Bs=1.24 T.展开更多
BACKGROUND： Many researches have indicated that the imbalances of various amino acid transmitters and neurotransmitters in brain are involved in the formation of alcohol withdrawal, especially that glutamic acid is o...BACKGROUND： Many researches have indicated that the imbalances of various amino acid transmitters and neurotransmitters in brain are involved in the formation of alcohol withdrawal, especially that glutamic acid is one of the important transmitters for alcohol tolerance in central nervous system. OBJECTIVE： To observe the changes of excitatory amino acids in hippocampal dentate gyrus in rats with long-term alcohol drinking after withdrawal under consciousness, and investigate the therapeutic effect of topiramate on alcohol withdrawal. DESIGN ： A randomized control animal experiment SETTING ： Department of Neurology, Affiliated Hospital of Yanbian University MATERIALS： Thirty male Wistar rats of 4 months old, weighing 300-350 g, were purchased from the Experimental Animal Department, Medical College of Yanbian University. Topiramate was produced by Swish Cilag Company, and the batch number was 02CS063. METHODS： The experiments were carried out in the Department of Physiology, Medical College of Yanbian University from August 2005 to February 2006. ① The rats were divided randomly into three groups： control group （n=10）, alcohol group （n=10） and topiramate-treated group （n=10）. Rats in the alcohol group and topiramate-treated group were given intragastric perfusion of 500 g/L alcohol （10 mL/kg）, once a day for 4 weeks successively, and then those in the topiramate-treated group were treated with 80 mg/kg topiramate at 24 hours after the last perfusion of alcohol, once a day for 3 days successively. Rats in the control group were intragastricly given isovolume saline. ② The withdrawal symptoms were assessed at 6, 30, 48 and 72 hours after the last perfusion of alcohol by using the withdrawal rating scale set by Erden et al, which had four observational indexes of stereotyped behaviors, agitation, tail stiffness and abnormal posture, each index was scored by 5 points, the higher the score, the more obvious the symptoms. ③ The contents of aspartic acid and glutamic acid in hippocampal dentate gyrus were detected with microdialysis technique and high-performance liquid chromatograpy （HPLC） respectively at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the three groups. MAIN OUTCOME MEASURES ： ① Scoring results of alcohol withdrawal symptoms; ② Changes of the contents of aspartic acid and glutamic acid in hippocampal dentate gyrus at the alcohol withdrawal symptoms, and the effects of topiramate. RESULTS： Seven rats were excluded due to inaccurate localization and natural death, and 23 rats were involved in the analysis of results. ①In the alcohol group, the scores of alcohol withdrawal symptoms at 30 and 48 hours after the last perfusion of alcohol were obviously higher than those in the control group （10.50±0.96, 14.17±1.25; 3.50±0.92, 3.16±0,31; P 〈 0.01）. In the topiramate-treated group, the scores at 30 hours after the last perfusion of alcohol （6.06±0.82, 3.50±0.92, P 〈 0.05）, and the withdrawal scores at 48 and 72 hours were close to those in the control group （4.57±0.58, 3.30±0.71; 3.16±0.31, 3.66±0.67; P 〉 0.05）.② Changes of the contents of glutamic acid in hippocampal dentate gyrus： In the alcohol group, the content of glutamic acid at 48 hours after the last perfusion of alcohol was significantly increased as compared with that at 6 hours [（143.32±11.42）%, （99.12±0.69）%; P 〈 0.05], and that at 72 hours was close to that at 6 hours [（78.50±16.40）%, （99.12±0.69）%; P 〉 0.05]. The contents of glutamic acid had no obvious differences at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the topiramate-treated group [（100.30±0.37）%, （118.91±10.40）%, （99.55±12.81）%, （99.08±11.42）%; P 〉 0.05], The content of glutamic acid at 48 hours after the last perfusion of alcohol in the topiramate-treated group was obviously lower than that in the alcohol group （P 〈 0.05）, and those at 30 and 72 hours were close （P 〉 0.05）. ③ Changes of the contents of aspartic acid in hippocampal dentate gyrus： In the alcohol group, the contents of aspartic acid at 30 and 48 hours after the last perfusion of alcohol were significantly increased as compared with that at 6 hours [（126.60±8.67）%, （129.17±10.40）%, （99.25±0.87）%; P 〈 0.05], and that at 72 hours was close to that at 6 hours [（89.87±9.93）%, （99.25±0.87）%; P 〉 0.05]. The contents of aspartic acid had no obvious differences at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the topiramate-treated group [（100.27±0.32）%, （120.81 ±12.63）%, （98.91±7.83）%, （85.92±8.07）%; P 〉 0.05]. The content of aspartic acid at 48 hours after the last perfusion of alcohol in the topiramate-treated group was obviously lower than that in the alcohol group （P 〈 0.05）, and those at 30 and 72 hours were close （P 〉 0.05）. CONCLUSION： ① The occurrences of alcohol withdrawal symptoms are correlated with the increased contents of excitatory amino acids in hippocampal dentate gyrus in rats. ② Topiramate can alleviate the alcohol withdrawal symptoms, which may be correlated with the decreased contents of excitatory amino acids in hippocampal dentate gyrus in rats.展开更多
The hysteresis effect in the output characteristics,originating from the floating body effect,has been measured in partially depleted（PD） silicon-on-insulator（SOI） MOSFETs at different back-gate biases.I D hystere...The hysteresis effect in the output characteristics,originating from the floating body effect,has been measured in partially depleted（PD） silicon-on-insulator（SOI） MOSFETs at different back-gate biases.I D hysteresis has been developed to clarify the hysteresis characteristics.The fabricated devices show the positive and negative peaks in the I D hysteresis.The experimental results show that the I D hysteresis is sensitive to the back gate bias in 0.13-渭m PD SOI MOSFETs and does not vary monotonously with the back-gate bias.Based on the steady-state Shockley-Read-Hall（SRH） recombination theory,we have successfully interpreted the impact of the back-gate bias on the hysteresis effect in PD SOI MOSFETs.展开更多
In this paper, an efficient shrinkage estimation procedure for the partially linear varying coefficient model (PLVC) with random effect is considered. By selecting the significant variable and estimating the nonzero c...In this paper, an efficient shrinkage estimation procedure for the partially linear varying coefficient model (PLVC) with random effect is considered. By selecting the significant variable and estimating the nonzero coefficient, the model structure specification is accomplished by introducing a novel penalized estimating equation. Under some mild conditions, the asymptotic properties for the proposed model selection and estimation results, such as the sparsity and oracle property, are established. Some numerical simulation studies and a real data analysis are presented to examine the finite sample performance of the procedure.展开更多
Objective To explore the effect of doxazosin on rabbit bladder compliance after partial bladder outlet ob- struction. Methods A total of 40 male New Zealand white rabbits were randomized into 4 groups,with 10 rabbits ...Objective To explore the effect of doxazosin on rabbit bladder compliance after partial bladder outlet ob- struction. Methods A total of 40 male New Zealand white rabbits were randomized into 4 groups,with 10 rabbits in each group. Partial bladder outlet展开更多
Objective: To review our open partial nephrectomy (OPN) experience and compare to known robotic partial nephrectomy (RPN) data to determine whether length of stay (LOS) and morbidity are significant drivers in the sur...Objective: To review our open partial nephrectomy (OPN) experience and compare to known robotic partial nephrectomy (RPN) data to determine whether length of stay (LOS) and morbidity are significant drivers in the surgical approach employed for partial nephrectomy. Methods: We reviewed our OPN experience during the last 3 years examining age, tumor size, LOS, pathology, blood loss, complications, recurences, and deaths. Results: Seventy-five patients underwent OPN during this period. Mean age was 59 years, tumor size 2.8 cm, percent malignant 75%, estimated blood loss 350 cc. With a median follow-up of 18 months, there was one urinoma managed by drain-age, one pseudo aneurysm that required embolization and one pulmonary embolism that required anticoagulation. There were no readmissions, no tumor recurences, and no deaths. Our major complication rate was 4% as compared to other trials that re-ported major complication rates between 1% - 9% for RPN and between 3% - 24% for OPN. In the first half of the experience (n = 37), median LOS was 57 hours. Using a pathway encouraging early ambulation and smaller incisions in the second half of the experience (n = 38), median LOS was 35 hours. This is much shorter than reported RPN LOS of 62 - 67 hours and OPN LOS of 108 - 142 hours. Conclusion: OPN can be performed safely and effectively with one night hospital stay. This provides a more cost-effective approach to partial nephrectomy with similar or better complication rates and calls into question the main value drivers of RPN.展开更多
Rational planning of spares configuration project is an effective approach to improve equipment availability as well as reduce life cycle cost （LCC）. With an analysis of various impacts on support system, the spares...Rational planning of spares configuration project is an effective approach to improve equipment availability as well as reduce life cycle cost （LCC）. With an analysis of various impacts on support system, the spares demand rate forecast model is constructed. According to systemic analysis method, spares support effectiveness evaluation indicators system is built, and then, initial spares configuration and optimization method is researched. To the issue of discarding and con-sumption for incomplete repairable items, its expected backorders function is approximated by Laplace demand distribution. Combining the （s-1, s） and （R, Q） inventory policy, the spares resup-ply model is established under the batch ordering policy based on inventory state, and the optimi-zation analysis flow for spares configuration is proposed. Through application on shipborne equipment spares configuration, the given scenarios are analyzed under two constraint targets：one is the support effectiveness, and the other is the spares cost. Analysis reveals that the result is consistent with practical regulation;therefore, the model＇s correctness, method＇s validity as well as optimization project＇s rationality are proved to a certain extent.展开更多
A new partial-SOI （PSOI） high voltage device structure called a CI PSOI （charge island PSOI） is proposed for the first time in this paper. The device is characterized by a charge island layer on the interface of t...A new partial-SOI （PSOI） high voltage device structure called a CI PSOI （charge island PSOI） is proposed for the first time in this paper. The device is characterized by a charge island layer on the interface of the top silicon layer and the dielectric buried layer in which a series of equidistant high concentration n＋-regions is inserted. Inversion holes resulting from the vertical electric field are located in the spacing between two neighbouring n＋-regions on the interface by the force with ionized donors in the undepleted n＋-regions, and therefore effectively enhance the electric field of the dielectric buried layer （Ei） and increase the breakdown voltage （BV）, thereby alleviating the self-heating effect （SHE） by the silicon window under the source. An analytical model of the vertical interface electric field for the CI PSOI is presented and the analytical results are in good agreement with the 2D simulation results. The BV and El of the CI PSOI LDMOS increase to 631 V and 584 V/μm from 246 V and 85.8 V/μm for the conventional PSOI with a lower SHE, respectively. The effects of the structure parameters on the device characteristics are analysed for the proposed device in detail.展开更多
A conceptual model for microscopic-macroscopic slow-fast stochastic systems is considered. A dynamical reduction procedure is presented in order to extract effective dynamics for this kind of systems. Under appropriat...A conceptual model for microscopic-macroscopic slow-fast stochastic systems is considered. A dynamical reduction procedure is presented in order to extract effective dynamics for this kind of systems. Under appropriate assumptions, the effective system is shown to approximate the original system, in the sense of a probabilistic convergence.展开更多
基金Supported by the National Basic Research Program of China under Grant Nos 2010CB327504,2011CB922100 and2011CB301900the National Natural Science Foundation of China under Grant Nos 11104130 and 61322112+2 种基金the Natural Science Foundation of Jiangsu Province under Grant Nos BK2011556 and BK2011050the Priority Academic Program Development of Jiangsu Higher Education Institutionsand the NUPTSF Grant Nos NY213069 and NY214028
文摘The effect of oxygen partial pressure （Po2） during the channel layer deposition on bias stability of amorphous indium-gallium-zinc oxide （a-IGZO） thin film transistors （TFTs） is investigated. As Po2 increases from 10% to 30%, it is found that the device shows enhanced bias stress stability with significantly reduced threshold voltage drift under positive gate bias stress. Based on the x-ray photoelectron spectroscopy measurement, the concentration of oxygen vacancies （Or） within the a-IGZO layer is suppressed by increasing Po2. Meanwhile, the low-frequency noise analysis indicates that the average trap density near the channel/dielectric interface continuously drops with increasing Po2. Therefore, the improved interface quality with increasing Po2 during the channel layer deposition can be attributed to the reduction of interface Ov-related defects, which agrees with the enhanced bias stress stability of the a-IGZO TFTs.
文摘Hippocampal volume loss is an important biomarker in distinguishing subjects with Alzheimer＇s disease （AD） and its measurement in magnetic resonance images （MRI） is influenced by partial volume effects （PVE）. This paper describes a post-processing approach to quantify PVE for correction of the hippocampal volume by using a spatial fuzzyC-means （SFCM） method. The algorithm is evaluated on a dataset of 20 T1-weighted MRI scans sampled at two different resolutions. The corrected volumes for left and right hippocampus （HC） which are 23% and 18% for the low resolution and 6% and 5% for the high resolution datasets, respectively are lower than hippocampal volume results from manual segmentation. Results show the importance of applying this technique in AD detection with low resolution datasets.
基金Project(50673033) supported by the National Natural Science Foundation of China
文摘The effect of salt solutions(NaCl,Na2SO4 and CaCl2) on the conformational properties of partially hydrolyzed polyacrylamide(HPAM) was investigated by using static laser light scattering(SLLS).The special interaction between CaCl2 solution and HPAM was also researched.Experimental results show that the chain structure of HPAM is interrelated with the charge density,the kind and the concentration of salt solutions.The mean-square radius of gyration(Rz) and the second virial coefficient(A2) of HPAM decrease with increasing concentration of salt solutions,and the salt effect tends towards the maximum when the concentration of salt solution is increased to some amount.
文摘To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim of this study was to analyse the impact of terlipressin ver-
文摘Magnetic resonance elastography (MRE) allows the quantitative assessment of the stiffness of tissues based on the tissue response to oscillatory shear stress. Shear wave displacements of the tissues are encoded as phase shifts and converted to stiffness (elastogram). Generally, a partial volume effect occurs when different materials are encompassed on the same voxel. In MRE, however, the partial volume effect occurs even if the voxel is filled with the same materials because wave displacements due to vibrations are spatially distributed. The purpose of this study was to investigate how the partial volume effect can affect the phase shift and the elastogram in MRE. We assumed that the partial volume effect appears only in the slice thickness direction and performed a simulation and MRE experiment with various slice thicknesses (1 - 19 mm), two types of imaging plane (coronal and axial) and two types of vibration frequency (100 and 200 Hz). The results of the simulation and the MRE experiment were similar, and indicated that the phase shift and the elastogram changed variously depending on the slice thickness, the wave pattern and the vibration frequency, even if the voxel was filled with the same material. To reduce the partial volume effect, it is necessary to perform the MRE under the following conditions: Use a wave pattern which barely causes this artefact, a smaller voxel size and a lower vibration frequency.
文摘The variation of the magnetic properties of the nanocrystalline alloys for the partial substitution of V for Nb with crystallizing treatment temperature and time was investigated. The variation law of the magnetic properties with the annealing temperature and time is essentially the same. The magnetic properties of the Fe-based nanocrystalline alloys for the partial substitution of V for Nb reduce, and the crystallizing treatment temperature of the alloys increases. The optimum properties of Fe74Cu1Nb3Si13B9 nanocrystalline alloys crystallized at 550℃x60 min are μ0=9.2xl0^4, μm=54.8xl0^4, Hc=1.14 A/m and Bs=1.26 T. The best properties for Fe74Cu1Nb3Si13B9 alloys annealed at 560℃x60 min are μ0=8.79x10^4, μm=50.18xl0^4, Hc=1.26 A/m and Bs=1.24 T.
文摘BACKGROUND： Many researches have indicated that the imbalances of various amino acid transmitters and neurotransmitters in brain are involved in the formation of alcohol withdrawal, especially that glutamic acid is one of the important transmitters for alcohol tolerance in central nervous system. OBJECTIVE： To observe the changes of excitatory amino acids in hippocampal dentate gyrus in rats with long-term alcohol drinking after withdrawal under consciousness, and investigate the therapeutic effect of topiramate on alcohol withdrawal. DESIGN ： A randomized control animal experiment SETTING ： Department of Neurology, Affiliated Hospital of Yanbian University MATERIALS： Thirty male Wistar rats of 4 months old, weighing 300-350 g, were purchased from the Experimental Animal Department, Medical College of Yanbian University. Topiramate was produced by Swish Cilag Company, and the batch number was 02CS063. METHODS： The experiments were carried out in the Department of Physiology, Medical College of Yanbian University from August 2005 to February 2006. ① The rats were divided randomly into three groups： control group （n=10）, alcohol group （n=10） and topiramate-treated group （n=10）. Rats in the alcohol group and topiramate-treated group were given intragastric perfusion of 500 g/L alcohol （10 mL/kg）, once a day for 4 weeks successively, and then those in the topiramate-treated group were treated with 80 mg/kg topiramate at 24 hours after the last perfusion of alcohol, once a day for 3 days successively. Rats in the control group were intragastricly given isovolume saline. ② The withdrawal symptoms were assessed at 6, 30, 48 and 72 hours after the last perfusion of alcohol by using the withdrawal rating scale set by Erden et al, which had four observational indexes of stereotyped behaviors, agitation, tail stiffness and abnormal posture, each index was scored by 5 points, the higher the score, the more obvious the symptoms. ③ The contents of aspartic acid and glutamic acid in hippocampal dentate gyrus were detected with microdialysis technique and high-performance liquid chromatograpy （HPLC） respectively at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the three groups. MAIN OUTCOME MEASURES ： ① Scoring results of alcohol withdrawal symptoms; ② Changes of the contents of aspartic acid and glutamic acid in hippocampal dentate gyrus at the alcohol withdrawal symptoms, and the effects of topiramate. RESULTS： Seven rats were excluded due to inaccurate localization and natural death, and 23 rats were involved in the analysis of results. ①In the alcohol group, the scores of alcohol withdrawal symptoms at 30 and 48 hours after the last perfusion of alcohol were obviously higher than those in the control group （10.50±0.96, 14.17±1.25; 3.50±0.92, 3.16±0,31; P 〈 0.01）. In the topiramate-treated group, the scores at 30 hours after the last perfusion of alcohol （6.06±0.82, 3.50±0.92, P 〈 0.05）, and the withdrawal scores at 48 and 72 hours were close to those in the control group （4.57±0.58, 3.30±0.71; 3.16±0.31, 3.66±0.67; P 〉 0.05）.② Changes of the contents of glutamic acid in hippocampal dentate gyrus： In the alcohol group, the content of glutamic acid at 48 hours after the last perfusion of alcohol was significantly increased as compared with that at 6 hours [（143.32±11.42）%, （99.12±0.69）%; P 〈 0.05], and that at 72 hours was close to that at 6 hours [（78.50±16.40）%, （99.12±0.69）%; P 〉 0.05]. The contents of glutamic acid had no obvious differences at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the topiramate-treated group [（100.30±0.37）%, （118.91±10.40）%, （99.55±12.81）%, （99.08±11.42）%; P 〉 0.05], The content of glutamic acid at 48 hours after the last perfusion of alcohol in the topiramate-treated group was obviously lower than that in the alcohol group （P 〈 0.05）, and those at 30 and 72 hours were close （P 〉 0.05）. ③ Changes of the contents of aspartic acid in hippocampal dentate gyrus： In the alcohol group, the contents of aspartic acid at 30 and 48 hours after the last perfusion of alcohol were significantly increased as compared with that at 6 hours [（126.60±8.67）%, （129.17±10.40）%, （99.25±0.87）%; P 〈 0.05], and that at 72 hours was close to that at 6 hours [（89.87±9.93）%, （99.25±0.87）%; P 〉 0.05]. The contents of aspartic acid had no obvious differences at 6, 30, 48 and 72 hours after the last perfusion of alcohol in the topiramate-treated group [（100.27±0.32）%, （120.81 ±12.63）%, （98.91±7.83）%, （85.92±8.07）%; P 〉 0.05]. The content of aspartic acid at 48 hours after the last perfusion of alcohol in the topiramate-treated group was obviously lower than that in the alcohol group （P 〈 0.05）, and those at 30 and 72 hours were close （P 〉 0.05）. CONCLUSION： ① The occurrences of alcohol withdrawal symptoms are correlated with the increased contents of excitatory amino acids in hippocampal dentate gyrus in rats. ② Topiramate can alleviate the alcohol withdrawal symptoms, which may be correlated with the decreased contents of excitatory amino acids in hippocampal dentate gyrus in rats.
基金Project supported by the TCAD Simulation and SPICE Modeling of 0.13μm SOI Technology,China (Grant No. 2009ZX02306-002)
文摘The hysteresis effect in the output characteristics,originating from the floating body effect,has been measured in partially depleted（PD） silicon-on-insulator（SOI） MOSFETs at different back-gate biases.I D hysteresis has been developed to clarify the hysteresis characteristics.The fabricated devices show the positive and negative peaks in the I D hysteresis.The experimental results show that the I D hysteresis is sensitive to the back gate bias in 0.13-渭m PD SOI MOSFETs and does not vary monotonously with the back-gate bias.Based on the steady-state Shockley-Read-Hall（SRH） recombination theory,we have successfully interpreted the impact of the back-gate bias on the hysteresis effect in PD SOI MOSFETs.
文摘In this paper, an efficient shrinkage estimation procedure for the partially linear varying coefficient model (PLVC) with random effect is considered. By selecting the significant variable and estimating the nonzero coefficient, the model structure specification is accomplished by introducing a novel penalized estimating equation. Under some mild conditions, the asymptotic properties for the proposed model selection and estimation results, such as the sparsity and oracle property, are established. Some numerical simulation studies and a real data analysis are presented to examine the finite sample performance of the procedure.
文摘Objective To explore the effect of doxazosin on rabbit bladder compliance after partial bladder outlet ob- struction. Methods A total of 40 male New Zealand white rabbits were randomized into 4 groups,with 10 rabbits in each group. Partial bladder outlet
文摘Objective: To review our open partial nephrectomy (OPN) experience and compare to known robotic partial nephrectomy (RPN) data to determine whether length of stay (LOS) and morbidity are significant drivers in the surgical approach employed for partial nephrectomy. Methods: We reviewed our OPN experience during the last 3 years examining age, tumor size, LOS, pathology, blood loss, complications, recurences, and deaths. Results: Seventy-five patients underwent OPN during this period. Mean age was 59 years, tumor size 2.8 cm, percent malignant 75%, estimated blood loss 350 cc. With a median follow-up of 18 months, there was one urinoma managed by drain-age, one pseudo aneurysm that required embolization and one pulmonary embolism that required anticoagulation. There were no readmissions, no tumor recurences, and no deaths. Our major complication rate was 4% as compared to other trials that re-ported major complication rates between 1% - 9% for RPN and between 3% - 24% for OPN. In the first half of the experience (n = 37), median LOS was 57 hours. Using a pathway encouraging early ambulation and smaller incisions in the second half of the experience (n = 38), median LOS was 35 hours. This is much shorter than reported RPN LOS of 62 - 67 hours and OPN LOS of 108 - 142 hours. Conclusion: OPN can be performed safely and effectively with one night hospital stay. This provides a more cost-effective approach to partial nephrectomy with similar or better complication rates and calls into question the main value drivers of RPN.
基金co-supported by the General Armament Department Pre-research Foundation of China (Nos. 51304010206, 51327 020105)
文摘Rational planning of spares configuration project is an effective approach to improve equipment availability as well as reduce life cycle cost （LCC）. With an analysis of various impacts on support system, the spares demand rate forecast model is constructed. According to systemic analysis method, spares support effectiveness evaluation indicators system is built, and then, initial spares configuration and optimization method is researched. To the issue of discarding and con-sumption for incomplete repairable items, its expected backorders function is approximated by Laplace demand distribution. Combining the （s-1, s） and （R, Q） inventory policy, the spares resup-ply model is established under the batch ordering policy based on inventory state, and the optimi-zation analysis flow for spares configuration is proposed. Through application on shipborne equipment spares configuration, the given scenarios are analyzed under two constraint targets：one is the support effectiveness, and the other is the spares cost. Analysis reveals that the result is consistent with practical regulation;therefore, the model＇s correctness, method＇s validity as well as optimization project＇s rationality are proved to a certain extent.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 60436030 and 60806025)
文摘A new partial-SOI （PSOI） high voltage device structure called a CI PSOI （charge island PSOI） is proposed for the first time in this paper. The device is characterized by a charge island layer on the interface of the top silicon layer and the dielectric buried layer in which a series of equidistant high concentration n＋-regions is inserted. Inversion holes resulting from the vertical electric field are located in the spacing between two neighbouring n＋-regions on the interface by the force with ionized donors in the undepleted n＋-regions, and therefore effectively enhance the electric field of the dielectric buried layer （Ei） and increase the breakdown voltage （BV）, thereby alleviating the self-heating effect （SHE） by the silicon window under the source. An analytical model of the vertical interface electric field for the CI PSOI is presented and the analytical results are in good agreement with the 2D simulation results. The BV and El of the CI PSOI LDMOS increase to 631 V and 584 V/μm from 246 V and 85.8 V/μm for the conventional PSOI with a lower SHE, respectively. The effects of the structure parameters on the device characteristics are analysed for the proposed device in detail.
基金supported by NSF of China (10901065, 10971225, and11028102)the NSF Grants 1025422 and 0731201the Cheung Kong Scholars Program, and an open research grant from the State Key Laboratory for Nonlinear Mechanics at the Chinese Academy of Sciences
文摘A conceptual model for microscopic-macroscopic slow-fast stochastic systems is considered. A dynamical reduction procedure is presented in order to extract effective dynamics for this kind of systems. Under appropriate assumptions, the effective system is shown to approximate the original system, in the sense of a probabilistic convergence.
