BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue...BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.展开更多
BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electr...BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.展开更多
Background Peripheral facial paralysis(PFP)caused by neurovascular structural anomalies frequently triggers an inflammatory cascade,leading to facial nerve edema.Standard treatments like corticosteroids usually don...Background Peripheral facial paralysis(PFP)caused by neurovascular structural anomalies frequently triggers an inflammatory cascade,leading to facial nerve edema.Standard treatments like corticosteroids usually don't work very well,while acupuncture shows special benefits in treating PFP.Objective This report discusses a case where acupuncture was used to treat hormone-insensitive PFP caused by swelling of the facial nerve due to an unusual physical structure of the right anterior inferior cerebellar artery(AICA).The goal is to improve clinicians'diagnosis and treatment accuracy for this possible cause and to highlight acupuncture's therapeutic effect.Methods We used the cranial magnetic resonance imaging(MRI)to clarify the etiology of hormone-insensitive PFP and formulated an acupuncture treatment plan.The acupuncture treatment restored the facial nerve's function after seven sessions.We performed a cranial MRI again to observe the facial nerve edema and its relationship with the surrounding vascular structures.Result Before acupuncture treatment,the patient's head MRI showed that the right AICA and the right facial nerve had a“U-shaped”abnormal physiological structure,and the local edema of the facial nerve was obvious.The left AICA had a cross interaction with the facial nerve and the auditory nerve in the inner ear canal.After 7 times of acupuncture treatment,the facial nerve function of the patient recovered,and reexamination of the head MRI showed that the local edema significantly subsided.Conclusion PFP which is caused by facial nerve edema resulting from abnormal neurovascular physiological structures is insensitive to hormonal therapy.Acupuncture can be used to promote the resolution of the edema and the restoration of facial nerve function.展开更多
Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such...Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.展开更多
终末期肝病(end-stage of liver disease,ESLD)为慢性肝脏损伤进展的终末阶段,与感染互为因果。在ESLD合并感染的免疫病理机制中,免疫失衡占据核心地位,具体表现为典型的“双相免疫失衡”:早期以免疫亢进伴全身炎症反应综合征(SIRS)为特...终末期肝病(end-stage of liver disease,ESLD)为慢性肝脏损伤进展的终末阶段,与感染互为因果。在ESLD合并感染的免疫病理机制中,免疫失衡占据核心地位,具体表现为典型的“双相免疫失衡”:早期以免疫亢进伴全身炎症反应综合征(SIRS)为特征,后期则进入免疫麻痹状态。肠道菌群移位等因素可进一步加剧免疫紊乱,推动“免疫紊乱-感染-器官损伤”恶性循环的形成。展开更多
Objective To observe the clinical efficacy of moxibustion at B ihuì（百会 GV 20） combined with penetration needling in treatment of intractable facial paralysis. Methods Sixty patients with intractable facial pa...Objective To observe the clinical efficacy of moxibustion at B ihuì（百会 GV 20） combined with penetration needling in treatment of intractable facial paralysis. Methods Sixty patients with intractable facial paralysis included in the study were divided into two groups according to the random number table, with 30 patients in observation group（group A）, and 30 patients in control group（group B）. Moxibustion at GV 20 combined with penetration needling were adopted in group A, and simple penetration needling was applied in group B. Once daily, thirty days of treatment were required. The House Brackmann（H-B） facial nerve function grading and improvement of clinical symptoms were observed. Results The H-B function grading and improvement of clinical symptoms in group A were superior to group B, and the difference was statistically significant（P〈0.05）. Conclusion The clinical efficacy of moxibustion at GV 20 combined with penetration needling in treatment of intractable facial paralysis is definite, and the treatment method is deserving of clinical promotion.展开更多
Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomot...Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jingming （晴明 BL 1）, Yangbai （阳白GB 14}, Sibai （四白 ST 24 Tongziliao （瞳子髎 GB I） on the affected side, and Ganshu （肝俞 BL 18） on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment. Results The effective rate of acupoint injection group was 91.7% （209/228）, and that of the control group was 73.6% （168/228）. There was statistical significance in comparing the difference between the two groups （P〈0.05）. TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment （P〈0.01, P〈0.05）, the score of acupoint injection group was more reduced than that of the control group （P〈0.05）. Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment Call P〈0.05）. The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group （both P〈0.05）. Conclusion Acupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.展开更多
Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- ...Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- central large-sample randomized controlled trial was carried out. Nine hundred cases of Bell＇ s palsy were randomly divided into 5 treatment groups, named as acupuncture by stages group, acupuncture by stages with moxibustion group, acupuncture by stages with electroacupuncture group, acupuncture by stages with line-puncture on muscle region of meridian group and acupuncture without stages group. Four sessions of treatment were required in each group. The clinical curative effects of groups were assessed by House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis Scale during the enrollment, after 4 sessions of treatment, and during 1 and 3 months of follow-up after treatment. The systematic analysis of curative effects was provided in view of the intervention time and nerve localization of disease separately. Results The cure rates of intervention treatment were 50.1% （223/445） in acute stage and 52.1% （162/311） in resting stage, superior to that of 25.9% （35/135） in recovery stage （both P〈0.001）. There was no statistically significant differences in comparison of curative effect in 5 solutions at the same stage （all P〉0.05）. The effect of treatment intervened at acute stage was superior to that at recovery stage in acupuncture by stages group and acupuncture without stages group （both P〈0.01）. There were statistically significant differences in curative effect of the localization above and below chorda tympani nerve in acupuncture by stages with line-puncture on muscle region of meridian group （P〈0.01）. The curative effect of the localization below chorda tympani nerve was superior to that above the nerve. Conclusion The best intervention time for Bell＇ s palsy is at acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All 5 solutions are clinical superiorities to Bell＇s palsy. Under the condition of limited medical sources, the simple filiform needle puncture is recommended at acute stage. For the patients with the disorder above chorda tympani nerve, line-puncture on muscle region of meridian is not recommended.展开更多
Objective To investigate the difference in the therapeutic effect of different methods in the treatment of peripheral facial paralysis （PFP） at different stages. Methods Sixty cases of PFP at different stages were d...Objective To investigate the difference in the therapeutic effect of different methods in the treatment of peripheral facial paralysis （PFP） at different stages. Methods Sixty cases of PFP at different stages were divided into a treatment group and a control group according to the sequence for visit, and 30 patients were included in each group. The patients in the treatment group were treated by using drugs, acupuncture （shallow puncture and subexcite） and microwave therapy during the acute stage, and they were subjected to electroacupuncture （EA） （heavy stimulation and penetration needling）, acupoint injection, electrotherapy and massage during the convalescence stage. In contrast, the patients in the control group were treated simply with drugs, and the therapeutic methods during the convalescence stage were the same to those for the treatment group, and the therapeutic effect of the two groups was observed after three treatment courses. Results The total effective rate in the treatment group was 100.0% （30/30）, the cured rate after one treatment course was 48.2% （13/27）, the cured rate after two treatment courses was 44.4% （12/27）, and the cured rate after three treatment courses was 7.4% （2/27）. The total effective rate in the control group was 90.0% （27/30）, the cured rate after one treatment course was 5.5% （1/18）, the cured rate after two treatment courses was 27.8% （5/18）, and the cured rate after three treatment courses was 66.7% （12/18）. The therapeutic effect and the treatment courses for healing of the treatment group were significantly better than those in the control group （P0.05）. Conclusion the therapeutic effect of different therapeutic methods on PFP is remarkable.展开更多
Objective To explore the best therapeutic method in the treatment of peripheral facial paralysis. Methods One hundred and twenty cases were randomized into a conventional acupuncture group [Yangbai （阳白 GB 24）, Sib...Objective To explore the best therapeutic method in the treatment of peripheral facial paralysis. Methods One hundred and twenty cases were randomized into a conventional acupuncture group [Yangbai （阳白 GB 24）, Sibai （四白 ST 2）, Yingxiang （迎香 LI 20）, etc.], a Renying （人迎ST 9） acupuncture group and an operation ＋ acupuncture group [acupuncture at ST 9 as the main acupoint and the stellate ganglion block （SGB）], 40 cases in each one. The treatment was given once a day, 7 treatments made one session. After 3 sessions of treatment, the latency and the amplitude of the direct stimulation evoked potential of the facial nerve （ENoG） were compared before and after treatment in three groups, as well as R2 and R2 values of blink reflex （BR）. The total clinical efficacy was assessed. Results The latency of ENoG was shortened and the amplitude was increased significantly in three groups. After treatment, ENoG latency was lower significantly in the operation ＋ acupuncture group as compared with that in the conventional acupuncture group （P〈0.05）. In the Renying （人迎 ST 9） acupuncture group, the amplitude of ENoG was increased as compared with P〈0.05）. After treatment in three groups, those in the other two groups （all R2 and R2 values were decreased significantly. The differences in R1 and R2 values in the Renying （人迎 ST 9） acupuncture group and the operation ＋ acupuncture group before and after treatment were bigger than those in the conventional acupuncture group （all P〈0.05）, and the difference in R2 value in the operation ＋ acupuncture group was bigger than that in the Renying （人迎 ST 9） acupuncture group （P〈O.05）. The clinical markedly effective and curative rate was 87.5% （35/40） in the operation ＋ acupuncture group, which was superior to 77.5% （32/40） in the Renying （）人迎 ST 9）acupuncture group and higher significantly than 65.0% （26/40） in the conventional acupuncture group （P〈0.05）. Conclusion Compared with the conventional acupuncture, the efficacy on peripheral facial paralysis is much better in the Renying （人迎 ST 9） acupuncture group and the operation ＋ acupuncture group. Moreover, the early reflex function of the damaged facial nerve is much better recovered in the operation ＋ acupuncture group as compared with that in the Renying （人迎 ST 9） acupuncture group.展开更多
Objective By using the evidence-based medicine approach to analyze the optimum timing in acupuncture treatment for facial paralysis, to provide the scientific evidence for acupuncture clinical practices. Methods Compu...Objective By using the evidence-based medicine approach to analyze the optimum timing in acupuncture treatment for facial paralysis, to provide the scientific evidence for acupuncture clinical practices. Methods Computer searches were conducted in the CNKI literature database from January 1994 to August 2009, using the keywords ＂facial paralysis acupuncture＂ and ＂treating opportunity/acupuncture opportunity＂. According to the standard of Cochrane, the literatures were retrieved and conducted with evidence-based analysis. The SPSS 13.0 software was used for the statistical analysis. Results Among the 133 retrieved literatures which met the inclusion criteria of the study, there were 11 literatures on the effect of acupuncture or electroacupuncture treatment in acute stage observation group and conventional medical treatment group. Using Mann-Whitney U test, the difference of treatment effect is statistically significant （P〈0.001）. Conclusion Early intervention in acupuncture treatment for facial paralysis in acute stage can improve the efficacy and promote neurological recovery. In the acute stage, animal experiments and clinical observations provide evidence to support the application of electric needle and traditional acupuncture treatments.展开更多
Objective To observe clinical effect of warm needing plus cupping at back on facial paralysis. Methods Forty cases of peripheral facial paralysis were firstly treated with warm needling. Cuánzhú （攒竹 BL 2...Objective To observe clinical effect of warm needing plus cupping at back on facial paralysis. Methods Forty cases of peripheral facial paralysis were firstly treated with warm needling. Cuánzhú （攒竹 BL 2）, Yángbái （阳白 GB 14）, Sīzhúkōng （丝竹空 TE 23）, Sìbái （四白 ST 2）, Tīnghuì （听会 GB 2）, Yìfēng （翳 风 TE 17）, Dìcāng （地仓 ST 4）, Jiáchē （颊车 ST 6）, Yíngxiāng （迎香 LI 20） and Hég （合谷 LI 4） were selected and warm needling was applied at Tīnghuì （听 会 GB 2）. Needles were retained for 30 min, once a day. Cupping at back was then applied at bilateral Fèishū （肺俞 BL 13）, Píshū （脾俞 BL 20）, Shènshū （肾 俞 BL 23） in the Bladder Meridian of Foot-Taiyang for 10 min, once a day for first five days and then once every other day. Ten days of treatment were taken as a treatment course with one day interval between courses. The efficacy was observed after two treatment courses. Results Twenty-six cases were cured, ten cases were markedly effective, three cases were effective and one case was failed. The total effective rate was 97.5% （39/40）. Conclusion From theory of coldness to treat facial paralysis, efficacy is significant with warm needling and cupping at the Bladder Meridian of Foot-Taiyang.展开更多
Objective To optimize acupuncture treatment programs for facial paralysis.Methods Sixty-three cases of facial paralysis were randomly grouped according to orthogonal design L9（3）4 table,and treated by different comb...Objective To optimize acupuncture treatment programs for facial paralysis.Methods Sixty-three cases of facial paralysis were randomly grouped according to orthogonal design L9（3）4 table,and treated by different combined programs of 4 factors,A（acupuncture opportunity）,B（combination of points）,C（stimulating quantity）,D（electroacupuncture time） and 3 levels,and changes of the functional score of the facial nerve were observed,and the different combined programs of the 4 factors,A（acupuncture opportunity）,B（combination of point）,C（stimulating quantity）,D（electroacupuncture time） and 3 levels influencing acupuncture therapeutic effect on facial paralysis were optimized.Results B（combination of points） and D（electroacupuncture time） were obvious factors（P0.05）,among them,B（combination of points） was the most main influencing factor;among the 3 levels of B（combination of points） and D（electroacupuncture time）,B3 （alternately needling two groups of acupoints） and D3 （electroacupuncture treatment at sparse-dense wave for 30 min） were the best.Conclusion Electroacupuncture at sparse-dense wave for 30 min,alternately needling two groups of acupoints is the best program for treatment of facial paralysis.展开更多
CACNA1 S gene is the gene encoding L-type calcium channel αa-subunit. CACNA1 S gene mutations can cause hypokalemic periodic pa- ralysis （HOKPP）. The related research speculated that CACNA1 S gene was the candidate...CACNA1 S gene is the gene encoding L-type calcium channel αa-subunit. CACNA1 S gene mutations can cause hypokalemic periodic pa- ralysis （HOKPP）. The related research speculated that CACNA1 S gene was the candidate genes which affect meat quality traits. In the present ar- ticle, the biological characteristics of CACNA1 S gene, structure, genetic diseases and the research development were respectively reviewed so as to provide a reference for further research.展开更多
Case of acupuncture for facial nucleus paralysis was reported. Compared with peripheral facial paralysis, facial nucleus paralysis is more complex with a high-level and high-degree injury, leading to a low cured rate ...Case of acupuncture for facial nucleus paralysis was reported. Compared with peripheral facial paralysis, facial nucleus paralysis is more complex with a high-level and high-degree injury, leading to a low cured rate in clinic. This case was cured successfully, which might be related to less bleeding amount from patients＇ lesion and more complete absorption of blood stasis, as well as accuracy of clinical syndrome differentiation, positioning and appropriateness of treatment method and acupoint selection of acupuncture in the mid to late stage.展开更多
The study explained features of severe facial paralysis of early stage from the level and degree of nerve injury,syndromes and clinical manifestations of peripheral facial paralysis.Treating protocols with acupuncture...The study explained features of severe facial paralysis of early stage from the level and degree of nerve injury,syndromes and clinical manifestations of peripheral facial paralysis.Treating protocols with acupuncture were worked out concerning its characteristics to acquire the law of treatment,especially on the severe case.Severe facial paralysis is not only known as the focus of the study on acupuncture treatment,but also the key point to approve the effectiveness of acupuncture on peripheral facial paralysis.展开更多
Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people...Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).展开更多
文摘BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.
文摘BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.
基金supported by Zhejiang Key Reasearch Projects of Traditional Chinese Medicine(Grant No.GZY-ZJ-KJ-24016[to LHL])。
文摘Background Peripheral facial paralysis(PFP)caused by neurovascular structural anomalies frequently triggers an inflammatory cascade,leading to facial nerve edema.Standard treatments like corticosteroids usually don't work very well,while acupuncture shows special benefits in treating PFP.Objective This report discusses a case where acupuncture was used to treat hormone-insensitive PFP caused by swelling of the facial nerve due to an unusual physical structure of the right anterior inferior cerebellar artery(AICA).The goal is to improve clinicians'diagnosis and treatment accuracy for this possible cause and to highlight acupuncture's therapeutic effect.Methods We used the cranial magnetic resonance imaging(MRI)to clarify the etiology of hormone-insensitive PFP and formulated an acupuncture treatment plan.The acupuncture treatment restored the facial nerve's function after seven sessions.We performed a cranial MRI again to observe the facial nerve edema and its relationship with the surrounding vascular structures.Result Before acupuncture treatment,the patient's head MRI showed that the right AICA and the right facial nerve had a“U-shaped”abnormal physiological structure,and the local edema of the facial nerve was obvious.The left AICA had a cross interaction with the facial nerve and the auditory nerve in the inner ear canal.After 7 times of acupuncture treatment,the facial nerve function of the patient recovered,and reexamination of the head MRI showed that the local edema significantly subsided.Conclusion PFP which is caused by facial nerve edema resulting from abnormal neurovascular physiological structures is insensitive to hormonal therapy.Acupuncture can be used to promote the resolution of the edema and the restoration of facial nerve function.
文摘Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.
文摘终末期肝病(end-stage of liver disease,ESLD)为慢性肝脏损伤进展的终末阶段,与感染互为因果。在ESLD合并感染的免疫病理机制中,免疫失衡占据核心地位,具体表现为典型的“双相免疫失衡”:早期以免疫亢进伴全身炎症反应综合征(SIRS)为特征,后期则进入免疫麻痹状态。肠道菌群移位等因素可进一步加剧免疫紊乱,推动“免疫紊乱-感染-器官损伤”恶性循环的形成。
文摘Objective To observe the clinical efficacy of moxibustion at B ihuì（百会 GV 20） combined with penetration needling in treatment of intractable facial paralysis. Methods Sixty patients with intractable facial paralysis included in the study were divided into two groups according to the random number table, with 30 patients in observation group（group A）, and 30 patients in control group（group B）. Moxibustion at GV 20 combined with penetration needling were adopted in group A, and simple penetration needling was applied in group B. Once daily, thirty days of treatment were required. The House Brackmann（H-B） facial nerve function grading and improvement of clinical symptoms were observed. Results The H-B function grading and improvement of clinical symptoms in group A were superior to group B, and the difference was statistically significant（P〈0.05）. Conclusion The clinical efficacy of moxibustion at GV 20 combined with penetration needling in treatment of intractable facial paralysis is definite, and the treatment method is deserving of clinical promotion.
基金Supported by designated project of 2008 Scientific Plan of TCM and Integrative Medicine of Hebei Administration of TCM:2008080
文摘Objective To evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines. Methods A total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jingming （晴明 BL 1）, Yangbai （阳白GB 14}, Sibai （四白 ST 24 Tongziliao （瞳子髎 GB I） on the affected side, and Ganshu （肝俞 BL 18） on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment. Results The effective rate of acupoint injection group was 91.7% （209/228）, and that of the control group was 73.6% （168/228）. There was statistical significance in comparing the difference between the two groups （P〈0.05）. TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment （P〈0.01, P〈0.05）, the score of acupoint injection group was more reduced than that of the control group （P〈0.05）. Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment Call P〈0.05）. The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group （both P〈0.05）. Conclusion Acupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.
基金Supported by 11th Five-Year Plan for Science and Technology Project: 2006 BAI 12 B 03
文摘Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- central large-sample randomized controlled trial was carried out. Nine hundred cases of Bell＇ s palsy were randomly divided into 5 treatment groups, named as acupuncture by stages group, acupuncture by stages with moxibustion group, acupuncture by stages with electroacupuncture group, acupuncture by stages with line-puncture on muscle region of meridian group and acupuncture without stages group. Four sessions of treatment were required in each group. The clinical curative effects of groups were assessed by House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis Scale during the enrollment, after 4 sessions of treatment, and during 1 and 3 months of follow-up after treatment. The systematic analysis of curative effects was provided in view of the intervention time and nerve localization of disease separately. Results The cure rates of intervention treatment were 50.1% （223/445） in acute stage and 52.1% （162/311） in resting stage, superior to that of 25.9% （35/135） in recovery stage （both P〈0.001）. There was no statistically significant differences in comparison of curative effect in 5 solutions at the same stage （all P〉0.05）. The effect of treatment intervened at acute stage was superior to that at recovery stage in acupuncture by stages group and acupuncture without stages group （both P〈0.01）. There were statistically significant differences in curative effect of the localization above and below chorda tympani nerve in acupuncture by stages with line-puncture on muscle region of meridian group （P〈0.01）. The curative effect of the localization below chorda tympani nerve was superior to that above the nerve. Conclusion The best intervention time for Bell＇ s palsy is at acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All 5 solutions are clinical superiorities to Bell＇s palsy. Under the condition of limited medical sources, the simple filiform needle puncture is recommended at acute stage. For the patients with the disorder above chorda tympani nerve, line-puncture on muscle region of meridian is not recommended.
文摘Objective To investigate the difference in the therapeutic effect of different methods in the treatment of peripheral facial paralysis （PFP） at different stages. Methods Sixty cases of PFP at different stages were divided into a treatment group and a control group according to the sequence for visit, and 30 patients were included in each group. The patients in the treatment group were treated by using drugs, acupuncture （shallow puncture and subexcite） and microwave therapy during the acute stage, and they were subjected to electroacupuncture （EA） （heavy stimulation and penetration needling）, acupoint injection, electrotherapy and massage during the convalescence stage. In contrast, the patients in the control group were treated simply with drugs, and the therapeutic methods during the convalescence stage were the same to those for the treatment group, and the therapeutic effect of the two groups was observed after three treatment courses. Results The total effective rate in the treatment group was 100.0% （30/30）, the cured rate after one treatment course was 48.2% （13/27）, the cured rate after two treatment courses was 44.4% （12/27）, and the cured rate after three treatment courses was 7.4% （2/27）. The total effective rate in the control group was 90.0% （27/30）, the cured rate after one treatment course was 5.5% （1/18）, the cured rate after two treatment courses was 27.8% （5/18）, and the cured rate after three treatment courses was 66.7% （12/18）. The therapeutic effect and the treatment courses for healing of the treatment group were significantly better than those in the control group （P0.05）. Conclusion the therapeutic effect of different therapeutic methods on PFP is remarkable.
基金Supported by Project of Science and Technology Bureau,Yichang,Hubei:A:01301-46
文摘Objective To explore the best therapeutic method in the treatment of peripheral facial paralysis. Methods One hundred and twenty cases were randomized into a conventional acupuncture group [Yangbai （阳白 GB 24）, Sibai （四白 ST 2）, Yingxiang （迎香 LI 20）, etc.], a Renying （人迎ST 9） acupuncture group and an operation ＋ acupuncture group [acupuncture at ST 9 as the main acupoint and the stellate ganglion block （SGB）], 40 cases in each one. The treatment was given once a day, 7 treatments made one session. After 3 sessions of treatment, the latency and the amplitude of the direct stimulation evoked potential of the facial nerve （ENoG） were compared before and after treatment in three groups, as well as R2 and R2 values of blink reflex （BR）. The total clinical efficacy was assessed. Results The latency of ENoG was shortened and the amplitude was increased significantly in three groups. After treatment, ENoG latency was lower significantly in the operation ＋ acupuncture group as compared with that in the conventional acupuncture group （P〈0.05）. In the Renying （人迎 ST 9） acupuncture group, the amplitude of ENoG was increased as compared with P〈0.05）. After treatment in three groups, those in the other two groups （all R2 and R2 values were decreased significantly. The differences in R1 and R2 values in the Renying （人迎 ST 9） acupuncture group and the operation ＋ acupuncture group before and after treatment were bigger than those in the conventional acupuncture group （all P〈0.05）, and the difference in R2 value in the operation ＋ acupuncture group was bigger than that in the Renying （人迎 ST 9） acupuncture group （P〈O.05）. The clinical markedly effective and curative rate was 87.5% （35/40） in the operation ＋ acupuncture group, which was superior to 77.5% （32/40） in the Renying （）人迎 ST 9）acupuncture group and higher significantly than 65.0% （26/40） in the conventional acupuncture group （P〈0.05）. Conclusion Compared with the conventional acupuncture, the efficacy on peripheral facial paralysis is much better in the Renying （人迎 ST 9） acupuncture group and the operation ＋ acupuncture group. Moreover, the early reflex function of the damaged facial nerve is much better recovered in the operation ＋ acupuncture group as compared with that in the Renying （人迎 ST 9） acupuncture group.
文摘Objective By using the evidence-based medicine approach to analyze the optimum timing in acupuncture treatment for facial paralysis, to provide the scientific evidence for acupuncture clinical practices. Methods Computer searches were conducted in the CNKI literature database from January 1994 to August 2009, using the keywords ＂facial paralysis acupuncture＂ and ＂treating opportunity/acupuncture opportunity＂. According to the standard of Cochrane, the literatures were retrieved and conducted with evidence-based analysis. The SPSS 13.0 software was used for the statistical analysis. Results Among the 133 retrieved literatures which met the inclusion criteria of the study, there were 11 literatures on the effect of acupuncture or electroacupuncture treatment in acute stage observation group and conventional medical treatment group. Using Mann-Whitney U test, the difference of treatment effect is statistically significant （P〈0.001）. Conclusion Early intervention in acupuncture treatment for facial paralysis in acute stage can improve the efficacy and promote neurological recovery. In the acute stage, animal experiments and clinical observations provide evidence to support the application of electric needle and traditional acupuncture treatments.
文摘Objective To observe clinical effect of warm needing plus cupping at back on facial paralysis. Methods Forty cases of peripheral facial paralysis were firstly treated with warm needling. Cuánzhú （攒竹 BL 2）, Yángbái （阳白 GB 14）, Sīzhúkōng （丝竹空 TE 23）, Sìbái （四白 ST 2）, Tīnghuì （听会 GB 2）, Yìfēng （翳 风 TE 17）, Dìcāng （地仓 ST 4）, Jiáchē （颊车 ST 6）, Yíngxiāng （迎香 LI 20） and Hég （合谷 LI 4） were selected and warm needling was applied at Tīnghuì （听 会 GB 2）. Needles were retained for 30 min, once a day. Cupping at back was then applied at bilateral Fèishū （肺俞 BL 13）, Píshū （脾俞 BL 20）, Shènshū （肾 俞 BL 23） in the Bladder Meridian of Foot-Taiyang for 10 min, once a day for first five days and then once every other day. Ten days of treatment were taken as a treatment course with one day interval between courses. The efficacy was observed after two treatment courses. Results Twenty-six cases were cured, ten cases were markedly effective, three cases were effective and one case was failed. The total effective rate was 97.5% （39/40）. Conclusion From theory of coldness to treat facial paralysis, efficacy is significant with warm needling and cupping at the Bladder Meridian of Foot-Taiyang.
基金Supported by Scientific Research Item of Department of Public Health of Hainan Province:2005-92
文摘Objective To optimize acupuncture treatment programs for facial paralysis.Methods Sixty-three cases of facial paralysis were randomly grouped according to orthogonal design L9（3）4 table,and treated by different combined programs of 4 factors,A（acupuncture opportunity）,B（combination of points）,C（stimulating quantity）,D（electroacupuncture time） and 3 levels,and changes of the functional score of the facial nerve were observed,and the different combined programs of the 4 factors,A（acupuncture opportunity）,B（combination of point）,C（stimulating quantity）,D（electroacupuncture time） and 3 levels influencing acupuncture therapeutic effect on facial paralysis were optimized.Results B（combination of points） and D（electroacupuncture time） were obvious factors（P0.05）,among them,B（combination of points） was the most main influencing factor;among the 3 levels of B（combination of points） and D（electroacupuncture time）,B3 （alternately needling two groups of acupoints） and D3 （electroacupuncture treatment at sparse-dense wave for 30 min） were the best.Conclusion Electroacupuncture at sparse-dense wave for 30 min,alternately needling two groups of acupoints is the best program for treatment of facial paralysis.
文摘CACNA1 S gene is the gene encoding L-type calcium channel αa-subunit. CACNA1 S gene mutations can cause hypokalemic periodic pa- ralysis （HOKPP）. The related research speculated that CACNA1 S gene was the candidate genes which affect meat quality traits. In the present ar- ticle, the biological characteristics of CACNA1 S gene, structure, genetic diseases and the research development were respectively reviewed so as to provide a reference for further research.
文摘Case of acupuncture for facial nucleus paralysis was reported. Compared with peripheral facial paralysis, facial nucleus paralysis is more complex with a high-level and high-degree injury, leading to a low cured rate in clinic. This case was cured successfully, which might be related to less bleeding amount from patients＇ lesion and more complete absorption of blood stasis, as well as accuracy of clinical syndrome differentiation, positioning and appropriateness of treatment method and acupoint selection of acupuncture in the mid to late stage.
文摘The study explained features of severe facial paralysis of early stage from the level and degree of nerve injury,syndromes and clinical manifestations of peripheral facial paralysis.Treating protocols with acupuncture were worked out concerning its characteristics to acquire the law of treatment,especially on the severe case.Severe facial paralysis is not only known as the focus of the study on acupuncture treatment,but also the key point to approve the effectiveness of acupuncture on peripheral facial paralysis.
基金supported by the Irish Research Council under the Government of Ireland Postdoctoral Fellowship Project ID-GOIPD/2023/1431(to AS).
文摘Spinal cord injury(SCI)is a debilitating ailment that leads to the loss of motor and sensory functions,often leaving the patient paralyzed below the injury site(Chen et al.,2013).Globally around 250,000-300,000 people are diagnosed with SCI annually(Singh et al.,2014),and while this number appears quite low,the effect that an SCI has on the patient’s quality of life is drastic,due to the current difficulties to comprehensively treat this illness.The cost of patient care can also be quite costly,amounting to an estimated$1.69 billion in healthcare costs in the USA alone(Mahabaleshwarkar and Khanna,2014).
