Neutrophil extracellular traps(NETs)have emerged as key mediators of cardiovascular diseases(CVDs),linking innate immune activation to vascular injury,thrombosis,and maladaptive remodeling.This review synthesizes rece...Neutrophil extracellular traps(NETs)have emerged as key mediators of cardiovascular diseases(CVDs),linking innate immune activation to vascular injury,thrombosis,and maladaptive remodeling.This review synthesizes recent insights into the molecular and cellular pathways driving NET formation,including post-translational modifications,metabolic reprogramming,inflammasome signaling,and autophagy.It highlights the role of NETs in atherosclerosis,thrombosis,myocardial ischemia-reperfusion injury,and hypertension,emphasizing common control points such as peptidylarginine deiminase 4(PAD4)-dependent histone citrullination and nicotinamide adenine dinucleotide phosphate oxidases 2(NOX2)-mediated oxidative stress.Mechanistic interpretation of circulating biomarkers,includingmyeloperoxidase(MPO)-DNA complexes,citrullinated histoneH3,and cell-free DNA,provides a translational bridge between NET biology and patient stratification.Therapeutic strategies targeting NETs are examined through three main approaches:inhibition of NET initiation,enhancement of chromatin clearance,and neutralization of toxic extracellular components,with attention to both established and emerging interventions.In contrast to previous reviews,this study highlights the novelty of a mechano-therapeutic framework by providing a mechanistic roadmap linking NET formation pathways to therapeutic targeting in cardiovascular disease.Moving forward,integrating mechanistic information with biomarker discovery,precision profiling,and targeted therapies offers innovative strategies to reduce vascular inflammation and improve outcomes in cardiovascular disease.展开更多
Non-contacting finger seals represent an advanced non-contacting and compliant seal in gas turbine sealing technology.This paper proposes a new structure of noncontacting finger seals with double interlocking pads.The...Non-contacting finger seals represent an advanced non-contacting and compliant seal in gas turbine sealing technology.This paper proposes a new structure of noncontacting finger seals with double interlocking pads.The numerical analysis model based on the thermo-fluid-structure coupling method for the new type finger seal was established.The influence of working conditions on leakage of the seal was studied and compared with the single padded non-contacting finger seal.The results show that the interface between the bottom of the finger pad and rotor surface is the main leakage path that forms the gas film with obvious variations of pressure and flow velocity.Under high temperature and high pressure operating conditions,the hydrodynamic effect of the gas film is enhanced,and lifting force is significantly improved.The deformation of fingers is composed of elastic deformation and thermal deformation.At room temperature,the deformation of fingers is mainly elastic deformation and points to the center of the rotor,which reduces the gas film clearance.The deformation of fingers at high temperature and high pressure creates a circumferentially convergent gap between the bottom of the pad and the rotor,which is beneficial to improve the loading capacity and to reduce leakage of the seal.Compared with the typical single padded noncontacting finger seal,the double interlocking padded finger seal proposed in this paper reduces the leakage factor by about 37%,which provides an advanced seal concept with the potential to improve sealing performance under high temperature and high pressure working conditions.展开更多
On the stage of China Media Group’s 2025 Spring Festival Gala,more than a dozen humanoid robots dressed in floral padded jackets danced alongside human counterparts in a creative folk dance performance.The robots not...On the stage of China Media Group’s 2025 Spring Festival Gala,more than a dozen humanoid robots dressed in floral padded jackets danced alongside human counterparts in a creative folk dance performance.The robots not only smoothly twisted their waists and mimicked human leg-kicking movements,but also spun handkerchiefs,displaying extremely dexterous moves and exceptional skills.展开更多
文摘Neutrophil extracellular traps(NETs)have emerged as key mediators of cardiovascular diseases(CVDs),linking innate immune activation to vascular injury,thrombosis,and maladaptive remodeling.This review synthesizes recent insights into the molecular and cellular pathways driving NET formation,including post-translational modifications,metabolic reprogramming,inflammasome signaling,and autophagy.It highlights the role of NETs in atherosclerosis,thrombosis,myocardial ischemia-reperfusion injury,and hypertension,emphasizing common control points such as peptidylarginine deiminase 4(PAD4)-dependent histone citrullination and nicotinamide adenine dinucleotide phosphate oxidases 2(NOX2)-mediated oxidative stress.Mechanistic interpretation of circulating biomarkers,includingmyeloperoxidase(MPO)-DNA complexes,citrullinated histoneH3,and cell-free DNA,provides a translational bridge between NET biology and patient stratification.Therapeutic strategies targeting NETs are examined through three main approaches:inhibition of NET initiation,enhancement of chromatin clearance,and neutralization of toxic extracellular components,with attention to both established and emerging interventions.In contrast to previous reviews,this study highlights the novelty of a mechano-therapeutic framework by providing a mechanistic roadmap linking NET formation pathways to therapeutic targeting in cardiovascular disease.Moving forward,integrating mechanistic information with biomarker discovery,precision profiling,and targeted therapies offers innovative strategies to reduce vascular inflammation and improve outcomes in cardiovascular disease.
文摘Non-contacting finger seals represent an advanced non-contacting and compliant seal in gas turbine sealing technology.This paper proposes a new structure of noncontacting finger seals with double interlocking pads.The numerical analysis model based on the thermo-fluid-structure coupling method for the new type finger seal was established.The influence of working conditions on leakage of the seal was studied and compared with the single padded non-contacting finger seal.The results show that the interface between the bottom of the finger pad and rotor surface is the main leakage path that forms the gas film with obvious variations of pressure and flow velocity.Under high temperature and high pressure operating conditions,the hydrodynamic effect of the gas film is enhanced,and lifting force is significantly improved.The deformation of fingers is composed of elastic deformation and thermal deformation.At room temperature,the deformation of fingers is mainly elastic deformation and points to the center of the rotor,which reduces the gas film clearance.The deformation of fingers at high temperature and high pressure creates a circumferentially convergent gap between the bottom of the pad and the rotor,which is beneficial to improve the loading capacity and to reduce leakage of the seal.Compared with the typical single padded noncontacting finger seal,the double interlocking padded finger seal proposed in this paper reduces the leakage factor by about 37%,which provides an advanced seal concept with the potential to improve sealing performance under high temperature and high pressure working conditions.
文摘On the stage of China Media Group’s 2025 Spring Festival Gala,more than a dozen humanoid robots dressed in floral padded jackets danced alongside human counterparts in a creative folk dance performance.The robots not only smoothly twisted their waists and mimicked human leg-kicking movements,but also spun handkerchiefs,displaying extremely dexterous moves and exceptional skills.
