针对国内船舶管路系统详细设计与生产设计分离导致的设计数据源不统一、人工信息转换效率低、模型与原理校对困难和设计更改难一致等问题,提出基于三维体验平台(3D Experience Platform,3DEXP)逻辑到物理(Logical to Physical,L2P)关联...针对国内船舶管路系统详细设计与生产设计分离导致的设计数据源不统一、人工信息转换效率低、模型与原理校对困难和设计更改难一致等问题,提出基于三维体验平台(3D Experience Platform,3DEXP)逻辑到物理(Logical to Physical,L2P)关联设计技术的解决方案。L2P关联设计技术紧密联系逻辑对象和物理对象,是对船舶管路系统设计模式的创新。分析现有设计模式下各种问题产生的原因,研究L2P关联设计的设计流程、设计准备、原理图设绘和三维建模等内容,打通原理图与三维建模关联设计的技术路线,创建原理图与三维模型之间的关联,实现快速三维建模、智能模型校对、设计更改一致和单一数据源。应用测试结果表明,采用管路系统L2P关联设计技术能有效提高管路系统设计的效率和质量。展开更多
Objective: To understand the relationship between the expression of ras and p53 and histological types, degree of differentiation, TNM classification, stage, and patients?prognoses of non-small-cell lung cancer, we ex...Objective: To understand the relationship between the expression of ras and p53 and histological types, degree of differentiation, TNM classification, stage, and patients?prognoses of non-small-cell lung cancer, we examined Ha-ras and p53 production in 143 non-small-cell lung carcinomas. Methods: One hundred and forty-three paraffin-embedded surgically resected specimens of primary non-small-cell lung carcinomas (57 squamous cell carcinomas, 63 acinar adenocarcinomas, 15 bronchio-loalveolar carcinomas, and 8 large-cell carcinomas) were stained by streptavidin-peroxidase immunohistochemical method using anti-Ha-ras monoclonal and anti-p53 monoclonal (DO-1) antibodies. Results: Ha-ras was found in 68% (87 of 143) of lung carcinomas. The positive rate of Ha-ras staining in well differentiated carcinoma was 89%, significantly higher than that in moderately differentiated carcinoma (66%, P<0.05) and that in poorly differentiated carcinoma (48%, P<0.01). The 5-year survival rates of patients whose tumors had no (39%, P<0.01) or moderate (33%, P<0.05) Ha-ras production were significantly higher than that of patients whose tumors had strong staining (14%) for Ha-ras. Sixty percent lung carcinomas (86 of 143) had p53 accumulation. Patients whose tumors did not express p53 survived, on average, significantly longer after tumor resection than did patients whose tumors expressed p53. With increasing p53 accumulation, the average length of survival after tumor resection significantly decreased. Conclusion: Ha-ras overproduction and p53 accumulation correlate with unfavorable prognoses of patients with non-small-cell lung carcinomas. Ha-ras production in non-small- cell lung carcinoma was related to the degree of differentiation.展开更多
文摘针对国内船舶管路系统详细设计与生产设计分离导致的设计数据源不统一、人工信息转换效率低、模型与原理校对困难和设计更改难一致等问题,提出基于三维体验平台(3D Experience Platform,3DEXP)逻辑到物理(Logical to Physical,L2P)关联设计技术的解决方案。L2P关联设计技术紧密联系逻辑对象和物理对象,是对船舶管路系统设计模式的创新。分析现有设计模式下各种问题产生的原因,研究L2P关联设计的设计流程、设计准备、原理图设绘和三维建模等内容,打通原理图与三维建模关联设计的技术路线,创建原理图与三维模型之间的关联,实现快速三维建模、智能模型校对、设计更改一致和单一数据源。应用测试结果表明,采用管路系统L2P关联设计技术能有效提高管路系统设计的效率和质量。
文摘Objective: To understand the relationship between the expression of ras and p53 and histological types, degree of differentiation, TNM classification, stage, and patients?prognoses of non-small-cell lung cancer, we examined Ha-ras and p53 production in 143 non-small-cell lung carcinomas. Methods: One hundred and forty-three paraffin-embedded surgically resected specimens of primary non-small-cell lung carcinomas (57 squamous cell carcinomas, 63 acinar adenocarcinomas, 15 bronchio-loalveolar carcinomas, and 8 large-cell carcinomas) were stained by streptavidin-peroxidase immunohistochemical method using anti-Ha-ras monoclonal and anti-p53 monoclonal (DO-1) antibodies. Results: Ha-ras was found in 68% (87 of 143) of lung carcinomas. The positive rate of Ha-ras staining in well differentiated carcinoma was 89%, significantly higher than that in moderately differentiated carcinoma (66%, P<0.05) and that in poorly differentiated carcinoma (48%, P<0.01). The 5-year survival rates of patients whose tumors had no (39%, P<0.01) or moderate (33%, P<0.05) Ha-ras production were significantly higher than that of patients whose tumors had strong staining (14%) for Ha-ras. Sixty percent lung carcinomas (86 of 143) had p53 accumulation. Patients whose tumors did not express p53 survived, on average, significantly longer after tumor resection than did patients whose tumors expressed p53. With increasing p53 accumulation, the average length of survival after tumor resection significantly decreased. Conclusion: Ha-ras overproduction and p53 accumulation correlate with unfavorable prognoses of patients with non-small-cell lung carcinomas. Ha-ras production in non-small- cell lung carcinoma was related to the degree of differentiation.
