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Data driven prediction of fragment velocity distribution under explosive loading conditions 被引量:4
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作者 Donghwan Noh Piemaan Fazily +4 位作者 Songwon Seo Jaekun Lee Seungjae Seo Hoon Huh Jeong Whan Yoon 《Defence Technology(防务技术)》 2025年第1期109-119,共11页
This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de... This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance. 展开更多
关键词 Data driven prediction Dynamic fracture model Dynamic hardening model FRAGMENTATION Fragment velocity distribution High strain rate Machine learning
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Solar-driven methane-to-ethanol conversion by “intramolecular junction” with both high activity and selectivity 被引量:1
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作者 Qijun Tang Wenguang Tu Zhigang Zou 《Chinese Journal of Structural Chemistry》 2025年第6期6-7,共2页
Methane(CH4),the predominant component of natural gas and shale gas,is regarded as a promising carbon feedstock for chemical synthesis[1].However,considering the extreme stability of CH4 molecules,it's quite chall... Methane(CH4),the predominant component of natural gas and shale gas,is regarded as a promising carbon feedstock for chemical synthesis[1].However,considering the extreme stability of CH4 molecules,it's quite challenging in simultaneously achieving high activity and selectivity for target products under mild conditions,especially when synthesizing high-value C2t chemicals such as ethanol[2].The conversion of methane to ethanol by photocatalysis is promising for achieving transformation under ambient temperature and pressure conditions.Currently,the apparent quantum efficiency(AQE)of solar-driven methane-to-ethanol conversion is generally below 0.5%[3,4].Furthermore,the stability of photocatalysts remains inadequate,offering substantial potential for further improvement. 展开更多
关键词 natural gas shale gasis target products carbon feedstock chemical synthesis howeverconsidering intramolecular junction solar driven methane ethanol conversion
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Driven Critical Dynamics in the Tricitical Point
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作者 Ting-Long Wang Yi-Fan Jiang Shuai Yin 《Chinese Physics Letters》 2025年第11期1-8,共8页
The conventional Kibble–Zurek mechanism,describing driven dynamics across critical points based on the adiabatic-impulse scenario(AIS),has attracted broad attention.However,the driven dynamics at the tricritical poin... The conventional Kibble–Zurek mechanism,describing driven dynamics across critical points based on the adiabatic-impulse scenario(AIS),has attracted broad attention.However,the driven dynamics at the tricritical point with two independent relevant directions have not been adequately studied.Here,we employ the time-dependent variational principle to study the driven critical dynamics at a one-dimensional supersymmetric Ising tricritical point.For the relevant direction along the Ising critical line,the AIS apparently breaks down.Nevertheless,we find that the critical dynamics can still be described by finite-time scaling in which the driving rate has a dimension of r_(μ)=z+1/v_(μ)with z and v_(μ)being the dynamic exponent and correlation length exponent in this direction,respectively.For driven dynamics along another direction,the driving rate has a dimension of r_(p)=z+1/v_(p)with v_(p)being another correlation length exponent.Our work brings a new fundamental perspective into nonequilibrium critical dynamics near the tricritical point,which could be realized in programmable quantum processors in Rydberg atomic systems. 展开更多
关键词 driven dynamics across critical points finite time scaling dynamic exponent driven dynamics time dependent variational principle Kibble Zurek mechanism tricritical point driven critical dynamics
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False Data Injection Attacks on Data-Driven Algorithms in Smart Grids Utilizing Distributed Power Supplies
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作者 Zengji Liu Mengge Liu +1 位作者 Qi Wang Yi Tang 《Engineering》 2025年第8期62-74,共13页
As the number of distributed power supplies increases on the user side,smart grids are becoming larger and more complex.These changes bring new security challenges,especially with the widespread adop-tion of data-driv... As the number of distributed power supplies increases on the user side,smart grids are becoming larger and more complex.These changes bring new security challenges,especially with the widespread adop-tion of data-driven control methods.This paper introduces a novel black-box false data injection attack(FDIA)method that exploits the measurement modules of distributed power supplies within smart grids,highlighting its effectiveness in bypassing conventional security measures.Unlike traditional methods that focus on data manipulation within communication networks,this approach directly injects false data at the point of measurement,using a generative adversarial network(GAN)to generate stealthy attack vectors.This method requires no detailed knowledge of the target system,making it practical for real-world attacks.The attack’s impact on power system stability is demonstrated through experiments,high-lighting the significant cybersecurity risks introduced by data-driven algorithms in smart grids. 展开更多
关键词 CYBERSECURITY Data driven Cyberattack Generative adversarial networks
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Scaling corrections in driven critical dynamics:Application to the two-dimensional dimerized quantum Heisenberg model
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作者 Jing-Wen Liu Shuai Yin Yu-Rong Shu 《Chinese Physics B》 2025年第5期171-176,共6页
Driven critical dynamics in quantum phase transitions holds significant theoretical importance,and also has practical applications in fast-developing quantum devices.While scaling corrections have been shown to play i... Driven critical dynamics in quantum phase transitions holds significant theoretical importance,and also has practical applications in fast-developing quantum devices.While scaling corrections have been shown to play important roles in fully characterizing equilibrium quantum criticality,their impact on nonequilibrium critical dynamics has not been extensively explored.In this work,we investigate the driven critical dynamics in a two-dimensional quantum Heisenberg model.We find that in this model the scaling corrections arising from both finite system size and finite driving rate must be incorporated into the finite-time scaling form in order to properly describe the nonequilibrium scaling behaviors.In addition,improved scaling relations are obtained from the expansion of the full scaling form.We numerically verify these scaling forms and improved scaling relations for different starting states using the nonequilibrium quantum Monte Carlo algorithm. 展开更多
关键词 driven critical dynamics scaling correction quantum Monte Carlo
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A Model-Data Driven Approach for Calibration of a 5-DOF Hybrid Machining Robot
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作者 Haitao Liu Zhibiao Yan +1 位作者 Conglin Wu Tian Huang 《Chinese Journal of Mechanical Engineering》 2025年第4期248-265,共18页
Current research on robot calibration can be roughly classified into two categories,and both of them have certain inherent limitations.Model-based methods are difficult to model and compensate the pose errors arising ... Current research on robot calibration can be roughly classified into two categories,and both of them have certain inherent limitations.Model-based methods are difficult to model and compensate the pose errors arising from configuration-dependent geometric and non-geometric source errors,whereas the accuracy of data-driven methods depends on a large amount of measurement data.Using a 5-DOF(degrees of freedom)hybrid machining robot as an exemplar,this study presents a model data-driven approach for the calibration of robotic manipulators.An f-DOF realistic robot containing various source errors is visualized as a 6-DOF fictitious robot having error-free parameters,but erroneous actuated/virtual joint motions.The calibration process essentially involves four steps:(1)formulating the linear map relating the pose error twist to the joint motion errors,(2)parameterizing the joint motion errors using second-order polynomials in terms of nominal actuated joint variables,(3)identifying the polynomial coefficients using the weighted least squares plus principal component analysis,and(4)compensating the compensable pose errors by updating the nominal actuated joint variables.The merit of this approach is that it enables compensation of the pose errors caused by configuration-dependent geometric and non-geometric source errors using finite measurement configurations.Experimental studies on a prototype machine illustrate the effectiveness of the proposed approach. 展开更多
关键词 Hybrid machining robot CALIBRATION Model-data driven approach
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Knowledge Driven Machine Learning Towards Interpretable Intelligent Prognostics and Health Management:Review and Case Study
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作者 Ruqiang Yan Zheng Zhou +6 位作者 Zuogang Shang Zhiying Wang Chenye Hu Yasong Li Yuangui Yang Xuefeng Chen Robert X.Gao 《Chinese Journal of Mechanical Engineering》 2025年第1期31-61,共31页
Despite significant progress in the Prognostics and Health Management(PHM)domain using pattern learning systems from data,machine learning(ML)still faces challenges related to limited generalization and weak interpret... Despite significant progress in the Prognostics and Health Management(PHM)domain using pattern learning systems from data,machine learning(ML)still faces challenges related to limited generalization and weak interpretability.A promising approach to overcoming these challenges is to embed domain knowledge into the ML pipeline,enhancing the model with additional pattern information.In this paper,we review the latest developments in PHM,encapsulated under the concept of Knowledge Driven Machine Learning(KDML).We propose a hierarchical framework to define KDML in PHM,which includes scientific paradigms,knowledge sources,knowledge representations,and knowledge embedding methods.Using this framework,we examine current research to demonstrate how various forms of knowledge can be integrated into the ML pipeline and provide roadmap to specific usage.Furthermore,we present several case studies that illustrate specific implementations of KDML in the PHM domain,including inductive experience,physical model,and signal processing.We analyze the improvements in generalization capability and interpretability that KDML can achieve.Finally,we discuss the challenges,potential applications,and usage recommendations of KDML in PHM,with a particular focus on the critical need for interpretability to ensure trustworthy deployment of artificial intelligence in PHM. 展开更多
关键词 PHM Knowledge driven machine learning Signal processing Physics informed INTERPRETABILITY
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NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS
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作者 Xiaoshuai Wu Bailei Wang +12 位作者 Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu 《Chinese Chemical Letters》 2025年第2期309-315,共7页
Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herei... Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herein,we designed a novel nanozyme(P@Co)comprised of polydopamine(PDA)nanoparticles(NPs)loading with ultra-small Co,combining with near infrared(NIR)irradiation,which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI.For lipopolysaccharide(LPS)induced macrophages,P@Co+NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels,decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)as well as inducing macrophage M2 directional polarization.Significantly,it displayed the outstanding activities of lowering acute lung inflammation,relieving diffuse alveolar damage,and up-regulating heat shock protein 70(HSP70)expression,resulting in synergistic enhanced ALI therapy effect.It offers a novel strategy for the clinical treatment of ROS related diseases. 展开更多
关键词 Acute lung injury NIR driven Nanozyme ROS scavenging M2 directional polarization
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Design and Additive Manufacturing of Metamaterial-Enabling Structure-Driven Material Properties
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作者 Ling Wang Bo Song 《Additive Manufacturing Frontiers》 2025年第1期1-2,共2页
Additive manufacturing(AM)technology has revolutionized engineering field by enabling the creation of intricate,high-performance structures that were once difficult or impossible to fabricate.This transformative techn... Additive manufacturing(AM)technology has revolutionized engineering field by enabling the creation of intricate,high-performance structures that were once difficult or impossible to fabricate.This transformative technology has particularly advanced the development of metamaterials-engineered materials whose unique properties arise from their structure rather than composition-unlocking immense potential in fields ranging from aerospace to biomedical engineering. 展开更多
关键词 METAMATERIALS structure driven additive manufacturing biomedical engineering material properties metamaterials engineered materials ENGINEERING
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Erratum to:Data-driven soft sensors in blast furnace ironmaking:a survey
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作者 Yueyang LUO Xinmin ZHANG +3 位作者 Manabu KANO Long DENG Chunjie YANG Zhihuan SONG 《Frontiers of Information Technology & Electronic Engineering》 2025年第9期1765-1765,共1页
The article "Data-driven soft sensors in blast furnace ironmaking:a survey,"written by Yueyang LUO,Xinmin ZHANG,Manabu KANO,Long DENG,Chunjie YANG,and Zhihuan SONG,was originally published electronically on ... The article "Data-driven soft sensors in blast furnace ironmaking:a survey,"written by Yueyang LUO,Xinmin ZHANG,Manabu KANO,Long DENG,Chunjie YANG,and Zhihuan SONG,was originally published electronically on the publisher's Internet portal on Mar.27,2023 without open access. 展开更多
关键词 open access SURVEY data driven soft sensors blast furnace blast furnace ironmaking
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A knowledge-data dually driven paradigm for accurate identification of key blocks in complex rock slopes
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作者 Xiaoyu Qi Han Meng +2 位作者 Nengxiong Xu Gang Mei Jianbing Peng 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第6期3726-3746,共21页
Accurate identification and effective support of key blocks are crucial for ensuring the stability and safety of rock slopes.The number of structural planes and rock blocks were reduced in previous studies.This impair... Accurate identification and effective support of key blocks are crucial for ensuring the stability and safety of rock slopes.The number of structural planes and rock blocks were reduced in previous studies.This impairs the ability to characterize complex rock slopes accurately and inhibits the identification of key blocks.In this paper,a knowledge-data dually driven paradigm for accurate identification of key blocks in complex rock slopes is proposed.Our basic idea is to integrate key block theory into data-driven models based on finely characterizing structural features to identify key blocks in complex rock slopes accurately.The proposed novel paradigm consists of(1)representing rock slopes as graph-structured data based on complex systems theory,(2)identifying key nodes in the graph-structured data using graph deep learning,and(3)mapping the key nodes of graph-structured data to corresponding key blocks in the rock slope.Verification experiments and real-case applications are conducted by the proposed method.The verification results demonstrate excellent model performance,strong generalization capability,and effective classification results.Moreover,the real case application is conducted on the northern slope of the Yanqianshan Iron Mine.The results show that the proposed method can accurately identify key blocks in complex rock slopes,which can provide a decision-making basis and rational recommendations for effective support and instability prevention of rock slopes,thereby ensuring the stability of rock engineering and the safety of life and property. 展开更多
关键词 Key blocks identification Rock slope stability Key block theory Knowledge-data dually driven Graph deep learning
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InvDesFlow: An AI-Driven Materials Inverse Design Workflow to Explore Possible High-Temperature Superconductors
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作者 Xiao-Qi Han Zhenfeng Ouyang +3 位作者 Peng-Jie Guo Hao Sun Ze-Feng Gao Zhong-Yi Lu 《Chinese Physics Letters》 2025年第4期85-98,共14页
The discovery of new superconducting materials,particularly those exhibiting high critical temperature(Tc),has been a vibrant area of study within the field of condensed matter physics.Conventional approaches primaril... The discovery of new superconducting materials,particularly those exhibiting high critical temperature(Tc),has been a vibrant area of study within the field of condensed matter physics.Conventional approaches primarily rely on physical intuition to search for potential superconductors within the existing databases.However,the known materials only scratch the surface of the extensive array of possibilities within the realm of materials. 展开更多
关键词 physical intuition superconducting materialsparticularly condensed matter physicsconventional high temperature superconductors AI driven materials exploration inverse design
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Trajectory prediction algorithm of ballistic missile driven by data and knowledge
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作者 Hongyan Zang Changsheng Gao +1 位作者 Yudong Hu Wuxing Jing 《Defence Technology(防务技术)》 2025年第6期187-203,共17页
Recently, high-precision trajectory prediction of ballistic missiles in the boost phase has become a research hotspot. This paper proposes a trajectory prediction algorithm driven by data and knowledge(DKTP) to solve ... Recently, high-precision trajectory prediction of ballistic missiles in the boost phase has become a research hotspot. This paper proposes a trajectory prediction algorithm driven by data and knowledge(DKTP) to solve this problem. Firstly, the complex dynamics characteristics of ballistic missile in the boost phase are analyzed in detail. Secondly, combining the missile dynamics model with the target gravity turning model, a knowledge-driven target three-dimensional turning(T3) model is derived. Then, the BP neural network is used to train the boost phase trajectory database in typical scenarios to obtain a datadriven state parameter mapping(SPM) model. On this basis, an online trajectory prediction framework driven by data and knowledge is established. Based on the SPM model, the three-dimensional turning coefficients of the target are predicted by using the current state of the target, and the state of the target at the next moment is obtained by combining the T3 model. Finally, simulation verification is carried out under various conditions. The simulation results show that the DKTP algorithm combines the advantages of data-driven and knowledge-driven, improves the interpretability of the algorithm, reduces the uncertainty, which can achieve high-precision trajectory prediction of ballistic missile in the boost phase. 展开更多
关键词 Ballistic missile Trajectory prediction The boost phase Data and knowledge driven The BP neural network
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Threat-Driven Social Plasticity:Switch from Innate Attraction to Conditioned Preference
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作者 Hongyu Zuo Jie Li +1 位作者 Xia Zhang Bin Zhang 《Neuroscience Bulletin》 2025年第8期1503-1506,共4页
Social behaviors,including social support and mating,play a critical role in survival and reproduction.Animals must make adaptive social decisions based on internal states and external contexts[1].The sex of a social ... Social behaviors,including social support and mating,play a critical role in survival and reproduction.Animals must make adaptive social decisions based on internal states and external contexts[1].The sex of a social partner is a crucial factor that shapes social decision-making,as oppositesex interactions are vital for fulfilling reproductive needs,whereas same-sex interactions are essential for both collaborative support and competitive behaviors.Under normal circumstances,mice typically exhibit a variety of prosocial behaviors that strengthen social bonds within their groups. 展开更多
关键词 social support internal states oppositesex interactions mating adaptive social decisions social behaviorsincluding social behavior threat driven social plasticity
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What’s New about the Energy Transition:From“Factor-Driven”to“Value-Led”
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作者 Cong Wei 《China Oil & Gas》 2025年第4期46-50,共5页
The 2025 National Energy Conference(hereinafter referred to as“the conference”)was held in Beijing on December 15,2024.The conference highlighted that“next year and the‘15th Five-Year Plan’period will be crucial ... The 2025 National Energy Conference(hereinafter referred to as“the conference”)was held in Beijing on December 15,2024.The conference highlighted that“next year and the‘15th Five-Year Plan’period will be crucial for accelerating the construction of a new energy system and promoting high-quality energy development and high-level security”.This marks the 16th national energy conference since the annual national energy conference was reinstated in January 2009 after a hiatus of over a decade. 展开更多
关键词 value led th five year plan construction new energy system energy transition national energy conference factor driven
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Editorial on the research topic:AI-driven fluorescence in situ hybridization test for early cancer detection
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作者 Simon James Fong Jia-Hui Yu Li Bao 《Medical Data Mining》 2025年第1期1-3,共3页
Introduction Early cancer detection represents a critical evolution in healthcare,addressing a significant pain point in cancer treatment:the tendency for diagnoses to occur at advanced stages.Traditionally,many cance... Introduction Early cancer detection represents a critical evolution in healthcare,addressing a significant pain point in cancer treatment:the tendency for diagnoses to occur at advanced stages.Traditionally,many cancers are not identified until they have progressed to late stages,where treatment options become limited,less effective,and more costly.This late detection results in poorer prognoses,higher mortality rates,and increased healthcare costs.Without early detection tools like Fluorescence In Situ Hybridization(FISH),these challenges persist,leaving patients with fewer opportunities for successful outcomes. 展开更多
关键词 cancer detection early cancer detection ai driven fluorescence situ hybridization fluorescence situ hybri FISH healthcare costs mortality rates
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A Novel Integrated Energy Management Strategy of Energy Storage System for a Pure Electric-Driven Mining Hydraulic Excavator
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作者 Tao Qin Yunhua Li +2 位作者 Long Quang Yu Yao Liman Yang 《Chinese Journal of Mechanical Engineering》 2025年第2期459-475,共17页
Using electric motors instead of diesel engines as the driving system for mining excavators can reduce the energy consumption and operating costs.However,pure electric-driven mining excavators are prone to unexpected ... Using electric motors instead of diesel engines as the driving system for mining excavators can reduce the energy consumption and operating costs.However,pure electric-driven mining excavators are prone to unexpected power outages in mines because of drastic changes in load power,leading to significant fluctuations in the power demand of the grid,which in turn affects production.To solve the above problem,a pure electric-driven mining hydraulic excavator based on electric-motor-driven swing platform and hydraulic pumps was used as the research object.Moreover,supercapacitors and DC/DC converter,as the energy storage system(ESS)adjust the output power of the grid and recover the braking kinetic energy of the swing platform.Subsequently,a novel integrated energy management strategy for a DC bus voltage predictive controller based on the power feedforward of fuzzy rules is proposed to run mining excavators efficiently and reliably.Specifically,the working modes of the ESS are determined by the DC bus voltage and state of charge(SOC)of the supercapacitor.Next,the output power of the supercapacitor and the DC bus voltage were controlled by adjusting the charging and discharging currents of the DC/DC converter using a predictive controller and fuzzy rules.In addition,a digital prototype of the excavator was verified using an original machine test.The performance of the different strategies and driven systems were analyzed using digital prototypes.The results showed that,compared with traditional excavators with diesel engines,the operational cost of the developed excavators was reduced by 54.02%.Compared to pure electric-driven excavators without an ESS,the peak power of the grid for the developed excavators was reduced by 10%.This study designed an integrated energy management strategy for a pure electric mining excavator that can regulate the power output of the grid and maintain the stability of the bus voltage and SOC of the ESS. 展开更多
关键词 Energy Management Strategy Pure Electric driven Mining Excavator Fuzzy Rules diesel engines mining excavators SUPERCAPACITORS electric motors Energy Storage System
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Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader
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作者 Yan Zhou Guanghui Wen +1 位作者 Jialing Zhou Tao Yang 《IEEE/CAA Journal of Automatica Sinica》 2025年第1期279-281,共3页
Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the ... Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur. 展开更多
关键词 fault tolerant actuator faults multi agent systems bipartite consensus tracking data driven bipartite consensus non autonomous leader observer design
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Research on the Data-Driven Fast Calculation Method of the Temperature Field Distribution of Valve-Side RIP Bushing Used in UHV DC Converter Transformer
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作者 Zehua Wu Luming Xin +5 位作者 Jianwei Cheng Baoying Wu Zeng Qiang Qingyu Wang Linjie Zhao Zhiye Du 《High Voltage》 2025年第5期1210-1220,共11页
Improving the computational efficiency of multi-physics simulation and constructing a real-time online simulation method is an important way to realise the virtual-real fusion of entities and data of power equipment w... Improving the computational efficiency of multi-physics simulation and constructing a real-time online simulation method is an important way to realise the virtual-real fusion of entities and data of power equipment with digital twin.In this paper,a datadriven fast calculation method for the temperature field of resin impregnated paper(RIP)bushing used in converter transformer valve-side is proposed,which combines the data dimensionality reduction technology and the surrogate model.After applying the finite element algorithm to obtain the temperature field distribution of RIP bushing under different operation conditions as the input dataset,the proper orthogonal decomposition(POD)algorithm is adopted to reduce the order and obtain the low-dimensional projection of the temperature data.On this basis,the surrogate model is used to construct the mapping relationship between the sensor monitoring data and the low-dimensional projection,so that it can achieve the fast calculation and reconstruction of temperature field distribution.The results show that this method can effectively and quickly calculate the overall temperature field distribution of the RIP bushing.The maximum relative error and the average relative error are less than 4.5%and 0.25%,respectively.The calculation speed is at the millisecond level,meeting the needs of digitalisation of power equipment. 展开更多
关键词 surrogate modelafter datadriven fast calculation method resin impregnated digital twinin power equipment data driven method computational efficiency finite e
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Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair
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作者 Xin Shen Hang Zhang +12 位作者 Zesheng Song Yangjiele Dong Xiao Ge Shenghao Jin Songsong Guo Ping Zhang Yu Fu Yuchi Zhu Na Xiao Dongmiao Wang Jie Cheng Rongyao Xu Hongbing Jiang 《Bone Research》 2025年第2期430-446,共17页
Plp1-lineage Schwann cells(SCs)of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing,and the abnormal plasticity of SCs would jeopardize ... Plp1-lineage Schwann cells(SCs)of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing,and the abnormal plasticity of SCs would jeopardize the bone regeneration.However,how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood.Here,by employing single-cell transcriptional profiling combined with lineage-specific tracing models,we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.Importantly,our data demonstrated that the Sonic hedgehog(Shh)signaling was responsible for the transition process initiation,which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers.Collectively,these findings depict an injuryspecific niche signal-mediated Plp1-lineage cells transition towards Gli1+MSCs and may be instructive for approaches to promote bone regeneration during aging or other bone diseases. 展开更多
关键词 glia mesenchyme transition bone repair enhancer driven osteogenic differentiation PLP lineage Schwann cells SHH signaling vascular remodeling vascularized osteogenesis
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