Steel catenary riser represents the pioneering riser technology implemented in China’s deep-sea oil and gas opera-tions.Given the complex mechanical conditions of the riser,extensive research has been conducted on it...Steel catenary riser represents the pioneering riser technology implemented in China’s deep-sea oil and gas opera-tions.Given the complex mechanical conditions of the riser,extensive research has been conducted on its dynamic analysis and structural design.This study investigates a deep-sea oil and gas field by developing a coupled model of a semi-submersible platform and steel catenary riser to analyze it mechanical behavior under extreme marine condi-tions.Through multi-objective optimization methodology,the study compares and analyzes suspension point tension and touchdown point stress under various conditions by modifying the suspension position,suspension angle,and catenary length.The optimal configuration parameters were determined:a suspension angle of 12°,suspension position in the southwest direction of the column,and a catenary length of approximately 2000 m.These findings elucidate the impact of configuration parameters on riser dynamic response and establish reasonable parameter layout ranges for adverse sea conditions,offering valuable optimization strategies for steel catenary riser deployment in domestic deep-sea oil and gas fields.展开更多
Intelligent Traffic Management(ITM)has progressively developed into a critical component of modern transportation networks,significantly enhancing traffic flow and reducing congestion in urban environments.This resear...Intelligent Traffic Management(ITM)has progressively developed into a critical component of modern transportation networks,significantly enhancing traffic flow and reducing congestion in urban environments.This research proposes an enhanced framework that leverages Deep Q-Learning(DQL),Game Theory(GT),and Stochastic Optimization(SO)to tackle the complex dynamics in transportation networks.The DQL component utilizes the distribution of traffic conditions for epsilon-greedy policy formulation and action and choice reward calculation,ensuring resilient decision-making.GT models the interaction between vehicles and intersections through probabilistic distributions of various features to enhance performance.Results demonstrate that the proposed framework is a scalable solution for dynamic optimization in transportation networks.展开更多
The uncertain nature of mapping user tasks to Virtual Machines(VMs) causes system failure or execution delay in Cloud Computing.To maximize cloud resource throughput and decrease user response time,load balancing is n...The uncertain nature of mapping user tasks to Virtual Machines(VMs) causes system failure or execution delay in Cloud Computing.To maximize cloud resource throughput and decrease user response time,load balancing is needed.Possible load balancing is needed to overcome user task execution delay and system failure.Most swarm intelligent dynamic load balancing solutions that used hybrid metaheuristic algorithms failed to balance exploitation and exploration.Most load balancing methods were insufficient to handle the growing uncertainty in job distribution to VMs.Thus,the Hybrid Spotted Hyena and Whale Optimization Algorithm-based Dynamic Load Balancing Mechanism(HSHWOA) partitions traffic among numerous VMs or servers to guarantee user chores are completed quickly.This load balancing approach improved performance by considering average network latency,dependability,and throughput.This hybridization of SHOA and WOA aims to improve the trade-off between exploration and exploitation,assign jobs to VMs with more solution diversity,and prevent the solution from reaching a local optimality.Pysim-based experimental verification and testing for the proposed HSHWOA showed a 12.38% improvement in minimized makespan,16.21% increase in mean throughput,and 14.84% increase in network stability compared to baseline load balancing strategies like Fractional Improved Whale Social Optimization Based VM Migration Strategy FIWSOA,HDWOA,and Binary Bird Swap.展开更多
The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilizat...The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilization,and nitrogen-filled packaging technologies can only improve production efficiency and reduce the generation of by-products,but also significantly extend the shelf life of drugs.In the future,process automation and intelligent technology will further optimize the large-scale production process,and the combination of nanotechnology and precision drug delivery will promote the improvement of effect in clinical applications.展开更多
As a core power device in strategic industries such as new energy power generation and electric vehicles,the thermal reliability of IGBT modules directly determines the performance and lifetime of the whole system.A s...As a core power device in strategic industries such as new energy power generation and electric vehicles,the thermal reliability of IGBT modules directly determines the performance and lifetime of the whole system.A synergistic optimization structure of“inlet plate-channel spoiler columns”is proposed for the local hot spot problem during the operation of Insulated Gate Bipolar Transistor(IGBT),combined with the inherent defect of uneven flow distribution of the traditional U-type liquid cooling plate in this paper.The influences of the shape,height(H),and spacing from the spoiler column(b)of the plate on the comprehensive heat dissipation performance of the liquid cooling plate are analyzed at different Reynolds numbers,A dual heat source strategy is introduced and the effect of the optimized structure is evaluated by the temperature inhomogeneity coefficient(Φ).The results show that the optimum effect is achieved when the shape of the plate is square,H=4.5 mm,b=2 mm,and u=0.05 m/s,at which the HTPE=1.09 and Φ are reduced by 40%.In contrast,the maximum temperatures of the IGBT and the FWD(Free Wheeling Diode)chips are reduced by 8.7 and 8.4 K,respectively,and ΔP rises by only 1.58 Pa while keeping ΔT not significantly increased.This optimized configuration achieves a significant reduction in the critical chip temperature and optimization of the flow field uniformity with almost no change in the system flow resistance.It breaks through the limitation of single structure optimization of the traditional liquid cooling plate and effectively solves the problem of uneven flow in the U-shaped cooling plate,which provides a new solution with important engineering value for the thermal management of IGBT modules.展开更多
[Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key ...[Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key factors, including crystallization temperature, stirring speed, solvent drop rate, and seed crystal content, were employed as independent variables, while the crystallization rate served as the response variable. The Box-Behnken response surface method was utilized for the optimization design. [Results] The optimal parameters for the crystallization process, determined through optimization, were as follows: a temperature of 10.6 ℃, a stirring rate of 150 rpm, a solvent drop rate of 1.50 mL/min, and a seed crystal content of 0.12 g. Validation tests conducted under these conditions yielded an average crystallization rate of 94.38% for the refined product. [Conclusions] The crystallization efficiency of ceftriaxone sodium is markedly enhanced, thereby offering substantial support for its industrial production and clinical application.展开更多
Refill friction stir spot welding process is difficultly optimized by accurate modeling because of the high-order functional relationship between welding parameters and joint strength.A database of the welding process...Refill friction stir spot welding process is difficultly optimized by accurate modeling because of the high-order functional relationship between welding parameters and joint strength.A database of the welding process was first established with 6061-T6 aluminum alloy and DP780 galvanized steel as base materials.This dataset was then optimized using a backpropagation neural network.Analyses and mining of the experimental data confirmed the multidimensional mapping relationship between welding parameters and joint strength.Subsequently,intelligent optimization of the welding process and prediction of joint strength were achieved.At the predicted welding parameter(plunging rotation speedω1=1733 r/min,refilling rotation speedω_(2)=1266 r/min,plunging depth p=1.9 mm,and welding speed v=0.5 mm/s),the tensile shear fracture load of the joint reached a maximum value of 10,172 N,while the experimental result was 9980 N,with an error of 1.92%.Furthermore,the correlation of welding parameters-microstructure-joint strength was established.展开更多
Exploring optimal operational schemes for synergistic development is crucial for sustainable management in river basins.This study introduces a multi-objective synergistic optimization framework aimed at analyzing the...Exploring optimal operational schemes for synergistic development is crucial for sustainable management in river basins.This study introduces a multi-objective synergistic optimization framework aimed at analyzing the interplay among flood control,ecological integrity,and desilting objectives under varying watersediment conditions.The framework encompasses multi-objective reservoir optimal operation,scheme decision,and trade-off analysis among competing objectives.To address the optimization model,an elite mutation-based multiobjective particle swarm optimization(MOPSO)algorithm that integrates genetic algorithms(GA)is developed.The coupling coordination degree is employed for optimal scheme decision-making,allowing for the adjustment of weight ratios to investigate the trade-offs between objectives.This research focuses on the Sanmenxia and Xiaolangdi cascade reservoirs in the Yellow River,utilizing three representative hydrological years:1967,1969,and 2002.The findings reveal that:(1)the proposed model effectively generates Pareto fronts for multi-objective operations,facilitating the recommendation of optimal schemes based on coupling coordination degrees;(2)as water-sediment conditions shift from flooding to drought,competition intensifies between the flood control and desilting objectives.While flood control and ecological objectives compete during flood and dry years,they demonstrate synergies in normal years(r=0.22);conversely,ecological and desilting objectives are consistently competitive across all three typical years,with the strongest competition observed in the normal year(r=-0.95);(3)the advantages conferred to ecological objectives increase as water-sediment conditions shift from flooding to drought.However,the promotion of the desilting objective requires more complex trade-offs.This study provides a model and methodological approach for the multi-objective optimization of flood control,sediment management,and ecological considerations in reservoir clusters.Moreover,the methodologies presented herein can be extended to other water resource systems for multi-objective optimization and decision-making.展开更多
In situ recycling is one of the most effective methods to dispose of earth pressure balance(EPB)shield waste muck with residual foaming agents with high moisture content.In this context,response surface methodology(RS...In situ recycling is one of the most effective methods to dispose of earth pressure balance(EPB)shield waste muck with residual foaming agents with high moisture content.In this context,response surface methodology(RSM)was employed to quantify the effects of independent variables,including flocculant dosage,defoamer dosage,and muck drying mass(MDM)and their interactions on defoaming-flocculation-dewatering indices.The polymeric aluminum chloride(PACL)and hydroxy silicone oil-glycerol polypropylene ether(H-G)were selected as the flocculant and defoamer.The contents of surfactants and foam stabilizers in residual foaming agents were determined using the proposed empirical equation.The defoaming ratio,antifoaming ratio,turbidity,moisture content,filtration loss ratio,and fall cone penetration depth were considered as dependent variables.The accuracy of developed RSM models was verified by the analysis results of variance,residuals,and paired t-test.Combined with the desirability approach,an optimal mixing ratio of 0.078 wt%PACL,0.016 wt%H-G,and 27.882 wt%MDM was recommended,leading to a defoaming ratio of 98.34 vol%for residual foams and a moisture content of 56.72 wt%for pressure-filtration cakes.Our findings were demonstrated to be able to provide useful guidance for prediction and optimization of the in situ recycling indicators of EPB shield waste muck in metro tunnel construction sites.展开更多
Traditional demand response(DR)programs for energy-intensive industries(EIIs)primarily rely on electricity price signals and often overlook carbon emission factors,limiting their effectiveness in supporting lowcarbon ...Traditional demand response(DR)programs for energy-intensive industries(EIIs)primarily rely on electricity price signals and often overlook carbon emission factors,limiting their effectiveness in supporting lowcarbon transitions.To address this challenge,this paper proposes an electricity–carbon integratedDR strategy based on a bi-level collaborative optimization framework that coordinates the interaction between the grid and EIIs.At the upper level,the grid operatorminimizes generation and curtailment costs by optimizing unit commitment while determining real-time electricity prices and dynamic carbon emission factors.At the lower level,EIIs respond to these dual signals by minimizing their combined electricity and carbon trading costs,considering their participation in medium-and long-term electricity markets,day-ahead spot markets,and carbon emissions trading schemes.The model accounts for direct and indirect carbon emissions,distributed photovoltaic(PV)generation,and battery energy storage systems.This interaction is structured as a Stackelberg game,where the grid acts as the leader and EIIs as followers,enabling dynamic feedback between pricing signals and load response.Simulation studies on an improved IEEE 30-bus system,with a cement plant as a representative user form EIIs,show that the proposed strategy reduces user-side carbon emissions by 7.95% and grid-side generation cost by 4.66%,though the user’s energy cost increases by 7.80% due to carbon trading.Theresults confirmthat the joint guidance of electricity and carbon prices effectively reshapes user load profiles,encourages peak shaving,and improves PV utilization.This coordinated approach not only achieves emission reduction and cost efficiency but also offers a theoretical and practical foundation for integrating carbon pricing into demand-side energy management in future low-carbon power systems.展开更多
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op...In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.展开更多
A systematic analysis is performed to assess the current situation of transportation and tourism integration in 20 districts and counties located along National Highway 310(Gansu-Qinghai section),and optimization stra...A systematic analysis is performed to assess the current situation of transportation and tourism integration in 20 districts and counties located along National Highway 310(Gansu-Qinghai section),and optimization strategies are explored based on the findings of this analysis.The findings indicate a pressing necessity for further improvement in the practice of transportation and tourism integration in both Gansu and Qinghai provinces.Based on this foundation,a development framework for transportation and tourism integration has been established.This framework simulates a“fast-forward-slow-travel”system in which tourists commence their journey from the origin,traverse through core,secondary,and subsidiary tourist destinations,and ultimately reach the core,secondary,and subsidiary attractions.Furthermore,this study presents optimization recommendations for the integrated development of regional transportation and tourism along the designated route.These suggestions encompass the establishment and optimization of facilities and service points,the planning and design of tourism routes,the promotion of regional synergistic development,the construction of intelligent tourism,and the implementation of green tourism pathways.展开更多
The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the S...The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the SSV.Therefore,this study proposes an optimized design method for an SSV to improve its dynamic performance.First,a multi-physics field-coupling model of the SSV is built,and the effects of different structural parameters on the electromagnetic characteristics are analyzed.After identifying the key influencing parameters,second-order response surface models are established to efficiently predict the opening and closing time.Subsequently,based on the nondominated sorting genetic algorithmⅡ(NSGA-Ⅱ),multi-objective optimization is applied to obtain the Pareto optimal solution of the structural parameters under the double-voltage driving strategy.The structure of the solenoid and valve as well as the dynamic characteristics of the valve are improved.Compared with those before optimization,the optimization results show that the opening and closing time of the optimized SSV are reduced by 24.38%and 51.8%,respectively,and the volume is reduced by 19.7%.The research results and the influence of the solenoid structural parameters on the electromagnetic force provide significant guidance for the design of this type of valve.展开更多
This study employed the Box-Behnken design in response surface methodology(RSM)to optimize predistillation and pressurized distillation column parameters in methanol distillation.Statistical and fittinganalyses demons...This study employed the Box-Behnken design in response surface methodology(RSM)to optimize predistillation and pressurized distillation column parameters in methanol distillation.Statistical and fittinganalyses demonstrated the effects of operational parameters and their interactions on product purity and operating costs.Results showed that for methanol mass fraction in the product,the top distillate of the predistillation column(D_(1)),the interaction between D_(1) and the top distillate of the pressurized distillation column(D_(2)),and the interaction between the theoretical plates of the pressurized distillation column(N_(2))and its refluxratio(R_(2))significantlyaffected the outcome,in addition to pressurized distillation column parameters.Acetone mass fraction was mainly influencedby predistillation column parameters and their interactions,with minimal relation to the pressurized distillation column.Operating costs were primarily affected by the refluxratio(R),withdrawal(D)of both columns,and their interactions.Optimization strategies involved increasing theoretical plates and reducing refluxratios compared to the initial plan,achieving energy-saving and consumption-reduction goals.The process required the pressurized distillation column‘s methanol mass fraction to exceed 99.80%,acetone mass fraction below 2×10^(-8),and formaldehyde mass fraction below 5×10^(-9),with a feed rate of 6100 kg·h^(-1).Plans A,B,and C achieved energy-savings of 29.80%,21.78%,and 25.50%respectively,while ensuring separation efficiencyand product quality.This research provides theoretical and practical guidance for optimizing the methanol distillation process,helping to reduce energy consumption and production costs,thereby enhancing corporate competitiveness.展开更多
To solve the problems of deformation,micro-cracks,and residual tensile stress in laser cladding coatings,the technique of laser cladding with Fe-based memory alloy can be considered.However,the process of in-situ synt...To solve the problems of deformation,micro-cracks,and residual tensile stress in laser cladding coatings,the technique of laser cladding with Fe-based memory alloy can be considered.However,the process of in-situ synthesis of Fe-based memory alloy coatings is extremely complex.At present,there is no clear guidance scheme for its preparation process,which limits its promotion and application to some extent.Therefore,in this study,response surface methodology(RSM)was used to model the response surface between the target values and the cladding process parameters.The NSGA-2 algorithm was employed to optimize the process parameters.The results indicate that the composite optimization method consisting of RSM and the NSGA-2 algorithm can establish a more accurate model,with an error of less than 4.5%between the predicted and actual values.Based on this established model,the optimal scheme for process parameters corresponding to different target results can be rapidly obtained.The prepared coating exhibits a uniform structure,with no defects such as pores,cracks,and deformation.The surface roughness and microhardness of the coating are enhanced,the shaping quality of the coating is effectively improved,and the electrochemical corrosion performance of the coating in 3.5%NaCl solution is obviously better than that of the substrate,providing an important guide for engineering applications.展开更多
Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durabili...Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durability,and corrosion resistance.These metals have body-centered cubic crystal structure,characterized by limited slip systems and impeded dislocation motion,resulting in significant low-temperature brittleness,which poses challenges for the conventional processing.Additive manufacturing technique provides an innovative approach,enabling the production of intricate parts without molds,which significantly improves the efficiency of material usage.This review provides a comprehensive overview of the advancements in additive manufacturing techniques for the production of refractory metals,such as W,Ta,Mo,and Nb,particularly the laser powder bed fusion.In this review,the influence mechanisms of key process parameters(laser power,scan strategy,and powder characteristics)on the evolution of material microstructure,the formation of metallurgical defects,and mechanical properties were discussed.Generally,optimizing powder characteristics,such as sphericity,implementing substrate preheating,and formulating alloying strategies can significantly improve the densification and crack resistance of manufactured parts.Meanwhile,strictly controlling the oxygen impurity content and optimizing the energy density input are also the key factors to achieve the simultaneous improvement in strength and ductility of refractory metals.Although additive manufacturing technique provides an innovative solution for processing refractory metals,critical issues,such as residual stress control,microstructure and performance anisotropy,and process stability,still need to be addressed.This review not only provides a theoretical basis for the additive manufacturing of high-performance refractory metals,but also proposes forward-looking directions for their industrial application.展开更多
Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion...Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.展开更多
基金financially supported by the National Key Research and Development Program of China(Grant No.2022YFC2806100)the National Natural Science Foundation of China(Grant Nos.U22B20126 and 52374020)+1 种基金Science Foundation of China University of Petroleum,Beijing(Grant No.2462025QNXZ009)Beijing Nova Program(Grant No.20250484913).
文摘Steel catenary riser represents the pioneering riser technology implemented in China’s deep-sea oil and gas opera-tions.Given the complex mechanical conditions of the riser,extensive research has been conducted on its dynamic analysis and structural design.This study investigates a deep-sea oil and gas field by developing a coupled model of a semi-submersible platform and steel catenary riser to analyze it mechanical behavior under extreme marine condi-tions.Through multi-objective optimization methodology,the study compares and analyzes suspension point tension and touchdown point stress under various conditions by modifying the suspension position,suspension angle,and catenary length.The optimal configuration parameters were determined:a suspension angle of 12°,suspension position in the southwest direction of the column,and a catenary length of approximately 2000 m.These findings elucidate the impact of configuration parameters on riser dynamic response and establish reasonable parameter layout ranges for adverse sea conditions,offering valuable optimization strategies for steel catenary riser deployment in domestic deep-sea oil and gas fields.
基金the Deanship of Scientific Research at King Khalid University for funding this research through the Large Group Research Project under grant number RGP2/324/46.
文摘Intelligent Traffic Management(ITM)has progressively developed into a critical component of modern transportation networks,significantly enhancing traffic flow and reducing congestion in urban environments.This research proposes an enhanced framework that leverages Deep Q-Learning(DQL),Game Theory(GT),and Stochastic Optimization(SO)to tackle the complex dynamics in transportation networks.The DQL component utilizes the distribution of traffic conditions for epsilon-greedy policy formulation and action and choice reward calculation,ensuring resilient decision-making.GT models the interaction between vehicles and intersections through probabilistic distributions of various features to enhance performance.Results demonstrate that the proposed framework is a scalable solution for dynamic optimization in transportation networks.
文摘The uncertain nature of mapping user tasks to Virtual Machines(VMs) causes system failure or execution delay in Cloud Computing.To maximize cloud resource throughput and decrease user response time,load balancing is needed.Possible load balancing is needed to overcome user task execution delay and system failure.Most swarm intelligent dynamic load balancing solutions that used hybrid metaheuristic algorithms failed to balance exploitation and exploration.Most load balancing methods were insufficient to handle the growing uncertainty in job distribution to VMs.Thus,the Hybrid Spotted Hyena and Whale Optimization Algorithm-based Dynamic Load Balancing Mechanism(HSHWOA) partitions traffic among numerous VMs or servers to guarantee user chores are completed quickly.This load balancing approach improved performance by considering average network latency,dependability,and throughput.This hybridization of SHOA and WOA aims to improve the trade-off between exploration and exploitation,assign jobs to VMs with more solution diversity,and prevent the solution from reaching a local optimality.Pysim-based experimental verification and testing for the proposed HSHWOA showed a 12.38% improvement in minimized makespan,16.21% increase in mean throughput,and 14.84% increase in network stability compared to baseline load balancing strategies like Fractional Improved Whale Social Optimization Based VM Migration Strategy FIWSOA,HDWOA,and Binary Bird Swap.
基金Supported by the Funds from Central Government for Guiding Local Science and Technology Development(ZY20230102)Planning Project of Scientific Research and Technology Development in Guilin(20220104-4,20210202-1)Science and Technology Planing Project of Guangxi(Guike AB24010263).
文摘The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilization,and nitrogen-filled packaging technologies can only improve production efficiency and reduce the generation of by-products,but also significantly extend the shelf life of drugs.In the future,process automation and intelligent technology will further optimize the large-scale production process,and the combination of nanotechnology and precision drug delivery will promote the improvement of effect in clinical applications.
基金supported by Tianjin Science and Technology Planning Project(22YDTPJC0020).
文摘As a core power device in strategic industries such as new energy power generation and electric vehicles,the thermal reliability of IGBT modules directly determines the performance and lifetime of the whole system.A synergistic optimization structure of“inlet plate-channel spoiler columns”is proposed for the local hot spot problem during the operation of Insulated Gate Bipolar Transistor(IGBT),combined with the inherent defect of uneven flow distribution of the traditional U-type liquid cooling plate in this paper.The influences of the shape,height(H),and spacing from the spoiler column(b)of the plate on the comprehensive heat dissipation performance of the liquid cooling plate are analyzed at different Reynolds numbers,A dual heat source strategy is introduced and the effect of the optimized structure is evaluated by the temperature inhomogeneity coefficient(Φ).The results show that the optimum effect is achieved when the shape of the plate is square,H=4.5 mm,b=2 mm,and u=0.05 m/s,at which the HTPE=1.09 and Φ are reduced by 40%.In contrast,the maximum temperatures of the IGBT and the FWD(Free Wheeling Diode)chips are reduced by 8.7 and 8.4 K,respectively,and ΔP rises by only 1.58 Pa while keeping ΔT not significantly increased.This optimized configuration achieves a significant reduction in the critical chip temperature and optimization of the flow field uniformity with almost no change in the system flow resistance.It breaks through the limitation of single structure optimization of the traditional liquid cooling plate and effectively solves the problem of uneven flow in the U-shaped cooling plate,which provides a new solution with important engineering value for the thermal management of IGBT modules.
基金Supported by Central Guided Local Science and Technology Development Funds(ZY20230102)Guilin Scientific Research and Technology Development Programme Project(2023010301-1,20220104-4)+1 种基金Guangxi Science and Technology Programme Project(GK AB24010263)Guangxi Innovation Driving Development Special Funds Project(GK AA22096020).
文摘[Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key factors, including crystallization temperature, stirring speed, solvent drop rate, and seed crystal content, were employed as independent variables, while the crystallization rate served as the response variable. The Box-Behnken response surface method was utilized for the optimization design. [Results] The optimal parameters for the crystallization process, determined through optimization, were as follows: a temperature of 10.6 ℃, a stirring rate of 150 rpm, a solvent drop rate of 1.50 mL/min, and a seed crystal content of 0.12 g. Validation tests conducted under these conditions yielded an average crystallization rate of 94.38% for the refined product. [Conclusions] The crystallization efficiency of ceftriaxone sodium is markedly enhanced, thereby offering substantial support for its industrial production and clinical application.
基金the financial supports provided by the National Key Research and Development Program of China(2023YFE0201500)the National Natural Science Foundation of China(52375315)+2 种基金the Key Talent Plan Project of Guangdong Province(2023TQ07C702)the Research and Development Program in Key Areas of Dongguan(20201200300122)the GDAS’Project of Science and Technology Development(2022GDASZH-2022010203).
文摘Refill friction stir spot welding process is difficultly optimized by accurate modeling because of the high-order functional relationship between welding parameters and joint strength.A database of the welding process was first established with 6061-T6 aluminum alloy and DP780 galvanized steel as base materials.This dataset was then optimized using a backpropagation neural network.Analyses and mining of the experimental data confirmed the multidimensional mapping relationship between welding parameters and joint strength.Subsequently,intelligent optimization of the welding process and prediction of joint strength were achieved.At the predicted welding parameter(plunging rotation speedω1=1733 r/min,refilling rotation speedω_(2)=1266 r/min,plunging depth p=1.9 mm,and welding speed v=0.5 mm/s),the tensile shear fracture load of the joint reached a maximum value of 10,172 N,while the experimental result was 9980 N,with an error of 1.92%.Furthermore,the correlation of welding parameters-microstructure-joint strength was established.
基金National Natural Science Foundation of China,Grant/Award Number:U2243228The Belt and Road Special Foundation of the National Key Laboratory of Water Disaster Prevention,Grant/Award Number:2022nkms04+1 种基金MOE(Ministry of Education in China)Liberal Arts and Social Sciences Foundation,Grant/Award Number:23YJCZH332Natural Science Foundation of Anhui Province,Grant/Award Numbers:2208085US03,2308085US13。
文摘Exploring optimal operational schemes for synergistic development is crucial for sustainable management in river basins.This study introduces a multi-objective synergistic optimization framework aimed at analyzing the interplay among flood control,ecological integrity,and desilting objectives under varying watersediment conditions.The framework encompasses multi-objective reservoir optimal operation,scheme decision,and trade-off analysis among competing objectives.To address the optimization model,an elite mutation-based multiobjective particle swarm optimization(MOPSO)algorithm that integrates genetic algorithms(GA)is developed.The coupling coordination degree is employed for optimal scheme decision-making,allowing for the adjustment of weight ratios to investigate the trade-offs between objectives.This research focuses on the Sanmenxia and Xiaolangdi cascade reservoirs in the Yellow River,utilizing three representative hydrological years:1967,1969,and 2002.The findings reveal that:(1)the proposed model effectively generates Pareto fronts for multi-objective operations,facilitating the recommendation of optimal schemes based on coupling coordination degrees;(2)as water-sediment conditions shift from flooding to drought,competition intensifies between the flood control and desilting objectives.While flood control and ecological objectives compete during flood and dry years,they demonstrate synergies in normal years(r=0.22);conversely,ecological and desilting objectives are consistently competitive across all three typical years,with the strongest competition observed in the normal year(r=-0.95);(3)the advantages conferred to ecological objectives increase as water-sediment conditions shift from flooding to drought.However,the promotion of the desilting objective requires more complex trade-offs.This study provides a model and methodological approach for the multi-objective optimization of flood control,sediment management,and ecological considerations in reservoir clusters.Moreover,the methodologies presented herein can be extended to other water resource systems for multi-objective optimization and decision-making.
基金supported by the National Youth Top-notch Talent Support Program of China(Grant No.00389335)the National Natural Science Foundation of China(Grant No.52378392)the“Foal Eagle Program”Youth Top-notch Talent Project of Fujian Province(Grant No.00387088).
文摘In situ recycling is one of the most effective methods to dispose of earth pressure balance(EPB)shield waste muck with residual foaming agents with high moisture content.In this context,response surface methodology(RSM)was employed to quantify the effects of independent variables,including flocculant dosage,defoamer dosage,and muck drying mass(MDM)and their interactions on defoaming-flocculation-dewatering indices.The polymeric aluminum chloride(PACL)and hydroxy silicone oil-glycerol polypropylene ether(H-G)were selected as the flocculant and defoamer.The contents of surfactants and foam stabilizers in residual foaming agents were determined using the proposed empirical equation.The defoaming ratio,antifoaming ratio,turbidity,moisture content,filtration loss ratio,and fall cone penetration depth were considered as dependent variables.The accuracy of developed RSM models was verified by the analysis results of variance,residuals,and paired t-test.Combined with the desirability approach,an optimal mixing ratio of 0.078 wt%PACL,0.016 wt%H-G,and 27.882 wt%MDM was recommended,leading to a defoaming ratio of 98.34 vol%for residual foams and a moisture content of 56.72 wt%for pressure-filtration cakes.Our findings were demonstrated to be able to provide useful guidance for prediction and optimization of the in situ recycling indicators of EPB shield waste muck in metro tunnel construction sites.
基金supported by the Science and Technology Project of Yunnan Power Grid Co.,Ltd.under Grant No.YNKJXM20222410.
文摘Traditional demand response(DR)programs for energy-intensive industries(EIIs)primarily rely on electricity price signals and often overlook carbon emission factors,limiting their effectiveness in supporting lowcarbon transitions.To address this challenge,this paper proposes an electricity–carbon integratedDR strategy based on a bi-level collaborative optimization framework that coordinates the interaction between the grid and EIIs.At the upper level,the grid operatorminimizes generation and curtailment costs by optimizing unit commitment while determining real-time electricity prices and dynamic carbon emission factors.At the lower level,EIIs respond to these dual signals by minimizing their combined electricity and carbon trading costs,considering their participation in medium-and long-term electricity markets,day-ahead spot markets,and carbon emissions trading schemes.The model accounts for direct and indirect carbon emissions,distributed photovoltaic(PV)generation,and battery energy storage systems.This interaction is structured as a Stackelberg game,where the grid acts as the leader and EIIs as followers,enabling dynamic feedback between pricing signals and load response.Simulation studies on an improved IEEE 30-bus system,with a cement plant as a representative user form EIIs,show that the proposed strategy reduces user-side carbon emissions by 7.95% and grid-side generation cost by 4.66%,though the user’s energy cost increases by 7.80% due to carbon trading.Theresults confirmthat the joint guidance of electricity and carbon prices effectively reshapes user load profiles,encourages peak shaving,and improves PV utilization.This coordinated approach not only achieves emission reduction and cost efficiency but also offers a theoretical and practical foundation for integrating carbon pricing into demand-side energy management in future low-carbon power systems.
基金Supported by the National Natural Science Foundation of China(12071133)Natural Science Foundation of Henan Province(252300421993)Key Scientific Research Project of Higher Education Institutions in Henan Province(25B110005)。
文摘In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.
文摘A systematic analysis is performed to assess the current situation of transportation and tourism integration in 20 districts and counties located along National Highway 310(Gansu-Qinghai section),and optimization strategies are explored based on the findings of this analysis.The findings indicate a pressing necessity for further improvement in the practice of transportation and tourism integration in both Gansu and Qinghai provinces.Based on this foundation,a development framework for transportation and tourism integration has been established.This framework simulates a“fast-forward-slow-travel”system in which tourists commence their journey from the origin,traverse through core,secondary,and subsidiary tourist destinations,and ultimately reach the core,secondary,and subsidiary attractions.Furthermore,this study presents optimization recommendations for the integrated development of regional transportation and tourism along the designated route.These suggestions encompass the establishment and optimization of facilities and service points,the planning and design of tourism routes,the promotion of regional synergistic development,the construction of intelligent tourism,and the implementation of green tourism pathways.
基金Supported by National Natural Science Foundation of China(Grant No.2018YFB1703000)State Key Laboratory of Metal Extrusion and Forging Equipment TechnologyChina National Heavy Machinery Research Institute Co.,Ltd.(Grant No.B2408100.W19)。
文摘The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the SSV.Therefore,this study proposes an optimized design method for an SSV to improve its dynamic performance.First,a multi-physics field-coupling model of the SSV is built,and the effects of different structural parameters on the electromagnetic characteristics are analyzed.After identifying the key influencing parameters,second-order response surface models are established to efficiently predict the opening and closing time.Subsequently,based on the nondominated sorting genetic algorithmⅡ(NSGA-Ⅱ),multi-objective optimization is applied to obtain the Pareto optimal solution of the structural parameters under the double-voltage driving strategy.The structure of the solenoid and valve as well as the dynamic characteristics of the valve are improved.Compared with those before optimization,the optimization results show that the opening and closing time of the optimized SSV are reduced by 24.38%and 51.8%,respectively,and the volume is reduced by 19.7%.The research results and the influence of the solenoid structural parameters on the electromagnetic force provide significant guidance for the design of this type of valve.
基金jointly supported by the National Key Research and Development Program of China(2022YFC2106300)the National Nature Science Foundation of China(U2267226).
文摘This study employed the Box-Behnken design in response surface methodology(RSM)to optimize predistillation and pressurized distillation column parameters in methanol distillation.Statistical and fittinganalyses demonstrated the effects of operational parameters and their interactions on product purity and operating costs.Results showed that for methanol mass fraction in the product,the top distillate of the predistillation column(D_(1)),the interaction between D_(1) and the top distillate of the pressurized distillation column(D_(2)),and the interaction between the theoretical plates of the pressurized distillation column(N_(2))and its refluxratio(R_(2))significantlyaffected the outcome,in addition to pressurized distillation column parameters.Acetone mass fraction was mainly influencedby predistillation column parameters and their interactions,with minimal relation to the pressurized distillation column.Operating costs were primarily affected by the refluxratio(R),withdrawal(D)of both columns,and their interactions.Optimization strategies involved increasing theoretical plates and reducing refluxratios compared to the initial plan,achieving energy-saving and consumption-reduction goals.The process required the pressurized distillation column‘s methanol mass fraction to exceed 99.80%,acetone mass fraction below 2×10^(-8),and formaldehyde mass fraction below 5×10^(-9),with a feed rate of 6100 kg·h^(-1).Plans A,B,and C achieved energy-savings of 29.80%,21.78%,and 25.50%respectively,while ensuring separation efficiencyand product quality.This research provides theoretical and practical guidance for optimizing the methanol distillation process,helping to reduce energy consumption and production costs,thereby enhancing corporate competitiveness.
基金financial supports from the National Natural Science Foundation of China-Youth Project(51801076)the Provincial Colleges and Universities Natural Science Research Project of Jiangsu Province(18KJB430009)+1 种基金the Postdoctoral Research Support Project of Jiangsu Province(1601055C)the Senior Talents Research Startup of Jiangsu University(14JDG126)。
文摘To solve the problems of deformation,micro-cracks,and residual tensile stress in laser cladding coatings,the technique of laser cladding with Fe-based memory alloy can be considered.However,the process of in-situ synthesis of Fe-based memory alloy coatings is extremely complex.At present,there is no clear guidance scheme for its preparation process,which limits its promotion and application to some extent.Therefore,in this study,response surface methodology(RSM)was used to model the response surface between the target values and the cladding process parameters.The NSGA-2 algorithm was employed to optimize the process parameters.The results indicate that the composite optimization method consisting of RSM and the NSGA-2 algorithm can establish a more accurate model,with an error of less than 4.5%between the predicted and actual values.Based on this established model,the optimal scheme for process parameters corresponding to different target results can be rapidly obtained.The prepared coating exhibits a uniform structure,with no defects such as pores,cracks,and deformation.The surface roughness and microhardness of the coating are enhanced,the shaping quality of the coating is effectively improved,and the electrochemical corrosion performance of the coating in 3.5%NaCl solution is obviously better than that of the substrate,providing an important guide for engineering applications.
基金National MCF Energy R&D Program(2024YFE03260300)。
文摘Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durability,and corrosion resistance.These metals have body-centered cubic crystal structure,characterized by limited slip systems and impeded dislocation motion,resulting in significant low-temperature brittleness,which poses challenges for the conventional processing.Additive manufacturing technique provides an innovative approach,enabling the production of intricate parts without molds,which significantly improves the efficiency of material usage.This review provides a comprehensive overview of the advancements in additive manufacturing techniques for the production of refractory metals,such as W,Ta,Mo,and Nb,particularly the laser powder bed fusion.In this review,the influence mechanisms of key process parameters(laser power,scan strategy,and powder characteristics)on the evolution of material microstructure,the formation of metallurgical defects,and mechanical properties were discussed.Generally,optimizing powder characteristics,such as sphericity,implementing substrate preheating,and formulating alloying strategies can significantly improve the densification and crack resistance of manufactured parts.Meanwhile,strictly controlling the oxygen impurity content and optimizing the energy density input are also the key factors to achieve the simultaneous improvement in strength and ductility of refractory metals.Although additive manufacturing technique provides an innovative solution for processing refractory metals,critical issues,such as residual stress control,microstructure and performance anisotropy,and process stability,still need to be addressed.This review not only provides a theoretical basis for the additive manufacturing of high-performance refractory metals,but also proposes forward-looking directions for their industrial application.
文摘Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.
