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BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury 被引量:1
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作者 Xin Han Shouyu Wang Zhen Zhang Decheng Lu Hairun Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第23期1775-1779,共5页
This study sought to elucidate the changes of nuclear factor kappa B (NF-KB) expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. T... This study sought to elucidate the changes of nuclear factor kappa B (NF-KB) expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury, compared with normal saline-treated rats. This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury. Overall, the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury. 展开更多
关键词 spinal cord injury BMS-345541 nuclear factor kappa B locomotor function neural regeneration
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Nuclear Effect on Gluon Distribution Function and Associate Production of J/Ψ and y with Large P_T in High Energy p-Fe Collision
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作者 Zhang Shu~2 He Zhe-min~(1,2) Peng Hong-an~(1,3) Duan Chun-gui~21 CCAST(World Laboratory)P.O.Box 8730,Biejing 1000802 Physics Department,Hebei Normal University,Shijiazhuang,0500163 Physics Department,Peking University,Beijing 100871 《Chinese journal of nuclear physics》 1995年第3期205-208,共4页
With three theoretical models of nuclear effects on gluon distribution functions,the differentialcross sections and the total cross sections for associate production of J/ψ and γ with large P_T in high energyp-Fe co... With three theoretical models of nuclear effects on gluon distribution functions,the differentialcross sections and the total cross sections for associate production of J/ψ and γ with large P_T in high energyp-Fe collisions are calculated. 展开更多
关键词 GLUON distribution function nuclear effect J/Ψ PRODUCTION
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Unit 1 of Ling’ao Nuclear Power Plant phase II underwent hot functional test successfully
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作者 Liu Chunsheng 《Electricity》 2010年第2期8-,共1页
On February 25, the Unit 1 of Ling’ao Nuclear Power Plant phase II underwent a 41-day-long hot functional test successfully with its major systems satisfying the requirements for
关键词 II TEST ao nuclear Power Plant phase II underwent hot functional test successfully Unit 1 of Ling
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前列腺素E1预处理抑制脊髓缺血再灌注损伤后模型大鼠内皮细胞的铁死亡
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作者 黄玉珊 王荣荣 +1 位作者 李湘淼 白金柱 《中国组织工程研究》 北大核心 2026年第22期5716-5727,共12页
背景:铁死亡是脊髓缺血再灌注损伤的重要病理机制。研究证实,前列腺素E1可减轻慢性脑灌注不足诱导的海马体中脑微血管内皮细胞损伤,但它对脊髓缺血再灌注损伤后内皮细胞铁死亡的作用尚缺乏深入研究。目的:探讨前列腺素E1预处理能否通过... 背景:铁死亡是脊髓缺血再灌注损伤的重要病理机制。研究证实,前列腺素E1可减轻慢性脑灌注不足诱导的海马体中脑微血管内皮细胞损伤,但它对脊髓缺血再灌注损伤后内皮细胞铁死亡的作用尚缺乏深入研究。目的:探讨前列腺素E1预处理能否通过抑制内皮细胞的铁死亡来减轻脊髓缺血再灌注损伤,并阐明可能的机制。方法:①细胞实验:将大鼠脊髓微血管内皮细胞分4组处理:对照组在常氧(体积分数20%O_(2))条件下加入完全培养基培养;模型组置于缺氧培养箱(体积分数95%N_(2)、5%CO_(2))中加入无葡萄糖无血清培养基3 h(氧-葡萄糖剥夺),随后在常氧(体积分数20%O_(2))条件下加入完全培养基培养12 h(复氧),建立氧-葡萄糖剥夺/复氧模型模拟脊髓缺血再灌注损伤;预处理组氧-葡萄糖剥夺3 h后继续培养2 h,添加前列腺素E1处理2 h后复氧培养12 h;抑制剂组氧-葡萄糖剥夺3 h后添加核因子红细胞2相关因子2抑制剂ML385处理2 h,再添加前列腺素E1处理2 h,复氧培养12 h。处理结束后,检测细胞内丙二醛、谷胱甘肽和Fe2+浓度,CCK-8法检测细胞活力,免疫荧光染色与Western blot检测酰基辅酶A合成酶长链家族成员4、谷胱甘肽过氧化物酶4表达,流式细胞术检测细胞内活性氧水平,Western blot检测核因子红细胞2相关因子2、血红素加氧酶1蛋白表达。②动物实验:将45只大鼠随机分为3组处理:假手术组(n=15)仅开腹,暴露腹主动脉但不阻断;模型组(n=15)夹闭腹主动脉30 min后经尾静脉注射生理盐水,随后恢复动脉血流(建立脊髓缺血再灌注损伤模型);预处理组(n=15)夹闭腹主动脉30 min后经尾静脉注射前列腺素E1,随后恢复动脉血流。恢复动脉血流24 h后,通过BBB评分、斜板实验和尼氏染色评估大鼠运动功能和神经元损伤情况,脊髓含水量检测、闭锁小带蛋白免疫荧光染色和CD34免疫组化染色评估血脊髓屏障完整性和微血管密度,免疫荧光染色、普鲁士蓝染色、Western blot和生化检测评估脊髓组织铁死亡情况。结果与结论:①细胞实验:氧-葡萄糖剥夺/复氧造模可降低大鼠脊髓微血管内皮细胞活力、诱导细胞铁死亡以及下调核因子红细胞2相关因子2、血红素加氧酶1蛋白表达,前列腺素E1预处理可抑制氧-葡萄糖剥夺/复氧造模对大鼠脊髓微血管内皮细胞的上述影响;ML385部分逆转了前列腺素E1预处理的作用。②动物实验:前列腺素E1预处理可减轻脊髓缺血再灌注损伤造成的大鼠运动功能缺陷与神经元损伤、血脊髓屏障损伤,改善微血管密度,抑制脊髓组织铁死亡。③结果表明,前列腺素E1预处理通过激活核因子红细胞2相关因子2/血红素加氧酶1信号通路抑制内皮细胞的铁死亡,对脊髓缺血再灌注损伤发挥保护作用。 展开更多
关键词 前列腺素E1 预处理 脊髓缺血再灌注损伤 铁死亡 内皮细胞 血脊髓屏障 神经功能 Nrf2/HO-1信号通路
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心俞穴位埋线预处理改善急性心肌缺血模型大鼠的心功能 被引量:1
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作者 陈小青 卞路瑶 +2 位作者 陆星宇 杨涛 李湘海 《中国组织工程研究》 北大核心 2026年第4期882-891,共10页
背景:针刺心俞穴能显著改善急性心肌缺血的心功能,保护心肌细胞,但心俞穴位埋线处理对急性心肌缺血心功能的效果及机制尚不明确。核因子κB激活常出现P65亚型的核内易位,核因子κB信号通路的活化标志是P65水平升高。目的:探究心俞穴位... 背景:针刺心俞穴能显著改善急性心肌缺血的心功能,保护心肌细胞,但心俞穴位埋线处理对急性心肌缺血心功能的效果及机制尚不明确。核因子κB激活常出现P65亚型的核内易位,核因子κB信号通路的活化标志是P65水平升高。目的:探究心俞穴位埋线预处理对急性心肌缺血大鼠心功能及白细胞介素10、肿瘤坏死因子α、P65基因和蛋白表达水平的影响。方法:采用随机数字表法将32只雄性SD大鼠分为空白组、模型组、心俞穴组、非经非穴组,每组8只,后3组构建急性心肌缺血大鼠模型。心俞穴组大鼠心俞穴位埋线14 d,随后背部皮下注射盐酸异丙肾上腺素构建急性心肌缺血大鼠模型;非经非穴组局部埋线14 d,余同上;模型组心俞仅标记,余同上;空白组心俞仅标记,随后背部皮下注射等量生理盐水。造模后24 h检测心电图、心脏超声,腹主动脉取血ELISA法检测血清肌酸激酶和肌酸激酶同工酶水平,随后麻醉处死大鼠取材。苏木精-伊红和TUNEL染色观察心肌组织病理学变化和心肌细胞凋亡情况;RT-qPCR和Western Blot法检测心肌组织肿瘤坏死因子α、白细胞介素10、P65 mRNA及蛋白表达。结果与结论:(1)心电图:与空白组比较,模型组、非经非穴组、心俞穴组心电图Ⅱ导联ST段显著抬高;(2)心脏超声:与模型组比较,心俞穴组左室收缩末期内径显著减小(P<0.05),左室射血分数、左室短轴短缩率显著升高(P<0.05);(3)血清肌酸激酶和肌酸激酶同工酶:与模型组比较,心俞穴组显著降低(P<0.05);(4)苏木精-伊红染色:与模型组比较,心俞穴组心肌纤维排列基本整齐,水肿较轻,有少许炎性细胞浸润;(5)TUNEL染色:与模型组比较,心俞穴组心肌细胞凋亡荧光强度显著降低,凋亡率显著降低(P<0.05);(6)RT-qPCR、WesternBlot:与模型组比较,心俞穴组心肌组织白细胞介素10表达水平显著增高(P<0.05)、肿瘤坏死因子α、P65表达水平显著降低(P<0.05);(7)提示心俞穴位埋线预处理可改善急性心肌缺血大鼠心功能,其作用机制可能与抑制核因子κB信号通路的活化有关。 展开更多
关键词 心俞 穴位埋线 急性心肌缺血 核因子κB 异丙肾上腺素 心功能 P65 白细胞介素10 工程化组织构建
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Evaluation of Excitation Functions of Reactions Used in Production of Some Medical Radioisotopes
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作者 Idris Ahmad Yahya Ibrahim Yola Fatima Salman Koki 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2017年第3期290-303,共14页
In this work, reaction cross-sections were calculated and Excitation Functions were evaluated for productions of 208Bi, 212,211,210At, 211,210Po isotopes using EXIFON code in the energy range from 0 MeV to 30 MeV. The... In this work, reaction cross-sections were calculated and Excitation Functions were evaluated for productions of 208Bi, 212,211,210At, 211,210Po isotopes using EXIFON code in the energy range from 0 MeV to 30 MeV. The code is based on an analytical model for statistical multistep direct and multistep compound reactions (SMD/SMC model). This work also investigates the shell structure effect on the reaction cross-section, the results obtained show that the cross-sections of (a, na) reaction for both with shell correction and without shell correction are zeros at energies range considered, this shows that the energy of the incident particle is below the threshold of this reaction due to the present of coulomb repulsive force between the projectile and target nucleus. 展开更多
关键词 nuclear Reaction CROSS-SECTION EXCITATION function RADIOISOTOPE nuclear Model
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Study of visualized simulation and analysis of nuclear fuel cycle system based on multilevel flow model 被引量:1
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作者 YOSHIKAWA Hidekazu 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第6期358-370,共13页
Complex energy and environment system, especially nuclear fuel cycle system recently raised socialconcerns about the issues of economic competitiveness, environmental effect and nuclear proliferation. Only underthe co... Complex energy and environment system, especially nuclear fuel cycle system recently raised socialconcerns about the issues of economic competitiveness, environmental effect and nuclear proliferation. Only underthe condition that those conflicting issues are gotten a consensus between stakeholders with different knowledgebackground, can nuclear power industry be continuingly developed. In this paper, a new analysis platform has beendeveloped to help stakeholders to recognize and analyze various socio-technical issues in the nuclear fuel cycle systembased on the functional modeling method named Multilevel Flow Models (MFM) according to the cognition theoryof human being. Its character is that MFM models define a set of mass, energy and information flow structures onmultiple levels of abstraction to describe the functional structure of a process system and its graphical symbol representationand the means-end and part-whole hierarchical flow structure to make the represented process easy to beunderstood. Based upon this methodology, a micro-process and a macro-process of nuclear fuel cycle system wereselected to be simulated and some analysis processes such as economics analysis, environmental analysis and energybalance analysis related to those flows were also integrated to help stakeholders to understand the process of decision-making with the introduction of some new functions for the improved Multilevel Flow Models Studio, and finallythe simple simulation such as spent fuel management process simulation and money flow of nuclear fuel cycleand its levelised cost analysis will be represented as feasible examples. 展开更多
关键词 核燃料 功能模型 能源工业 核能 环境友好性 核电厂
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Approximating the Radial Distribution Function of the Electron in a Hydrogen Atom by a Normal Distribution Suggests That Magnetic Confinement Fusion Would Be Less Energy Efficient than Inertial Confinement Fusion
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作者 Motohisa Osaka 《Applied Mathematics》 2024年第9期585-593,共9页
Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the s... Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the single electron in 1s orbit is expressed as φ2, a function of distance from the nucleus. However, the probability of existence of the electron is expressed as a radial distribution function at an arbitrary distance from the nucleus, so it is estimated as the probability of the entire spherical shape of that radius. In this study, it has been found that the electron existence probability approximates the radial distribution function by assuming that the probability of existence of the electron being in the vicinity of the nucleus follows a normal distribution for arbitrary x-, y-, and z-axis directions. This implies that the probability of existence of the electron, which has been known only from the distance information, would follow a normal distribution independently in the three directions. When the electrons’ motion is extremely restricted in a certain direction by the magnetic field of both tokamak and helical fusion reactors, the probability of existence of the electron increases with proximity to the nucleus, and as a result, it is less likely to be liberated from the nucleus. Therefore, more and more energy is required to free the nucleus from the electron in order to generate plasma. 展开更多
关键词 Electron Cloud Radial Distribution function nuclear Fusion TOKAMAK Laser
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Fermi Function and Its Applications 被引量:1
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作者 Asma A. Elahwel Najat A. ALjalali +1 位作者 Mariam Barbash Ali M. Awin 《Journal of Applied Mathematics and Physics》 2023年第1期135-146,共12页
In this paper, we give a definition of the Fermi function, or the so-called Woods-Saxon potential, a well-known potential in nuclear physics;then, we give a few of its applications as examples. Some important integral... In this paper, we give a definition of the Fermi function, or the so-called Woods-Saxon potential, a well-known potential in nuclear physics;then, we give a few of its applications as examples. Some important integrals, which involve this function, are computed discussing the integrability and convergence of these integrals. Following, we derive formulae that encounter the above-mentioned function to get nuclear and generalized moments;the radial Fourier transformation is also exposed. Some related applications are then given that use such important integrals;in particular, we give the computation in conjunction with the problem of getting the optical-model potential for heavy-ion interactions at intermediate energies. Finally, we conclude with important remarks to do with the evolution of the subject. 展开更多
关键词 Fermi function INTEGRALS Optical Model POTENTIAL nuclear Interactions CONVERGENCE
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7.0T nuclear magnetic resonance evaluation of the amyloid beta(1–40) animal model of Alzheimer's disease: comparison of cytology verification 被引量:6
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作者 Lei Zhang Shuai Dong +1 位作者 Guixiang Zhao Yu Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第4期430-435,共6页
3.0T magnetic resonance spectroscopic imaging brain function in Alzheimer's disease. However, is a commonly used method in the research ot the role of 7.0T high-field magnetic resonance spectroscopic imaging in brain... 3.0T magnetic resonance spectroscopic imaging brain function in Alzheimer's disease. However, is a commonly used method in the research ot the role of 7.0T high-field magnetic resonance spectroscopic imaging in brain function of Alzheimer's disease remains unclear. In this study, 7.0T magnetic resonance spectroscopy showed that in the hippocampus of Alzheimer's disease rats, the N-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was elevated. This finding was further supported by hematoxylin-eosin staining, which showed a loss of hippocampal neurons and more glial cells. Moreover, electron microscopy showed neuronal shrinkage and mitochondrial rupture, and scanning electron microscopy revealed small size hippocampal synaptic vesicles, incomplete synaptic structure, and reduced number. Overall, the results revealed that 7.0T high-field nuclear magnetic resonance spectroscopy detected the lesions and functional changes in hippocampal neurons of Alzheimer's disease rats in vivo, allowing the possibility for assessing the success rate and grading of the amyloid beta (1-40) animal model of Alzheimer's disease. 展开更多
关键词 nerve regeneration Alzheimer's disease AΒ1-40 high-field functional magnetic resonance nuclear magnetic resonance spectroscopy NEUROPATHOLOGY N-ACETYLASPARTATE CREATINE CHOLINE hippocampus NSFC grant neural regeneration
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Calculations Energy of the (<i>nl</i><sup>2</sup>) <sup>1</sup><i>L<sup>π</sup></i>Doubly Excited States of Two-Electron Systems via the Screening Constant by Unit Nuclear Charge Formalism
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作者 Momar Talla Gning Ibrahima Sakho Malick Sow 《Journal of Modern Physics》 2020年第11期1891-1910,共20页
In this work, the total energies of doubly excited states (<em>ns</em><sup>2</sup>) <sup>1</sup>S<sup>e</sup>, (<em>np</em><sup>2</sup>) <sup&... In this work, the total energies of doubly excited states (<em>ns</em><sup>2</sup>) <sup>1</sup>S<sup>e</sup>, (<em>np</em><sup>2</sup>) <sup>1</sup>D<sup>e</sup>, (<em>nd</em><sup>2</sup>) <sup>1</sup>G<sup>e</sup>, (<em>nf</em><sup>2</sup>) <sup>1</sup>I<sup>e</sup>, (<em>ng</em><sup>2</sup>) <sup>1</sup>K<sup>e</sup>, and (<em>nh</em><sup>2</sup>) <sup>1</sup>M<sup>e</sup> of the helium isoelectronic sequence with Z ≤ 10 are calculated in the framework of the variational method of the Screening Constant by Unit Nuclear Charge (SCUNC). These calculations are performed using a new wavefunction correlated to Hylleraas-type. The possibility of using the SCUNC method in the investigation of high-lying Doubly Excited States(DES) in two-electron systems is demonstrated in the present work in the case of the (<em>nl</em><sup>2</sup>) <sup>1</sup><em>L</em><sup><span style="white-space:nowrap;"><span style="white-space:nowrap;"><span style="white-space:nowrap;"><em>&pi;</em></span></span></span></sup> doubly excited states, where accurate total energies are tabulated up to <em>n</em> = 20. All the results obtained in this paper are in agreement with the values of the available literature and may be useful for future experimental and theoretical studies on the doubly excited (<em>nl</em><sup>2</sup>) <sup>1</sup><em>L</em><sup><span style="white-space:nowrap;"><span style="white-space:nowrap;"><em>π</em></span></span></sup> states of two-electron systems. 展开更多
关键词 Doubly Excited States Helium-Like Systems Screening Constant by Unit nuclear Charge (SCUNC) Wave functions Correlated Total Energy
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Nrf2在2型糖尿病合并脑损伤后神经功能恢复中的作用研究
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作者 热依拉·牙合甫 杨烨 +1 位作者 李瑞晟 穆清爽 《脑与神经疾病杂志》 2025年第6期388-393,共6页
目的探讨核因子红细胞2相关因子2(Nrf2)在2型糖尿病合并脑损伤(T2D-BD)后神经功能恢复中的作用及相关机制.方法使用C57BL/6小鼠建立T2D模型和T2D-BD模型,并进行神经功能评分.采用Western blot检测小鼠脑组织中Nrf2和γH2AX蛋白表达水平... 目的探讨核因子红细胞2相关因子2(Nrf2)在2型糖尿病合并脑损伤(T2D-BD)后神经功能恢复中的作用及相关机制.方法使用C57BL/6小鼠建立T2D模型和T2D-BD模型,并进行神经功能评分.采用Western blot检测小鼠脑组织中Nrf2和γH2AX蛋白表达水平.构建Nrf2敲除(Nrf2^(-/-))小鼠模型,对Nrf2^(+/+)和Nrf2^(-/-)C57BL/6小鼠进行T2D-BD建模,并进行神经功能评分.检测脑组织中的γH2AX蛋白表达、总超氧化物歧化酶(T-SOD)、丙二醛(MDA)、还原型谷胱甘肽(GSH)以及白细胞介素-6(IL-6)和肿瘤坏死因子α(TNF-α)水平.结果与T2D组相比,T2D-BD组小鼠神经功能评分显著升高,脑组织中Nrf2和γH2AX蛋白表达水平增加,T-SOD、GSH及IL-6、TNF-α水平升高,而MDA水平降低(P<0.05).与Nrf2^(+/+)组相比,Nrf2^(-/-)组小鼠神经功能评分升高,脑组织中γH2AX蛋白表达水平增加,T-SOD、GSH及IL-6、TNF-α水平升高,而MDA水平降低(P<0.05).结论Nrf2能够缓解小鼠T2D-BD的症状,减少脑组织氧化应激反应和炎症水平,并促进神经功能的恢复. 展开更多
关键词 2型糖尿病 脑损伤 神经功能 核因子红细胞2相关因子2
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苦黄注射液联合熊去氧胆酸治疗胆汁淤积型肝炎的效果评价及对Nrf2/HO-1信号通路因子的影响
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作者 王亚钦 李旭飞 孙趁意 《海南医学》 2025年第24期3522-3528,共7页
目的探讨苦黄注射液联合熊去氧胆酸治疗胆汁淤积型肝炎的效果评价及对核因子E2相关因子2(Nrf2)/血红素加氧酶-1(HO-1)信号通路因子的影响。方法选取郑州市第三人民医院2022年1月至2024年12月胆汁淤积型肝炎患者102例作为观察对象进行前... 目的探讨苦黄注射液联合熊去氧胆酸治疗胆汁淤积型肝炎的效果评价及对核因子E2相关因子2(Nrf2)/血红素加氧酶-1(HO-1)信号通路因子的影响。方法选取郑州市第三人民医院2022年1月至2024年12月胆汁淤积型肝炎患者102例作为观察对象进行前瞻性研究,按照随机数表法分为常规组51例、观察组51例。两组患者均给予基础治疗,同时常规组患者给予熊去氧胆酸,观察组患者予以熊去氧胆酸联合苦黄注射液,连续治疗两周。比较两组患者的治疗效果,治疗前及治疗两周后肝功能指标[总胆汁酸(TBA)、总胆红素(TBIL)、天冬氨酸氨基转移酶(AST)、丙氨酸转氨酶(ALT)、γ-谷氨酰基转移酶(GGT)]、肝纤维化指标[Ⅲ型前胶原(PC-Ⅲ)、透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原蛋白(Ⅳ-C)]、Nrf2/HO-1信号通路因子[Nrf2、HO-1、醌氧化还原酶-1(NQO1)]、炎性因子[白细胞介素-1β(IL-1β)、转化生长因子β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)]水平,统计不良反应发生率。结果观察组患者的总有效率为94.12%,明显高于常规组的80.39%,差异有统计学意义(P<0.05);治疗两周后观察组患者的血清TBIL、TBA、ALT、AST、GGT水平分别为(18.74±4.82)μmol/L、(16.57±4.05)μmol/L、(45.13±7.02)U/L、(43.20±8.89)U/L、(105.32±13.35)U/L,明显低于常规组(25.40±5.27)μmol/L、(23.92±5.10)μmol/L、(51.77±8.46)U/L、(51.18±10.24)U/L、(121.47±17.82)U/L,差异均有统计学意义(P<0.05);治疗两周后观察组患者的血清LN、HA、PC-Ⅲ、Ⅳ-C水平分别为(108.51±14.29)ng/L、(203.10±30.47)ng/L、(160.22±21.08)ng/L、(113.30±15.52)ng/L,明显低于常规组的(126.34±18.02)ng/L、(231.68±34.28)ng/L、(181.40±24.64)ng/L、(132.43±17.14)ng/L,差异均有统计学意义(P<0.05);治疗两周后观察组患者的血清Nrf2、HO-1、NQO1分别为(3.15±0.41)ng/mL、(2.33±0.40)ng/mL、(2.88±0.53)ng/mL,明显高于常规组(2.80±0.38)ng/mL、(1.98±0.34)ng/mL、(2.41±0.44)ng/mL,差异均有统计学意义(P<0.05);治疗两周后观察组患者的血清IL-1β、TNF-α、TGF-β1水平分别为(15.32±3.21)pg/mL、(43.16±8.73)pg/mL、(30.26±4.38)ng/mL,明显低于常规组(18.69±4.06)pg/mL、(60.10±12.27)pg/mL、(38.15±6.75)ng/mL,差异均有统计学意义(P<0.05);观察组患者的不良反应发生率11.76%,与常规组的7.84%比较差异无统计学意义(P>0.05)。结论苦黄注射液联合熊去氧胆酸治疗胆汁淤积型肝炎疗效确切,可改善肝功能,延缓肝纤维化进程,可能与其调节Nrf2/HO-1信号通路因子、炎症因子水平有关。 展开更多
关键词 胆汁淤积型肝炎 苦黄注射液 熊去氧胆酸 肝功能 核因子E2相关因子2/血红素加氧酶-1信号通路
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Study of A Multi-criteria Evaluation Methodology for Nuclear Fuel Cycle System Based on Sustainability
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作者 Hidekazu Yoshikawa 《工程科学(英文版)》 2006年第1期33-39,共7页
This paper presents a multi-criteria evaluation methodology for nuclear fuel cycle options in terms of energy sustainability. Starting from the general sustainability concept and the public acceptance questionnaire, a... This paper presents a multi-criteria evaluation methodology for nuclear fuel cycle options in terms of energy sustainability. Starting from the general sustainability concept and the public acceptance questionnaire, a set of indicators reflecting specific criteria for the evaluation of nuclear fuel cycle options are defined. Particular attention is devoted to the resource utility efficiency, environmental effect, human health hazard and economic effect, which represent the different concerns of different stakeholders. This methodology also integrated a special mathematic processing approach, namely the Extentics Evaluation Method, which quantifies the human being subjective perception to provide the intuitionistic judgement and comparison for different options. The once-through option and reprocessing option of nuclear fuel cycle are examined by using the proposed methodology. The assessment process and result can give us some guidance in nuclear fuel cycle evaluation under the constraint of limited data. 展开更多
关键词 核燃料循环系统 多标准评估方法论 主观感知 核能
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基于IEC 61513的核电厂功能安全挑战与创新研究
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作者 姚日煌 鹿洵 《电子产品可靠性与环境试验》 2025年第2期123-129,共7页
基于IEC 61513标准,深入探讨了核电厂在功能安全管理中面临的主要挑战,并提出了创新性的解决方案。研究分析了核电行业在应用该标准时遇到的实际问题,尤其是在新型核电技术和极端环境下的适应性问题。通过引入人工智能、大数据分析和物... 基于IEC 61513标准,深入探讨了核电厂在功能安全管理中面临的主要挑战,并提出了创新性的解决方案。研究分析了核电行业在应用该标准时遇到的实际问题,尤其是在新型核电技术和极端环境下的适应性问题。通过引入人工智能、大数据分析和物联网等前沿技术,展示了这些技术在提升核电厂安全性和实时监控能力方面的潜力。研究结果表明,尽管现有的功能安全管理体系在常规运行中表现良好,但在应对新技术和极端条件时仍有改进空间。最后,为核电行业的未来发展提供了新的思路,并对IEC 61513标准的优化提出了建议。 展开更多
关键词 核电厂 功能安全 IEC 61513 人工智能 大数据分析 物联网
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AI4S里程碑式重大成果综述 被引量:1
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作者 李国杰 《计算》 2025年第5期6-15,共10页
本文综述了人工智能技术在数学、物理、化学、生物、材料、能源、制药、集成电路设计等领域的科研和人工智能的递归自我进化(AI4AI)中取得的里程碑式的突破。AI4S的重大进展表明:先用人工智能推动科学技术研究,再用新的科学技术推动经... 本文综述了人工智能技术在数学、物理、化学、生物、材料、能源、制药、集成电路设计等领域的科研和人工智能的递归自我进化(AI4AI)中取得的里程碑式的突破。AI4S的重大进展表明:先用人工智能推动科学技术研究,再用新的科学技术推动经济和社会发展,比在人类的生产和生活中直接采用现在的人工智能技术,可能会获得更大的效益。文章最后也指出,发展AI4S仍面临巨大挑战。 展开更多
关键词 智能化科研 李雅普诺夫函数 矩阵乘法 核聚变 病毒发现模型 高温超导材料 递归自我进化
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非凸混合范数误差编码人脸图像识别方法 被引量:1
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作者 郭俊博 马祥 《计算机工程》 北大核心 2025年第3期208-215,共8页
针对人脸图像在复杂环境下存在噪声污染、光照变化和遮挡等情况,提出一种新的人脸识别方法,即基于非凸混合范数误差编码的人脸识别方法(NMN),旨在统一基于向量和基于矩阵的回归方法于一个回归模型中,以更好地应对多样化的识别挑战。在... 针对人脸图像在复杂环境下存在噪声污染、光照变化和遮挡等情况,提出一种新的人脸识别方法,即基于非凸混合范数误差编码的人脸识别方法(NMN),旨在统一基于向量和基于矩阵的回归方法于一个回归模型中,以更好地应对多样化的识别挑战。在考虑重构图像的低秩性质的同时,引入核范数约束捕捉图像的低秩特征。为缓解由异常值引起的偏差问题,引入非凸函数提高模型的鲁棒性。为进一步提升性能,充分考虑标签信息,以更有效地区分不同类别之间的特征差异。在分类阶段,综合考虑非连续误差和连续误差,利用类重构误差来判别待识别图像。在Extended Yale B、ORL和AR数据集上进行了实验验证,结果表明,相较于其他对比方法,NMN在遮挡人脸识别方面展现出更为卓越的性能。在Extended Yale B数据集上,针对测试样本添加40%的“狒狒”图像遮挡块,该方法的识别率达到80.40%,比其他对比方法至少高出11.68百分点。 展开更多
关键词 人脸识别 非凸函数 核范数约束 混合范数误差编码 复杂环境
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糖尿病性白内障行超声乳化吸除联合人工晶状体植入术后视功能恢复情况及影响因素分析
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作者 邹媛媛 王志学 +2 位作者 张敬一 戴冬姝 侯四清 《临床误诊误治》 2025年第15期77-81,共5页
目的 探讨糖尿病性白内障行超声乳化吸除联合人工晶状体植入术后视功能恢复情况及影响因素。方法 回顾性选取2021年6月至2024年10月收治的糖尿病性白内障患者106例为观察组,另选取同期单纯老年性白内障患者110例为对照组,所有患者均接... 目的 探讨糖尿病性白内障行超声乳化吸除联合人工晶状体植入术后视功能恢复情况及影响因素。方法 回顾性选取2021年6月至2024年10月收治的糖尿病性白内障患者106例为观察组,另选取同期单纯老年性白内障患者110例为对照组,所有患者均接受白内障超声乳化吸除联合人工晶状体植入术,比较两组术后最佳矫正视力(BCVA)恢复情况。再根据术后3个月BCVA将观察组患者分为恢复良好组(BCVA>0.3 LogMAR,n=70)与恢复不良组(BCVA≤0.3 LogMAR,n=36),通过单因素及多因素logistic回归分析影响糖尿病性白内障术后视功能恢复的相关影响因素。结果 观察组术后1周、1个月、3个月BCVA改善幅度小于对照组(P<0.05)。恢复不良组年龄、糖尿病病程、核硬度分级为Ⅳ级的比例、术前糖化血红蛋白、术前BCVA、合并糖尿病视网膜病变、合并黄斑水肿、术后炎症反应的比例均高于恢复良好组(P<0.05,P<0.01)。多因素logistic回归分析显示,年龄、糖尿病病程、核硬度分级、术前糖化血红蛋白、术前BCVA、合并糖尿病视网膜病变、黄斑水肿、术后炎症反应是影响糖尿病性白内障患者术后视功能恢复的独立影响因素(P<0.05,P<0.01)。结论 糖尿病性白内障患者的术后视功能恢复受多种因素影响,其中年龄、糖尿病病程、核硬度分级、术前糖化血红蛋白水平、术前BCVA、合并糖尿病视网膜病变或黄斑水肿、术后炎症反应是独立影响因素。 展开更多
关键词 糖尿病性白内障 超声乳化吸除术 视功能 最佳矫正视力 核硬度 糖化血红蛋白 糖尿病视网膜病变 黄斑水肿
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乙醛肟还原Np(Ⅵ)的机理研究
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作者 李小波 张萌 +1 位作者 吴群燕 石伟群 《原子能科学技术》 北大核心 2025年第1期35-45,共11页
在Purex流程中,调控Np的价态能实现乏燃料中镎的分离。乙醛肟(CH_(3)CHNOH)作为无盐还原剂可有效将Np(Ⅵ)还原为Np(Ⅴ),但微观还原机理尚不清楚。CH_(3)CHNOH存在顺式(Z)和反式(E)异构体,这两种异构体对Np(Ⅵ)可能具有不同的还原能力和... 在Purex流程中,调控Np的价态能实现乏燃料中镎的分离。乙醛肟(CH_(3)CHNOH)作为无盐还原剂可有效将Np(Ⅵ)还原为Np(Ⅴ),但微观还原机理尚不清楚。CH_(3)CHNOH存在顺式(Z)和反式(E)异构体,这两种异构体对Np(Ⅵ)可能具有不同的还原能力和反应过程。本研究利用标量相对论密度泛函理论分别探讨了Z/E-CH_(3)CHNOH还原Np(Ⅵ)的反应机理。反应的热力学结果表明,Z-CH_(3)CHNOH还原Np(Ⅵ)的过程比E-CH_(3)CHNOH更有利,这可能归因于前者形成更多的氢键和反应过程中结构变化较小。动力学结果表明,两种同分异构体还原Np(Ⅵ)的决速步能垒非常相近,分别为22.36、23.03 kcal/mol,表明两者的还原能力基本一致。键长分析结果表明,Z/E-CH_(3)CHNOH还原2个Np(Ⅵ)的过程都伴随着相关键的断裂与形成。第1个Np(Ⅵ)还原属于氢原子转移,第2个Np(Ⅵ)还原是水参与的单电子转移。自旋密度和Np-O_(yl)键长的结果也证实了乙醛肟还原Np(Ⅵ)的本质。本研究解释了Z/E-CH_(3)CHNOH还原Np(Ⅵ)的微小差异,并揭示了其还原本质,为乏燃料中镎的分离提供了理论依据和支持。 展开更多
关键词 乙醛肟 还原反应 密度泛函理论 乏燃料
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基于因果图的核电厂智能报警分析
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作者 陈建华 陈思娟 +6 位作者 杨明 张宸熙 王吉浦 邓士光 郭金烨 李沛林 聂云飞 《哈尔滨工程大学学报》 北大核心 2025年第11期2287-2295,共9页
针对核电厂报警系统的报警过载问题,本文提出了一种基于因果关联网络的报警定位与溯源分析方法。通过系统功能建模,构建了报警传播的因果关系网络,帮助操纵员快速识别报警的根原因。与传统报警系统进行人因实验对比,结果表明该方法平均... 针对核电厂报警系统的报警过载问题,本文提出了一种基于因果关联网络的报警定位与溯源分析方法。通过系统功能建模,构建了报警传播的因果关系网络,帮助操纵员快速识别报警的根原因。与传统报警系统进行人因实验对比,结果表明该方法平均缩短了73%的报警分析时间,显著减轻了操纵员的认知负荷,为核电站数字化主控室的人机交互设计提供了理论依据,具有重要的工程应用价值。 展开更多
关键词 核电厂主控室 报警系统 功能建模 多层流模型 报警分析 根原因定位 因果推理
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