Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In...Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury.展开更多
Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limit...Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limited long-term efficacy.In recent years,peripheral nerve stimulation(PNS)has emerged as a promising neuromodulation technique for these difficult-to-treat conditions.Accumulating clinical evidence,including randomized trials,demonstrates the efficacy of PNS approaches-such as transcutaneous auricular vagus nerve stimulation(taVNS)for depression[1],and trigeminal nerve stimulation(TNS)for attention deficit hyperactivity disorder(ADHD)[2]-with broader applications continuing to be explored[3-6](Fig.1).展开更多
基金supported by the National Natural Science Foundation of China,Nos. 81772453 and 81974358 (both to DSX)Shanghai Municipal Key Clinical Specialty Program,No. shslczdzk02701 (to QX)。
文摘Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury.
基金supported by the National Key Research and Development Program of China(2023YFC2506800)the National Programs for Brain Science and Brain-like Intelligence Technology of China(STI2030-Major Projects,2021ZD0200800)+1 种基金the National Natural Science Foundation of China(82201644 and 82471505)supported by the German Research Foundation(DFG KR 4555/10-1)。
文摘Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limited long-term efficacy.In recent years,peripheral nerve stimulation(PNS)has emerged as a promising neuromodulation technique for these difficult-to-treat conditions.Accumulating clinical evidence,including randomized trials,demonstrates the efficacy of PNS approaches-such as transcutaneous auricular vagus nerve stimulation(taVNS)for depression[1],and trigeminal nerve stimulation(TNS)for attention deficit hyperactivity disorder(ADHD)[2]-with broader applications continuing to be explored[3-6](Fig.1).
