Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.F...Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.展开更多
The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could...The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could not match with the emission pathway for the global to keep a global temperature rise this century well below 2 ℃ and to drive efforts to limit the temperature increase even further to 1.5 ℃ above pre- industrial levels. It is important for countries to do more than their commitment in INDCs, especially in near term. This paper looks at the near term trend for possibilities for further emission reduction compared with INDCs, and found there do have the possibility. It concludes there is space for the four countries/regions to do more than their INDCs submitted to UNFCCC, and see the light towards to a global 2 ℃ target.展开更多
基金supported by grants from the Weifang Municipal Health Commission Research Programme Project(No.WFWSJK-2023-032)the Weifang Science and Technology Development Project(No.2023YX053)the Weifang Young Medical Talent Support Program Funding。
文摘Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.
文摘The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could not match with the emission pathway for the global to keep a global temperature rise this century well below 2 ℃ and to drive efforts to limit the temperature increase even further to 1.5 ℃ above pre- industrial levels. It is important for countries to do more than their commitment in INDCs, especially in near term. This paper looks at the near term trend for possibilities for further emission reduction compared with INDCs, and found there do have the possibility. It concludes there is space for the four countries/regions to do more than their INDCs submitted to UNFCCC, and see the light towards to a global 2 ℃ target.
