Improving device efficiency is fundamental for advancing energy harvesting technology,particularly in systems designed to convert light energy into electrical output.In our previous studies,we developed a basic struct...Improving device efficiency is fundamental for advancing energy harvesting technology,particularly in systems designed to convert light energy into electrical output.In our previous studies,we developed a basic structure light pressure electric generator(Basic-LPEG),which utilized a layered configuration of Ag/Pb(Zr,Ti)O_(3)(PZT)/Pt/GaAs to generate electricity based on light-induced pressure on the PZT.In this study,we sought to enhance the performance of this Basic-LPEG by introducing Ag nanoparticles/graphene oxide(AgNPs/GO)composite units(NP-LPEG),creating upgraded harvesting device.Specifically,by depositing the AgNPs/GO units twice onto the Basic-LPEG,we observed an increase in output voltage and current from 241 mV and 3.1μA to 310 mV and 9.3μA,respectively,under a solar simulator.The increase in electrical output directly correlated with the intensity of the light pressure impacting the PZT,as well as matched the Raman measurements,finite-difference time-domain simulations,and COMSOL Multiphysics Simulation.Experimental data revealed that the enhancement in electrical output was proportional to the number of hot spots generated between Ag nanoparticles,where the electric field experienced substantial amplification.These results underline the effectiveness of AgNPs/GO units in boosting the light-induced electric generation capacity,thereby providing a promising pathway for high-efficiency energy harvesting devices.展开更多
The surge in environmental pollution in recent years driven by numerous pollutants has necessitated the search for efficient removal methods.Phytoremediation is an eco-friendly technique that provides multiple benefit...The surge in environmental pollution in recent years driven by numerous pollutants has necessitated the search for efficient removal methods.Phytoremediation is an eco-friendly technique that provides multiple benefits over conventional methods of removing contaminants.Despite the numerous benefits of this technique,it has certain limitations that can be addressed by incorporating nanoparticles to improve its effectiveness.This review paper aims to explore the impact of heavy metal pollution on plants and human health.It highlights the role and mechanism of nanoparticles in enhancing phytoremediation,their application in the detection of heavy metals,and the strategies for the safe disposal of phytoremediation biomass.Biosynthesized nanoparticles are eco-friendly and non-toxic,with applications in biomedical and environmental fields.Nanoparticles can be used in the form of nano biosensors like smartphone-operated wireless sensors made from Cinnamomum camphora,enabling efficient detection of heavy metal ions.According to the studies,nanoparticles remove 80%–97%of heavy metals by various methods like reduction,precipitation,adsorption,etc.The phytoremediation biomass disposal can be done by heat treatment,phytomining,and microbial treatment with some modifications to further enhance their results.Phytoremediation is an environmentally friendly technique but requires further research and integration with biomass energy production to overcome scalability challenges and ensure safe biomass disposal.展开更多
Developing biomass platform compounds into high value-added chemicals is a key step in renewable resource utilization.Herein,we report porous carbon-supported Ni-ZnO nanoparticles catalyst(Ni-ZnO/AC)synthesized via lo...Developing biomass platform compounds into high value-added chemicals is a key step in renewable resource utilization.Herein,we report porous carbon-supported Ni-ZnO nanoparticles catalyst(Ni-ZnO/AC)synthesized via low-temperature coprecipitation,exhibiting excellent performance for the selective hydrogenation of 5-hydroxymethylfurfural(HMF).A linear correlation is first observed between solvent polarity(E_(T)(30))and product selectivity within both polar aprotic and protic solvent classes,suggesting that solvent properties play a vital role in directing reaction pathways.Among these,1,4-dioxane(aprotic)favors the formation of 2,5-bis(hydroxymethyl)furan(BHMF)with 97.5%selectivity,while isopropanol(iPrOH,protic)promotes 2,5-dimethylfuran production with up to 99.5%selectivity.Mechanistic investigations further reveal that beyond polarity,proton-donating ability is critical in facilitating hydrodeoxygenation.iPrOH enables a hydrogen shuttle mechanism where protons assist in hydroxyl group removal,lowering the activation barrier.In contrast,1,4-dioxane,lacking hydrogen bond donors,stabilizes BHMF and hinders further conversion.Density functional theory calculations confirm a lower activation energy in iPrOH(0.60 eV)compared to 1,4-dioxane(1.07 eV).This work offers mechanistic insights and a practical strategy for solvent-mediated control of product selectivity in biomass hydrogenation,highlighting the decisive role of solvent-catalyst-substrate interactions.展开更多
Functional neurological recovery remains the primary objective when treating ischemic stroke.However,current therapeutic approaches often fall short of achieving optimal outcomes.One of the most significant challenges...Functional neurological recovery remains the primary objective when treating ischemic stroke.However,current therapeutic approaches often fall short of achieving optimal outcomes.One of the most significant challenges in stroke treatment is the effective delivery of neuroprotective agents across the blood–brain barrier to ischemic regions within the brain.The blood–brain barrier,while essential for protecting the brain from harmful substances,also restricts the passage of many therapeutic compounds,thus limiting their efficacy.In this review,we summarizes the emerging role of nanoparticle-based therapies for the treatment of ischemic stroke and investigate their potential to revolutionize drug delivery,enhance neuroprotection,and promote functional recovery.Recent advancements in nanotechnology have led to the development of engineered nanoparticles specifically designed to overcome the blood–brain barrier,thus enabling the targeted delivery of therapeutic agents directly to the affected brain areas.Preclinical studies have demonstrated the remarkable potential of nanoparticle-based therapies to activate key neuroprotective pathways,such as the phosphoinositide 3-kinase/protein kinase B/c AMP response element-binding protein signaling cascade,which is crucial for neuronal survival,synaptic plasticity,and post-stroke recovery.By modulating these pathways,nanoparticles could mitigate neuronal damage,reduce inflammation,and promote tissue repair.Furthermore,nanoparticles offer a unique advantage by enabling multimodal therapeutic strategies that simultaneously target multiple pathological mechanisms of ischemic stroke,including oxidative stress,neuroinflammation,and apoptosis.This multifaceted approach enhances the overall efficacy of treatment,addressing the complex and interconnected processes that contribute to stroke-related brain injury.Surface modifications,such as functionalization with specific ligands or targeting molecules,further improve the precision of drug delivery,enhance targeting specificity,and prolong systemic circulation,thereby optimizing therapeutic outcomes.Nanoparticlebased therapeutics represent a paradigm shift for the management of stroke and provide a promising avenue for reducing post-stroke disability and improving the outcomes of long-term rehabilitation.By combining targeted drug delivery with the ability to modulate critical neuroprotective pathways,nanoparticles hold the potential to transform the treatment landscape for ischemic stroke.However,while preclinical data are highly encouraging,significant challenges remain in translating these advancements into clinical practice.Further research is needed to refine nanoparticle designs,optimize their safety profiles,and ensure their scalability for widespread application.Rigorous clinical trials are essential to validate their efficacy,assess long-term biocompatibility,and address potential off-target effects.The integration of interdisciplinary approaches,combining insights from nanotechnology,neuroscience,and pharmacology,will be critical if we are to overcome these challenges.Ultimately,nanoparticle-based therapies offer a foundation for innovative,precision-based treatments that could significantly improve outcomes for stroke patients,thus paving the way for a new era in stroke care and neurological rehabilitation.展开更多
Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(...Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(III)nanoparticles with the most commonly identified FRB,Geobacter sulfurreducens PCA,remains poorly understood.Herein,we demonstrated that the synergistic role of outer membrane proteins and periplasmic proteins in the EET process for-Fe_(2)O_(3),Fe3O4,and𝛽α-FeOOH nanoparticles by construction of multiple gene knockout strain.oxpG(involved in the type II secretion system)and omcST(outer membrane c-type cytochrome)medi-ated pathways accounted for approximately 67%of the total reduction of𝛼α-Fe_(2)O_(3) nanoparticles.The residual reduction of𝛼α-Fe_(2)O_(3) nanoparticles in∆oxpG-omcST strain was likely caused by redox-active substances in cell supernatant.Conversely,the reduction of dissolved Fe(III)was almost unaffected in∆oxpG-omcST strain at the same concentration.However,at high dissolved Fe(III)concentration,the reduction significantly decreased due to the formation of Fe(III)nanoparticles,suggesting that this EET process is specific to Fe(III)nanoparticles.Overall,our study provided a more comprehensive understanding for the EET pathways between G.sulfurreducens PCA and different Fe(III)species,enriching our knowledge on the role of microorganisms in iron biogeochemical cycles and remediation strategies of pollutants.展开更多
Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as...Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as the strongly enhanced synergistic interactions between Pt and Co atoms,the obtained Pt-on-Co/C400 catalysts exhib-ited excellent catalytic activity toward the hydrolysis of ammonia borane with an extremely high turnover frequency(TOF)value of 3022 min^(-1)at 303 K.Durability test indicated that the obtained Pt-on-Co/C400 catalysts possessed high catalytic stability,and there were no changes in the catalyst structures and catalytic activities after 10 cycles.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
Photocatalysis is widely regarded as a highly promising sustainable technique for addressing the challenges posed by environmental pollution and energy provision.In recent years,metal-loaded MOFs has become a rising s...Photocatalysis is widely regarded as a highly promising sustainable technique for addressing the challenges posed by environmental pollution and energy provision.In recent years,metal-loaded MOFs has become a rising star within the domain of photocatalysis due to its high specific surface area and porosity,adjustable structure,diverse and abundant catalytic components,which has exhibited excellent photocatalytic activity and exhibit great potential in a range of disciplines.In this paper,the principles for evaluating the photocatalytic performance of MOFs-based materials were firstly introduced,and some typical examples were also listed accordingly.Along with this,particular emphasis is paid to the main factors affecting the photocatalytic performance of metal-loaded MOFs.Then the synthesis and design strategies of MOFs loaded metal entities of varying sizes(single atoms,nanoclusters,and nanoparticles),and their applications in photocatalytic CO_(2)reduction,hydrogen production,photooxidation and photocatalytic hydrogenation were summarized and discussed.Finally,the opportunities and challenges faced in this kind of MOFs-based composites were analyzed from different perspectives.This report is expected to help researchers design and develop high-performance MOFs-based photocatalytic materials.展开更多
Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are...Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water pollution.In this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing agent.Experimental analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag NPs.The surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their aggregation.After the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite hydrogel.The inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag NPs.The prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.展开更多
High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental sta...High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy consumption.However,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron scale.Here,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand exchange.This strategy enabled us to achieve ultra-high resolution efficiently(line width<4μm,the best resolution for reported inorganic electrochromic materials).Additionally,the resulting device exhibited impressive electrochromic performance,such as fast response(<1 s at 0 V),high coloration efficiency(119.5 cm^(2) C^(−1)),good optical modulation(55.9%),and durability(>3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,etc.The success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.展开更多
Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes pathology.This condition could be protected by the upregulation of t...Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes pathology.This condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express PCBP1.As the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein nanoparticles.First,PCBP1 is small and druggable.Second,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed degradation.Furthermore,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and activity.Notably,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.展开更多
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a s...Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.展开更多
The cluster-shaped plasmonic nanostructures are used to manage the incident light inside an ultra-thin silicon solar cell.Here we simulate spherical,conical,pyramidal,and cylindrical nanoparticles in a form of a clust...The cluster-shaped plasmonic nanostructures are used to manage the incident light inside an ultra-thin silicon solar cell.Here we simulate spherical,conical,pyramidal,and cylindrical nanoparticles in a form of a cluster at the rear side of a thin silicon cell,using the finite difference time domain(FDTD)method.By calculating the optical absorption and hence the photocurrent,it is shown that the clustering of nanoparticles significantly improves them.The photocurrent enhancement is the result of the plasmonic effects of clustering the nanoparticles.For comparison,first a cell with a single nanoparticle at the rear side is evaluated.Then four smaller nanoparticles are put around it to make a cluster.The photocurrents of 20.478 mA/cm2,23.186 mA/cm2,21.427 mA/cm2,and 21.243 mA/cm2 are obtained for the cells using clustering conical,spherical,pyramidal,cylindrical NPs at the backside,respectively.These values are 13.987 mA/cm2,16.901 mA/cm2,16.507 mA/cm2,17.926 mA/cm2 for the cell with one conical,spherical,pyramidal,cylindrical NPs at the backside,respectively.Therefore,clustering can significantly improve the photocurrents.Finally,the distribution of the electric field and the generation rate for the proposed structures are calculated.展开更多
Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors.Its median survival time is typically less than a year after diagnosis.One of the major challenges in tr...Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors.Its median survival time is typically less than a year after diagnosis.One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system.The blood-brain barrier is cooperating with advanced stages of malignancy.The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors.Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier.Additionally,the development of smart nanoparticles brings new hope for cancer diagnosis and treatment.These nanoparticles improve drug delivery efficiency,allowing for the creation of targeted and stimuli-responsive delivery methods.This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment,exploring the range of nanoparticles under development,their applications,targeting strategies,and the latest progress in enhancing transport across the blood-brain barrier.It also addresses the ongoing challenges and potential benefits of these innovative approaches.展开更多
Combining single atoms with clusters or nanoparticles is an emerging tactic to design efficient electrocatalysts.Both synergy effect and high atomic utilization of active sites in the composite catalysts result in enh...Combining single atoms with clusters or nanoparticles is an emerging tactic to design efficient electrocatalysts.Both synergy effect and high atomic utilization of active sites in the composite catalysts result in enhanced electrocatalytic performance,simultaneously provide a radical analysis of the interrelationship between structure and activity.In this review,the recent advances of single-atomic site catalysts coupled with clusters or nanoparticles are emphasized.Firstly,the synthetic strategies,characterization,dynamics and types of single atoms coupled with clusters/nanoparticles are introduced,and then the key factors controlling the structure of the composite catalysts are discussed.Next,several clean energy catalytic reactions performed over the synergistic composite catalysts are illustrated.Eventually,the encountering challenges and recommendations for the future advancement of synergistic structure in energy-transformation electrocatalysis are outlined.展开更多
We demonstrate that,in a simple linearly-polarized plane wave,the optical pulling forces on nanoparticle clusters with gain can be induced by the Fano-like resonance.The numerical results based on the full-wave calcul...We demonstrate that,in a simple linearly-polarized plane wave,the optical pulling forces on nanoparticle clusters with gain can be induced by the Fano-like resonance.The numerical results based on the full-wave calculation show that the optical pulling forces can be attributed to the recoil forces for the nanoparticle clusters composed of dipolar nanoparticles with three different configurations.Interestingly,the recoil forces giving rise to optical pulling forces are exactly dominated by the coupling term between the electric and magnetic dipoles excited in the nanoparticle clusters,while other higherorder terms have a negligible contribution.In addition,the optical pulling force can be tailored by modulating the Fano-like resonance via either the particle size or the gain magnitude,offering an alternative freedom degree for optical manipulations of particle clusters.展开更多
The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effecti...The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effective and sustainable methods for antibiotics and antitumor drug degradation.Here,the hybrid nanomaterial(g-C_(3)N_(4)@Fe/Pd)was synthesized and used to remove a kind of both an antibiotic and antitumor drug named mitoxantrone(MTX)with 92.0%removal efficiency,and the MTX removal capacity is 450 mg/g.After exposing to the hybrid material the MTX aqueous solution changed color from dark blue to lighter progressively,and LC-UV results of residual solutions showthat a newpeak at 3.0min(MTX:13.2min)after removal by g-C_(3)N_(4)@Fe/Pd appears,with the simultaneous detection of intermediate products indicating that g-C_(3)N_(4)@Fe/Pd indeed degrades MTX.Detailed mass spectrometric analysis suggests that the nuclear mass ratio decreased from 445.2(M+1H)to 126.0(M+1H),169.1(M+1H),239.2(M+1H),267.3(M+1H),285.2(M+1H),371.4(M+1H)and 415.2(M+1H),and the maximum proportion(5.63%)substance of all degradation products(126.0(M+1H))is 40-100 times less toxic than MTX.A mechanism for the removal and degradation of mitoxantrone was proposed.Besides,actual water experiments confirmed that the maximum removal capacity of MTX by g-C_(3)N_(4)@Fe/Pd is up to 492.4 mg/g(0.02 g/L,10 ppm).展开更多
Atherosclerosis(AS)is a progressive inflammatory disease,and thrombosis most likely leads to cardiovascular morbidity and mortality globally.Thrombolytic drugs alone cannot completely prevent thrombotic events,and tre...Atherosclerosis(AS)is a progressive inflammatory disease,and thrombosis most likely leads to cardiovascular morbidity and mortality globally.Thrombolytic drugs alone cannot completely prevent thrombotic events,and treatments targeting thrombosis also need to regulate the inflammatory process.Based on the dynamic pathological development of AS,biomimetic thrombus-targeted nanoparticles HMTL@PM were prepared.Hirudin and lumbrukinase,effective substances of traditional Chinese medicine,were self-assembled under the action of tannic acid and Mn^(2+).HMTL@PM dissociated in the weakly acidic microenvironment of atherosclerosis and exhibited excellent therapeutic effects,including alleviating inflammation,dissolving thrombus,anticoagulation,and promoting cholesterol efflux.HMTL@PM effectively regulated the progression of AS and provided a newperspective for the development of drug delivery systems for AS therapy,which holds important research significance for reducing the mortality of cardiovascular and cerebrovascular diseases.展开更多
A steady rise in the overall population is creating an overburden on crops due to their global demand.On the other hand,given the current climate change and population growth,agricultural practices established during ...A steady rise in the overall population is creating an overburden on crops due to their global demand.On the other hand,given the current climate change and population growth,agricultural practices established during the Green Revolution are no longer viable.Consequently,innovative practices are the prerequisite of the time struggle with the rising global food demand.The potential of nanotechnology to reduce the phytotoxic effects of these ecological restrictions has shown significant promise.Nanoparticles(NPs)typically enhance plant resilience to stressors by fortifying the physical barrier,optimizing photosynthesis,stimulating enzymatic activity for defense,elevating the concentration of stress-resistant compounds,and activating the expression of genes associated with defense mechanisms.In this review,we thoroughly cover the uptake and translocations of NPs crops and their potential valuable functions in enhancing plant growth and development at different growth stages.Additionally,we addressed how NPs improve plant resistance to biotic and abiotic stress.Generally,this review presents a thorough understanding of the significance of NPs in plants and their prospective value for plant antioxidant and crop development.展开更多
基金supported by Korea Evaluation Institute of Industrial Technology(KEIT)grant funded by the Korea Government(MOTIE)(RS-2022-00154720,Technology Innovation Program Development of next-generation power semiconductor based on Si-on-SiC structure)the National Research Foundation of Korea(NRF)by the Korea government(RS-2023-NR076826)Global-Learning&Academic Research Institution for Master's·PhD students,and Postdocs(LAMP)Program of the National Research Foundation of Korea(NRF)by the Ministry of Education(No.RS-2024-00443714).
文摘Improving device efficiency is fundamental for advancing energy harvesting technology,particularly in systems designed to convert light energy into electrical output.In our previous studies,we developed a basic structure light pressure electric generator(Basic-LPEG),which utilized a layered configuration of Ag/Pb(Zr,Ti)O_(3)(PZT)/Pt/GaAs to generate electricity based on light-induced pressure on the PZT.In this study,we sought to enhance the performance of this Basic-LPEG by introducing Ag nanoparticles/graphene oxide(AgNPs/GO)composite units(NP-LPEG),creating upgraded harvesting device.Specifically,by depositing the AgNPs/GO units twice onto the Basic-LPEG,we observed an increase in output voltage and current from 241 mV and 3.1μA to 310 mV and 9.3μA,respectively,under a solar simulator.The increase in electrical output directly correlated with the intensity of the light pressure impacting the PZT,as well as matched the Raman measurements,finite-difference time-domain simulations,and COMSOL Multiphysics Simulation.Experimental data revealed that the enhancement in electrical output was proportional to the number of hot spots generated between Ag nanoparticles,where the electric field experienced substantial amplification.These results underline the effectiveness of AgNPs/GO units in boosting the light-induced electric generation capacity,thereby providing a promising pathway for high-efficiency energy harvesting devices.
文摘The surge in environmental pollution in recent years driven by numerous pollutants has necessitated the search for efficient removal methods.Phytoremediation is an eco-friendly technique that provides multiple benefits over conventional methods of removing contaminants.Despite the numerous benefits of this technique,it has certain limitations that can be addressed by incorporating nanoparticles to improve its effectiveness.This review paper aims to explore the impact of heavy metal pollution on plants and human health.It highlights the role and mechanism of nanoparticles in enhancing phytoremediation,their application in the detection of heavy metals,and the strategies for the safe disposal of phytoremediation biomass.Biosynthesized nanoparticles are eco-friendly and non-toxic,with applications in biomedical and environmental fields.Nanoparticles can be used in the form of nano biosensors like smartphone-operated wireless sensors made from Cinnamomum camphora,enabling efficient detection of heavy metal ions.According to the studies,nanoparticles remove 80%–97%of heavy metals by various methods like reduction,precipitation,adsorption,etc.The phytoremediation biomass disposal can be done by heat treatment,phytomining,and microbial treatment with some modifications to further enhance their results.Phytoremediation is an environmentally friendly technique but requires further research and integration with biomass energy production to overcome scalability challenges and ensure safe biomass disposal.
基金the National Nature Science Foundation of China for Excellent Young Scientists Fund(32222058)Fundamental Research Foundation of CAF(CAFYBB2022QB001).
文摘Developing biomass platform compounds into high value-added chemicals is a key step in renewable resource utilization.Herein,we report porous carbon-supported Ni-ZnO nanoparticles catalyst(Ni-ZnO/AC)synthesized via low-temperature coprecipitation,exhibiting excellent performance for the selective hydrogenation of 5-hydroxymethylfurfural(HMF).A linear correlation is first observed between solvent polarity(E_(T)(30))and product selectivity within both polar aprotic and protic solvent classes,suggesting that solvent properties play a vital role in directing reaction pathways.Among these,1,4-dioxane(aprotic)favors the formation of 2,5-bis(hydroxymethyl)furan(BHMF)with 97.5%selectivity,while isopropanol(iPrOH,protic)promotes 2,5-dimethylfuran production with up to 99.5%selectivity.Mechanistic investigations further reveal that beyond polarity,proton-donating ability is critical in facilitating hydrodeoxygenation.iPrOH enables a hydrogen shuttle mechanism where protons assist in hydroxyl group removal,lowering the activation barrier.In contrast,1,4-dioxane,lacking hydrogen bond donors,stabilizes BHMF and hinders further conversion.Density functional theory calculations confirm a lower activation energy in iPrOH(0.60 eV)compared to 1,4-dioxane(1.07 eV).This work offers mechanistic insights and a practical strategy for solvent-mediated control of product selectivity in biomass hydrogenation,highlighting the decisive role of solvent-catalyst-substrate interactions.
基金supported by the National Natural Science Foundations of China,Nos.82272163,82472164(both MF)。
文摘Functional neurological recovery remains the primary objective when treating ischemic stroke.However,current therapeutic approaches often fall short of achieving optimal outcomes.One of the most significant challenges in stroke treatment is the effective delivery of neuroprotective agents across the blood–brain barrier to ischemic regions within the brain.The blood–brain barrier,while essential for protecting the brain from harmful substances,also restricts the passage of many therapeutic compounds,thus limiting their efficacy.In this review,we summarizes the emerging role of nanoparticle-based therapies for the treatment of ischemic stroke and investigate their potential to revolutionize drug delivery,enhance neuroprotection,and promote functional recovery.Recent advancements in nanotechnology have led to the development of engineered nanoparticles specifically designed to overcome the blood–brain barrier,thus enabling the targeted delivery of therapeutic agents directly to the affected brain areas.Preclinical studies have demonstrated the remarkable potential of nanoparticle-based therapies to activate key neuroprotective pathways,such as the phosphoinositide 3-kinase/protein kinase B/c AMP response element-binding protein signaling cascade,which is crucial for neuronal survival,synaptic plasticity,and post-stroke recovery.By modulating these pathways,nanoparticles could mitigate neuronal damage,reduce inflammation,and promote tissue repair.Furthermore,nanoparticles offer a unique advantage by enabling multimodal therapeutic strategies that simultaneously target multiple pathological mechanisms of ischemic stroke,including oxidative stress,neuroinflammation,and apoptosis.This multifaceted approach enhances the overall efficacy of treatment,addressing the complex and interconnected processes that contribute to stroke-related brain injury.Surface modifications,such as functionalization with specific ligands or targeting molecules,further improve the precision of drug delivery,enhance targeting specificity,and prolong systemic circulation,thereby optimizing therapeutic outcomes.Nanoparticlebased therapeutics represent a paradigm shift for the management of stroke and provide a promising avenue for reducing post-stroke disability and improving the outcomes of long-term rehabilitation.By combining targeted drug delivery with the ability to modulate critical neuroprotective pathways,nanoparticles hold the potential to transform the treatment landscape for ischemic stroke.However,while preclinical data are highly encouraging,significant challenges remain in translating these advancements into clinical practice.Further research is needed to refine nanoparticle designs,optimize their safety profiles,and ensure their scalability for widespread application.Rigorous clinical trials are essential to validate their efficacy,assess long-term biocompatibility,and address potential off-target effects.The integration of interdisciplinary approaches,combining insights from nanotechnology,neuroscience,and pharmacology,will be critical if we are to overcome these challenges.Ultimately,nanoparticle-based therapies offer a foundation for innovative,precision-based treatments that could significantly improve outcomes for stroke patients,thus paving the way for a new era in stroke care and neurological rehabilitation.
基金supported by the National Key Research and Development Project(No.2020YFA0907500)the National Natural Science Foundation of China(No.22476206)+1 种基金the supports from the National Young Top-Notch Talents(No.W03070030)Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.Y202011).
文摘Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(III)nanoparticles with the most commonly identified FRB,Geobacter sulfurreducens PCA,remains poorly understood.Herein,we demonstrated that the synergistic role of outer membrane proteins and periplasmic proteins in the EET process for-Fe_(2)O_(3),Fe3O4,and𝛽α-FeOOH nanoparticles by construction of multiple gene knockout strain.oxpG(involved in the type II secretion system)and omcST(outer membrane c-type cytochrome)medi-ated pathways accounted for approximately 67%of the total reduction of𝛼α-Fe_(2)O_(3) nanoparticles.The residual reduction of𝛼α-Fe_(2)O_(3) nanoparticles in∆oxpG-omcST strain was likely caused by redox-active substances in cell supernatant.Conversely,the reduction of dissolved Fe(III)was almost unaffected in∆oxpG-omcST strain at the same concentration.However,at high dissolved Fe(III)concentration,the reduction significantly decreased due to the formation of Fe(III)nanoparticles,suggesting that this EET process is specific to Fe(III)nanoparticles.Overall,our study provided a more comprehensive understanding for the EET pathways between G.sulfurreducens PCA and different Fe(III)species,enriching our knowledge on the role of microorganisms in iron biogeochemical cycles and remediation strategies of pollutants.
文摘Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as the strongly enhanced synergistic interactions between Pt and Co atoms,the obtained Pt-on-Co/C400 catalysts exhib-ited excellent catalytic activity toward the hydrolysis of ammonia borane with an extremely high turnover frequency(TOF)value of 3022 min^(-1)at 303 K.Durability test indicated that the obtained Pt-on-Co/C400 catalysts possessed high catalytic stability,and there were no changes in the catalyst structures and catalytic activities after 10 cycles.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
基金supported by the Beijing Natural Science Foundation(No.L233011)Guangdong Province Natural Science Foundation(No.2022A1515011918)USTB Research Center for International People-to-People Exchange in Science.Technology and Civilization(No.2023KFYB003)。
文摘Photocatalysis is widely regarded as a highly promising sustainable technique for addressing the challenges posed by environmental pollution and energy provision.In recent years,metal-loaded MOFs has become a rising star within the domain of photocatalysis due to its high specific surface area and porosity,adjustable structure,diverse and abundant catalytic components,which has exhibited excellent photocatalytic activity and exhibit great potential in a range of disciplines.In this paper,the principles for evaluating the photocatalytic performance of MOFs-based materials were firstly introduced,and some typical examples were also listed accordingly.Along with this,particular emphasis is paid to the main factors affecting the photocatalytic performance of metal-loaded MOFs.Then the synthesis and design strategies of MOFs loaded metal entities of varying sizes(single atoms,nanoclusters,and nanoparticles),and their applications in photocatalytic CO_(2)reduction,hydrogen production,photooxidation and photocatalytic hydrogenation were summarized and discussed.Finally,the opportunities and challenges faced in this kind of MOFs-based composites were analyzed from different perspectives.This report is expected to help researchers design and develop high-performance MOFs-based photocatalytic materials.
基金financially supported by the National Natural Science Foundation of China(No.52203209)the State Key Laboratory of Solid Waste Reuse for Building Materials,China(No.SWR-2022-009)the Fundamental Research Funds for the Central Universities,China(No.FRF-IDRY22-012)。
文摘Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water pollution.In this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing agent.Experimental analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag NPs.The surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their aggregation.After the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite hydrogel.The inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag NPs.The prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.
基金supported by the National Key R&D Program of China(2022YFB3606501,2022YFB3602902)the Key projects of National Natural Science Foundation of China(62234004)+8 种基金the National Natural Science Foundation of China(U23A2092)Pioneer and Leading Goose R&D Program of Zhejiang(2024C01191,2024C01092)Innovation and Entrepreneurship Team of Zhejiang Province(2021R01003)Ningbo Key Technologies R&D Program(2022Z085),Ningbo 3315 Programme(2020A-01-B)YONGJIANG Talent Introduction Programme(2021A-038-B,2021A-159-G)“Innovation Yongjiang 2035”Key R&D Programme(2024Z146)Ningbo JiangBei District public welfare science and technology project(2022C07)the China National Postdoctoral Program for Innovative Talents(grant no.BX20240391)the China Postdoctoral Science Foundation(grant no.2023M743623).
文摘High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy consumption.However,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron scale.Here,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand exchange.This strategy enabled us to achieve ultra-high resolution efficiently(line width<4μm,the best resolution for reported inorganic electrochromic materials).Additionally,the resulting device exhibited impressive electrochromic performance,such as fast response(<1 s at 0 V),high coloration efficiency(119.5 cm^(2) C^(−1)),good optical modulation(55.9%),and durability(>3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,etc.The success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.
文摘Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes pathology.This condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express PCBP1.As the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein nanoparticles.First,PCBP1 is small and druggable.Second,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed degradation.Furthermore,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and activity.Notably,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.
基金supported by the Key Research Projects of Universities of Henan Province,No.21A320064 (to XS)the National Key Research and Development Program of China,No.2021YFA1201504 (to LZ)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Science,No.XDB36000000 (to CW)the National Natural Science Foundation of China,Nos.31971295,12374406 (both to LZ)。
文摘Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.
文摘The cluster-shaped plasmonic nanostructures are used to manage the incident light inside an ultra-thin silicon solar cell.Here we simulate spherical,conical,pyramidal,and cylindrical nanoparticles in a form of a cluster at the rear side of a thin silicon cell,using the finite difference time domain(FDTD)method.By calculating the optical absorption and hence the photocurrent,it is shown that the clustering of nanoparticles significantly improves them.The photocurrent enhancement is the result of the plasmonic effects of clustering the nanoparticles.For comparison,first a cell with a single nanoparticle at the rear side is evaluated.Then four smaller nanoparticles are put around it to make a cluster.The photocurrents of 20.478 mA/cm2,23.186 mA/cm2,21.427 mA/cm2,and 21.243 mA/cm2 are obtained for the cells using clustering conical,spherical,pyramidal,cylindrical NPs at the backside,respectively.These values are 13.987 mA/cm2,16.901 mA/cm2,16.507 mA/cm2,17.926 mA/cm2 for the cell with one conical,spherical,pyramidal,cylindrical NPs at the backside,respectively.Therefore,clustering can significantly improve the photocurrents.Finally,the distribution of the electric field and the generation rate for the proposed structures are calculated.
文摘Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors.Its median survival time is typically less than a year after diagnosis.One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system.The blood-brain barrier is cooperating with advanced stages of malignancy.The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors.Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier.Additionally,the development of smart nanoparticles brings new hope for cancer diagnosis and treatment.These nanoparticles improve drug delivery efficiency,allowing for the creation of targeted and stimuli-responsive delivery methods.This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment,exploring the range of nanoparticles under development,their applications,targeting strategies,and the latest progress in enhancing transport across the blood-brain barrier.It also addresses the ongoing challenges and potential benefits of these innovative approaches.
基金financially supported by the National Natural Science Foundation of China(22279036)the Innovation Talent Recruitment Base of New Energy Chemistry Device(B21003)the Fundamental Research Funds for the Central Universities(no.2019kfyRCPY100).
文摘Combining single atoms with clusters or nanoparticles is an emerging tactic to design efficient electrocatalysts.Both synergy effect and high atomic utilization of active sites in the composite catalysts result in enhanced electrocatalytic performance,simultaneously provide a radical analysis of the interrelationship between structure and activity.In this review,the recent advances of single-atomic site catalysts coupled with clusters or nanoparticles are emphasized.Firstly,the synthetic strategies,characterization,dynamics and types of single atoms coupled with clusters/nanoparticles are introduced,and then the key factors controlling the structure of the composite catalysts are discussed.Next,several clean energy catalytic reactions performed over the synergistic composite catalysts are illustrated.Eventually,the encountering challenges and recommendations for the future advancement of synergistic structure in energy-transformation electrocatalysis are outlined.
基金Project supported by the Natural Science Foundation of Guangxi Province of China (Grant No.2021GXNSFDA196001)the National Natural Science Foundation of China (Grant Nos.12174076,12074084,and 12204117)+1 种基金Guangxi Science and Technology Project (Grant Nos.AD22080042 and AB21220052)Open Project of State Key Laboratory of Surface Physics in Fudan University (Grant No.KF2022_15)。
文摘We demonstrate that,in a simple linearly-polarized plane wave,the optical pulling forces on nanoparticle clusters with gain can be induced by the Fano-like resonance.The numerical results based on the full-wave calculation show that the optical pulling forces can be attributed to the recoil forces for the nanoparticle clusters composed of dipolar nanoparticles with three different configurations.Interestingly,the recoil forces giving rise to optical pulling forces are exactly dominated by the coupling term between the electric and magnetic dipoles excited in the nanoparticle clusters,while other higherorder terms have a negligible contribution.In addition,the optical pulling force can be tailored by modulating the Fano-like resonance via either the particle size or the gain magnitude,offering an alternative freedom degree for optical manipulations of particle clusters.
基金Financial support from the National Natural Science Foundation of China (No.22176147)the National Science Fund for Excellent Young Scholars of China (No.21822607)+1 种基金the Fundamental Research Funds for Central Universities (No.22120230295)the State Key Laboratory for Pollution Control is acknowledged.
文摘The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effective and sustainable methods for antibiotics and antitumor drug degradation.Here,the hybrid nanomaterial(g-C_(3)N_(4)@Fe/Pd)was synthesized and used to remove a kind of both an antibiotic and antitumor drug named mitoxantrone(MTX)with 92.0%removal efficiency,and the MTX removal capacity is 450 mg/g.After exposing to the hybrid material the MTX aqueous solution changed color from dark blue to lighter progressively,and LC-UV results of residual solutions showthat a newpeak at 3.0min(MTX:13.2min)after removal by g-C_(3)N_(4)@Fe/Pd appears,with the simultaneous detection of intermediate products indicating that g-C_(3)N_(4)@Fe/Pd indeed degrades MTX.Detailed mass spectrometric analysis suggests that the nuclear mass ratio decreased from 445.2(M+1H)to 126.0(M+1H),169.1(M+1H),239.2(M+1H),267.3(M+1H),285.2(M+1H),371.4(M+1H)and 415.2(M+1H),and the maximum proportion(5.63%)substance of all degradation products(126.0(M+1H))is 40-100 times less toxic than MTX.A mechanism for the removal and degradation of mitoxantrone was proposed.Besides,actual water experiments confirmed that the maximum removal capacity of MTX by g-C_(3)N_(4)@Fe/Pd is up to 492.4 mg/g(0.02 g/L,10 ppm).
基金funded by the National Natural Science Foundation of China,grant numbers 82374048 and 82174096Natural Science Foundation of Zhejiang Province,grant number LZ21H280001.
文摘Atherosclerosis(AS)is a progressive inflammatory disease,and thrombosis most likely leads to cardiovascular morbidity and mortality globally.Thrombolytic drugs alone cannot completely prevent thrombotic events,and treatments targeting thrombosis also need to regulate the inflammatory process.Based on the dynamic pathological development of AS,biomimetic thrombus-targeted nanoparticles HMTL@PM were prepared.Hirudin and lumbrukinase,effective substances of traditional Chinese medicine,were self-assembled under the action of tannic acid and Mn^(2+).HMTL@PM dissociated in the weakly acidic microenvironment of atherosclerosis and exhibited excellent therapeutic effects,including alleviating inflammation,dissolving thrombus,anticoagulation,and promoting cholesterol efflux.HMTL@PM effectively regulated the progression of AS and provided a newperspective for the development of drug delivery systems for AS therapy,which holds important research significance for reducing the mortality of cardiovascular and cerebrovascular diseases.
基金The authors extend their gratitude to the Deanship of Scientific Research(DSR),King Faisal University,Saudi Arabia,for funding the publication of this work(Project number:KFU250560).
文摘A steady rise in the overall population is creating an overburden on crops due to their global demand.On the other hand,given the current climate change and population growth,agricultural practices established during the Green Revolution are no longer viable.Consequently,innovative practices are the prerequisite of the time struggle with the rising global food demand.The potential of nanotechnology to reduce the phytotoxic effects of these ecological restrictions has shown significant promise.Nanoparticles(NPs)typically enhance plant resilience to stressors by fortifying the physical barrier,optimizing photosynthesis,stimulating enzymatic activity for defense,elevating the concentration of stress-resistant compounds,and activating the expression of genes associated with defense mechanisms.In this review,we thoroughly cover the uptake and translocations of NPs crops and their potential valuable functions in enhancing plant growth and development at different growth stages.Additionally,we addressed how NPs improve plant resistance to biotic and abiotic stress.Generally,this review presents a thorough understanding of the significance of NPs in plants and their prospective value for plant antioxidant and crop development.
