摘要
Atherosclerosis(AS)is a progressive inflammatory disease,and thrombosis most likely leads to cardiovascular morbidity and mortality globally.Thrombolytic drugs alone cannot completely prevent thrombotic events,and treatments targeting thrombosis also need to regulate the inflammatory process.Based on the dynamic pathological development of AS,biomimetic thrombus-targeted nanoparticles HMTL@PM were prepared.Hirudin and lumbrukinase,effective substances of traditional Chinese medicine,were self-assembled under the action of tannic acid and Mn^(2+).HMTL@PM dissociated in the weakly acidic microenvironment of atherosclerosis and exhibited excellent therapeutic effects,including alleviating inflammation,dissolving thrombus,anticoagulation,and promoting cholesterol efflux.HMTL@PM effectively regulated the progression of AS and provided a newperspective for the development of drug delivery systems for AS therapy,which holds important research significance for reducing the mortality of cardiovascular and cerebrovascular diseases.
基金
funded by the National Natural Science Foundation of China,grant numbers 82374048 and 82174096
Natural Science Foundation of Zhejiang Province,grant number LZ21H280001.
