Tebufenozide,an efficient insect growth regulator(IGR)against lepidopteran pests,presents a novel mode of action with minimal non-target impact.By competing with ecdysteroids for ecdysone receptor(EcR)binding,it regul...Tebufenozide,an efficient insect growth regulator(IGR)against lepidopteran pests,presents a novel mode of action with minimal non-target impact.By competing with ecdysteroids for ecdysone receptor(EcR)binding,it regulates insect growth precisely.This study explores tebufenozide's potential as a multitarget IGR,targeting both EcR and Ostrinia furnacalis chitinase I(OfChtI).The inhibitory activity against OfChtI is comparable to that of substrates(GlcNAc)5,with an IC50 of 45.77μM.Our computational findings indicate that tebufenozide binds at the subsite1 to t1 of OfChtI through various interactions.Notably,tebufenozide establishes a pi-pi interaction with the flipped sidechain of Trp107,enabling tebufenozide to deeply penetrate into the S1 pocket,thereby obstructing substrate binding to OfChtI.These insights highlight the potency of multitarget strategies,laying the groundwork for innovative IGR designs that offer comprehensive pest management solutions.展开更多
This paper studies the dynamic estimation problem for multitarget tracking. A novel gat- ing strategy that is based on the measurement likelihood of the target state space is proposed to improve the overall effectiven...This paper studies the dynamic estimation problem for multitarget tracking. A novel gat- ing strategy that is based on the measurement likelihood of the target state space is proposed to improve the overall effectiveness of the probability hypothesis density （PHD） filter. Firstly, a measurement-driven mechanism based on this gating technique is designed to classify the measure- ments. In this mechanism, only the measurements for the existing targets are considered in the update step of the existing targets while the measurements of newborn targets are used for exploring newborn targets. Secondly, the gating strategy enables the development of a heuristic state estima- tion algorithm when sequential Monte Carlo （SMC） implementation of the PHD filter is investi- gated, where the measurements are used to drive the particle clustering within the space gate. The resulting PHD filter can achieve a more robust and accurate estimation of the existing targets by reducing the interference from clutter. Moreover, the target birth intensity can be adaptive to detect newborn targets, which is in accordance with the birth measurements. Simulation results demonstrate the computational efficiency and tracking performance of the proposed algorithm.展开更多
Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).T...Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.展开更多
Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neur...Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.展开更多
AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare patients.METHODS This cross sectional primary care office...AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare patients.METHODS This cross sectional primary care office-based study examined mt-s DNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015. Investigators performed a Health Insurance Portability and Accountability Act compliant retrospective review of electronic health records to identify mt-s DNA use in patients who were either > 10 years since last colonoscopy and/or > 1 year since last fecal occult blood test. Test positive patients were advised to get diagnostic colonoscopy and thereafter patients were characterized by the most clinically significant lesion documented on histopathology of biopsies or excisional tissue. Descriptive statistics were employed. Key outcome measures included mt-s DNA compliance and diagnostic colonoscopy compliance on positive cases.RESULTS Over 12 mo, 77 providers ordered 393 mt-sD NA studies with 347 completed (88.3% compliance). Patient mean age was 69.8 (50-85) and patients were 64% female. Mt-sD NA was negative in 85.3%(296/347) and positive in 14.7%(51/347). Follow-up colonoscopy was performed in 49 positive patients (96.1% colonoscopy compliance) with two patients lost to follow up. Index findings included: colon cancer(4/49, 8.2%), advanced adenomas (21/49, 42.9%), non-advanced adenomas(15/49, 30.6%), and negative results (9/49, 18.4%). The positive predictive value for advanced colorectal lesions was 51.0% and for any colorectal neoplasia was 81.6%. The mean age of patients with colorectal cancer was 70.3 and all CRC's were localized Stage Ⅰ(2) and Stage Ⅱ (2), three were located in the proximal colon and one was located in the distal colon.CONCLUSION Mt-s DNA provided medical benefit to screening noncompliant Medicare population. High compliance with mt-s DNA and subsequent follow-up diagnostic colonoscopy identified patients with clinically critical advanced colorectal neoplasia.展开更多
A fast joint probabilistic data association （FJPDA） algorithm is proposed in tiffs paper. Cluster probability matrix is approximately calculated by a new method, whose elements βi^t（K） can be taken as evaluation ...A fast joint probabilistic data association （FJPDA） algorithm is proposed in tiffs paper. Cluster probability matrix is approximately calculated by a new method, whose elements βi^t（K） can be taken as evaluation functions. According to values of βi^t（K）, N events with larger joint probabilities can be searched out as the events with guiding joint probabilities, tiros, the number of searching nodes will be greatly reduced. As a result, this method effectively reduces the calculation load and nnkes it possible to be realized on real-thne, Theoretical ,analysis and Monte Carlo simulation results show that this method is efficient.展开更多
For data association in multisensor and multitarget tracking, a novel parallel algorithm is developed to improve the efficiency and real-time performance of FGAs-based algorithm. One Cluster of Workstation （COW） wit...For data association in multisensor and multitarget tracking, a novel parallel algorithm is developed to improve the efficiency and real-time performance of FGAs-based algorithm. One Cluster of Workstation （COW） with Message Passing Interface （MPI） is built. The proposed Multi-Deme Parallel FGA （MDPFGA） is run on the platform. A serial of special MDPFGAs are used to determine the static and the dynamic solutions of generalized m-best S-D assignment problem respectively, as well as target states estimation in track management. Such an assignment-based parallel algorithm is demonstrated on simulated passive sensor track formation and maintenance problem. While illustrating the feasibility of the proposed algorithm in multisensor multitarget tracking, simulation results indicate that the MDPFGAs-based algorithm has greater efficiency and speed than the FGAs-based algorithm.展开更多
In this paper, an adaptive digital filter algorithm is presented to optimize the signal-to-noise ratio of an antenna array with multiuser signal inputs. These synchronous communication signals have constant envelope p...In this paper, an adaptive digital filter algorithm is presented to optimize the signal-to-noise ratio of an antenna array with multiuser signal inputs. These synchronous communication signals have constant envelope property and are transmitted through a Multiple-Input/Multiple-Output （MIMO） linear channel. This Multiuser Constant Modulus Algorithm （MU-CMA） using an antenna array can compensate for both Interuser Interference （IUI） and Intersymbol Interference （ISI）. The method is derived by minimizing the cost function of the constant modulus signals as well as cross-correlations between them. The simulation result in this paper shows the performance of this algorithm.展开更多
Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk of resistance.Insect chitinolytic enzymes,including GH18 chitinases and GH20β-N-acetyl-D-hexosaminidase,are attr...Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk of resistance.Insect chitinolytic enzymes,including GH18 chitinases and GH20β-N-acetyl-D-hexosaminidase,are attractive targets for multitarget insecticide design by virtue of their similar substrate binding mode and catalytic mechanism.On the other hand,natural products with diverse skeletal structures are potential repositories of chitinolytic enzyme inhibitors.This minireview first presents the theoretical basis of developing multitargeted inhibitors against insect chitinolytic enzymes and then focuses on the progress in developing multitarget inhibitors derived from natural products.These may provide ideas for the exploitation of novel pesticide leads from natural products by targeting multiple targets.展开更多
For swarm robots moving in a harsh or uncharted outdoor environment without GPS guidance and global communication,algorithms that rely on global-based information are infeasible.Typically,traditional gene regulatory n...For swarm robots moving in a harsh or uncharted outdoor environment without GPS guidance and global communication,algorithms that rely on global-based information are infeasible.Typically,traditional gene regulatory networks(GRNs)that achieve superior performance in forming trapping pattern towards targets require accurate global positional information to guide swarm robots.This article presents a gene regulatory network with Self-organized grouping and entrapping method for swarms(SUNDER-GRN)to achieve adequate trapping performance with a large-scale swarm in a confined multitarget environment with access to only local information.A hierarchical self-organized grouping method(HSG)is proposed to structure subswarms in a distributed way.In addition,a modified distributed controller,with a relative coordinate system that is established to relieve the need for global information,is leveraged to facilitate subswarms entrapment toward different targets,thus improving the global multi-target entrapping performance.The results demonstrate the superiority of SUNDERGRN in the performance of structuring subswarms and entrapping 10 targets with 200 robots in an environment confined by obstacles and with only local information accessible.展开更多
Alzheimer’s disease(AD)is a neurodegenerative disorder associated with brain aging,and the accumulation ofβ-amyloid(Aβ)and hyperphosphorylated Tau proteins are key pathological features.Currently,drugs for the trea...Alzheimer’s disease(AD)is a neurodegenerative disorder associated with brain aging,and the accumulation ofβ-amyloid(Aβ)and hyperphosphorylated Tau proteins are key pathological features.Currently,drugs for the treatment of AD are mainly single-targeted,but the complex pathogenesis of AD makes it difficult to achieve the desired results.Therefore,the development of multitargeted therapies is crucial for future interventions.Rice bran oil(RBO)has been recognized as an edible oil with several health benefits,but its effects on AD caused by brain aging remain underexplored.In this study,the effects of RBO on memory dysfunction in D-galactose(D-gal)mice and its molecular mechanisms were investigated via in vivo and in silico methods from the perspective of AD pathologies.Our results suggested that compounds in RBO could modulate the activities of Aβprecursor protein cleaving enzyme 1(BACE1),mitogen-activated protein kinase 3(MAPK3),matrix metalloproteinase 3(MMP3),and intercellular adhesion molecule 1(ICAM1),leading to inhibition of Aβaccumulation and Tau protein hyperphosphorylation.Moreover,RBO reduced Aβ-induced oxidative stress by inhibiting the activity of mouse double minute 2 homolog(MDM2)and cyclic adenosine monophosphate(cAMP)response element binding protein binding protein(CREBBP),and attenuated neuroinflammation by inhibiting the activity of nitric oxide synthase 2(NOS2)and reducing Aβaccumulation and Tau protein hyperphosphorylation.Additionally,α-linolenic acid in RBO exhibited inhibitory effects on D-gal-induced apoptosis in PC12 cells through modulation of NOS2,MDM2,ICAM1,and phospho-extracellular signal-regulated kinase 1/2(p-ERK1/2).Similarly,stigmastanol inhibited apoptosis in D-gal-induced PC12 cells through the regulation of NOS2.Thus,RBO can be considered as a potential functional food to attenuate AD owing to its multicomponent and multitarget effects.展开更多
The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of cancer.TCM is a new choice and hot spot in the field of can...The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of cancer.TCM is a new choice and hot spot in the field of cancer treatment.We have also previously published studies on TCM and network pharmacology.In this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.展开更多
Multiple sources localization is an important technique applied in many areasl such as sonar, radar, biomedical, and geology exploration. High resolution localization needs to employ jointly two sorts of high resoluti...Multiple sources localization is an important technique applied in many areasl such as sonar, radar, biomedical, and geology exploration. High resolution localization needs to employ jointly two sorts of high resolution estimators, time-delay estimator and Direction Of Arrival (DOA) estimator, both of which are tough problems attracting many signal processing researchers. There is also another difficulty that is to pair two groups of parameters in timedelay and DOA domains. In underwater environment, multiple sources localization research faces more difficulties because of the long duration emitted wave, limit aperture of array, and short data record of echoes. In this paper, an new extended ESPRIT (Estimation of Signal Parameters via Rotational Invariance Technique) method is presented. With a single echo wave, both time-delay and DOA parameters of multiple sources are estimated simultaneously.No additional pairing algorithm is needed to obtain the source locations. The performance of the new estimators and the probability of correct pairing is given by computer simulations, andthe results shows that good estimation can be obtained in low SNR (Signal to Noise Ratio) for multiple sources localization.展开更多
In this paper, the sharp threshold properties of a （2n ＋ 1）-dimensional delayed viral infection model are investigated. This model combines with n classes of uninfected tar- get cells, n classes of infected cells a...In this paper, the sharp threshold properties of a （2n ＋ 1）-dimensional delayed viral infection model are investigated. This model combines with n classes of uninfected tar- get cells, n classes of infected cells and nonlinear incidence rate h（x,v）. Two kinds of distributed time delays are incorporated into the model to describe the time needed for infection of uninfected target cells and virus replication. Under certain conditions, it is shown that the basic reproduction number is a threshold parameter for the existence of the equilibria, uniform persistence, as well as for global stability of the equilibria of the model.展开更多
This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unman...This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unmanned aerial vehicles(UAVs)for target tracking,a multitarget tracking control algorithm under local information selection interaction is proposed.First,on the basis of location,number,and perceived target information of neighboring UAVs,a temporary leader selection strategy is designed to realize the local follow-up movement of UAVs when the UAVs cannot fully perceive the target.Second,in combination with the basic rules of cluster movement and target information perception factors,distributed control equations are designed to achieve a rapid gathering of UAVs and consistent tracking of multiple targets.Lastly,the simulation experiments are conducted in two-and three-dimensional spaces.Under a certain number of UAVs,clustering speed of the proposed algorithm is less than 3 s,and the equal probability of the UAV subgroup size after group separation is over 78%.展开更多
基金financially supported by the National Natural Science Foundation of China(No.22177132 and 21977114).
文摘Tebufenozide,an efficient insect growth regulator(IGR)against lepidopteran pests,presents a novel mode of action with minimal non-target impact.By competing with ecdysteroids for ecdysone receptor(EcR)binding,it regulates insect growth precisely.This study explores tebufenozide's potential as a multitarget IGR,targeting both EcR and Ostrinia furnacalis chitinase I(OfChtI).The inhibitory activity against OfChtI is comparable to that of substrates(GlcNAc)5,with an IC50 of 45.77μM.Our computational findings indicate that tebufenozide binds at the subsite1 to t1 of OfChtI through various interactions.Notably,tebufenozide establishes a pi-pi interaction with the flipped sidechain of Trp107,enabling tebufenozide to deeply penetrate into the S1 pocket,thereby obstructing substrate binding to OfChtI.These insights highlight the potency of multitarget strategies,laying the groundwork for innovative IGR designs that offer comprehensive pest management solutions.
基金supported by the Aeronautical Science Foundation of China(No.201401P6001)
文摘This paper studies the dynamic estimation problem for multitarget tracking. A novel gat- ing strategy that is based on the measurement likelihood of the target state space is proposed to improve the overall effectiveness of the probability hypothesis density （PHD） filter. Firstly, a measurement-driven mechanism based on this gating technique is designed to classify the measure- ments. In this mechanism, only the measurements for the existing targets are considered in the update step of the existing targets while the measurements of newborn targets are used for exploring newborn targets. Secondly, the gating strategy enables the development of a heuristic state estima- tion algorithm when sequential Monte Carlo （SMC） implementation of the PHD filter is investi- gated, where the measurements are used to drive the particle clustering within the space gate. The resulting PHD filter can achieve a more robust and accurate estimation of the existing targets by reducing the interference from clutter. Moreover, the target birth intensity can be adaptive to detect newborn targets, which is in accordance with the birth measurements. Simulation results demonstrate the computational efficiency and tracking performance of the proposed algorithm.
文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.
文摘Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.
文摘AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare patients.METHODS This cross sectional primary care office-based study examined mt-s DNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015. Investigators performed a Health Insurance Portability and Accountability Act compliant retrospective review of electronic health records to identify mt-s DNA use in patients who were either > 10 years since last colonoscopy and/or > 1 year since last fecal occult blood test. Test positive patients were advised to get diagnostic colonoscopy and thereafter patients were characterized by the most clinically significant lesion documented on histopathology of biopsies or excisional tissue. Descriptive statistics were employed. Key outcome measures included mt-s DNA compliance and diagnostic colonoscopy compliance on positive cases.RESULTS Over 12 mo, 77 providers ordered 393 mt-sD NA studies with 347 completed (88.3% compliance). Patient mean age was 69.8 (50-85) and patients were 64% female. Mt-sD NA was negative in 85.3%(296/347) and positive in 14.7%(51/347). Follow-up colonoscopy was performed in 49 positive patients (96.1% colonoscopy compliance) with two patients lost to follow up. Index findings included: colon cancer(4/49, 8.2%), advanced adenomas (21/49, 42.9%), non-advanced adenomas(15/49, 30.6%), and negative results (9/49, 18.4%). The positive predictive value for advanced colorectal lesions was 51.0% and for any colorectal neoplasia was 81.6%. The mean age of patients with colorectal cancer was 70.3 and all CRC's were localized Stage Ⅰ(2) and Stage Ⅱ (2), three were located in the proximal colon and one was located in the distal colon.CONCLUSION Mt-s DNA provided medical benefit to screening noncompliant Medicare population. High compliance with mt-s DNA and subsequent follow-up diagnostic colonoscopy identified patients with clinically critical advanced colorectal neoplasia.
文摘A fast joint probabilistic data association （FJPDA） algorithm is proposed in tiffs paper. Cluster probability matrix is approximately calculated by a new method, whose elements βi^t（K） can be taken as evaluation functions. According to values of βi^t（K）, N events with larger joint probabilities can be searched out as the events with guiding joint probabilities, tiros, the number of searching nodes will be greatly reduced. As a result, this method effectively reduces the calculation load and nnkes it possible to be realized on real-thne, Theoretical ,analysis and Monte Carlo simulation results show that this method is efficient.
基金Supported by National Defence Scientific Research Foundation
文摘For data association in multisensor and multitarget tracking, a novel parallel algorithm is developed to improve the efficiency and real-time performance of FGAs-based algorithm. One Cluster of Workstation （COW） with Message Passing Interface （MPI） is built. The proposed Multi-Deme Parallel FGA （MDPFGA） is run on the platform. A serial of special MDPFGAs are used to determine the static and the dynamic solutions of generalized m-best S-D assignment problem respectively, as well as target states estimation in track management. Such an assignment-based parallel algorithm is demonstrated on simulated passive sensor track formation and maintenance problem. While illustrating the feasibility of the proposed algorithm in multisensor multitarget tracking, simulation results indicate that the MDPFGAs-based algorithm has greater efficiency and speed than the FGAs-based algorithm.
基金Supported by the National Natural Science Foundation ofChina (60671040)
文摘In this paper, an adaptive digital filter algorithm is presented to optimize the signal-to-noise ratio of an antenna array with multiuser signal inputs. These synchronous communication signals have constant envelope property and are transmitted through a Multiple-Input/Multiple-Output （MIMO） linear channel. This Multiuser Constant Modulus Algorithm （MU-CMA） using an antenna array can compensate for both Interuser Interference （IUI） and Intersymbol Interference （ISI）. The method is derived by minimizing the cost function of the constant modulus signals as well as cross-correlations between them. The simulation result in this paper shows the performance of this algorithm.
基金supported by the National Key R&D Program of China(2022YFD1700200)the Project of Natural Science Foundation of Liaoning Province(2022-KF-15-02).
文摘Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk of resistance.Insect chitinolytic enzymes,including GH18 chitinases and GH20β-N-acetyl-D-hexosaminidase,are attractive targets for multitarget insecticide design by virtue of their similar substrate binding mode and catalytic mechanism.On the other hand,natural products with diverse skeletal structures are potential repositories of chitinolytic enzyme inhibitors.This minireview first presents the theoretical basis of developing multitargeted inhibitors against insect chitinolytic enzymes and then focuses on the progress in developing multitarget inhibitors derived from natural products.These may provide ideas for the exploitation of novel pesticide leads from natural products by targeting multiple targets.
基金supported in part by National Key R&D Program of China(Grant Nos.2021ZD0111501,2021ZD0111502)the Key Laboratory of Digital Signal and Image Processing of Guangdong Province+8 种基金the Key Laboratory of Intelligent Manufacturing Technology(Shantou University)Ministry of Education,the Science and Technology Planning Project of Guangdong Province of China(Grant No.180917144960530)the Project of Educational Commission of Guangdong Province of China(Grant No.2017KZDXM032)the State Key Lab of Digital Manufacturing Equipment&Technology(grant number DMETKF2019020)National Natural Science Foundation of China(Grant Nos.62176147,62002369)STU Scientific Research Foundation for Talents(Grant No.NTF21001)Science and Technology Planning Project of Guangdong Province of China(Grant Nos.2019A050520001,2021A0505030072,2022A1515110660)Science and Technology Special Funds Project of Guangdong Province of China(Grant Nos.STKJ2021176,STKJ2021019)Guangdong Special Support Program for Outstanding Talents(Grant No.2021JC06X549)。
文摘For swarm robots moving in a harsh or uncharted outdoor environment without GPS guidance and global communication,algorithms that rely on global-based information are infeasible.Typically,traditional gene regulatory networks(GRNs)that achieve superior performance in forming trapping pattern towards targets require accurate global positional information to guide swarm robots.This article presents a gene regulatory network with Self-organized grouping and entrapping method for swarms(SUNDER-GRN)to achieve adequate trapping performance with a large-scale swarm in a confined multitarget environment with access to only local information.A hierarchical self-organized grouping method(HSG)is proposed to structure subswarms in a distributed way.In addition,a modified distributed controller,with a relative coordinate system that is established to relieve the need for global information,is leveraged to facilitate subswarms entrapment toward different targets,thus improving the global multi-target entrapping performance.The results demonstrate the superiority of SUNDERGRN in the performance of structuring subswarms and entrapping 10 targets with 200 robots in an environment confined by obstacles and with only local information accessible.
基金supported by the Science and Technology Innovation Program of Hunan Province(2022RC1148)the Natural Science Foundation of Hunan Province(2022JJ31009,2022JJ50260)+4 种基金the Program for Science and Technology of Changsha,China(kh2301028)the Science and Technology Innovation Plan Project of Hunan Province(2023NK2033)the Innovation Leading Plan Project of Hunan Province(2021GK4022)the“Kemen Food”Graduate Science and Technology Innovation Project of Central South University of Forestry and Technology(2023KMCX02)the Graduate Science and Technology Innovation Fund Project of Hunan Province(QL20220182).
文摘Alzheimer’s disease(AD)is a neurodegenerative disorder associated with brain aging,and the accumulation ofβ-amyloid(Aβ)and hyperphosphorylated Tau proteins are key pathological features.Currently,drugs for the treatment of AD are mainly single-targeted,but the complex pathogenesis of AD makes it difficult to achieve the desired results.Therefore,the development of multitargeted therapies is crucial for future interventions.Rice bran oil(RBO)has been recognized as an edible oil with several health benefits,but its effects on AD caused by brain aging remain underexplored.In this study,the effects of RBO on memory dysfunction in D-galactose(D-gal)mice and its molecular mechanisms were investigated via in vivo and in silico methods from the perspective of AD pathologies.Our results suggested that compounds in RBO could modulate the activities of Aβprecursor protein cleaving enzyme 1(BACE1),mitogen-activated protein kinase 3(MAPK3),matrix metalloproteinase 3(MMP3),and intercellular adhesion molecule 1(ICAM1),leading to inhibition of Aβaccumulation and Tau protein hyperphosphorylation.Moreover,RBO reduced Aβ-induced oxidative stress by inhibiting the activity of mouse double minute 2 homolog(MDM2)and cyclic adenosine monophosphate(cAMP)response element binding protein binding protein(CREBBP),and attenuated neuroinflammation by inhibiting the activity of nitric oxide synthase 2(NOS2)and reducing Aβaccumulation and Tau protein hyperphosphorylation.Additionally,α-linolenic acid in RBO exhibited inhibitory effects on D-gal-induced apoptosis in PC12 cells through modulation of NOS2,MDM2,ICAM1,and phospho-extracellular signal-regulated kinase 1/2(p-ERK1/2).Similarly,stigmastanol inhibited apoptosis in D-gal-induced PC12 cells through the regulation of NOS2.Thus,RBO can be considered as a potential functional food to attenuate AD owing to its multicomponent and multitarget effects.
文摘The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of cancer.TCM is a new choice and hot spot in the field of cancer treatment.We have also previously published studies on TCM and network pharmacology.In this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.
文摘Multiple sources localization is an important technique applied in many areasl such as sonar, radar, biomedical, and geology exploration. High resolution localization needs to employ jointly two sorts of high resolution estimators, time-delay estimator and Direction Of Arrival (DOA) estimator, both of which are tough problems attracting many signal processing researchers. There is also another difficulty that is to pair two groups of parameters in timedelay and DOA domains. In underwater environment, multiple sources localization research faces more difficulties because of the long duration emitted wave, limit aperture of array, and short data record of echoes. In this paper, an new extended ESPRIT (Estimation of Signal Parameters via Rotational Invariance Technique) method is presented. With a single echo wave, both time-delay and DOA parameters of multiple sources are estimated simultaneously.No additional pairing algorithm is needed to obtain the source locations. The performance of the new estimators and the probability of correct pairing is given by computer simulations, andthe results shows that good estimation can be obtained in low SNR (Signal to Noise Ratio) for multiple sources localization.
基金The authors would like to thank the anonymous referees and the editor for very helpful suggestions and comments which led to improvements of our orig- inal paper. J. Wang was supported by National Natural Science Foundation of China （Nos. 11401182 and 11471089）, Natural Science Foundation of Heilongjiang Province （No. A201415）, Science and Technology Innovation Team in Higher Edu- cation Institutions of Heilongjiang Province （No. 2014TD005）, Project funded by China Postdoctoral Science Foundation （No. 2014M552295） and Project funded by Chongqing Postdoctoral Foundation （No. Xm2014024）. X. Wang is supported by the National Natural Science Foundation of China （No. 11301453）, Postdoctoral Science Foundation of China （No. 2014M562366）, Postdoctoral Science Foundation of Shaanxi Province （No. 2014010）, the Universities Young Teachers Program of Henan Province （No. 2014GGJS-093）.
文摘In this paper, the sharp threshold properties of a （2n ＋ 1）-dimensional delayed viral infection model are investigated. This model combines with n classes of uninfected tar- get cells, n classes of infected cells and nonlinear incidence rate h（x,v）. Two kinds of distributed time delays are incorporated into the model to describe the time needed for infection of uninfected target cells and virus replication. Under certain conditions, it is shown that the basic reproduction number is a threshold parameter for the existence of the equilibria, uniform persistence, as well as for global stability of the equilibria of the model.
文摘This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unmanned aerial vehicles(UAVs)for target tracking,a multitarget tracking control algorithm under local information selection interaction is proposed.First,on the basis of location,number,and perceived target information of neighboring UAVs,a temporary leader selection strategy is designed to realize the local follow-up movement of UAVs when the UAVs cannot fully perceive the target.Second,in combination with the basic rules of cluster movement and target information perception factors,distributed control equations are designed to achieve a rapid gathering of UAVs and consistent tracking of multiple targets.Lastly,the simulation experiments are conducted in two-and three-dimensional spaces.Under a certain number of UAVs,clustering speed of the proposed algorithm is less than 3 s,and the equal probability of the UAV subgroup size after group separation is over 78%.
