摘要
花生四烯酸可通过环氧合酶、脂氧合酶、细胞色素P450酶等代谢通路转化为多种触发炎症反应的代谢产物,在炎症疾病的发生、发展过程中发挥着关键作用。近年来,基于花生四烯酸代谢通路的多靶点药物已成为抗炎药物研究的重要方向并呈现出良好的应用前景。本文总结了花生四烯酸代谢通路及其相互串扰对抗炎药物研发带来的机遇和挑战,随后重点综述了基于花生四烯酸代谢通路的多靶点药物设计、合成及抗炎活性研究进展,最后讨论了花生四烯酸代谢通路多靶点药物在药物研发中的难点与未来发展方向,为基于花生四烯酸代谢通路的多靶点抗炎药物研究提供了参考和借鉴。
Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase,lipoxygenase,cytochrome P450 enzymes,and other metabolic pathways.Moreover,it plays a key role in the occurrence and development of inflammatory diseases.In recent years,multitarget drugs based on the arachidonic acid metabolic pathway have become an important direction of antiinflammatory drug research.This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs,reviews the research progress of multi-target drug design,synthesis,and anti-inflammatory activity based on the arachidonic acid metabolic pathway,and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development,aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.
作者
乌丹
崔珑琛
徐富梅
王洁
续艳丽
张启立
李娇娇
赵磊
WU Dan;CUI Longchen;XU Fumei;WANG Jie;XU Yanli;ZHANG Qili;LI Jiaojiao;ZHAO Lei(Gansu University of Chinese Medicine,Lanzhou 730000;Department of Laboratory Medicine,The First Hospital of Lanzhou University,Lanzhou 730000;Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine(TCM)of Colleges of Gansu Province,Lanzhou 730000;Gansu Provincial Engineering Laboratory for TCM Standardization Technology and Popularization,Lanzhou 730000;Lanzhou Institute for Food and Drug Control,Lanzhou 730000,China)
出处
《中国药科大学学报》
北大核心
2025年第6期782-792,共11页
Journal of China Pharmaceutical University
基金
国家自然科学基金项目(No.82160457,No.81660577)
甘肃省科技计划资助项目(No.21JR7RA564)
甘肃省青年科技基金计划项目(No.22JR11RA045)。
关键词
炎症
花生四烯酸
抗炎药
多靶点药物
inflammation
arachidonic acid
anti-inflammatory drugs
multitarget-drugs
