Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapi...Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapidly and slowly warming periods in ecosystems with varying climatic conditions remains limited.By using tree-ring data from temperate broadleaf(Fraxinus mandshurica,Phellodendron amurense,Quercus mongolica,and Juglans mandshurica)and Korean pine(Pinus koraiensis)mixed forests in northeast China,we investigated the effects of climate change,particularly warming,on the growth synchrony of five dominant temperate tree species across contrasting warm-dry and cool-wet climate conditions.Results show that temperature over water availability was the primary factor driving the growth and growth synchrony of the five species.Growth synchrony was significantly higher in warm-dry than in cool-wet areas,primarily due to more uniform climate conditions and higher climate sensitivity in the former.Rapid warming from the 1960s to the 1990s significantly enhanced tree growth synchrony in both areas,followed by a marked reversal as temperatures exceeded a certain threshold or warming slowed down,particularly in the warm-dry area.The growth synchrony variation patterns of the five species were highly consistent over time,although broadleaves exhibited higher synchrony than conifers,suggesting potential risks to forest resilience and stability under future climate change scenarios.Growing season temperatures and non-growing season temperatures and precipitation had a stronger positive effect on tree growth in the cool-wet area compared to the warm-dry area.High relative humidity hindered growth in the cool-wet area but enhanced it in the warm-dry area.Overall,our study highlights that the diversity and sensitivity of climate-growth relationships directly determine spatiotemporal growth synchrony.Temperature,along with water availability,shape long-term forest dynamics by affecting tree growth and synchrony.These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate changeinduced synchrony shifts.展开更多
DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plast...DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plasticity,behavioral state,and contextual information[1].展开更多
Although seasonal breeding has been documented in many non-human primates, it is not clear whether sexual behaviors show seasonal variation among male individuals. To test this hypothesis, the focal animal sampling me...Although seasonal breeding has been documented in many non-human primates, it is not clear whether sexual behaviors show seasonal variation among male individuals. To test this hypothesis, the focal animal sampling method and continuous recording were used to investigate seasonal variation and synchronization of sexual behaviors in five male Tibetan macaques （Macaca thibetana） at Mt. Huangshan from Oct 2005 to Sept 2006. Both copulatory and sexually motivated behaviors （i.e., sexual chase, grimace, and sexual-inspection）, which were significantly higher in the mating season than non-mating season. Furthermore, seasonal variations of sexual behaviors, including copulatory and sexually motivated behaviors, were synchronized among males. The results shed light on sexual competition and tactics for reproductive success of male M. thibetana and other non-human primates with seasonal breeding.展开更多
Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eig...Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eighty seven patients with first AMI were divided into two groups: group A ( n =42), pPCI group, the patients underwent PCI within 6h after onset of AMI; group B ( n =45), rtPA+PCI group, the patients underwent PCI after thrombolysis within 6h after onset of AMI; Myocardial viability was measured by 99m Tc MIBI SPECT. While, the parameters of cardiac function LVEF and ventricular systolic synchrony LVPS were measured by 99m Tc gated cardiac blood pool image on the first and the fourth weekend. Results (1) The peak CK MB was significantly lower in group A than that in group B( P <0.01 ). (2) Myocardial infarction area (MIA) was decreased and radioactivity counts in MIA was significantly increased in group A and B on the 4th weekend compared with that on the first weekend ( P <0.01 ), but there were no significant difference between group A and group B. (3) LVEF, LVPS were no significant difference between group A and group B.Conclusions (1)pPCI in acute myocardial infartion can limit infarct area, maintain ventricular systolic synchrony and improve ventricular function; (2) but, in those hospitals that there were no any condition for PCI, they should transfer the patients to central hospital for PCI after thrombolysis at the first time. It is beneficial to improve myocardial viability and ventricular systolic synchrony of AMI patients in short time.展开更多
目的:分析射波刀Synchrony同步追踪系统的质量保证验证方法是否符合临床肿瘤三维运动的要求,以保证射波刀临床治疗的质量。方法:利用改进的Synchrony模体采集CT影像信息,制订同步呼吸追踪的E2E(end to end)治疗验证计划。执行治疗计划,...目的:分析射波刀Synchrony同步追踪系统的质量保证验证方法是否符合临床肿瘤三维运动的要求,以保证射波刀临床治疗的质量。方法:利用改进的Synchrony模体采集CT影像信息,制订同步呼吸追踪的E2E(end to end)治疗验证计划。执行治疗计划,将装有EBT胶片的球方模体放在治疗床上,球方在不同运动条件下执行模拟验证计划,利用E2E软件对照射后的胶片进行分析,得出同步追踪的治疗误差。结果:射波刀Synchrony同步追踪系统在一维、二维、三维方向的治疗误差分别为0.91、1.03、0.90 mm。结论:射波刀Synchrony同步追踪系统的质量保证验证方法满足临床肿瘤精确治疗的要求。展开更多
Simultaneous heading of plants within the same rice variety, also refer to heading synchrony, is an important factor that affects simultaneous ripening of the variety. Understanding of the genetic basis of heading syn...Simultaneous heading of plants within the same rice variety, also refer to heading synchrony, is an important factor that affects simultaneous ripening of the variety. Understanding of the genetic basis of heading synchrony may contribute to molecular breeding of rice with simultaneous heading and ripening. In the present study, a doubled haploid （DH） population, derived from a cross between Chunjiang 06 and TN1 was used to analyze quantitative trait locus （QTL） for heading synchrony related traits, i.e., early heading date （EHD）, late heading date （LHD）, heading asynchrony （HAS）, and tiller number （PN）. A total of 19 QTLs for four traits distributed on nine chromosomes were detected in two environments. One QTL, qHAS-8 for HAS, explained 27.7% of the phenotypic variation, co-located with the QTLs for EHD and LHD, but it was only significant under long-day conditions in Hangzhou, China. The other three QTLs, qHAS-6, qHAS-9, and qHAS-10, were identified under short-day conditions in Hainan, China, each of which explained about 11% of the phenotypic variation. Two of them, qHAS-6 and qHAS-9, were co-located with the QTLs for EHD and LHD. Two QTLs, qPN-4 and qPN-5 for PN, were detected in Hangzhou, and qPN-5 was also detected in Hainan. However, none of them was co-located with QTLs for EHD, LHD, and HAS, suggesting that PN and HAS were controlled by different genetic factors. The results of this study can be useful in marker assisted breeding for improvement of heading synchrony.展开更多
目的利用模体端到端(End to End,E2E)系统测试分析呼吸运动对射波刀Synchrony追踪肿瘤目标定位精度的影响。方法利用射波刀Synchrony同步追踪系统的模体,设置不同的呼吸模式,将装有EBT2型号胶片的模体置于治疗床上,执行模体E2E验证计划...目的利用模体端到端(End to End,E2E)系统测试分析呼吸运动对射波刀Synchrony追踪肿瘤目标定位精度的影响。方法利用射波刀Synchrony同步追踪系统的模体,设置不同的呼吸模式,将装有EBT2型号胶片的模体置于治疗床上,执行模体E2E验证计划。E2E验证计划执行完毕后取出胶片,利用E2E软件分析不同呼吸模式下射波刀的目标追踪定位精度。结果不同呼吸周期(0、2、4、6和8 s)下anterior/superior(A/S)胶片的前方向误差比较,差异具有统计学意义(P=0.016);不同呼吸幅值(0、2、4、6和8 mm)下总体靶误差和前方向平均误差比较,差异均具有统计学意义(均P<0.05),且呼吸幅值越高,总体靶误差越高。结论患者的呼吸运动对射波刀Synchrony追踪目标的定位精度有影响,通过提高呼吸周期和降低呼吸幅值可提高射波刀追踪的精度。展开更多
By applying multiple wavelet coherence (MWC) to data from human body movements in triadic interaction, this study quantified triadic synchrony, rhythmic similarity among three interactants. Thirty-nine Japanese underg...By applying multiple wavelet coherence (MWC) to data from human body movements in triadic interaction, this study quantified triadic synchrony, rhythmic similarity among three interactants. Thirty-nine Japanese undergraduates were randomly assigned in a triad, and engaged in a brain-storming task. Triadic synchrony was quantified by calculating MWC to the time-series movement data collected by Kinect v2 sensor. The existence of synchrony was statistically tested by using a pseudo-synchrony paradigm. Results showed that the averaged value of MWC was higher in the experimental participant trio than in those of the pseudo trio in the frequency band of 0.5 - 1 Hz. The result supports the possible utility of applying multiple wavelet coherence to evaluate triadic synchrony in a small group interaction.展开更多
Laparoscopic skills training has always been crucial for novice surgeons. Readily accessible equipment, aswell as structured training curriculum should be provided to guarantee adequate practice hours and skillprofici...Laparoscopic skills training has always been crucial for novice surgeons. Readily accessible equipment, aswell as structured training curriculum should be provided to guarantee adequate practice hours and skillproficiency. Dry-lab training is typically adopted before animal model surgery, usually comprising ofpurpose-built bulky simulators that is neither accessible nor portable. In this technical note, we designed ahome-made simulator, using two 4 L water jugs as operating space that are communicated inside, plus anobservation hole taped in between to mimic the triangular working space of laparoscopic surgery. Imagingwas achieved via smartphone camera, which was wirelessly connected to a laptop and a projector for realtime display on multiple screens, using built-in multi-screen collaboration software. A self-regulated andproficiency-based training curriculum was adopted. This dry-lab simulator is low-cost, highly portable andeasily replicable for basic laparoscopic skills training for the beginners to intermediate surgeons, whichmay serve as a good way for the standardized residency and specialist training program.展开更多
Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains unclear.Compared with wild-type mice,our in vivo two-photon imaging sho...Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains unclear.Compared with wild-type mice,our in vivo two-photon imaging showed that transgenic(Tgl)mice over-expressing human autism risk gene MeCP2 exhibited higher neuronal synchrony in the young but lower synchrony in the adult stage.Whole-cell recording of neuronal pairs in brain slices revealed that higher neuronal synchrony in young postnatal Tgl mice was atributed mainly to more prevalent giant slow inward currents(SICs).Both in vivo and slice imaging further demonstrated more dynamic activity and higher synchrony in astrocytes from young Tgl mice.Blocking astrocytic gap junctions markedly decreased the generation of SICs and overall cell synchrony in the Tgl brain.Furthermore,the expression level of Cx43 protein and the coupling efficiency of astrocyte gap junctions remained unchanged in Tgi mice.Thus,astrocytic gap junctions facilitate but do not act as a direct trigger for the abnormal neuronal synchrony in young Tgl mice,revealing the potential role of the astrocyte network in the pathogenesis of MeCP2 duplication syndrome.展开更多
To reveal the mechanism of control of the Woolly Apple Aphid （Eriosoma lanigerum Hausm, WAA） by increase of biodiversity in the apple orchard, a consecutive two-year field trials were conducted in Yurman province, C...To reveal the mechanism of control of the Woolly Apple Aphid （Eriosoma lanigerum Hausm, WAA） by increase of biodiversity in the apple orchard, a consecutive two-year field trials were conducted in Yurman province, China. The results showed that the peak of natural enemy density curve in the cover cropping orchard was well temporally synchronized with that of the WAA density on trees, but did not synchronize with that of WAA density on trees in clean orchard. In addition, the frequency of natural enemies and WAA within a same sample in cover cropping orchard was obviously higher than that in clean cultivated orchard during the peak of population curves, indicating that natural enemies spatially synchronized with aphids. The density of WAA for the whole growing season in cover cropping orchard was much less than that in clean orchard. Therefore, the temporal-spatial synchrony of natural enemy and aphid populations was proposed as one of the mechanisms for aphid control in cover cropped orchards.展开更多
Objective:To study the correlation of the ultrasound parameters of left ventricular remodeling and systolic synchrony in patients with primary hypertension with serum cytokines and matrix metalloproteinases (MMPs).Met...Objective:To study the correlation of the ultrasound parameters of left ventricular remodeling and systolic synchrony in patients with primary hypertension with serum cytokines and matrix metalloproteinases (MMPs).Methods:134 patients with primary hypertension receiving three-dimensional echocardiography examination in our hospital between May 2013 and March 2016 were selected and divided into the group A with normal pattern (n=71), group B with concentric hypertrophy (n=39) and group C with eccentric hypertrophy (n=24) according to the left ventricular internal diameter at end-diastole (LVIDd) and left ventricular mass index (LVMI), and the ultrasound parameters of left ventricular remodeling and systolic synchrony as well as serum content of cytokines and MMPs were determined.Results: The time to minimal systolic volume of 16-segmental standard deviation (SDI), maximum time difference (DIF), Tpe, Tpe interphase and its correction (Tpec), LVIDd, LVMI and left ventricular remodeling index (LVRI) of group B and group C were significantly higher than those of group A (P<0.05), and SDI, DIF, Tpe, Tpec, LVIDd, LVMI and LVRI of group C were significantly higher than those of group B (P<0.05);serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP2), MMP3 and MMP9 content of group B and group C were significantly higher than those of group A (P<0.05), and serum TNF-α, IL-17, TGF-β1, MMP2, MMP3 and MMP9 content of group C were significantly higher than those of group B (P<0.05) and positively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec;serum TIMP1 and TIMP2 content of group B and group C were significantly lower than those of group A (P<0.05), and serum TIMP1 and TIMP2 content of group C were significantly lower than those of group B (P<0.05) and negatively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec.Conclusions:The ultrasound parameters of left ventricular remodeling and systolic synchrony significantly change in patients with primary hypertension and are closely related to the changes in the content of serum cytokines and MMPs.展开更多
基金supported by the National Natural Science Foundation of China(Nos.42107476 and 42177421)the China Postdoctoral International Exchange Fellowship Program(No.PC2021099)+1 种基金the Science and Technology Innovation Program of Hunan Province(No.2020RC2058)the China Scholarship Council(CSC,No.202206600004,to D.Yuan).
文摘Tree growth synchrony serves as a valuable ecological indicator of forest resilience to climate stress and disturbances.However,our understanding of how increasing temperature affects tree growth synchrony during rapidly and slowly warming periods in ecosystems with varying climatic conditions remains limited.By using tree-ring data from temperate broadleaf(Fraxinus mandshurica,Phellodendron amurense,Quercus mongolica,and Juglans mandshurica)and Korean pine(Pinus koraiensis)mixed forests in northeast China,we investigated the effects of climate change,particularly warming,on the growth synchrony of five dominant temperate tree species across contrasting warm-dry and cool-wet climate conditions.Results show that temperature over water availability was the primary factor driving the growth and growth synchrony of the five species.Growth synchrony was significantly higher in warm-dry than in cool-wet areas,primarily due to more uniform climate conditions and higher climate sensitivity in the former.Rapid warming from the 1960s to the 1990s significantly enhanced tree growth synchrony in both areas,followed by a marked reversal as temperatures exceeded a certain threshold or warming slowed down,particularly in the warm-dry area.The growth synchrony variation patterns of the five species were highly consistent over time,although broadleaves exhibited higher synchrony than conifers,suggesting potential risks to forest resilience and stability under future climate change scenarios.Growing season temperatures and non-growing season temperatures and precipitation had a stronger positive effect on tree growth in the cool-wet area compared to the warm-dry area.High relative humidity hindered growth in the cool-wet area but enhanced it in the warm-dry area.Overall,our study highlights that the diversity and sensitivity of climate-growth relationships directly determine spatiotemporal growth synchrony.Temperature,along with water availability,shape long-term forest dynamics by affecting tree growth and synchrony.These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate changeinduced synchrony shifts.
基金supported by the National Natural Science Foundation of China(T2394531)the National Key R&D Program of China(2024YFF1206500)+1 种基金the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJ Lab,and the Shanghai Center for Brain Science and Brain-Inspired Technology,China.
文摘DDeeaarr EEddiittoorr,,The encoding and retrieval of emotional memories demands intricate interplay within the limbic network,where the network state is subject to significant reconfiguration by learning-induced plasticity,behavioral state,and contextual information[1].
文摘Although seasonal breeding has been documented in many non-human primates, it is not clear whether sexual behaviors show seasonal variation among male individuals. To test this hypothesis, the focal animal sampling method and continuous recording were used to investigate seasonal variation and synchronization of sexual behaviors in five male Tibetan macaques （Macaca thibetana） at Mt. Huangshan from Oct 2005 to Sept 2006. Both copulatory and sexually motivated behaviors （i.e., sexual chase, grimace, and sexual-inspection）, which were significantly higher in the mating season than non-mating season. Furthermore, seasonal variations of sexual behaviors, including copulatory and sexually motivated behaviors, were synchronized among males. The results shed light on sexual competition and tactics for reproductive success of male M. thibetana and other non-human primates with seasonal breeding.
文摘Objective To evaluate short time effects of primary percutaneous coronary intervention (pPCI) and rtPA thrombolysis+PCI (rtPA+PCI) on myocardial viability and ventricular systolic synchrony in AMI patients.Methods Eighty seven patients with first AMI were divided into two groups: group A ( n =42), pPCI group, the patients underwent PCI within 6h after onset of AMI; group B ( n =45), rtPA+PCI group, the patients underwent PCI after thrombolysis within 6h after onset of AMI; Myocardial viability was measured by 99m Tc MIBI SPECT. While, the parameters of cardiac function LVEF and ventricular systolic synchrony LVPS were measured by 99m Tc gated cardiac blood pool image on the first and the fourth weekend. Results (1) The peak CK MB was significantly lower in group A than that in group B( P <0.01 ). (2) Myocardial infarction area (MIA) was decreased and radioactivity counts in MIA was significantly increased in group A and B on the 4th weekend compared with that on the first weekend ( P <0.01 ), but there were no significant difference between group A and group B. (3) LVEF, LVPS were no significant difference between group A and group B.Conclusions (1)pPCI in acute myocardial infartion can limit infarct area, maintain ventricular systolic synchrony and improve ventricular function; (2) but, in those hospitals that there were no any condition for PCI, they should transfer the patients to central hospital for PCI after thrombolysis at the first time. It is beneficial to improve myocardial viability and ventricular systolic synchrony of AMI patients in short time.
文摘目的:分析射波刀Synchrony同步追踪系统的质量保证验证方法是否符合临床肿瘤三维运动的要求,以保证射波刀临床治疗的质量。方法:利用改进的Synchrony模体采集CT影像信息,制订同步呼吸追踪的E2E(end to end)治疗验证计划。执行治疗计划,将装有EBT胶片的球方模体放在治疗床上,球方在不同运动条件下执行模拟验证计划,利用E2E软件对照射后的胶片进行分析,得出同步追踪的治疗误差。结果:射波刀Synchrony同步追踪系统在一维、二维、三维方向的治疗误差分别为0.91、1.03、0.90 mm。结论:射波刀Synchrony同步追踪系统的质量保证验证方法满足临床肿瘤精确治疗的要求。
基金supported by the Chinese Ministry of Agriculture (948 project No.2006-G1 and ANTA project No.200803034)the Science and Technology Department of Zhejiang Province (No.2006C12091 and 2007C32014)Zhejiang Provincial Natural Science Foundation of China (No.R3080016)
文摘Simultaneous heading of plants within the same rice variety, also refer to heading synchrony, is an important factor that affects simultaneous ripening of the variety. Understanding of the genetic basis of heading synchrony may contribute to molecular breeding of rice with simultaneous heading and ripening. In the present study, a doubled haploid （DH） population, derived from a cross between Chunjiang 06 and TN1 was used to analyze quantitative trait locus （QTL） for heading synchrony related traits, i.e., early heading date （EHD）, late heading date （LHD）, heading asynchrony （HAS）, and tiller number （PN）. A total of 19 QTLs for four traits distributed on nine chromosomes were detected in two environments. One QTL, qHAS-8 for HAS, explained 27.7% of the phenotypic variation, co-located with the QTLs for EHD and LHD, but it was only significant under long-day conditions in Hangzhou, China. The other three QTLs, qHAS-6, qHAS-9, and qHAS-10, were identified under short-day conditions in Hainan, China, each of which explained about 11% of the phenotypic variation. Two of them, qHAS-6 and qHAS-9, were co-located with the QTLs for EHD and LHD. Two QTLs, qPN-4 and qPN-5 for PN, were detected in Hangzhou, and qPN-5 was also detected in Hainan. However, none of them was co-located with QTLs for EHD, LHD, and HAS, suggesting that PN and HAS were controlled by different genetic factors. The results of this study can be useful in marker assisted breeding for improvement of heading synchrony.
文摘目的利用模体端到端(End to End,E2E)系统测试分析呼吸运动对射波刀Synchrony追踪肿瘤目标定位精度的影响。方法利用射波刀Synchrony同步追踪系统的模体,设置不同的呼吸模式,将装有EBT2型号胶片的模体置于治疗床上,执行模体E2E验证计划。E2E验证计划执行完毕后取出胶片,利用E2E软件分析不同呼吸模式下射波刀的目标追踪定位精度。结果不同呼吸周期(0、2、4、6和8 s)下anterior/superior(A/S)胶片的前方向误差比较,差异具有统计学意义(P=0.016);不同呼吸幅值(0、2、4、6和8 mm)下总体靶误差和前方向平均误差比较,差异均具有统计学意义(均P<0.05),且呼吸幅值越高,总体靶误差越高。结论患者的呼吸运动对射波刀Synchrony追踪目标的定位精度有影响,通过提高呼吸周期和降低呼吸幅值可提高射波刀追踪的精度。
文摘By applying multiple wavelet coherence (MWC) to data from human body movements in triadic interaction, this study quantified triadic synchrony, rhythmic similarity among three interactants. Thirty-nine Japanese undergraduates were randomly assigned in a triad, and engaged in a brain-storming task. Triadic synchrony was quantified by calculating MWC to the time-series movement data collected by Kinect v2 sensor. The existence of synchrony was statistically tested by using a pseudo-synchrony paradigm. Results showed that the averaged value of MWC was higher in the experimental participant trio than in those of the pseudo trio in the frequency band of 0.5 - 1 Hz. The result supports the possible utility of applying multiple wavelet coherence to evaluate triadic synchrony in a small group interaction.
基金This study is supported by the 2021 Changhai Hospital Educational Sponsorship Fund(CHPY2021B24,General Program,YC).
文摘Laparoscopic skills training has always been crucial for novice surgeons. Readily accessible equipment, aswell as structured training curriculum should be provided to guarantee adequate practice hours and skillproficiency. Dry-lab training is typically adopted before animal model surgery, usually comprising ofpurpose-built bulky simulators that is neither accessible nor portable. In this technical note, we designed ahome-made simulator, using two 4 L water jugs as operating space that are communicated inside, plus anobservation hole taped in between to mimic the triangular working space of laparoscopic surgery. Imagingwas achieved via smartphone camera, which was wirelessly connected to a laptop and a projector for realtime display on multiple screens, using built-in multi-screen collaboration software. A self-regulated andproficiency-based training curriculum was adopted. This dry-lab simulator is low-cost, highly portable andeasily replicable for basic laparoscopic skills training for the beginners to intermediate surgeons, whichmay serve as a good way for the standardized residency and specialist training program.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100)a National Natural Science Foundation of China project(31671113)+1 种基金a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)and the State Key Laboratory of Neuroscience.
文摘Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains unclear.Compared with wild-type mice,our in vivo two-photon imaging showed that transgenic(Tgl)mice over-expressing human autism risk gene MeCP2 exhibited higher neuronal synchrony in the young but lower synchrony in the adult stage.Whole-cell recording of neuronal pairs in brain slices revealed that higher neuronal synchrony in young postnatal Tgl mice was atributed mainly to more prevalent giant slow inward currents(SICs).Both in vivo and slice imaging further demonstrated more dynamic activity and higher synchrony in astrocytes from young Tgl mice.Blocking astrocytic gap junctions markedly decreased the generation of SICs and overall cell synchrony in the Tgl brain.Furthermore,the expression level of Cx43 protein and the coupling efficiency of astrocyte gap junctions remained unchanged in Tgi mice.Thus,astrocytic gap junctions facilitate but do not act as a direct trigger for the abnormal neuronal synchrony in young Tgl mice,revealing the potential role of the astrocyte network in the pathogenesis of MeCP2 duplication syndrome.
文摘To reveal the mechanism of control of the Woolly Apple Aphid （Eriosoma lanigerum Hausm, WAA） by increase of biodiversity in the apple orchard, a consecutive two-year field trials were conducted in Yurman province, China. The results showed that the peak of natural enemy density curve in the cover cropping orchard was well temporally synchronized with that of the WAA density on trees, but did not synchronize with that of WAA density on trees in clean orchard. In addition, the frequency of natural enemies and WAA within a same sample in cover cropping orchard was obviously higher than that in clean cultivated orchard during the peak of population curves, indicating that natural enemies spatially synchronized with aphids. The density of WAA for the whole growing season in cover cropping orchard was much less than that in clean orchard. Therefore, the temporal-spatial synchrony of natural enemy and aphid populations was proposed as one of the mechanisms for aphid control in cover cropped orchards.
文摘Objective:To study the correlation of the ultrasound parameters of left ventricular remodeling and systolic synchrony in patients with primary hypertension with serum cytokines and matrix metalloproteinases (MMPs).Methods:134 patients with primary hypertension receiving three-dimensional echocardiography examination in our hospital between May 2013 and March 2016 were selected and divided into the group A with normal pattern (n=71), group B with concentric hypertrophy (n=39) and group C with eccentric hypertrophy (n=24) according to the left ventricular internal diameter at end-diastole (LVIDd) and left ventricular mass index (LVMI), and the ultrasound parameters of left ventricular remodeling and systolic synchrony as well as serum content of cytokines and MMPs were determined.Results: The time to minimal systolic volume of 16-segmental standard deviation (SDI), maximum time difference (DIF), Tpe, Tpe interphase and its correction (Tpec), LVIDd, LVMI and left ventricular remodeling index (LVRI) of group B and group C were significantly higher than those of group A (P<0.05), and SDI, DIF, Tpe, Tpec, LVIDd, LVMI and LVRI of group C were significantly higher than those of group B (P<0.05);serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP2), MMP3 and MMP9 content of group B and group C were significantly higher than those of group A (P<0.05), and serum TNF-α, IL-17, TGF-β1, MMP2, MMP3 and MMP9 content of group C were significantly higher than those of group B (P<0.05) and positively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec;serum TIMP1 and TIMP2 content of group B and group C were significantly lower than those of group A (P<0.05), and serum TIMP1 and TIMP2 content of group C were significantly lower than those of group B (P<0.05) and negatively correlated with LVIDd, LVMI, LVRI, SDI, DIF, Tpe and Tpec.Conclusions:The ultrasound parameters of left ventricular remodeling and systolic synchrony significantly change in patients with primary hypertension and are closely related to the changes in the content of serum cytokines and MMPs.
