BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach durin...BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach during NAT remains controversial.In this single-center retrospective case series,we report the use of a novel multi-hole self-expandable metallic stent(MH-SEMS)for preoperative biliary drainage during NACRT in patients with PC.AIM To assess the feasibility of endoscopic biliary drainage using MH-SEMS during NACRT in patients with malignant distal biliary obstruction secondary to resectable and borderline resectable PC.METHODS We included 14 patients—10 with resectable,2 with borderline resectable,and 2 with unresectable locally advanced disease—who had undergone surgery after biliary drainage using MH-SEMS(diameter:10 mm).Clinical and technical success was achieved in all patients,with a median interval of 105 days between stent placement and surgery.RESULTS A partial response was observed in five patients(35.7%),whereas nine patients(64.3%)exhibited stable disease.Only one patient(7.1%)developed moderate cholangitis from recurrent biliary obstruction caused by sludge 337 days after stent placement during systemic chemotherapy,requiring MH-SEMS replacement.Pathological examination of postoperative specimens revealed tumor shrinkage in many cases,and no stent migration was observed.Adverse events included mild pancreatitis in two patients(14.3%)and moderate pancreatitis in one patient(7.1%),as defined by the Tokyo Criteria 2024.CONCLUSION No cases of cholecystitis,liver abscess,or hemorrhage were reported.No disadvantages in surgical procedures or postoperative complications related to MH-SEMS placement were observed.展开更多
A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion f...A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion film cooling is analyzed and a preliminary relationship evaluating the film development from developing state to developed state is brought forward. Results show that the coolant jets from front rows of multi-holes merge rapidly and the strength of the kidney vortices due to mainstream-coolant jet interaction in the downstream region are mitigated under super-long-diamond arrangement where the streamwise hole-to-hole pitch is bigger than spanwise hole-to-hole pitch. The holes array arranged in super-long-diamond mode is not only in favor of obtaining developed film layer, but also improving averaged adiabatic film cooling effectiveness.展开更多
This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diame...This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diameter ratio and distribution density of perforated holes, which are to quantify MO structure. This paper built the throttling test apparatus for nice test MO plates, which were designed according to orthogonal theory. The experiments were conducted to investigate the effect of three critical geometerical parameters on the pressure loss coefficient of test MOs. Results show that equivalent diameter ratio is the dominant prameter affecting MO throttling characterstic.展开更多
In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle rat...In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle ratio of 0.45 was considered in the present study.The flow field characteristics were determined in the framework of a CFD technique.The results show that the multi-hole orifice flowmeter with filleting transition around the throttle orifice has higher accuracy in a wide range of the space of parameters,and is more suitable for accurate measurement of fluid in process control.展开更多
Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic...Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic exploration adopts a geometry in which the sources are downhole and receivers are on the ground which can reduce the influence of complex surfaces on seismic wave propagation(to some extent).Through numerical simulations and real data analysis,it was noted that in areas with complex surfaces and large numbers of underground karst caves,seismic waves generated in shallow boreholes are easily affected by various surface and multiple waves as well as by scattering from karst bodies.Therefore,the quality of the reflected seismic data is extremely low.Also,it is difficult to improve the signal to noise ratio(SNR)with conventional noise filtering methods.However,when the source depth is increased,the quality of the reflected waves can be improved.This is exactly what the RVSP method accomplishes.Besides,for the RVSP method,due to its particular geometry,the apparent velocities of the reflected waves and most interference waves are quite different,which can help to filter most noise to further improve the SNR of the reflected signals.In this study,a 3 D-RVSP exploration study using 8-hole joint acquisition was conducted in a typical karst landform.The results show that the 3 D-RVSP method can obtain higher quality seismic data for complex surface conditions that have large numbers of underground karst caves.Furthermore,multi-hole joint acquisition for 3 D-RVSP has higher data collection efficiency and better uniformity of underground coverage.Therefore,in this study,38 faults were accurately revealed and at high resolution based on the 3 D-RVSP imaging results.展开更多
Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remot...Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remote stresses and arbitrarily distributed stresses applied to the circular boundaries.The validity of this new analytical-numerical method is verified by the analytical solution of the bi-harmonic stress function method,the numerical solution of the finite element method,and the analytical-numerical solutions of the series expansion and Laurent series methods.Some numerical examples are presented to investigate the effects of the hole geometry parameters(radii and relative positions)and loading conditions(remote stresses and surface stresses)on the interacting tangential stresses and interacting stress concentration factors(SCFs).The results show that whether the interference effect is shielding(k<1)or amplifying(k>1)depends on the relative orientation of holes(α)and remote stresses(σ^∞x,σ^∞y).When the maximum principal stress is aligned with the connecting line of two-hole centers andσ^∞y<0.5σ^∞x,the plate containing two circular holes has greater stability than that containing one circular hole,and the smaller circular hole has greater stability than the bigger one.This new method not only has a simple formulation and high accuracy,but also has an advantage of wide applications over common analytical methods and analytical-numerical methods in calculating the interacting stresses of a multi-hole problem under both remote and arbitrary surface stresses.展开更多
A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） w...A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） were designed for the throttling experiment to compare the throttling effect using the equivalent diameter ratio （RED） and diameter ratio （RD ） as key parameters, respectively. Meanwhile, effective metrical conditions were provided for experimental accuracy. The throttling model form was determined according to the theoretical throttling model of SO. Then the unknown parameters involved were identified by experimental data. A good concordance between the modeling computation and experimental results shows a validation of the MO throtting model.展开更多
A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of...A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.展开更多
BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct br...BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct branches and are at risk of migration. We have developed a multi-hole self-expandable metallic stent (MHSEMS), with a hole in each cell, to prevent the obstruction of bile duct branches. In addition, the holes may prevent migration due to small ingrowths by reducing the tension of the membrane. CASE SUMMARY MHSEMS were placed in five patients with a malignant obstruction and one with post-endoscopic sphincterotomy bleeding. Each MHSEMS was successfully deployed in all cases. Patients showed no complications. Two cases were reviewed. Case 1: A 74-year-old male presented with jaundice and was diagnosed with a sigmoid colon cancer and giant liver metastases in the right liver lobe. A MHSEMS was placed in the left bile duct. The jaundice improved and peroral cholangioscopy was performed. Case 2: A 90-year-old female was admitted to hospital for jaundice and diagnosed with cholangiocarcinoma. A MHSEMS was placed in the left bile duct but after 8 months the stent became obstructed by tumor ingrowth. We treated the patient by ablation therapy. A silicone cover separated the internal bile duct from the surrounding tissue, protecting the latter from thermal injury during treatment by endobiliary ablation of the reobstruction. CONCLUSION A MHSEMS is a new choice of stent for biliary tract diseases.展开更多
Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In w...Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In which the advanced convergence and easily to run into partial optimization were avoid. Applied the RAGA to solving the problem in the optimization design of fixed piping sprinkler irrigation system. The optimized parameters, such as diameters and the length of pipe were calculated and the result was reasonable, which provides as a reference to readers who work at related research.展开更多
In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distanc...In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still unclear.Besides,wetting front migration distance and leaching time are usually required to optimize the leaching process.In this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head height.At the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were identical.At the postintersection stage,the intersection accelerated the wetting front migration.By using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the intersection.Finally,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was established.Error analysis results showed that the proposed model can accurately simulate the infiltration process under experimental conditions.The research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.展开更多
The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mod...The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mode along geometry parameters are studied. Results show the destroy mode depends on the geometry parameter greatly. Curves of buckling critical load and strength limited load along geometry parameters have a point of intersection. The point implies the multi-holes shell has different destroy mode and the value of point is change in geometry parameters.展开更多
Bubble column reactors fitted with tube bundles(BCR TB)belong to common heat transfer equipment in the field of chemical engineering,yet the complicated thermal-hydraulics performance of BCR TB has not been deeply rev...Bubble column reactors fitted with tube bundles(BCR TB)belong to common heat transfer equipment in the field of chemical engineering,yet the complicated thermal-hydraulics performance of BCR TB has not been deeply revealed.To fill this gap,the present study proposes a novel variable bubble size modeling approach based on the Euler-Euler two-fluid framework,which is coupled with the population balance model considering comprehensive interphase forces.On the basis of verifying numerical reliability using experimental data,the mechanism of bubble swarm flow around the tube bundle and the effects of gas sparger configurations on the thermal-hydraulics performance of BCR TB are investigated.Results indicate that the entire tube bundle can be divided into three distinct zones,namely the sparger effect zone,fully developed zone and interface effect zone in view of the local mixture-to-wall heat transfer coefficient.The maximum peak value of the mixture-to-wall heat transfer coefficient always appears at 210°of heat exchange tubes.When the orifice diameter is 4 mm,the axial gradient of gas holdup is relatively large due to more intense shearing and fragmentation effects.Interestingly,the fractions of medium-sized and large-sized bubbles are not sensitive to orifice angle.Both the mixture-to-wall heat transfer coefficient and the friction factor decrease initially and then increase when the installation height increases.Under the optimized gas sparger structure configuration,the mixture-to-wall heat transfer coefficient increases by 10.23%,accompanied by the reduction of pressure drop by 8.14%,ultimately attaining a system energy conversion efficiency of 97.88%and performance evaluation criterion of 1.087.Finally,a new dimensionless and semi-theoretical Nusselt correlation incorporating a structural correction factor with an average absolute deviation of 5.15%is developed.The findings can offer useful guidance for the optimal design of BCR TB.展开更多
Bubble dispersion greatly relies on spargers. Single or ifice and porous spargers were tested inside a bubble column under a low gas thr oughput to study their influences on gas dispersion and gas-liquid interface ar ...Bubble dispersion greatly relies on spargers. Single or ifice and porous spargers were tested inside a bubble column under a low gas thr oughput to study their influences on gas dispersion and gas-liquid interface ar ea. A PBE model without considering the effect of bubble coalescence was develo ped to describe axial bubble distribution. Both simulation and experimental res ults showed that bubbles broke up much faster than coalesced under low gas veloc ity. For a single orifice sparger, breakage was a dominant feature for bubbles after they left the orifice. Initial bubbles formed over the orifice were mostl y larger than the largest stable bubble. They broke up quickly and their sizes were reduced below the maximum diameter d_s of stable bubbles. In contrast , a porous sparger produced a large amount of initial bubbles smaller than the l argest stable bubble. The bubbles possessed smaller size and narrower distribut ion compared with the bubbles obtained by single orifice spargers. With the por ous sparger, gas-liquid surface area was increased by 5—6 times even though th e gas holdup changed insignificantly. High mass transfer area could be obtained by injecting more small initial bubbles with diameters under d_s.展开更多
文摘BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach during NAT remains controversial.In this single-center retrospective case series,we report the use of a novel multi-hole self-expandable metallic stent(MH-SEMS)for preoperative biliary drainage during NACRT in patients with PC.AIM To assess the feasibility of endoscopic biliary drainage using MH-SEMS during NACRT in patients with malignant distal biliary obstruction secondary to resectable and borderline resectable PC.METHODS We included 14 patients—10 with resectable,2 with borderline resectable,and 2 with unresectable locally advanced disease—who had undergone surgery after biliary drainage using MH-SEMS(diameter:10 mm).Clinical and technical success was achieved in all patients,with a median interval of 105 days between stent placement and surgery.RESULTS A partial response was observed in five patients(35.7%),whereas nine patients(64.3%)exhibited stable disease.Only one patient(7.1%)developed moderate cholangitis from recurrent biliary obstruction caused by sludge 337 days after stent placement during systemic chemotherapy,requiring MH-SEMS replacement.Pathological examination of postoperative specimens revealed tumor shrinkage in many cases,and no stent migration was observed.Adverse events included mild pancreatitis in two patients(14.3%)and moderate pancreatitis in one patient(7.1%),as defined by the Tokyo Criteria 2024.CONCLUSION No cases of cholecystitis,liver abscess,or hemorrhage were reported.No disadvantages in surgical procedures or postoperative complications related to MH-SEMS placement were observed.
基金National Natural Science Foundation of China (50876041)
文摘A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion film cooling is analyzed and a preliminary relationship evaluating the film development from developing state to developed state is brought forward. Results show that the coolant jets from front rows of multi-holes merge rapidly and the strength of the kidney vortices due to mainstream-coolant jet interaction in the downstream region are mitigated under super-long-diamond arrangement where the streamwise hole-to-hole pitch is bigger than spanwise hole-to-hole pitch. The holes array arranged in super-long-diamond mode is not only in favor of obtaining developed film layer, but also improving averaged adiabatic film cooling effectiveness.
基金Sponsored by National Natural Science Foundation of China (Grant No50578049)
文摘This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diameter ratio and distribution density of perforated holes, which are to quantify MO structure. This paper built the throttling test apparatus for nice test MO plates, which were designed according to orthogonal theory. The experiments were conducted to investigate the effect of three critical geometerical parameters on the pressure loss coefficient of test MOs. Results show that equivalent diameter ratio is the dominant prameter affecting MO throttling characterstic.
基金supports of Hebei province high-tech industry multiplier project(No.16211702D)Chengde science and technology&development project(No.20152013).
文摘In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle ratio of 0.45 was considered in the present study.The flow field characteristics were determined in the framework of a CFD technique.The results show that the multi-hole orifice flowmeter with filleting transition around the throttle orifice has higher accuracy in a wide range of the space of parameters,and is more suitable for accurate measurement of fluid in process control.
基金funded jointly by National Key Research and Development Program of China(2017YFC0804105)Fundamental Research Funds for the Central Universities of China(2015XKMS036)+1 种基金Natural Science Foundation of Jiangsu Province(BK20160245)a Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic exploration adopts a geometry in which the sources are downhole and receivers are on the ground which can reduce the influence of complex surfaces on seismic wave propagation(to some extent).Through numerical simulations and real data analysis,it was noted that in areas with complex surfaces and large numbers of underground karst caves,seismic waves generated in shallow boreholes are easily affected by various surface and multiple waves as well as by scattering from karst bodies.Therefore,the quality of the reflected seismic data is extremely low.Also,it is difficult to improve the signal to noise ratio(SNR)with conventional noise filtering methods.However,when the source depth is increased,the quality of the reflected waves can be improved.This is exactly what the RVSP method accomplishes.Besides,for the RVSP method,due to its particular geometry,the apparent velocities of the reflected waves and most interference waves are quite different,which can help to filter most noise to further improve the SNR of the reflected signals.In this study,a 3 D-RVSP exploration study using 8-hole joint acquisition was conducted in a typical karst landform.The results show that the 3 D-RVSP method can obtain higher quality seismic data for complex surface conditions that have large numbers of underground karst caves.Furthermore,multi-hole joint acquisition for 3 D-RVSP has higher data collection efficiency and better uniformity of underground coverage.Therefore,in this study,38 faults were accurately revealed and at high resolution based on the 3 D-RVSP imaging results.
基金Project supported by the National Natural Science Foundation of China(Nos.51474251,51874351,and 11502226)the Natural Science Foundation of Hunan Province of China(No.2019JJ50625)and the Key Research and Development Plan of Hunan Province of China(No.2017WK2032)。
文摘Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remote stresses and arbitrarily distributed stresses applied to the circular boundaries.The validity of this new analytical-numerical method is verified by the analytical solution of the bi-harmonic stress function method,the numerical solution of the finite element method,and the analytical-numerical solutions of the series expansion and Laurent series methods.Some numerical examples are presented to investigate the effects of the hole geometry parameters(radii and relative positions)and loading conditions(remote stresses and surface stresses)on the interacting tangential stresses and interacting stress concentration factors(SCFs).The results show that whether the interference effect is shielding(k<1)or amplifying(k>1)depends on the relative orientation of holes(α)and remote stresses(σ^∞x,σ^∞y).When the maximum principal stress is aligned with the connecting line of two-hole centers andσ^∞y<0.5σ^∞x,the plate containing two circular holes has greater stability than that containing one circular hole,and the smaller circular hole has greater stability than the bigger one.This new method not only has a simple formulation and high accuracy,but also has an advantage of wide applications over common analytical methods and analytical-numerical methods in calculating the interacting stresses of a multi-hole problem under both remote and arbitrary surface stresses.
基金the National Natural Science Foundation of China(Grant No.50578049)
文摘A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） were designed for the throttling experiment to compare the throttling effect using the equivalent diameter ratio （RED） and diameter ratio （RD ） as key parameters, respectively. Meanwhile, effective metrical conditions were provided for experimental accuracy. The throttling model form was determined according to the theoretical throttling model of SO. Then the unknown parameters involved were identified by experimental data. A good concordance between the modeling computation and experimental results shows a validation of the MO throtting model.
基金Project supported by the National High Technology Research and Development Program of China (Grant No. 2008AA03Z402)the National Natural Science Foundation of China (Grant No. 61076044)the Natural Science Foundation of Beijing,China(Grant Nos. 4092007 and 4102003)
文摘A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.
文摘BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct branches and are at risk of migration. We have developed a multi-hole self-expandable metallic stent (MHSEMS), with a hole in each cell, to prevent the obstruction of bile duct branches. In addition, the holes may prevent migration due to small ingrowths by reducing the tension of the membrane. CASE SUMMARY MHSEMS were placed in five patients with a malignant obstruction and one with post-endoscopic sphincterotomy bleeding. Each MHSEMS was successfully deployed in all cases. Patients showed no complications. Two cases were reviewed. Case 1: A 74-year-old male presented with jaundice and was diagnosed with a sigmoid colon cancer and giant liver metastases in the right liver lobe. A MHSEMS was placed in the left bile duct. The jaundice improved and peroral cholangioscopy was performed. Case 2: A 90-year-old female was admitted to hospital for jaundice and diagnosed with cholangiocarcinoma. A MHSEMS was placed in the left bile duct but after 8 months the stent became obstructed by tumor ingrowth. We treated the patient by ablation therapy. A silicone cover separated the internal bile duct from the surrounding tissue, protecting the latter from thermal injury during treatment by endobiliary ablation of the reobstruction. CONCLUSION A MHSEMS is a new choice of stent for biliary tract diseases.
文摘Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In which the advanced convergence and easily to run into partial optimization were avoid. Applied the RAGA to solving the problem in the optimization design of fixed piping sprinkler irrigation system. The optimized parameters, such as diameters and the length of pipe were calculated and the result was reasonable, which provides as a reference to readers who work at related research.
基金This research was funded by the National Natural Science Foundation of China(Grant No.52174113)the Young Jinggang Scholars Award Program in Jiangxi Province,China(Grant No.QNJG2018051)the“Thousand Talents”of Jiangxi Province,China(Grant No.jxsq2019201043).
文摘In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still unclear.Besides,wetting front migration distance and leaching time are usually required to optimize the leaching process.In this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head height.At the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were identical.At the postintersection stage,the intersection accelerated the wetting front migration.By using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the intersection.Finally,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was established.Error analysis results showed that the proposed model can accurately simulate the infiltration process under experimental conditions.The research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.
基金supported by the Under graduate Thesis Foundation of Northwestern Polytechnic University
文摘The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mode along geometry parameters are studied. Results show the destroy mode depends on the geometry parameter greatly. Curves of buckling critical load and strength limited load along geometry parameters have a point of intersection. The point implies the multi-holes shell has different destroy mode and the value of point is change in geometry parameters.
基金supported by the project 2024J01421supported by Fujian Provincial Natural Science Foundation.
文摘Bubble column reactors fitted with tube bundles(BCR TB)belong to common heat transfer equipment in the field of chemical engineering,yet the complicated thermal-hydraulics performance of BCR TB has not been deeply revealed.To fill this gap,the present study proposes a novel variable bubble size modeling approach based on the Euler-Euler two-fluid framework,which is coupled with the population balance model considering comprehensive interphase forces.On the basis of verifying numerical reliability using experimental data,the mechanism of bubble swarm flow around the tube bundle and the effects of gas sparger configurations on the thermal-hydraulics performance of BCR TB are investigated.Results indicate that the entire tube bundle can be divided into three distinct zones,namely the sparger effect zone,fully developed zone and interface effect zone in view of the local mixture-to-wall heat transfer coefficient.The maximum peak value of the mixture-to-wall heat transfer coefficient always appears at 210°of heat exchange tubes.When the orifice diameter is 4 mm,the axial gradient of gas holdup is relatively large due to more intense shearing and fragmentation effects.Interestingly,the fractions of medium-sized and large-sized bubbles are not sensitive to orifice angle.Both the mixture-to-wall heat transfer coefficient and the friction factor decrease initially and then increase when the installation height increases.Under the optimized gas sparger structure configuration,the mixture-to-wall heat transfer coefficient increases by 10.23%,accompanied by the reduction of pressure drop by 8.14%,ultimately attaining a system energy conversion efficiency of 97.88%and performance evaluation criterion of 1.087.Finally,a new dimensionless and semi-theoretical Nusselt correlation incorporating a structural correction factor with an average absolute deviation of 5.15%is developed.The findings can offer useful guidance for the optimal design of BCR TB.
文摘Bubble dispersion greatly relies on spargers. Single or ifice and porous spargers were tested inside a bubble column under a low gas thr oughput to study their influences on gas dispersion and gas-liquid interface ar ea. A PBE model without considering the effect of bubble coalescence was develo ped to describe axial bubble distribution. Both simulation and experimental res ults showed that bubbles broke up much faster than coalesced under low gas veloc ity. For a single orifice sparger, breakage was a dominant feature for bubbles after they left the orifice. Initial bubbles formed over the orifice were mostl y larger than the largest stable bubble. They broke up quickly and their sizes were reduced below the maximum diameter d_s of stable bubbles. In contrast , a porous sparger produced a large amount of initial bubbles smaller than the l argest stable bubble. The bubbles possessed smaller size and narrower distribut ion compared with the bubbles obtained by single orifice spargers. With the por ous sparger, gas-liquid surface area was increased by 5—6 times even though th e gas holdup changed insignificantly. High mass transfer area could be obtained by injecting more small initial bubbles with diameters under d_s.
