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LINC00431 modulates KRAS and p53 stability to drive pancreatic cancer progression under hypoxia
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作者 Zhiwei Cai Meng Liu +7 位作者 Weiyi Wang Hongfei Yao Shuo Yang Chunjing Li Xiao Hu Yunlong Pu Jianxia Ma Chongyi Jiang 《Genes & Diseases》 2026年第1期99-102,共4页
Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by ... Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by an excess of stromal cells and extracellular matrix and insufficient vascularization,is a distinctive feature of pancreatic ductal adenocarcinoma(PDAC). 展开更多
关键词 LINC pancreatic ductal adenocarcinoma pdac stromal cells HYPOXIA hypoxic tumor microenvironmentcharacterized KRAS extracellular matrix p
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