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LINC00431 modulates KRAS and p53 stability to drive pancreatic cancer progression under hypoxia

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摘要 Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by an excess of stromal cells and extracellular matrix and insufficient vascularization,is a distinctive feature of pancreatic ductal adenocarcinoma(PDAC).
出处 《Genes & Diseases》 2026年第1期99-102,共4页 基因与疾病(英文)
基金 supported by the National Natural Science Foundation of China(No.82372968) the Shanghai Shenkang Hospital Development Center(No.SHDC2024CRI080) the Medical Engineering Joint Fund of Fudan University,Shanghai,China(No.XM03231533) the Shanghai Science and Technology Development Funds(Shanghai,China)(No.22YF1406200).

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