Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always...Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always struggle to balance mechanical properties and thermal insulation,resulting in their inability to meet the demands for both washing resistance and personal protection.Herein,inspired by the natural spring-like structures of cucumber tendrils,a superelastic and washable micro/nanofibrous sponge(MNFS)based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.By regulating the conductivity of polyvinylidene fluoride solution,multiple-jet ejection and multiple-stage whipping of jets are achieved,and further control of phase separation rates enables the rapid solidification of jets to form spring-like helical fibers,which are directly entangled to assemble MNFS.The resulting MNFS exhibits superelasticity that can withstand large tensile strain(200%),1000 cyclic tensile or compression deformations,and retain good resilience even in liquid nitrogen(-196℃).Furthermore,the MNFS shows efficient thermal insulation with low thermal conductivity(24.85 mW m^(-1)K^(-1)),close to the value of dry air,and remains structural stability even after cyclic washing.This work offers new possibilities for advanced fibrous sponges in transportation,environmental,and energy applications.展开更多
Mine filling materials urgently need to improve mechanical properties and achieve low-carbon transformation.This study explores the mechanism of the synergistic effect of optimizing aggregate fractal grading and intro...Mine filling materials urgently need to improve mechanical properties and achieve low-carbon transformation.This study explores the mechanism of the synergistic effect of optimizing aggregate fractal grading and introducing CO_(2)nanobubble technology to improve the performance of cement-fly ash-based backfill materials(CFB).The properties including fluidity,setting time,uniaxial compressive strength,elastic modulus,porosity,microstructure and CO_(2)storage performance were systematically studied through methods such as fluidity evaluation,time test,uniaxial compression test,mercury intrusion porosimetry(MIP),scanning electron microscopy-energy dispersive spectroscopy analysis(SEM-EDS),and thermogravimetric-differential thermogravimetric analysis(TG-DTG).The experimental results show that the density and strength of the material are significantly improved under the synergistic effect of fractal dimension and CO_(2)nanobubbles.When the fractal dimension reaches 2.65,the mass ratio of coarse and fine aggregates reaches the optimal balance,and the structural density is greatly improved at the same time.At this time,the uniaxial compressive strength and elastic modulus reach their peak values,with increases of up to 13.46%and 27.47%,respectively.CO_(2)nanobubbles enhance the material properties by promoting hydration reaction and carbonization.At the microscopic level,CO_(2)nanobubble water promotes the formation of C-S-H(hydrated calcium silicate),C-A-S-H(hydrated calcium aluminium silicate)gel and CaCO_(3),which is the main way to enhance the performance.Thermogravimetric studies have shown that when the fractal dimension is 2.65,the dehydration of hydration products and the decarbonization process of CaCO_(3)are most obvious,and CO_(2)nanobubble water promotes the carbonization reaction,making it surpass the natural state.The CO_(2)sequestration quality of cement-fly ash-based materials treated with CO_(2)nanobubble water at different fractal dimensions increased by 12.4wt%to 99.8wt%.The results not only provide scientific insights for the design and implementation of low-carbon filling materials,but also provide a solid theoretical basis for strengthening green mining practices and promoting sustainable resource utilization.展开更多
Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing ...Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing techniques are mainly used in laboratory research settings.This review provides an over-view of the fundamentals,techniques,and applications of microassemblies.Manipulation techniques based on magnetic,optical,acoustic fields,and mechanical systems are discussed,and control systems that rely on machine vision and force feedback are introduced.Additionally,recent applications of microassemblies in microstructure fabrication,microelectromechanical operation,and biomedical engi-neering are examined.This review also highlights unmet technical demands and emerging trends,as well as new research opportunities in this expanding field of research driven by allied technologies such as microrobotics.展开更多
Microwave sensing technology has become increasingly widely applied in the biomedical field,playing a significant role in medical diagnosis,biological monitoring,and environmental warning.In recent years,the introduct...Microwave sensing technology has become increasingly widely applied in the biomedical field,playing a significant role in medical diagnosis,biological monitoring,and environmental warning.In recent years,the introduction of metamaterials has brought new possibilities and opportunities to microwave biosensors.This paper aims to explore the applications of microwave sensors in biosensing,with a particular emphasis on analyzing the crucial role of metamaterials in enhancing sensor performance and sensitivity.It provides a thorough examination of the fundamental principles,design strategies,fabrication techniques,and applications of microwave biosensors leveraging metamaterial enhancement.Moreover,it meticulously explores the latest applications spanning biomedical diagnostics,environmental monitoring,and food safety,shedding light on their transformative potential in healthcare,environmental sustainability,and food quality assurance.By delving into future research directions and confronting present challenges such as standardization and validation protocols,cost-effectiveness and scalability considerations and exploration of emerging applications,the paper provides a roadmap for advancing microwave biosensors with metamaterial enhancement,promising breakthroughs in multifaceted bioanalytical realms.展开更多
Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step...Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step and controllable fabrication.Accordingly,based on tip-based fabrication techniques,this study proposed a micro-amplitude vibration-assisted scratching method by introducing a periodic backward displacement into the conventional scratching process,which enabled the synchronous creation of the microscale V-groove and nanoscale ripples,i.e.a typical micro/nano hierarchical structure.The experiments and finite element modeling were employed to explore the formation process and mechanism of the micro/nano hierarchical structures.Being different from conventional cutting,this method was mainly based on the plow mechanism,and it could accurately replicate the shape of the indenter on the material surface.The microscale V-groove was formed due to the scratching action,and the nanoscale ripple was formed due to the extrusion action of the indenter on the microscale V-groove’s surface.Furthermore,the relationships between the processing parameters and the dimensions of the micro/nano hierarchical structures were established through experiments,and optimized processing parameters were determined to achieve regular micro/nano hierarchical structures.By this method,complex patterns constructed by various micro/nano hierarchical structures were fabricated on both flat and curved surfaces,achieving diverse surface structural colors.展开更多
Sn-based solder is a widely used interconnection material in the field of electronic packaging;however,the performance requirements for these solders are becoming increasingly demanding owing to the rapid development ...Sn-based solder is a widely used interconnection material in the field of electronic packaging;however,the performance requirements for these solders are becoming increasingly demanding owing to the rapid development in this area.In recent years,the addition of micro/nanoreinforcement phases to Sn-based solders has provided a solution to improve the intrinsic properties of the solders.This paper reviews the progress in Sn-based micro/nanoreinforced composite solders over the past decade.The types of reinforcement particles,preparation methods of the composite solders,and strengthening effects on the microstructure,wettability,melting point,mechanical properties,and corrosion resistance under different particle-addition levels are discussed and summarized.The mechanisms of performance enhancement are summarized based on material-strengthening effects such as grain refinement and second-phase dispersion strengthening.In addition,we discuss the current shortcomings of such composite solders and possible future improvements,thereby establishing a theoretical foundation for the future development of Sn-based solders.展开更多
Magnesium is distinguished by its highly anisotropic inelastic deformation involving a profuse activity of deformation twinning.Instrumented micro/nano-indentation technique has been widely applied to characterize the...Magnesium is distinguished by its highly anisotropic inelastic deformation involving a profuse activity of deformation twinning.Instrumented micro/nano-indentation technique has been widely applied to characterize the mechanical properties of magnesium,typically through the analysis of the indentation load-depth response,surface topography,and less commonly,the post-mortem microstructure within the bulk material.However,experimental limitations prevent the real-time observation of the evolving microstructure.To bridge this gap,we employ a recently-developed finite-strain model that couples the phase-field method and conventional crystal plasticity to simulate the evolution of the indentation-induced twin microstructure and its interaction with plastic slip in a magnesium single-crystal.Particular emphasis is placed on two aspects:orientation-dependent inelastic deformation and indentation size effects.Several outcomes of our 2D computational study are consistent with prior experimental observations.Chief among them is the intricate morphology of twin microstructure obtained at large spatial scales,which,to our knowledge,represents a level of detail that has not been captured in previous modeling studies.To further elucidate on size effects,we extend the model by incorporating gradient-enhanced crystal plasticity,and re-examine the notion of‘smaller is stronger’.The corresponding results underscore the dominant influence of gradient plasticity over the interfacial energy of twin boundaries in governing the size-dependent mechanical response.展开更多
Approximately 99%of micro(nano)plastics in wastewater are retained in waste activated sludge,inhibiting anaerobic digestion,while their specific effects on functional microbes remain unclear.To break through the limit...Approximately 99%of micro(nano)plastics in wastewater are retained in waste activated sludge,inhibiting anaerobic digestion,while their specific effects on functional microbes remain unclear.To break through the limitations of current knowledge,in this review,we focused on summarizing the impacts of micro(nano)plastics on the microbial communities within anaerobic digestion systems,analyzing the toxicity mechanisms and developing strategies to mitigate their inhibitory effects.Firstly,the impacts of micro(nano)plastics on methane production and functional microbes were summarized,including direct cell pitting effects,inhibition caused by toxic leachates,and the adsorption of pollutants onto micro(nano)plastics surfaces,which further interfere with microbial activity and metabolic processes.Then,the specific performances and potential mechanisms by which micro(nano)plastics affect microbes were innovatively analyzed from the aspects of community variation,cellular activity and genetic expression.Moreover,various factors of micro(nano)plastics were found to influence their effects on microbes,including hormesis-like effects at different dosages,increased toxicity with decreasing particle size,enhanced biotoxicity due to surface functional groups,and variations in toxicity based on morphology and aggregation state.Furthermore,potential mitigation strategies,including activated carbon addition,thermal hydrolysis and cationic polyacrylamide application,were firstly summarized in here to alleviate inhibition on microbe.Finally,the current challenges and future directions were fully discussed and prospected.These insights could not only elucidate the biotoxic effects of micro(nano)plastics,but also provide a new avenue for helping to develop effective remediation techniques in micro(nano)plastic pollution management.展开更多
The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are ...The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are preferred. In order to achieve the transition from disordered pore formation to ordered pore formation, Al_(2)O_(3) ceramic cores with triply periodic minimal surface(TPMS) micro lattice structures with different structural configurations(gyroid, diamond, and neovius) and different volume fractions of lattice structures(30, 40, and 50, vol.%) were designed and prepared by vat photopolymerization 3D printing. The effects of structural configuration and volume fraction of the lattice structure on the following structural shrinkage, microstructure, and flexural strength were investigated. The shrinkage relationship of the three lattice configurations is: neovius>diamond>gyroid. Besides, it is found that with an increase in the volume fraction of the 3D printed Al_(2)O_(3) ceramic micro lattice structures, their fiexural strength correspondingly increases ranging from 54.95 MPa to 139.1 MPa. The maximum average fiexural strength of the 3D printed Al_(2)O_(3) ceramic micro lattice structures is obtained when the structural configuration is diamond and with a volume fraction of 50vol.%, which is 139.1 MPa. Even when the volume fraction of the lattice structure is 30vol.%, that is to say the porosity is 70%, the fiexural strength is as high as 50-70 MPa, which can still be maintained at a high level. In addition, when the volume fraction of the lattice structure is a certain value, the sample with diamond configuration has a higher strength. The internal pore morphology, pore size, and porosity of the cores are precisely controlled, achieving both a high porosity and a high strength. Therefore, this study maintains high porosity and high strength simultaneously, providing a new lattice structure design idea for 3D printed ceramic cores.展开更多
The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several differen...The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several different bacteria,can actively contribute to the regulation of host metabolism,immunity,and inflammation.Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer.In particular,a causal relationship among ncRNAs,gut microbiota,and immune cells has been shown for their potential importance in the development of breast cancer.Alteration of ncRNA expression and/or gut microbiota profiles could also influence several intracellular signaling pathways with the function of anti-proliferative(APRO)family proteins associated with the malignancy.Targeting ncRNAs and/or APRO family proteins for the treatment of various cancers has been revealed with novel immune therapies.Here,the most recent studies to underline the key role of ncRNAs,APRO family proteins,and gut microbiota in breast cancer progression have been discussed.For more effective breast cancer therapy,it would be imperative to figure out the collective mechanism of ncRNAs,APRO family proteins,and gut microbiota.展开更多
基金supported by Young Elite Scientists Sponsorship Program by China Association for Science and Technology(No.2022QNRC001)the National Natural Science Foundation of China(No.52273053)the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(No.21CGA41)。
文摘Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always struggle to balance mechanical properties and thermal insulation,resulting in their inability to meet the demands for both washing resistance and personal protection.Herein,inspired by the natural spring-like structures of cucumber tendrils,a superelastic and washable micro/nanofibrous sponge(MNFS)based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.By regulating the conductivity of polyvinylidene fluoride solution,multiple-jet ejection and multiple-stage whipping of jets are achieved,and further control of phase separation rates enables the rapid solidification of jets to form spring-like helical fibers,which are directly entangled to assemble MNFS.The resulting MNFS exhibits superelasticity that can withstand large tensile strain(200%),1000 cyclic tensile or compression deformations,and retain good resilience even in liquid nitrogen(-196℃).Furthermore,the MNFS shows efficient thermal insulation with low thermal conductivity(24.85 mW m^(-1)K^(-1)),close to the value of dry air,and remains structural stability even after cyclic washing.This work offers new possibilities for advanced fibrous sponges in transportation,environmental,and energy applications.
基金financially supported by the China Scholarship Council(CSC)。
文摘Mine filling materials urgently need to improve mechanical properties and achieve low-carbon transformation.This study explores the mechanism of the synergistic effect of optimizing aggregate fractal grading and introducing CO_(2)nanobubble technology to improve the performance of cement-fly ash-based backfill materials(CFB).The properties including fluidity,setting time,uniaxial compressive strength,elastic modulus,porosity,microstructure and CO_(2)storage performance were systematically studied through methods such as fluidity evaluation,time test,uniaxial compression test,mercury intrusion porosimetry(MIP),scanning electron microscopy-energy dispersive spectroscopy analysis(SEM-EDS),and thermogravimetric-differential thermogravimetric analysis(TG-DTG).The experimental results show that the density and strength of the material are significantly improved under the synergistic effect of fractal dimension and CO_(2)nanobubbles.When the fractal dimension reaches 2.65,the mass ratio of coarse and fine aggregates reaches the optimal balance,and the structural density is greatly improved at the same time.At this time,the uniaxial compressive strength and elastic modulus reach their peak values,with increases of up to 13.46%and 27.47%,respectively.CO_(2)nanobubbles enhance the material properties by promoting hydration reaction and carbonization.At the microscopic level,CO_(2)nanobubble water promotes the formation of C-S-H(hydrated calcium silicate),C-A-S-H(hydrated calcium aluminium silicate)gel and CaCO_(3),which is the main way to enhance the performance.Thermogravimetric studies have shown that when the fractal dimension is 2.65,the dehydration of hydration products and the decarbonization process of CaCO_(3)are most obvious,and CO_(2)nanobubble water promotes the carbonization reaction,making it surpass the natural state.The CO_(2)sequestration quality of cement-fly ash-based materials treated with CO_(2)nanobubble water at different fractal dimensions increased by 12.4wt%to 99.8wt%.The results not only provide scientific insights for the design and implementation of low-carbon filling materials,but also provide a solid theoretical basis for strengthening green mining practices and promoting sustainable resource utilization.
基金supported by Shanghai Municipal Science and Technology Major Project(2021SHZDZX)also in part supported by the Science and Technology Commission of Shanghai Municipality(20DZ2220400).
文摘Microassembly platforms have attracted significant attention recently because of their potential for developing microsystems and devices for a wide range of applications.Despite their considerable poten-tial,existing techniques are mainly used in laboratory research settings.This review provides an over-view of the fundamentals,techniques,and applications of microassemblies.Manipulation techniques based on magnetic,optical,acoustic fields,and mechanical systems are discussed,and control systems that rely on machine vision and force feedback are introduced.Additionally,recent applications of microassemblies in microstructure fabrication,microelectromechanical operation,and biomedical engi-neering are examined.This review also highlights unmet technical demands and emerging trends,as well as new research opportunities in this expanding field of research driven by allied technologies such as microrobotics.
基金support from the National Key R&D Program of China(Grant No.2021YFC3002204)the National Natural Science Foundation of China(Grant No.U2233206)。
文摘Microwave sensing technology has become increasingly widely applied in the biomedical field,playing a significant role in medical diagnosis,biological monitoring,and environmental warning.In recent years,the introduction of metamaterials has brought new possibilities and opportunities to microwave biosensors.This paper aims to explore the applications of microwave sensors in biosensing,with a particular emphasis on analyzing the crucial role of metamaterials in enhancing sensor performance and sensitivity.It provides a thorough examination of the fundamental principles,design strategies,fabrication techniques,and applications of microwave biosensors leveraging metamaterial enhancement.Moreover,it meticulously explores the latest applications spanning biomedical diagnostics,environmental monitoring,and food safety,shedding light on their transformative potential in healthcare,environmental sustainability,and food quality assurance.By delving into future research directions and confronting present challenges such as standardization and validation protocols,cost-effectiveness and scalability considerations and exploration of emerging applications,the paper provides a roadmap for advancing microwave biosensors with metamaterial enhancement,promising breakthroughs in multifaceted bioanalytical realms.
基金supported by the Jilin Province Key Research and Development Plan Project(20240302066GX)the National Natural Science Foundation of China(Grant No.52075221)the Fundamental Research Funds for the Central Universities(2023-JCXK-02)。
文摘Micro/nano hierarchical structures could endow materials with various surface functions.However,the multilayer and multiscale characteristics of micro/nano hierarchical structures bring difficulties for their one step and controllable fabrication.Accordingly,based on tip-based fabrication techniques,this study proposed a micro-amplitude vibration-assisted scratching method by introducing a periodic backward displacement into the conventional scratching process,which enabled the synchronous creation of the microscale V-groove and nanoscale ripples,i.e.a typical micro/nano hierarchical structure.The experiments and finite element modeling were employed to explore the formation process and mechanism of the micro/nano hierarchical structures.Being different from conventional cutting,this method was mainly based on the plow mechanism,and it could accurately replicate the shape of the indenter on the material surface.The microscale V-groove was formed due to the scratching action,and the nanoscale ripple was formed due to the extrusion action of the indenter on the microscale V-groove’s surface.Furthermore,the relationships between the processing parameters and the dimensions of the micro/nano hierarchical structures were established through experiments,and optimized processing parameters were determined to achieve regular micro/nano hierarchical structures.By this method,complex patterns constructed by various micro/nano hierarchical structures were fabricated on both flat and curved surfaces,achieving diverse surface structural colors.
基金financially supported by the State Key Laboratory for Mechanical Behavior of Materials,China(No.202325012)the National Natural Science Foundation of China(No.U21A20128).
文摘Sn-based solder is a widely used interconnection material in the field of electronic packaging;however,the performance requirements for these solders are becoming increasingly demanding owing to the rapid development in this area.In recent years,the addition of micro/nanoreinforcement phases to Sn-based solders has provided a solution to improve the intrinsic properties of the solders.This paper reviews the progress in Sn-based micro/nanoreinforced composite solders over the past decade.The types of reinforcement particles,preparation methods of the composite solders,and strengthening effects on the microstructure,wettability,melting point,mechanical properties,and corrosion resistance under different particle-addition levels are discussed and summarized.The mechanisms of performance enhancement are summarized based on material-strengthening effects such as grain refinement and second-phase dispersion strengthening.In addition,we discuss the current shortcomings of such composite solders and possible future improvements,thereby establishing a theoretical foundation for the future development of Sn-based solders.
文摘Magnesium is distinguished by its highly anisotropic inelastic deformation involving a profuse activity of deformation twinning.Instrumented micro/nano-indentation technique has been widely applied to characterize the mechanical properties of magnesium,typically through the analysis of the indentation load-depth response,surface topography,and less commonly,the post-mortem microstructure within the bulk material.However,experimental limitations prevent the real-time observation of the evolving microstructure.To bridge this gap,we employ a recently-developed finite-strain model that couples the phase-field method and conventional crystal plasticity to simulate the evolution of the indentation-induced twin microstructure and its interaction with plastic slip in a magnesium single-crystal.Particular emphasis is placed on two aspects:orientation-dependent inelastic deformation and indentation size effects.Several outcomes of our 2D computational study are consistent with prior experimental observations.Chief among them is the intricate morphology of twin microstructure obtained at large spatial scales,which,to our knowledge,represents a level of detail that has not been captured in previous modeling studies.To further elucidate on size effects,we extend the model by incorporating gradient-enhanced crystal plasticity,and re-examine the notion of‘smaller is stronger’.The corresponding results underscore the dominant influence of gradient plasticity over the interfacial energy of twin boundaries in governing the size-dependent mechanical response.
基金financially sponsored by the funding from the National Key Research and Development Program of China(No.2023YFC3207404)the National Nature Science Foundation of China(No.52270034)State Key Laboratory of Urban Water Resource and Environment(No.2023TS16)。
文摘Approximately 99%of micro(nano)plastics in wastewater are retained in waste activated sludge,inhibiting anaerobic digestion,while their specific effects on functional microbes remain unclear.To break through the limitations of current knowledge,in this review,we focused on summarizing the impacts of micro(nano)plastics on the microbial communities within anaerobic digestion systems,analyzing the toxicity mechanisms and developing strategies to mitigate their inhibitory effects.Firstly,the impacts of micro(nano)plastics on methane production and functional microbes were summarized,including direct cell pitting effects,inhibition caused by toxic leachates,and the adsorption of pollutants onto micro(nano)plastics surfaces,which further interfere with microbial activity and metabolic processes.Then,the specific performances and potential mechanisms by which micro(nano)plastics affect microbes were innovatively analyzed from the aspects of community variation,cellular activity and genetic expression.Moreover,various factors of micro(nano)plastics were found to influence their effects on microbes,including hormesis-like effects at different dosages,increased toxicity with decreasing particle size,enhanced biotoxicity due to surface functional groups,and variations in toxicity based on morphology and aggregation state.Furthermore,potential mitigation strategies,including activated carbon addition,thermal hydrolysis and cationic polyacrylamide application,were firstly summarized in here to alleviate inhibition on microbe.Finally,the current challenges and future directions were fully discussed and prospected.These insights could not only elucidate the biotoxic effects of micro(nano)plastics,but also provide a new avenue for helping to develop effective remediation techniques in micro(nano)plastic pollution management.
基金supported by the National Natural Science Foundation of China (Grant No. 52275310)。
文摘The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are preferred. In order to achieve the transition from disordered pore formation to ordered pore formation, Al_(2)O_(3) ceramic cores with triply periodic minimal surface(TPMS) micro lattice structures with different structural configurations(gyroid, diamond, and neovius) and different volume fractions of lattice structures(30, 40, and 50, vol.%) were designed and prepared by vat photopolymerization 3D printing. The effects of structural configuration and volume fraction of the lattice structure on the following structural shrinkage, microstructure, and flexural strength were investigated. The shrinkage relationship of the three lattice configurations is: neovius>diamond>gyroid. Besides, it is found that with an increase in the volume fraction of the 3D printed Al_(2)O_(3) ceramic micro lattice structures, their fiexural strength correspondingly increases ranging from 54.95 MPa to 139.1 MPa. The maximum average fiexural strength of the 3D printed Al_(2)O_(3) ceramic micro lattice structures is obtained when the structural configuration is diamond and with a volume fraction of 50vol.%, which is 139.1 MPa. Even when the volume fraction of the lattice structure is 30vol.%, that is to say the porosity is 70%, the fiexural strength is as high as 50-70 MPa, which can still be maintained at a high level. In addition, when the volume fraction of the lattice structure is a certain value, the sample with diamond configuration has a higher strength. The internal pore morphology, pore size, and porosity of the cores are precisely controlled, achieving both a high porosity and a high strength. Therefore, this study maintains high porosity and high strength simultaneously, providing a new lattice structure design idea for 3D printed ceramic cores.
文摘The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several different bacteria,can actively contribute to the regulation of host metabolism,immunity,and inflammation.Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer.In particular,a causal relationship among ncRNAs,gut microbiota,and immune cells has been shown for their potential importance in the development of breast cancer.Alteration of ncRNA expression and/or gut microbiota profiles could also influence several intracellular signaling pathways with the function of anti-proliferative(APRO)family proteins associated with the malignancy.Targeting ncRNAs and/or APRO family proteins for the treatment of various cancers has been revealed with novel immune therapies.Here,the most recent studies to underline the key role of ncRNAs,APRO family proteins,and gut microbiota in breast cancer progression have been discussed.For more effective breast cancer therapy,it would be imperative to figure out the collective mechanism of ncRNAs,APRO family proteins,and gut microbiota.
