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基于DM2的异构数据一致性校验方法研究
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作者 朱文 方文崇 +3 位作者 周志峰 李文朝 攀腾飞 吴海勇 《自动化技术与应用》 2025年第2期75-79,共5页
随着物联网技术的快速发展,网络中存在大量的异构数据库,其异构性表现在多个方面。当数据库模式不同时,产生的数据类型也不尽相同,为保证数据的一致性,研究基于DM2的异构数据一致性校验方法。在异构系统中捕获异构数据包,通过良性和恶... 随着物联网技术的快速发展,网络中存在大量的异构数据库,其异构性表现在多个方面。当数据库模式不同时,产生的数据类型也不尽相同,为保证数据的一致性,研究基于DM2的异构数据一致性校验方法。在异构系统中捕获异构数据包,通过良性和恶意线程运行模式,分析异构数据的特点。划分异构数据类型,处理并计算数据值。基于DM2技术构建输出图,设定一致性校验原则。以校验原则为基础,构建一致性验证矩阵,实现异构数据的一致性校验。实验结果表明:在不同数据源的并发过程中,所提方法能够有效召回错误数据记录,且召回正确率均在95%以上,具有较好的应用效果。 展开更多
关键词 异构数据 一致性校验 校验方法 dm2技术
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沙格列汀与达格列净分别联合阿法骨化醇对T2DM性骨质疏松症患者疗效和25-羟维生素D水平,骨代谢指标的影响
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作者 吴静 姜惠 +2 位作者 王丽 束燕雯 孙璐 《现代生物医学进展》 2025年第3期468-473,共6页
目的:对比研究沙格列汀与达格列净分别联合阿法骨化醇对T2DM性骨质疏松症(DOP)患者疗效、25-羟维生素D[25(OH)D]及骨代谢指标的影响。方法:选入2021.4~2024.4收治的DOP患者84例,分为沙格列汀组(42例)和达格列净组(42例),两组均联合阿法... 目的:对比研究沙格列汀与达格列净分别联合阿法骨化醇对T2DM性骨质疏松症(DOP)患者疗效、25-羟维生素D[25(OH)D]及骨代谢指标的影响。方法:选入2021.4~2024.4收治的DOP患者84例,分为沙格列汀组(42例)和达格列净组(42例),两组均联合阿法骨化醇治疗。比较临床疗效、25(OH)D水平及骨代谢指标。结果:(1)两组治疗后FPG、2hPG、HbA1c降低(P<0.05),组间比较无差异(P>0.05)。(2)两组治疗后BMD、血清25(OH)D和OC升高,PINP降低(P<0.05),而沙格列汀组升高/降低幅度明显大于达格列净组(P<0.05);(3)沙格列汀组治疗总有效率显著高于达格列净组(95.24%vs.76.19%,P<0.05)。(4)两组均未见明显不良反应。结论:沙格列汀与达格列净均可有效控制血糖水平,而前者在增加BMD、改善骨代谢指标、提高DOP整体疗法方面更具优势。 展开更多
关键词 沙格列汀 达格列净 阿法骨化醇 T2dm 骨质疏松症 疗效 25(OH)D 骨代谢指标
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基于经典Hippo信号通路探索Neu-P11改善T2DM胰岛素抵抗的机制 被引量:1
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作者 李秀平 蔡世昌 +3 位作者 谢柳 贺娟 陈玲群 孟雯雯 《中国药理学通报》 CAS 北大核心 2025年第1期199-200,共2页
褪黑素(melatonin,Mel)是主要由松果体释放的一种循环激素,有一定的抗糖尿病作用,但其进入人体后,代谢较快,半衰期短,直接药用效果不明显,提取与合成较难,剂量过高还会产生副作用。Neu-P11是一种新式褪黑素非选择性受体激动剂,体外合成... 褪黑素(melatonin,Mel)是主要由松果体释放的一种循环激素,有一定的抗糖尿病作用,但其进入人体后,代谢较快,半衰期短,直接药用效果不明显,提取与合成较难,剂量过高还会产生副作用。Neu-P11是一种新式褪黑素非选择性受体激动剂,体外合成容易,作用时间持久,副作用小,能代替褪黑素,与其受体结合,发挥生物学作用[1]。 展开更多
关键词 Hippo信号通路 褪黑素 Neu-P11 dm T2dm 胰岛素抵抗
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磁共振IDEAL-IQ定量预测T2DM合并骨质疏松症患者骨折风险的价值
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作者 马娟 马依迪丽·尼加提 +6 位作者 马海婷 任镇伟 仇馨悦 栾丽 张梅 袁雁 郭辉 《中国CT和MRI杂志》 2025年第10期183-185,共3页
目的分析磁共振(MRI)非对称回波的最小二程估算法迭代水脂分离(IDEAL-IQ)预测T2DM合并骨质疏松症患者骨折风险的价值。方法选取2022年7月至2024年8月新疆医科大学附属中医医院影像中心收治的T2DM合并骨质疏松症患者148例为研究对象,依... 目的分析磁共振(MRI)非对称回波的最小二程估算法迭代水脂分离(IDEAL-IQ)预测T2DM合并骨质疏松症患者骨折风险的价值。方法选取2022年7月至2024年8月新疆医科大学附属中医医院影像中心收治的T2DM合并骨质疏松症患者148例为研究对象,依据是否发生椎体压缩性骨折分为骨折组(n=85)、无骨折组(n=63),均接受脊柱MRI IDEAL-IQ检查,测定L_(1-5)各椎体脂肪分数值(FF)及L_(1-5)椎体平均FF,比较骨折组、无骨折组骨代谢生化指标[25-(OH)D水平、β-胶原特殊序列(β-CTX)、Ⅰ型胶原氨基端延长肽(PⅠNP)]及骨密度(BMD)与IDEAL-IQ定量参数,分析FF值与各指标相关性,绘制受试者工作特征曲线(ROC)分析FF值对T2DM合并骨质疏松症患者骨折风险的预测价值。结果骨折组血清25-(OH)D、BMD低于无骨折组,而β-CTX、PⅠNP高于无骨折组(P<0.05);骨折组L1FF值、L2FF值及L_(1-5)椎体平均FF值均高于无骨折组(P<0.05);Pearson相关分析发现,T2DM合并骨质疏松症患者L1FF值、L2FF值及L_(1-5)椎体平均FF值均与25-(OH)D、BMD呈负相关,而与β-CTX、PⅠNP呈正相关(P<0.05);ROC显示,L1FF值、L2FF值及L_(1-5)椎体平均FF值预测T2DM合并骨质疏松症患者骨折风险的曲线下面积分别为0.791、0.806、0.876。结论MRI IDEAL-IQ定量预测T2DM合并骨质疏松症患者骨折风险的价值较高,值得在临床推广实践。 展开更多
关键词 磁共振 IDEAL-IQ T2dm 骨质疏松症 骨折风险
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Study of the Transport Behavior of Multispherical Proppant in Intersecting Fracture Based on Discrete Element Method 被引量:1
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作者 Chengyong Peng JianshuWu +2 位作者 Mao Jiang Biao Yin Yishan Lou 《Energy Engineering》 EI 2025年第1期185-201,共17页
To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fract... To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fractures,this study considered the combined impact of geological-engineering factors on conductivity.Using reservoir production parameters and the discrete elementmethod,multispherical proppants were constructed.Additionally,a 3D fracture model,based on the specified conditions of the L block,employed coupled(Computational Fluid Dynamics)CFD-DEM(Discrete ElementMethod)for joint simulations to quantitatively analyze the transport and placement patterns of multispherical proppants in intersecting fractures.Results indicate that turbulent kinetic energy is an intrinsic factor affecting proppant transport.Moreover,the efficiency of placement and migration distance of low-sphericity quartz sand constructed by the DEM in the main fracture are significantly reduced compared to spherical ceramic proppants,with a 27.7%decrease in the volume fraction of the fracture surface,subsequently affecting the placement concentration and damaging fracture conductivity.Compared to small-angle fractures,controlling artificial and natural fractures to expand at angles of 45°to 60°increases the effective support length by approximately 20.6%.During hydraulic fracturing of gas wells,ensuring the fracture support area and post-closure conductivity can be achieved by controlling the sphericity of proppants and adjusting the perforation direction to control the direction of artificial fractures. 展开更多
关键词 Hydraulic fracturing discrete element method PROPPANT SPHERICITY CFD-DEM
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黄芪葛根配伍通过调控线粒体自噬抑制铁死亡改善T2DM大鼠IR的机制研究
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作者 魏爽 章文春 +2 位作者 邢欢 西旺 郝峰 《中国医院药学杂志》 北大核心 2025年第9期1006-1014,共9页
目的:探讨黄芪葛根配伍改善2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠胰岛素抵抗(insulin resistance,IR)的作用机制。方法:将SD大鼠随机分为正常组与造模组,造模组采用高脂饮食联合STZ尾静脉注射法建立T2DM IR模型,成模大鼠随机... 目的:探讨黄芪葛根配伍改善2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠胰岛素抵抗(insulin resistance,IR)的作用机制。方法:将SD大鼠随机分为正常组与造模组,造模组采用高脂饮食联合STZ尾静脉注射法建立T2DM IR模型,成模大鼠随机分为模型(Model)、T2DM IR+黄芪葛根配伍(T2DM IR+QG)、T2DM IR+铁死亡抑制剂(T2DM IR+Fer-1)、T2DM IR+黄芪葛根配伍+铁死亡诱导剂(T2DM IR+QG+Erastin)、T2DM IR+线粒体自噬激动剂(T2DM IR+CCCP)、T2DM IR+黄芪葛根配伍+线粒体自噬抑制剂(T2DM IR+QG+3-MA)6组。使用血糖仪检测大鼠空腹血糖(FBG)水平、酶联免疫吸附法(ELISA)检测空腹胰岛素(FINS)水平并依据FBG及FINS值计算胰岛素敏感指数(ISI)及胰岛素抵抗指数(HOMA-IR);比色法检测肝组织超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、丙二醛(MDA)、铁离子(Fe2+)、铁(Fe)水平;流式细胞仪检测肝组织活性氧簇(ROS)水平;微板法检测肝脏组织还原型辅酶Ⅱ/辅酶Ⅱ(NADPH/NADP+)水平及极谱法检测线粒体RCR、ATP、MMP水平;透射电镜观察肝脏线粒体形态结构;蛋白免疫印迹法(Western blot)检测铁死亡及线粒体自噬相关蛋白水平。结果:与正常组相比,Model组FBG、FINS、MDA、ROS水平,HOMA-IR值,Fe2+及Fe含量,LC3Ⅱ、PINK1、Parkin、P62、ACSL4蛋白表达,以及LC3Ⅱ/LC3Ⅰ、NADPH/NADP+水平升高(P<0.05);GSH、SOD水平,胰岛素敏感指数对数(IAI)值,MMP、ATP、RCR水平,TOM20、TIM23、GPX4、FTH1、ACSL3、FTMT、xCT表达显著降低(P<0.01)。与Model组相比,T2DM IR+QG、T2DM IR+Fer-1及T2DM IR+CCCP组FBG、FINS、MDA、ROS、Fe2+及Fe水平,HOMAIR值,ACSL4表达,NADPH/NADP+水平降低(P<0.05);GPX4、FTH1、ACSL3、GSH、SOD、xCT水平及IAI值升高(P<0.05);T2DM IR+QG组FTMT表达显著升高(P<0.01);T2DM IR+CCCP组TOM20、P62蛋白表达降低(P<0.05);MMP、ATP、RCR水平,LC3Ⅱ、PINK1、Parkin蛋白表达及LC3Ⅱ/LC3Ⅰ水平显著升高(P<0.01)。透射电镜观察见正常组大鼠肝脏组织中线粒体大小、形态良好且分布于整个细胞质中,线粒体内外膜完整光滑,内部基质存在且分布均匀;模型组中见线粒体体积缩小,存在核周聚集,外膜不规则或碎裂。与模型组相比,T2DM IR+QG、T2DM IR+Fer-1与T2DM IR+CCCP组正常形态的线粒体比例明显增多,结构与分布整体有显著改善;而T2DM IR+QG+Erastin及T2DM IR+QG+3-MA组中线粒体形态结构未见改善,且损害更加严重。结论:黄芪葛根配伍提高胰岛素敏感性,改善IR,防治T2DM的作用可能是通过PINK1/Parkin通路调控线粒体自噬抑制铁死亡机制实现的。 展开更多
关键词 黄芪葛根配伍 线粒体自噬 铁死亡 PINK1/Parkin通路 T2dm 胰岛素抵抗
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低氧诱导自噬促进T2DM大鼠骨折愈合
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作者 沈佳康 李腾 +2 位作者 赵志坚 陈坤峰 徐继胜 《临床医学进展》 2025年第5期2239-2246,共8页
目的:研究低氧状态下自噬对2型糖尿病(Diabetes mellitus type 2, T2DM)合并股骨骨折大鼠模型不同时间点的骨折愈合程度及低氧诱导因子-1α (HIF-1α)、碱性磷酸酶(alkaline phosphatase, ALP)、Runt-相关转录因子-2 (Runx2)、微管相关... 目的:研究低氧状态下自噬对2型糖尿病(Diabetes mellitus type 2, T2DM)合并股骨骨折大鼠模型不同时间点的骨折愈合程度及低氧诱导因子-1α (HIF-1α)、碱性磷酸酶(alkaline phosphatase, ALP)、Runt-相关转录因子-2 (Runx2)、微管相关蛋白1A/1B-轻链3 (LC3II/I)表达情况。方法:大鼠随机分为高糖高脂饲养前(Control)组、高糖高脂饲养8周后(HFD)组及T2DM模型(T2DM)组,采用高糖髙脂饲料联合链脲佐菌素制备T2DM模型,在T2DM模型基础上制作股骨骨折模型。实验大鼠分为对照组(T2DM合并股骨骨折模型组,Model)及治疗组(氯化钴(CoCl2)治疗的T2DM合并股骨骨折模型组,Treatment),根据检测时间点每组继续分为造模后7 d、28 d、42 d的三个亚组。X线评估股骨愈合情况,WB检测HIF-1α、ALP、Runx2、LC3II/I表达。结果:T2DM合并股骨骨折模型随时间的增长,治疗组在第28 d相比于对照组已有较好的恢复,骨组织中ALP、Runx2表达增加,自噬蛋白LC3II/I的检测结果显示随时间增长自噬水平有所减弱。结论:低氧可以诱导自噬来促进T2DM大鼠骨折愈合。Objective: To investigate fracture healing and hypoxia-inducible factor-1α (HIF-1α), alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), and microtubule associated protein-II/I (LC3II/I) expression at different time points in T2DM rats with femoral fracture under hypoxic conditions. Methods: The rats were randomly divided into high-sugar and high-fat pre-feeding groups, high-sugar and high-fat feeding groups after 8 weeks of feeding and a T2DM model group, T2DM was prepared with high-glucose and high-fat diet combined with streptavidin. Femoral fractures were modeled on the basis of T2DM. Experimental rats were divided into a control group (T2DM with femoral fracture model group, Model) and a treatment group (CoCl2 treatment group, Treatment) and continued to be divided into three subgroups on days 7, 28, and 42 post-molecularization for each group at the time of measurement. Femoral healing was assessed by X-ray. HIF-1α, ALP, Runx2, and LC3II/I expression was measured by Western blotting. Result: In the T2DM combined femoral fracture model, as time progresses, the treatment group shows better recovery compared to the control group at day 28. The expression of ALP and Runx2 in bone tissue increases, and the detection results of autophagy protein LC3II/I indicate that autophagy levels weaken over time. Conclusion: Hypoxia can induce autophagy to promote fracture healing in T2DM rats. 展开更多
关键词 低氧 自噬 骨折愈合 T2dm合并骨折 低氧诱导因子
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运动联合二甲双胍对T2DM大鼠血糖及骨骼肌AMPK信号通路的影响
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作者 王宝明 常一行 +1 位作者 廉珍珍 衣雪洁 《锦州医科大学学报》 2025年第3期1-6,31,共7页
目的探讨运动联合二甲双胍是否通过修复2型糖尿病(type 2 diabetes mullitus,T2DM)大鼠骨骼肌腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路来调控血糖稳态,并进一步明确其是否具有叠加增效作用。方法55只刚断乳的SD... 目的探讨运动联合二甲双胍是否通过修复2型糖尿病(type 2 diabetes mullitus,T2DM)大鼠骨骼肌腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路来调控血糖稳态,并进一步明确其是否具有叠加增效作用。方法55只刚断乳的SD大鼠随机分为5组,分别为普通对照组(NC)、糖尿病对照组(DC)、糖尿病运动组(DE)、糖尿病药物组(DM)、糖尿病运动药物组(DEM)。建模成功后,DE组仅进行游泳训练;DM组仅给予二甲双胍干预(灌胃,剂量为500 mg/kg);DEM组同时进行游泳训练和二甲双胍干预。6周后,提取各组大鼠静脉血和腓肠肌样本,用于检测血糖水平、血清胰岛素浓度以及骨骼肌中LKB1/AMPK/GLUT4信号通路相关蛋白的表达水平。结果干预6周后,与NC组相比,DC组的血糖、胰岛素水平明显升高(P<0.05),与DC组相比,DEM组的血糖,DE组、DM组、DEM组的胰岛素水平明显降低(P<0.05);同时DEM组的葡萄糖清除率(glucose clearance rate,GCR)、肌糖原含量明显升高(P<0.05)。在骨骼肌中,与NC组相比,DC组的p-LKB1、AMPKα2、p-AMPKα2和GLUT4水平明显降低(P<0.05),与DC组相比,DE组的AMPKα2、GLUT4水平明显升高(P<0.05),DM组的p-LKB1、AMPKα2水平明显升高(P<0.05),DEM组的p-LKB1、AMPKα2、p-AMPKα2、GLUT4水平明显升高(P<0.05)。结论运动6周或二甲双胍干预可改善T2DM大鼠的高胰岛素血症,但单一干预的降糖效果不明显,可能受干预周期和样本数量限制。相比之下,联合干预6周可明显提高胰岛素敏感性并降低血糖水平,其机制或涉及p-LKB1介导的AMPK激活和GLUT4表达上调。未来应进一步探讨联合干预10周对骨骼肌糖氧化代谢的作用,以优化T2DM防治策略。 展开更多
关键词 T2dm 骨骼肌 联合干预 AMPK信号通路
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DM-Mpedia,一个用于制药污染微生物风险评估的数字化知识库
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作者 麻鲁鹏 李珏 +3 位作者 陈欢 王知坚 柴惠 刘程智 《药物分析杂志》 北大核心 2025年第6期1056-1066,共11页
目的:为识别制药环境中的污染微生物,并评估其对药品质量的影响,建立应对策略,提供信息参考。方法:对《伯杰氏系统细菌学手册》、权威文献、监督机构文件的收集、汇总、分析、提取,总结制药行业的微生物特性和风险信息注释模式,并通过... 目的:为识别制药环境中的污染微生物,并评估其对药品质量的影响,建立应对策略,提供信息参考。方法:对《伯杰氏系统细菌学手册》、权威文献、监督机构文件的收集、汇总、分析、提取,总结制药行业的微生物特性和风险信息注释模式,并通过对微生物关键特性信息的结构化,将其存储于基于MySQL的知识库管理系统。利用Vue+node.js进行前端设计、ECharts进行数据可视化,构建了便捷、可统计的综合性知识库。结果:获得包含20678个微生物物种特性及风险信息的查询云平台——DM-Mpedia(http://dmcloud.dmicrobe.cn/#/preview)。结论:DM-Mpedia的建立有助于微生物工作者对污染微生物及不可接受微生物进行更好的评估和控制。 展开更多
关键词 dm-Mpedia 微生物知识库 风险评估 不可接受微生物 制药环境
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Impact Force Localization and Reconstruction via ADMM-based Sparse Regularization Method
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作者 Yanan Wang Lin Chen +3 位作者 Junjiang Liu Baijie Qiao Weifeng He Xuefeng Chen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期170-188,共19页
In practice,simultaneous impact localization and time history reconstruction can hardly be achieved,due to the illposed and under-determined problems induced by the constrained and harsh measuring conditions.Although ... In practice,simultaneous impact localization and time history reconstruction can hardly be achieved,due to the illposed and under-determined problems induced by the constrained and harsh measuring conditions.Although l_(1) regularization can be used to obtain sparse solutions,it tends to underestimate solution amplitudes as a biased estimator.To address this issue,a novel impact force identification method with l_(p) regularization is proposed in this paper,using the alternating direction method of multipliers(ADMM).By decomposing the complex primal problem into sub-problems solvable in parallel via proximal operators,ADMM can address the challenge effectively.To mitigate the sensitivity to regularization parameters,an adaptive regularization parameter is derived based on the K-sparsity strategy.Then,an ADMM-based sparse regularization method is developed,which is capable of handling l_(p) regularization with arbitrary p values using adaptively-updated parameters.The effectiveness and performance of the proposed method are validated on an aircraft skin-like composite structure.Additionally,an investigation into the optimal p value for achieving high-accuracy solutions via l_(p) regularization is conducted.It turns out that l_(0.6)regularization consistently yields sparser and more accurate solutions for impact force identification compared to the classic l_(1) regularization method.The impact force identification method proposed in this paper can simultaneously reconstruct impact time history with high accuracy and accurately localize the impact using an under-determined sensor configuration. 展开更多
关键词 Impact force identification Non-convex sparse regularization Alternating direction method of multipliers Proximal operators
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功法静力性训练通过PINK1/Parkin通路调控T2DM小鼠骨骼肌线粒体自噬的作用机制
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作者 甘丽祯 吴霞 +4 位作者 陈沛 章志 陈哲炜 韦庆波 吴云川 《南京中医药大学学报》 北大核心 2025年第2期151-159,共9页
目的探讨功法静力性训练通过PTEN诱导的激酶1(PINK1)/帕金蛋白(Parkin)通路调控线粒体自噬在2型糖尿病(T2DM)骨骼肌胰岛素抵抗中的作用机制。方法采用高脂饮食联合链脲佐菌素(STZ)腹腔注射建立T2DM小鼠模型,随机分为模型组、二甲双胍组... 目的探讨功法静力性训练通过PTEN诱导的激酶1(PINK1)/帕金蛋白(Parkin)通路调控线粒体自噬在2型糖尿病(T2DM)骨骼肌胰岛素抵抗中的作用机制。方法采用高脂饮食联合链脲佐菌素(STZ)腹腔注射建立T2DM小鼠模型,随机分为模型组、二甲双胍组、有氧运动组和功法静力性训练组。通过检测血糖、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、脂质代谢指标以及腓肠肌线粒体功能和PINK1、Parkin相关基因和蛋白表达,评估功法静力性训练的干预效果。结果功法静力性训练显著降低了T2DM小鼠的FBG、糖化血红蛋白及胰岛素抵抗指数,改善了脂质代谢,并增强了胰岛素敏感性,通过上调PINK1、Parkin的mRNA和蛋白表达,改善腓肠肌线粒体的结构和功能。结论功法静力性训练通过调控PINK1/Parkin通路,改善了T2DM小鼠骨骼肌线粒体功能和胰岛素抵抗。 展开更多
关键词 功法静力性训练 线粒体自噬 T2dm HOMA-IR HbA1c PINK1 PARKIN
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Combing the Entropy Weight Method with Fuzzy Mathematics for Assessing the Quality and Post-Ripening Mechanism of High-Temperature Daqu during Storage 被引量:1
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作者 YANG Junlin YANG Shaojuan +8 位作者 WU Cheng YIN Yanshun YOU Xiaolong ZHAO Wenyu ZHU Anran WANG Jia HU Feng HU Jianfeng WANG Diqiang 《食品科学》 北大核心 2025年第9期48-62,共15页
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar... This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu. 展开更多
关键词 microbial community high-temperature Daqu comprehensive quality evaluation entropy weight method maturation process
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In situ stress inversion using nonlinear stress boundaries achieved by the bubbling method 被引量:1
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作者 Xige Liu Chenchun Huang +3 位作者 Wancheng Zhu Joung Oh Chengguo Zhang Guangyao Si 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1510-1527,共18页
Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this cha... Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this challenge,nonlinear stress boundaries for a numerical model are determined through regression analysis of a series of nonlinear coefficient matrices,which are derived from the bubbling method.Considering the randomness and flexibility of the bubbling method,a parametric study is conducted to determine recommended ranges for these parameters,including the standard deviation(σb)of bubble radii,the non-uniform coefficient matrix number(λ)for nonlinear stress boundaries,and the number(m)and positions of in situ stress measurement points.A model case study provides a reference for the selection of these parameters.Additionally,when the nonlinear in situ stress inversion method is employed,stress distortion inevitably occurs near model boundaries,aligning with the Saint Venant's principle.Two strategies are proposed accordingly:employing a systematic reduction of nonlinear coefficients to achieve high inversion accuracy while minimizing significant stress distortion,and excluding regions with severe stress distortion near the model edges while utilizing the central part of the model for subsequent simulations.These two strategies have been successfully implemented in the nonlinear in situ stress inversion of the Xincheng Gold Mine and have achieved higher inversion accuracy than the linear method.Specifically,the linear and nonlinear inversion methods yield root mean square errors(RMSE)of 4.15 and 3.2,and inversion relative errors(δAve)of 22.08%and 17.55%,respectively.Therefore,the nonlinear inversion method outperforms the traditional multiple linear regression method,even in the presence of a systematic reduction in the nonlinear stress boundaries. 展开更多
关键词 In situ stress field Inversion method The bubbling method Nonlinear stress boundary Multiple linear regression method
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一种输出参数可调的ADM-MPPT方法
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作者 孔德彭 孙玉婷 董琦 《浙江工业大学学报》 北大核心 2025年第2期171-178,196,共9页
光伏发电系统的发电效率与最大功率点的捕捉与跟踪技术密切相关。当辐照度、温度及其他外部环境变化时,光伏电池的开路电压、短路电流和最大功率点电压及电流也随之变化。为提高光伏发电效率,寻求光伏电池的最优工作状态,大多数的最大... 光伏发电系统的发电效率与最大功率点的捕捉与跟踪技术密切相关。当辐照度、温度及其他外部环境变化时,光伏电池的开路电压、短路电流和最大功率点电压及电流也随之变化。为提高光伏发电效率,寻求光伏电池的最优工作状态,大多数的最大功率点跟踪(Maximum power point tracking,MPPT)主要作用于DC-DC变换器的输入端,该方式在MPPT时会受到变换器损耗的影响,降低最大功率点寻优精度。基于Boost电路,在DC-DC变换器的输出端搭建MPPT系统,通过调节输出电压参数来实现对效果变化的控制,且在MPPT系统引入了导纳微分法(Admittance differentiation method,ADM),实现对MPPT控制器的重构,实施中搭建不同的仿真模型,再借助仿真模型达到对ADM的修正与优化,综合论证该方法具有更优的指标和更好的效果。 展开更多
关键词 光伏发电 导纳微分法 MPPT BOOST电路
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基于客观化多模态数据融合的T2DM血瘀证诊断模型构建
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作者 丁艳 王烨 +1 位作者 刘佳 汪南玥 《中国中医基础医学杂志》 2025年第9期1592-1598,共7页
目的基于客观化多模态数据融合构建2型糖尿病(type 2 diabetes mellitus,T2DM)血瘀证诊断模型。方法纳入2020年10月—2024年7月全国各医疗机构及社区筛选的676例T2DM患者,分为血瘀证组和非血瘀证组。采用四诊设备采集T2DM的客观化四诊信... 目的基于客观化多模态数据融合构建2型糖尿病(type 2 diabetes mellitus,T2DM)血瘀证诊断模型。方法纳入2020年10月—2024年7月全国各医疗机构及社区筛选的676例T2DM患者,分为血瘀证组和非血瘀证组。采用四诊设备采集T2DM的客观化四诊信息,构建T2DM中医客观化四诊数据库;然后进行数据处理,在单模态分析上,脉诊采用主成分分析(PCA)、最小二乘回归(LS)与套索回归(Lasso)等方法进行判别;舌诊采用卷积神经网络进行分类;在多模态建模上,通过深度学习对T2DM血瘀证人群的脉、舌、声音等多源信息以全连接层与问诊进行拼接,从而实现诊断模型的构建。结果在脉诊分析方面,血瘀证组和非血瘀证组的脉诊信息具有显著差异,区别两组的PCA差异主要为第6、7主成分,LS及Lasso分类判别准确率分别为75%和67%,与非血瘀证组的时域参数相比,血瘀证组两手关脉力h1、S、S2明显降低,而左手尺脉力h1、S、S1、S2及右手尺t1、S1显著升高,同时频域参数差异主要分布于两手寸尺、左手关。在舌诊分析方面,与非血瘀证组相比,血瘀证组的舌下络脉的平均血管宽度、血管宽度变异度变化更大,具有显著差异;在声诊分析方面,注意力热图的时间分布特征分析表明,血瘀证组和非血瘀证组的语音特征存在显著差异。此外,血瘀证组单模态辨别准确率低于多模态组合;最优模态组合(舌诊+脉诊+问诊+声诊)准确率达到86.12%。结论基于多模态数据融合的诊断模型能有效实现T2DM血瘀证的客观化辨识,为中医证候诊断的客观化研究提供了科学依据。 展开更多
关键词 T2dm 血瘀证 四诊客观化 多模态数据融合 诊断模型
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Biotransformation of minocycline by a novel strain Kluyvera sp.DM13 isolated from municipal sludge:Performances,removal pathways,and toxicity 被引量:1
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作者 Xingdu Chen Mengzhu Yu +4 位作者 Hui Jiang Xin Liu Xinting Ma Hao Jiang Jinsuo Lu 《Journal of Environmental Sciences》 2025年第8期509-520,共12页
Minocycline has been widely used in clinical treatment and its residues were considered to have environmental safety risks due to complex chemical structure.Therefore,it is necessary to find an efficient and environme... Minocycline has been widely used in clinical treatment and its residues were considered to have environmental safety risks due to complex chemical structure.Therefore,it is necessary to find an efficient and environmentally friendly method to remove minocycline from the environment.This study screened and isolated a minocycline degrading strain DM13 from the activated sludge for municipal sewage pipeline,and optimized the biodegradation of minocycline by DM13 under various environmental conditions.The maximum biodegradation efficiency of 50 mg/L minocycline reached 93%at 72 h with the temperature of 30℃,the initial pH of 7.0,and the inoculation rate of 3%.Two potential biotransformation pathways were proposed,including deamination,demethylation,and decarbonylation.The acute toxicity assessment showed that the biotransformation products of minocycline had lower toxicity than the parent compound.In addition,the first-generation tetracycline antibiotics could be removed,suggesting that strain DM13 has the potential for application in treating antibiotic wastewater. 展开更多
关键词 MINOCYCLINE BIOTRANSFORMATION Biotransformation pathway Kluyvera sp.dm13
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Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates
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作者 Yufeng Xing Ye Yuan Gen Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期329-355,共27页
The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytica... The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical shells.By taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue equations.Besides,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are investigated.It is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well. 展开更多
关键词 Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method
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Improved methods,properties,applications and prospects of microbial induced carbonate precipitation(MICP)treated soil:A review 被引量:2
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作者 Xuanshuo Zhang Hongyu Wang +3 位作者 Ya Wang Jinghui Wang Jing Cao Gang Zhang 《Biogeotechnics》 2025年第1期34-54,共21页
Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vi... Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications. 展开更多
关键词 Soil improvement Bio-cement MICP Improved methods Field application cases
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脱硫废水DM一体化预处理技术应用及运行探讨
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作者 陈亚飞 牛万忠 《资源节约与环保》 2025年第3期69-73,共5页
以金陵公司石化石灰石-石膏湿法脱硫废水处理为例,简述脱硫废水水质特点及其预处理的必要性,从工艺流程、运行成本、稳定性和处理效果等方面对比传统三联箱技术和DM一体化预处理技术;介绍DM一体化预处理技术工艺流程和实际投运过程中出... 以金陵公司石化石灰石-石膏湿法脱硫废水处理为例,简述脱硫废水水质特点及其预处理的必要性,从工艺流程、运行成本、稳定性和处理效果等方面对比传统三联箱技术和DM一体化预处理技术;介绍DM一体化预处理技术工艺流程和实际投运过程中出现的问题,并提出合理的改进措施,达到连续稳定运行的目的,从而实现脱硫废水悬浮物和重金属等污染因子的达标排放,为电厂后续脱硫废水零排放处理创造良好的基础条件。 展开更多
关键词 脱硫废水 dm一体化 预处理 达标排放
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一种基于Least Square Method算法的城轨车辆车门动作时间精准判断的研究
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作者 李宏菱 宋华杰 +3 位作者 马仲智 周辉 李晴 陈龙 《时代汽车》 2025年第3期190-192,共3页
为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波... 为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波形矫正模型,利用数学方法校准波形,让MCU找出最佳计时点并处理(误差不超过10ms),采用最小二乘法模型,通过最小化误差的平方和找到一组数据的最佳函数匹配,求得未知的数据,并使得这些求得的数据与实际数据之间误差的平方和为最小,可精准地得到门动作时间。模拟测试结果表明,门动作时间测算误差所示其误差为7.42ms,小于10ms。 展开更多
关键词 城轨车辆 客室车门 电机码盘 Least Square method算法 门动作时间精准
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