Emerging evidence suggests that metabolic signals regulate mitochondrial homeostasis,with mitochondria-derived vesicles(MDVs)serving as a critical link between metabolites and mitochondrial quality control.In a recent...Emerging evidence suggests that metabolic signals regulate mitochondrial homeostasis,with mitochondria-derived vesicles(MDVs)serving as a critical link between metabolites and mitochondrial quality control.In a recent study,Tang et al.uncovered a novel mechanism in which metabolites modulate mitochondrial homeostasis throughβ-hydroxybutyrylation of sorting nexin 9(SNX9),thereby promoting MDV biogenesis[1].展开更多
基金supported by research grants from the National Natural Science Foundation of China(32470795)the Guangdong Basic and Applied Basic Research Foundation(2025A1515010506 and 2022A1515111047)+4 种基金the Guangzhou Basic and Applied Basic Research Foundation(2023A04J1951)the Fundamental Research Funds for the Central UniversitiesSun Yat-sen University(24pnpy249)supported by the following research grants from University of Macao(CPG2025-0031-FHS and UM-MYRG2020-00022-FHS)the Macao Science and Technology Development Fund(FDCT0078/2020/A2,FDCT0031/2021/A1,FDCT0081/2022/AMJ,and FDCT 0004/2021/AKP)。
文摘Emerging evidence suggests that metabolic signals regulate mitochondrial homeostasis,with mitochondria-derived vesicles(MDVs)serving as a critical link between metabolites and mitochondrial quality control.In a recent study,Tang et al.uncovered a novel mechanism in which metabolites modulate mitochondrial homeostasis throughβ-hydroxybutyrylation of sorting nexin 9(SNX9),thereby promoting MDV biogenesis[1].
