摘要
Emerging evidence suggests that metabolic signals regulate mitochondrial homeostasis,with mitochondria-derived vesicles(MDVs)serving as a critical link between metabolites and mitochondrial quality control.In a recent study,Tang et al.uncovered a novel mechanism in which metabolites modulate mitochondrial homeostasis throughβ-hydroxybutyrylation of sorting nexin 9(SNX9),thereby promoting MDV biogenesis[1].
基金
supported by research grants from the National Natural Science Foundation of China(32470795)
the Guangdong Basic and Applied Basic Research Foundation(2025A1515010506 and 2022A1515111047)
the Guangzhou Basic and Applied Basic Research Foundation(2023A04J1951)
the Fundamental Research Funds for the Central Universities
Sun Yat-sen University(24pnpy249)
supported by the following research grants from University of Macao(CPG2025-0031-FHS and UM-MYRG2020-00022-FHS)
the Macao Science and Technology Development Fund(FDCT0078/2020/A2,FDCT0031/2021/A1,FDCT0081/2022/AMJ,and FDCT 0004/2021/AKP)。
