背景:急性缺血性脑卒中是各种原因导致的脑组织血液供应障碍,并由此产生缺血缺氧性坏死,进而出现神经功能障碍的一组临床综合征。方法:进行前瞻性随机对照临床试验,病例来源于乌鲁木齐市友谊医院急诊科就诊的前循环AIS患者。采用16 cm宽...背景:急性缺血性脑卒中是各种原因导致的脑组织血液供应障碍,并由此产生缺血缺氧性坏死,进而出现神经功能障碍的一组临床综合征。方法:进行前瞻性随机对照临床试验,病例来源于乌鲁木齐市友谊医院急诊科就诊的前循环AIS患者。采用16 cm宽体CT (Revolution CT, GE, USA)进行扫描,图像后处理。通过ASPECTS评分方法,CTP各参数的计算方法,常规mCTA软脑膜侧枝评分进行影像评估。由两名经验丰富的放射科医生,在不知道患者临床结果及临床评分的情况下,间隔一定时间,将患者各种图像进行评分。对主要结局指标及随访指标进行数据分析。结果:AIS患者得到的图像质量良好,并请影像科及神经内科医生按课题设计的研究方法进行阅片,阅片的结果比较接近:ColorVizmCTA图像的解读较常规mCTA、CTP图像更简单、直观、迅速、可操作性强,对医生的基础及背景要求不高,而且大部分医生的诊断一致性好。用ColorVizmCTA图像诊断结果与用常规mCTA、CTP诊断的结果一致性较好。结论:ColorVizmCTA图像的解读较常规mCTA、CTP图像更简单、直观、迅速、可操作性强。ColorViz mCTA对于前循环AIS患者的侧枝循环的评价效能与常规mCTA具有良好的一致性,对患者最终梗死体积的预测与CTP参数的评估一致性良好。Background: Acute ischemic stroke is a group of clinical syndromes in which the blood supply of brain tissue is impaired due to various causes, which leads to hypoxic-ischemic necrosis, and then neurological dysfunction. Methods: A prospective randomized controlled clinical trial was conducted. Patients with anterior circulation AIS were recruited from the emergency department of Urumqi Friendship Hospital. Scanning was performed on a 16 cm wide-body CT (Revolution CT, GE, USA), and the images were post-processed. The ASPECTS score method, CTP parameter calculation method, and conventional mCTA leptomeningeal collateral score were used for imaging evaluation. The images of the patients were scored by two experienced radiologists at a certain interval without knowing the clinical results and clinical scores of the patients. The primary outcome indicators and follow-up indicators were analyzed. Results: The quality of the images obtained from AIS patients was good, and the results were similar when the images were read by radiologists and neurologists according to the study design. The interpretation of ColorViz mCTA images is simpler, more intuitive, faster and more operable than conventional mCTA and CTP images. It does not require high basic and background requirements for doctors, and most doctors have good diagnostic consistency. The diagnostic results of ColorViz mCTA images were consistent with those of conventional mCTA and CTP images. Conclusion: ColorViz mCTA image interpretation is simpler, more intuitive, faster and more maneuverable than conventional mCTA and CTP images. ColorViz mCTA is in good agreement with conventional mCTA in evaluating the collateral circulation of patients with anterior circulation AIS. The prediction of the final infarct volume of patients is in good agreement with the evaluation of CTP parameters.展开更多
背景:越来越多的青壮年患者在接受全髋关节置换术(total hip arthroplasty,THA)中使用羟基磷灰石(hydroxyapatite,HA)涂层股骨柄假体,评价HA涂层多孔股骨柄假体的相关临床对照研究的报道并不完全一致,且样本量较少,存在一定局限性。目的...背景:越来越多的青壮年患者在接受全髋关节置换术(total hip arthroplasty,THA)中使用羟基磷灰石(hydroxyapatite,HA)涂层股骨柄假体,评价HA涂层多孔股骨柄假体的相关临床对照研究的报道并不完全一致,且样本量较少,存在一定局限性。目的:通过Meta分析评价THA使用HA涂层股骨柄假体的有效性及安全性。方法:计算机检索数据库Medline(1966年至2012年2月)、PubMed(1966年至2012年2月)、Embase(1966年至2012年2月)、Cochrane图书馆(2011年第4期)、中国生物医学光盘数据库(1978年至2012年2月)、中国生物医学文献数据库(1978年至2012年2月)和维普中文科技期刊数据库(1978年至2012年2月),收集THA使用HA涂层股骨柄假体和多孔股骨柄假体的临床随机对照试验,提取数据进行分析,采用统计软件RevMan5.1进行Meta分析。结果:共纳入10个随机对照研究,其中试验组480例,对照组478例。Meta分析结果显示,与对照组相比,接受HA涂层股骨柄假体的患者THA术后Harris评分无统计学差异(均数差=1.49,95%置信区间[-2.32,5.31],P=0.44),周围透光线的发生率无统计学差异(优势比=1.06,95%置信区间[0.76,1.48],P=0.74),点焊现象发生率无统计学差异(优势比=1.09,95%置信区间[0.74,1.62],P=0.66)。结论:HA喷涂于股骨柄假体多孔表面,对于初次THA无临床益处。限于纳入文献的数量和质量,Meta分析结果尚有待于更多高质量大样本随机对照试验以予证实。展开更多
文摘背景:急性缺血性脑卒中是各种原因导致的脑组织血液供应障碍,并由此产生缺血缺氧性坏死,进而出现神经功能障碍的一组临床综合征。方法:进行前瞻性随机对照临床试验,病例来源于乌鲁木齐市友谊医院急诊科就诊的前循环AIS患者。采用16 cm宽体CT (Revolution CT, GE, USA)进行扫描,图像后处理。通过ASPECTS评分方法,CTP各参数的计算方法,常规mCTA软脑膜侧枝评分进行影像评估。由两名经验丰富的放射科医生,在不知道患者临床结果及临床评分的情况下,间隔一定时间,将患者各种图像进行评分。对主要结局指标及随访指标进行数据分析。结果:AIS患者得到的图像质量良好,并请影像科及神经内科医生按课题设计的研究方法进行阅片,阅片的结果比较接近:ColorVizmCTA图像的解读较常规mCTA、CTP图像更简单、直观、迅速、可操作性强,对医生的基础及背景要求不高,而且大部分医生的诊断一致性好。用ColorVizmCTA图像诊断结果与用常规mCTA、CTP诊断的结果一致性较好。结论:ColorVizmCTA图像的解读较常规mCTA、CTP图像更简单、直观、迅速、可操作性强。ColorViz mCTA对于前循环AIS患者的侧枝循环的评价效能与常规mCTA具有良好的一致性,对患者最终梗死体积的预测与CTP参数的评估一致性良好。Background: Acute ischemic stroke is a group of clinical syndromes in which the blood supply of brain tissue is impaired due to various causes, which leads to hypoxic-ischemic necrosis, and then neurological dysfunction. Methods: A prospective randomized controlled clinical trial was conducted. Patients with anterior circulation AIS were recruited from the emergency department of Urumqi Friendship Hospital. Scanning was performed on a 16 cm wide-body CT (Revolution CT, GE, USA), and the images were post-processed. The ASPECTS score method, CTP parameter calculation method, and conventional mCTA leptomeningeal collateral score were used for imaging evaluation. The images of the patients were scored by two experienced radiologists at a certain interval without knowing the clinical results and clinical scores of the patients. The primary outcome indicators and follow-up indicators were analyzed. Results: The quality of the images obtained from AIS patients was good, and the results were similar when the images were read by radiologists and neurologists according to the study design. The interpretation of ColorViz mCTA images is simpler, more intuitive, faster and more operable than conventional mCTA and CTP images. It does not require high basic and background requirements for doctors, and most doctors have good diagnostic consistency. The diagnostic results of ColorViz mCTA images were consistent with those of conventional mCTA and CTP images. Conclusion: ColorViz mCTA image interpretation is simpler, more intuitive, faster and more maneuverable than conventional mCTA and CTP images. ColorViz mCTA is in good agreement with conventional mCTA in evaluating the collateral circulation of patients with anterior circulation AIS. The prediction of the final infarct volume of patients is in good agreement with the evaluation of CTP parameters.
文摘背景:越来越多的青壮年患者在接受全髋关节置换术(total hip arthroplasty,THA)中使用羟基磷灰石(hydroxyapatite,HA)涂层股骨柄假体,评价HA涂层多孔股骨柄假体的相关临床对照研究的报道并不完全一致,且样本量较少,存在一定局限性。目的:通过Meta分析评价THA使用HA涂层股骨柄假体的有效性及安全性。方法:计算机检索数据库Medline(1966年至2012年2月)、PubMed(1966年至2012年2月)、Embase(1966年至2012年2月)、Cochrane图书馆(2011年第4期)、中国生物医学光盘数据库(1978年至2012年2月)、中国生物医学文献数据库(1978年至2012年2月)和维普中文科技期刊数据库(1978年至2012年2月),收集THA使用HA涂层股骨柄假体和多孔股骨柄假体的临床随机对照试验,提取数据进行分析,采用统计软件RevMan5.1进行Meta分析。结果:共纳入10个随机对照研究,其中试验组480例,对照组478例。Meta分析结果显示,与对照组相比,接受HA涂层股骨柄假体的患者THA术后Harris评分无统计学差异(均数差=1.49,95%置信区间[-2.32,5.31],P=0.44),周围透光线的发生率无统计学差异(优势比=1.06,95%置信区间[0.76,1.48],P=0.74),点焊现象发生率无统计学差异(优势比=1.09,95%置信区间[0.74,1.62],P=0.66)。结论:HA喷涂于股骨柄假体多孔表面,对于初次THA无临床益处。限于纳入文献的数量和质量,Meta分析结果尚有待于更多高质量大样本随机对照试验以予证实。
